{"id":"https://openalex.org/W7214094755","doi":"https://doi.org/10.64898/2026.09.22.26363720","title":"Alcohol use disorder accelerates age-related cognitive decline","display_name":"Alcohol use disorder accelerates age-related cognitive decline","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214094755","doi":"https://doi.org/10.64898/2026.09.22.26363720","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622372"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.26363720","doi":"https://doi.org/10.64898/2026.09.22.26363720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363720","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.22.26363720.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.22.26363720.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023228841","display_name":"Sarah M. Hartz","orcid":"https://orcid.org/0000-0002-5429-3799","observed_orcids":["https://orcid.org/0000-0002-5429-3799"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah M. Hartz","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":"https://orcid.org/0000-0002-5429-3799","affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128350586","display_name":"Jacquelyn Meyers","orcid":"https://orcid.org/0000-0003-3863-8555","observed_orcids":["https://orcid.org/0000-0003-3863-8555"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacquelyn Meyers","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078607124","display_name":"Martin Henry Plawecki","orcid":"https://orcid.org/0000-0003-0708-9514","observed_orcids":["https://orcid.org/0000-0003-0708-9514"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin H. Plawecki","raw_affiliation_strings":["Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034870861","display_name":"Kathleen Keenan Bucholz","orcid":"https://orcid.org/0000-0003-3794-0736","observed_orcids":["https://orcid.org/0000-0003-3794-0736"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen K. Bucholz","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022474851","display_name":"Grace Chan","orcid":"https://orcid.org/0000-0002-1257-6889","observed_orcids":["https://orcid.org/0000-0002-1257-6889"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Chan","raw_affiliation_strings":["University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021811638","display_name":"Danielle M. Dick","orcid":"https://orcid.org/0000-0002-1636-893X","observed_orcids":["https://orcid.org/0000-0002-1636-893X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle Dick","raw_affiliation_strings":["Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Wood Johnson Medical School","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138672121","display_name":"Fanghong Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanghong Dong","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044635265","display_name":"Howard J. Edenberg","orcid":"https://orcid.org/0000-0003-0344-9690","observed_orcids":["https://orcid.org/0000-0003-0344-9690"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Edenberg","raw_affiliation_strings":["Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116178191","display_name":"Christina Elizabeth Garasky","orcid":"https://orcid.org/0000-0002-0453-5796","observed_orcids":["https://orcid.org/0000-0002-0453-5796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Garasky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012200474","display_name":"Emma C. Johnson","orcid":"https://orcid.org/0000-0003-0394-777X","observed_orcids":["https://orcid.org/0000-0003-0394-777X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Johnson","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077384411","display_name":"Chella Kamarajan","orcid":"https://orcid.org/0000-0003-2291-6880","observed_orcids":["https://orcid.org/0000-0003-2291-6880"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chella Kamarajan","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":"https://orcid.org/0000-0003-2291-6880","affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026092513","display_name":"Sivan Kinreich","orcid":"https://orcid.org/0000-0001-6480-1622","observed_orcids":["https://orcid.org/0000-0001-6480-1622"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sivan Kinreich","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069777857","display_name":"John R. Kramer","orcid":"https://orcid.org/0000-0002-1321-7087","observed_orcids":["https://orcid.org/0000-0002-1321-7087"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Kramer","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043678926","display_name":"Jodi Kutzner","orcid":"https://orcid.org/0000-0002-0073-1298","observed_orcids":["https://orcid.org/0000-0002-0073-1298"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jodi Kutzner","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072244208","display_name":"Alex P. Miller","orcid":"https://orcid.org/0000-0001-9163-8947","observed_orcids":["https://orcid.org/0000-0001-9163-8947"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex P. Miller","raw_affiliation_strings":["Indiana University"],"raw_orcid":"https://orcid.org/0000-0001-9163-8947","affiliations":[{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059899924","display_name":"Zoe E. Neale","orcid":"https://orcid.org/0000-0001-6440-2445","observed_orcids":["https://orcid.org/0000-0001-6440-2445"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoe Neale","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152525731","display_name":"Ashwini Pandey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwini Pandey","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010945910","display_name":"Gayathri Pandey","orcid":"https://orcid.org/0000-0003-0889-3117","observed_orcids":["https://orcid.org/0000-0003-0889-3117"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayathri Pandey","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134575852","display_name":"Gita Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gita Pathak","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000611728","display_name":"Jessica E. Salvatore","orcid":"https://orcid.org/0000-0001-5504-5087","observed_orcids":["https://orcid.org/0000-0001-5504-5087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica E. Salvatore","raw_affiliation_strings":["Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Wood Johnson Medical School","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064307399","display_name":"Marc Alan Schuckit","orcid":"https://orcid.org/0000-0002-2323-7858","observed_orcids":["https://orcid.org/0000-0002-2323-7858"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc A. Schuckit","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113890481","display_name":"Maggie Clapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggie Clapp Sullivan","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046860140","display_name":"Andrey P. Anokhin","orcid":"https://orcid.org/0000-0001-8158-6346","observed_orcids":["https://orcid.org/0000-0001-8158-6346"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey Anokhin","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085626269","display_name":"Bernice Porjesz","orcid":"https://orcid.org/0000-0003-2489-0389","observed_orcids":["https://orcid.org/0000-0003-2489-0389"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernice Porjesz","raw_affiliation_strings":["SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077159635","display_name":"Laura Jean Bierut","orcid":"https://orcid.org/0000-0002-9952-4810","observed_orcids":["https://orcid.org/0000-0002-9952-4810"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura J. Bierut","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023228841"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age-related-cognitive-decline","display_name":"age-related cognitive decline","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.640999972820282},{"id":"https://openalex.org/keywords/fluid-intelligence","display_name":"fluid intelligence","score":0.7059999704360962},{"id":"https://openalex.org/keywords/crystallized-intelligence","display_name":"crystallized intelligence","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6389999985694885},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.8650000095367432},{"id":"https://openalex.org/keywords/alcohol-consumption-patterns","display_name":"alcohol consumption patterns","score":0.6629999876022339},{"id":"https://openalex.org/keywords/nih-toolbox-cognition-battery","display_name":"NIH Toolbox Cognition Battery","score":0.6420000195503235},{"id":"https://openalex.org/keywords/collaborative-study-on-the-genetics-of-alcoholism","display_name":"Collaborative Study on the Genetics of Alcoholism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/neurocognitive-impairment","display_name":"neurocognitive impairment","score":0.6809999942779541},{"id":"https://openalex.org/keywords/alcohol-related-brain-damage","display_name":"alcohol-related brain damage","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.7451000213623047},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6887000203132629},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.6617000102996826},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6381000280380249},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.49059998989105225},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.48829999566078186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4763000011444092},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.428600013256073},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.42340001463890076},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.40610000491142273},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38929998874664307},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C2986811735","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Cognitive aging","level":3,"score":0.3727000057697296},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.3612000048160553},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.32749998569488525},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.22.26363720","doi":"https://doi.org/10.64898/2026.09.22.26363720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363720","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.22.26363720.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42818401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622372","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622372/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.26363720","doi":"https://doi.org/10.64898/2026.09.22.26363720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363720","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.22.26363720.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3455473179","display_name":null,"funder_award_id":"UL1 TR002345","funder_id":"https://openalex.org/F4320310181","funder_display_name":"Institute of Clinical and Translational Sciences"},{"id":"https://openalex.org/G7799114258","display_name":"Investigating the longitudinal relationship between alcohol use, neurophysiological functioning, and Alzheimer disease biomarkers in the Collaborative Study on the Genetics of Alcoholism","funder_award_id":"R01AA029308","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000893777","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR002345","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000914127","display_name":"Collaborative Study on the Genetics of Alcoholism (COGA).","funder_award_id":"U10AA008401","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000915971","display_name":"Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study","funder_award_id":"P01AG026276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310181","display_name":"Institute of Clinical and Translational Sciences","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214094755.pdf","grobid_xml":"https://content.openalex.org/works/W7214094755.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1991038807","https://openalex.org/W2004927913","https://openalex.org/W2061475982","https://openalex.org/W2085143064","https://openalex.org/W2097544796","https://openalex.org/W2099117009","https://openalex.org/W2114629989","https://openalex.org/W2134369415","https://openalex.org/W2593431579","https://openalex.org/W2613914741","https://openalex.org/W2769955740","https://openalex.org/W2790529391","https://openalex.org/W2886976326","https://openalex.org/W2914535606","https://openalex.org/W2975537434","https://openalex.org/W4385827455","https://openalex.org/W4401164724","https://openalex.org/W4415294234","https://openalex.org/W4415314940","https://openalex.org/W4416827424","https://openalex.org/W7131301871"],"related_works":["https://openalex.org/W4388418242","https://openalex.org/W4404790066","https://openalex.org/W7150856370","https://openalex.org/W4360897298","https://openalex.org/W6887693002","https://openalex.org/W2160001212","https://openalex.org/W4283739030","https://openalex.org/W2086338531","https://openalex.org/W3202347160","https://openalex.org/W1964677901"],"abstract_inverted_index":{"Background:":[0],"Alcohol":[1],"use":[2],"disorder":[3],"(AUD)":[4],"is":[5,401],"an":[6,153],"established":[7],"contributor":[8],"to":[9,23,30,36,132,309,390],"neurocognitive":[10],"impairment":[11],"and":[12,52,67,104,136,148,230,259,323,340,373],"a":[13,46,171,181,359],"major":[14],"modifiable":[15],"risk":[16],"factor":[17],"for":[18,113,157,214,242,280,361,403],"dementia.":[19,383],"However,":[20],"the":[21,78,82,110,114,127,162,167,244,299,366,379],"extent":[22],"which":[24],"lifetime":[25,47,212,233,353,398],"AUD":[26,51,91,147,215,234,356],"interacts":[27],"with":[28,60,180,229,238,349],"aging":[29,315],"accelerate":[31],"subtle":[32],"cognitive":[33,63,165,222,301,314,362,375,406],"trajectories":[34],"prior":[35],"overt":[37],"clinical":[38,382],"dementia":[39],"remains":[40],"unclear.":[41],"Objective:":[42],"To":[43],"investigate":[44],"whether":[45],"history":[48,354,400],"of":[49,55,84,116,146,164,174,186,313,335,355,368,381,386],"DSM-5":[50,98],"correlated":[53],"indices":[54],"alcohol":[56],"consumption":[57],"are":[58],"associated":[59,237],"accelerated":[61],"age-related":[62,240,369],"decline":[64,241,370],"in":[65,371],"middle-aged":[66],"older":[68],"adults.":[69],"Methods:":[70],"Participants":[71],"(N":[72],"=":[73,178,190,217,250,257,265,272,286,293],"1,421)":[74],"were":[75,107,225],"drawn":[76],"from":[77,109],"Collaborative":[79],"Study":[80],"on":[81,296,303],"Genetics":[83,115],"Alcoholism":[85,117],"(COGA)":[86],"prospective":[87],"longitudinal":[88,183],"study.":[89],"Lifetime":[90],"status":[92,339],"(defined":[93],"as":[94,150,152,358],"2":[95],"or":[96],"more":[97],"criteria":[99,213],"endorsed":[100],"at":[101,316,327],"peak":[102],"drinking)":[103],"drinking":[105,338,388,399],"patterns":[106],"derived":[108],"Semi-Structured":[111],"Assessment":[112],"(SSAGA).":[118],"Cognitive":[119],"performance":[120],"across":[121],"multiple":[122],"domains":[123],"was":[124,194,235,278,307],"evaluated":[125],"using":[126],"NIH":[128],"Toolbox":[129],"Cognition":[130],"Battery":[131],"yield":[133],"Total,":[134],"Fluid,":[135],"Crystallized":[137,281],"Composite":[138,246,261,282,305],"Scores.":[139],"Linear":[140],"mixed-effects":[141],"models":[142],"examined":[143],"main":[144],"effects":[145],"age,":[149],"well":[151,377],"AUD-by-age":[154,276],"interaction,":[155],"controlling":[156],"testing":[158],"site.":[159],"Results:":[160],"At":[161],"time":[163],"assessment,":[166],"overall":[168],"sample":[169,193],"had":[170],"mean":[172,182,221],"age":[173,317,328],"52.5":[175],"years":[176,188,312,326],"(SD":[177,189],"14.5)":[179],"observation":[184],"period":[185],"25.0":[187],"4.7).":[191],"The":[192],"60%":[195],"female,":[196],"40%":[197],"male,":[198],"7%":[199],"Hispanic,":[200],"23%":[201],"non-Hispanic":[202,205],"Black,":[203],"68%":[204],"White,":[206],"2%":[207],"other":[208],"race/ethnicity.":[209],"64%":[210],"met":[211],"(n":[216],"908).":[218],"While":[219],"baseline":[220],"composite":[223],"scores":[224,283,306],"similar":[226],"between":[227],"those":[228],"without":[231],"AUD,":[232],"significantly":[236,364],"steeper":[239],"both":[243],"Total":[245,304],"score":[247,262],"(interaction":[248,263,284],"estimate":[249,264,285],"-0.092,":[251],"95%":[252,267,288],"CI":[253,268,289,320,331],"[-0.173,":[254],"-0.010],":[255],"p":[256,271,292],"0.03)":[258],"Fluid":[260],"-0.13,":[266],"[-0.220,":[269],"-0.040],":[270],"0.005).":[273],"No":[274],"significant":[275,347],"interaction":[277,348],"observed":[279],"-0.026,":[287],"[-0.092,":[290],"0.041],":[291],"0.449).":[294],"Based":[295],"model":[297],"projections,":[298],"AUD-associated":[300],"deficit":[302],"equivalent":[308],"7.1":[310],"additional":[311,325],"60":[318],"(95%":[319,330],"[-0.5,":[321],"14.7])":[322],"13.8":[324],"75":[329],"[0.2,":[332],"27.3]).":[333],"Measures":[334],"current":[336,341,387],"(past-year)":[337],"drinks":[342],"per":[343],"week":[344],"showed":[345],"no":[346],"age.":[350],"Conclusions:":[351],"A":[352],"acts":[357],"catalyst":[360],"aging,":[363],"steepening":[365],"trajectory":[367],"total":[372],"fluid":[374],"functioning":[376],"before":[378],"onset":[380],"Cross-sectional":[384],"measures":[385],"failed":[389],"capture":[391],"these":[392],"effects,":[393],"demonstrating":[394],"that":[395],"evaluating":[396],"cumulative":[397],"important":[402],"assessing":[404],"alcohol-related":[405],"decline.":[407]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-24T00:00:00"}
