{"id":"https://openalex.org/W7214093015","doi":"https://doi.org/10.64898/2026.09.21.26363464","title":"Age-related alterations in blood fatty acid composition and ratios, omega-3 fatty acid Levels and association with PhenoAge acceleration: a cross-sectional analysis of the NHANES 2021-2023 data","display_name":"Age-related alterations in blood fatty acid composition and ratios, omega-3 fatty acid Levels and association with PhenoAge acceleration: a cross-sectional analysis of the NHANES 2021-2023 data","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214093015","doi":"https://doi.org/10.64898/2026.09.21.26363464"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.21.26363464","doi":"https://doi.org/10.64898/2026.09.21.26363464","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363464","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.21.26363464.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.21.26363464.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008519112","display_name":"Anne Pietzner","orcid":"https://orcid.org/0009-0008-1514-2729","observed_orcids":["https://orcid.org/0009-0008-1514-2729"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210145679","display_name":"Medizinische Hochschule Brandenburg Theodor Fontane","ror":"https://ror.org/04839sh14","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210145679"]},{"id":"https://openalex.org/I51783024","display_name":"Brandenburg University of Technology Cottbus-Senftenberg","ror":"https://ror.org/02wxx3e24","country_code":"DE","type":"education","lineage":["https://openalex.org/I51783024"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Pietzner","raw_affiliation_strings":["Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I51783024"]},{"raw_affiliation_string":"Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany","institution_ids":["https://openalex.org/I4210145679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043099245","display_name":"Nadine Rohwer","orcid":"https://orcid.org/0000-0001-6170-1327","observed_orcids":["https://orcid.org/0000-0001-6170-1327"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210145679","display_name":"Medizinische Hochschule Brandenburg Theodor Fontane","ror":"https://ror.org/04839sh14","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210145679"]},{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]},{"id":"https://openalex.org/I51783024","display_name":"Brandenburg University of Technology Cottbus-Senftenberg","ror":"https://ror.org/02wxx3e24","country_code":"DE","type":"education","lineage":["https://openalex.org/I51783024"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Rohwer","raw_affiliation_strings":["Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany","Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I51783024"]},{"raw_affiliation_string":"Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany","institution_ids":["https://openalex.org/I4210145679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088300809","display_name":"Karsten Henrich Weylandt","orcid":"https://orcid.org/0000-0002-5361-4327","observed_orcids":["https://orcid.org/0000-0002-5361-4327"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210145679","display_name":"Medizinische Hochschule Brandenburg Theodor Fontane","ror":"https://ror.org/04839sh14","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210145679"]},{"id":"https://openalex.org/I51783024","display_name":"Brandenburg University of Technology Cottbus-Senftenberg","ror":"https://ror.org/02wxx3e24","country_code":"DE","type":"education","lineage":["https://openalex.org/I51783024"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Karsten H. Weylandt","raw_affiliation_strings":["Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5361-4327","affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology, Brandenburg Medical School and University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I51783024"]},{"raw_affiliation_string":"Medical Department B, Division of Hepatology, Gastroenterology, Endocrinology, Diabetes, Lipidology and Nutrition, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany","institution_ids":["https://openalex.org/I4210145679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088300809"],"corresponding_institution_ids":["https://openalex.org/I176453806","https://openalex.org/I4210145679","https://openalex.org/I51783024"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/omega-3-index","display_name":"omega-3 index","score":0.7519999742507935},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7940000295639038},{"id":"https://openalex.org/keywords/erythrocyte-fatty-acids","display_name":"erythrocyte fatty acids","score":0.890999972820282},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.5659999847412109},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5180000066757202},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.878000020980835},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/elovl2","display_name":"ELOVL2","score":0.7160000205039978},{"id":"https://openalex.org/keywords/elovl5","display_name":"ELOVL5","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fatty-acid-elongation","display_name":"fatty acid elongation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.7020000219345093},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dihomo-gamma-linolenic-acid","display_name":"dihomo-gamma-linolenic acid","score":0.8450000286102295},{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":0.925000011920929},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.8108999729156494},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7778000235557556},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.7663999795913696},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.6477000117301941},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5126000046730042},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.44130000472068787},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4406000077724457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4253999888896942},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.35830000042915344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33469998836517334},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3075000047683716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28349998593330383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C2777300220","wikidata":"https://www.wikidata.org/wiki/Q378154","display_name":"Essential fatty acid","level":4,"score":0.27469998598098755},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2689000070095062},{"id":"https://openalex.org/C2780516434","wikidata":"https://www.wikidata.org/wiki/Q127980","display_name":"Polyunsaturated fat","level":4,"score":0.26460000872612},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.21.26363464","doi":"https://doi.org/10.64898/2026.09.21.26363464","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363464","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.21.26363464.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.21.26363464","doi":"https://doi.org/10.64898/2026.09.21.26363464","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363464","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/23/2026.09.21.26363464.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214093015.pdf","grobid_xml":"https://content.openalex.org/works/W7214093015.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1973527091","https://openalex.org/W1980326316","https://openalex.org/W2003347868","https://openalex.org/W2051648756","https://openalex.org/W2087246553","https://openalex.org/W2115826909","https://openalex.org/W2126432238","https://openalex.org/W2142347023","https://openalex.org/W2158369256","https://openalex.org/W2531708927","https://openalex.org/W2597054569","https://openalex.org/W2789096972","https://openalex.org/W2899720772","https://openalex.org/W2900151286","https://openalex.org/W2908077673","https://openalex.org/W2949100461","https://openalex.org/W2980777290","https://openalex.org/W3010378056","https://openalex.org/W3029942857","https://openalex.org/W3100332341","https://openalex.org/W3103257019","https://openalex.org/W3155934512","https://openalex.org/W4205733825","https://openalex.org/W4232596743","https://openalex.org/W4254404248","https://openalex.org/W4317907787","https://openalex.org/W4386615105","https://openalex.org/W4399391556","https://openalex.org/W4399632251","https://openalex.org/W4400281637","https://openalex.org/W4407088006","https://openalex.org/W4416008526","https://openalex.org/W4416040585","https://openalex.org/W7152969741","https://openalex.org/W7161118825","https://openalex.org/W7164759869"],"related_works":["https://openalex.org/W7152969741","https://openalex.org/W2897853995","https://openalex.org/W2055523143","https://openalex.org/W2806357359","https://openalex.org/W2226103167","https://openalex.org/W2126432238","https://openalex.org/W4408249229","https://openalex.org/W2219640064","https://openalex.org/W2112183383","https://openalex.org/W2312500402"],"abstract_inverted_index":{"A":[0],"bstract":[1],"Introduction":[2],"Polyunsaturated":[3],"fatty":[4,54,112,221],"acid":[5,37,41,55,113,237,240,244],"(PUFA)":[6],"status":[7,92,333],"is":[8,43],"an":[9,85],"important":[10],"marker":[11],"of":[12,35,62,72,101,124,126,198,209,288],"metabolic":[13],"health":[14],"across":[15,226],"the":[16,78,127,163,253,284,293],"lifespan,":[17],"and":[18,27,39,52,64,88,130,150,181,194,201,212,230,242,252,267,307,310],"omega-3":[19,31],"(n-3)":[20],"PUFA":[21,49,74,200,203,211,305],"were":[22,145,256,270],"shown":[23],"to":[24,46,94,179,192],"have":[25],"anti-inflammatory":[26],"cardioprotective":[28],"effects.":[29],"The":[30,247],"index,":[32],"a":[33,69,98,141,167,317,325],"composite":[34,99],"eicosapentaenoic":[36],"(EPA)":[38],"docosahexaenoic":[40],"(DHA),":[42],"widely":[44],"used":[45,58],"assess":[47],"n-3":[48,73,91,210,332],"supplementation":[50],"status,":[51],"product-to-precursor":[53],"ratios":[56],"are":[57,322],"as":[59],"proxy":[60,312],"indices":[61,313],"desaturation":[63],"elongation.":[65],"Previous":[66],"data":[67],"indicate":[68],"higher":[70],"proportion":[71],"with":[75,140,166,205,233,259,279,283,295,337],"age.":[76],"Whether":[77],"same":[79],"pattern":[80],"can":[81],"be":[82],"found":[83],"in":[84,122,190,292,303,308,316,324],"NHANES":[86],"cohort,":[87],"whether":[89],"long-chain":[90,331],"relates":[93],"phenotypic":[95],"age":[96,154,206,227],"(PhenoAge),":[97],"measure":[100],"biological":[102],"age,":[103,234,260],"has":[104],"not":[105,224],"been":[106],"established.":[107],"Methods":[108],"We":[109],"analyzed":[110],"erythrocyte":[111,304],"profiles":[114],"measured":[115,168],"by":[116],"electron":[117],"capture":[118],"negative-ion":[119],"mass":[120],"spectrometry":[121],"erythrocytes":[123],"participants":[125],"National":[128],"Health":[129],"Nutrition":[131],"Examination":[132],"Survey":[133],"(NHANES)":[134],"2021-2023.":[135],"Adults":[136],"aged":[137],"20-79":[138],"years":[139,291],"complete":[142],"21-fatty-acid":[143],"panel":[144],"included":[146],"(n":[147,171],"=":[148,172],"4,863)":[149],"stratified":[151],"into":[152],"five":[153],"groups":[155],"(20-34,":[156],"35-44,":[157],"45-54,":[158],"55-64,":[159],"65-79":[160],"years).":[161],"In":[162,217,329],"fasting":[164,169],"subsample":[165],"glucose":[170],"2,822)":[173],"we":[174],"additionally":[175],"computed":[176],"PhenoAge":[177,183,281,338],"according":[178],"Levine":[180],"assessed":[182],"acceleration":[184,282],"(PhenoAge":[185],"regressed":[186],"on":[187],"chronological":[188],"age)":[189],"relation":[191],"EPA":[193,213,229,274],"DHA.":[195],"Results":[196],"Percentage":[197],"summarized":[199],"n-6":[202],"decreased":[204],"while":[207,261],"percentage":[208],"+":[214,275],"DHA":[215,231,276],"increased.":[216],"contrast,":[218],"total":[219],"saturated":[220],"acids":[222],"did":[223],"differ":[225],"groups.":[228],"rose":[232],"whereas":[235],"linoleic":[236],"(LA),":[238],"dihomo-\u03b3-linolenic":[239],"(DGLA)":[241],"\u03b1-linolenic":[243],"(ALA)":[245],"declined.":[246],"delta-5-desaturase":[248],"(D5D)":[249],"index":[250],"(AA/DGLA)":[251],"AA/LA":[254],"ratio":[255],"positively":[257],"associated":[258,278,336],"elongation-related":[262],"proxies":[263],"ELOVL2":[264],"(DTA/AA,":[265],"DPA/EPA)":[266],"ELOVL5":[268],"(DGLA/GLA)":[269],"inversely":[271,335],"associated.":[272],"Higher":[273],"was":[277,334],"lower":[280],"most":[285],"pronounced":[286],"effect":[287],"-":[289],"4,7":[290],"group":[294],"highest":[296],"(\u22658%)":[297],"EPA+DHA":[298],"content.":[299],"Discussion":[300],"Age-related":[301],"shifts":[302],"composition":[306],"desaturase":[309],"elongase":[311],"reported":[314],"previously":[315],"clinical":[318],"cohort":[319],"from":[320],"Germany":[321],"reproduced":[323],"large":[326],"US":[327],"population.":[328],"addition,":[330],"acceleration.":[339]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-24T00:00:00"}