{"id":"https://openalex.org/W7214087066","doi":"https://doi.org/10.3390/ijms27198495","title":"PARylation at the Genome\u2013Proteome Interface: Regulation of DNA Repair Protein Dynamics","display_name":"PARylation at the Genome\u2013Proteome Interface: Regulation of DNA Repair Protein Dynamics","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214087066","doi":"https://doi.org/10.3390/ijms27198495","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13664745"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198495","doi":"https://doi.org/10.3390/ijms27198495","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198495","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198495","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051416913","display_name":"Su\u2010Jin Kang","orcid":"https://orcid.org/0000-0003-3276-8957","observed_orcids":["https://orcid.org/0000-0003-3276-8957"]},"institutions":[{"id":"https://openalex.org/I110217816","display_name":"Dongduk Women's University","ror":"https://ror.org/039p7ck60","country_code":"KR","type":"education","lineage":["https://openalex.org/I110217816"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Jin Kang","raw_affiliation_strings":["College of Pharmacy, Dongduk Women\u2019s University, Seoul 02748, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3276-8957","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Dongduk Women\u2019s University, Seoul 02748, Republic of Korea","institution_ids":["https://openalex.org/I110217816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113071476","display_name":"Jiwon Eom","orcid":"https://orcid.org/0009-0009-9266-2274","observed_orcids":["https://orcid.org/0009-0009-9266-2274"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Eom","raw_affiliation_strings":["College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-9266-2274","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133998172","display_name":"Yubin Ko","orcid":"https://orcid.org/0009-0000-1608-5174","observed_orcids":["https://orcid.org/0009-0000-1608-5174","https://orcid.org/0009-0004-6995-7158"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yubin Ko","raw_affiliation_strings":["College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0000-1608-5174","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113350462","display_name":"Soobin Yang","orcid":"https://orcid.org/0009-0005-3753-0747","observed_orcids":["https://orcid.org/0009-0005-3753-0747"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soobin Yang","raw_affiliation_strings":["College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0005-3753-0747","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015465896","display_name":"Sunbok Jang","orcid":"https://orcid.org/0000-0001-7371-0124","observed_orcids":["https://orcid.org/0000-0001-7371-0124"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sunbok Jang","raw_affiliation_strings":["College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","Graduate Program in Regulatory Science Convergence, Ewha Womans University, Seoul 03760, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7371-0124","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Graduate Program in Innovative Biomaterial Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Graduate Program in Regulatory Science Convergence, Ewha Womans University, Seoul 03760, Republic of Korea","institution_ids":["https://openalex.org/I138925566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015465896"],"corresponding_institution_ids":["https://openalex.org/I138925566"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38949871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"19","first_page":"8495","last_page":"8495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.7409999966621399},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.7699999809265137},{"id":"https://openalex.org/keywords/xrcc1","display_name":"XRCC1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ddb2","display_name":"DDB2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/alc1","display_name":"ALC1","score":0.871999979019165},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8500000238418579},{"id":"https://openalex.org/keywords/poly-adp-ribose-glycohydrolase","display_name":"poly(ADP-ribose) glycohydrolase","score":0.6399999856948853},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.7110000252723694},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.734000027179718},{"id":"https://openalex.org/keywords/ufd1","display_name":"Ufd1","score":0.6129999756813049},{"id":"https://openalex.org/keywords/vcp-p97","display_name":"VCP/p97","score":0.8899999856948853},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7774999737739563},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.7657999992370605},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6455000042915344},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.6208999752998352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6198999881744385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5674999952316284},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.4959999918937683},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.49230000376701355},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.44920000433921814},{"id":"https://openalex.org/C2776999993","wikidata":"https://www.wikidata.org/wiki/Q14911899","display_name":"XRCC1","level":5,"score":0.3833000063896179},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.33149999380111694},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.3133000135421753},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.3131999969482422},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.31049999594688416},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.27140000462532043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26910001039505005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2676999866962433},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2653000056743622},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C45413362","wikidata":"https://www.wikidata.org/wiki/Q6013254","display_name":"Prophase","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.2535000145435333},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000074747","descriptor_name":"Poly ADP Ribosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000097147","descriptor_name":"Excision Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27198495","doi":"https://doi.org/10.3390/ijms27198495","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198495","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13664745","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664745/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664745/pdf/ijms-27-08495.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42883743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198495","doi":"https://doi.org/10.3390/ijms27198495","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198495","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1765523463","display_name":null,"funder_award_id":"2021R1A6C101A442","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G3551429833","display_name":null,"funder_award_id":"2021R1A6C101A442","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G362621434","display_name":null,"funder_award_id":"RS-2026-25521357","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"},{"id":"https://openalex.org/G4261003836","display_name":null,"funder_award_id":"2021R1A6C101A442","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G611985554","display_name":null,"funder_award_id":"RS-2024-00401816","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G6725110150","display_name":null,"funder_award_id":"RS-2025-21322968","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7459392749","display_name":null,"funder_award_id":"RS-2024-00401816","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G9000362815","display_name":null,"funder_award_id":"RS-2025-21322968","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G936223973","display_name":null,"funder_award_id":"2021R1A6C101A442","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"}],"funders":[{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320322111","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214087066.pdf","grobid_xml":"https://content.openalex.org/works/W7214087066.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1896064250","https://openalex.org/W1980788640","https://openalex.org/W1993046370","https://openalex.org/W1994659363","https://openalex.org/W2015122435","https://openalex.org/W2023788813","https://openalex.org/W2050164541","https://openalex.org/W2057834096","https://openalex.org/W2065107886","https://openalex.org/W2073569331","https://openalex.org/W2076700051","https://openalex.org/W2091118082","https://openalex.org/W2098737737","https://openalex.org/W2114794865","https://openalex.org/W2127403047","https://openalex.org/W2127839852","https://openalex.org/W2143989418","https://openalex.org/W2151209400","https://openalex.org/W2165912346","https://openalex.org/W2587610309","https://openalex.org/W2597556742","https://openalex.org/W2686389580","https://openalex.org/W2792729825","https://openalex.org/W2808113406","https://openalex.org/W2887213234","https://openalex.org/W2929293804","https://openalex.org/W2950612020","https://openalex.org/W2994666581","https://openalex.org/W3004782200","https://openalex.org/W3088843380","https://openalex.org/W3135024668","https://openalex.org/W3170669380","https://openalex.org/W3173764271","https://openalex.org/W3210604043","https://openalex.org/W3212892569","https://openalex.org/W3216415322","https://openalex.org/W4200023783","https://openalex.org/W4206662285","https://openalex.org/W4220779662","https://openalex.org/W4220864127","https://openalex.org/W4220908091","https://openalex.org/W4221088553","https://openalex.org/W4283750789","https://openalex.org/W4291006609","https://openalex.org/W4291222654","https://openalex.org/W4302424483","https://openalex.org/W4308147072","https://openalex.org/W4311630673","https://openalex.org/W4313907650","https://openalex.org/W4322729470","https://openalex.org/W4360874185","https://openalex.org/W4367311715","https://openalex.org/W4367319294","https://openalex.org/W4367320884","https://openalex.org/W4387441936","https://openalex.org/W4387566852","https://openalex.org/W4390739386","https://openalex.org/W4391100936","https://openalex.org/W4391542423","https://openalex.org/W4395479661","https://openalex.org/W4397012943","https://openalex.org/W4399018846","https://openalex.org/W4399326232","https://openalex.org/W4401665986","https://openalex.org/W4402911047","https://openalex.org/W4404411352","https://openalex.org/W4404443129","https://openalex.org/W4405178075","https://openalex.org/W4406331950","https://openalex.org/W4407256830","https://openalex.org/W4407265273","https://openalex.org/W4410843183","https://openalex.org/W4413117916","https://openalex.org/W4417303129","https://openalex.org/W7127279561","https://openalex.org/W7162580045"],"related_works":["https://openalex.org/W1983759525","https://openalex.org/W2333199631","https://openalex.org/W2399338035","https://openalex.org/W4390739386","https://openalex.org/W2517488059","https://openalex.org/W2755719902","https://openalex.org/W160349565","https://openalex.org/W2049314985","https://openalex.org/W4242052600","https://openalex.org/W2174867240"],"abstract_inverted_index":{"Poly(ADP-ribosyl)ation":[0],"(PARylation)":[1],"is":[2],"a":[3,125,153],"rapid,":[4],"reversible":[5],"DNA":[6],"damage":[7],"response":[8],"that":[9,98],"promotes":[10,88],"chromatin":[11,26,68,114,171],"remodeling":[12,115],"and":[13,29,56,67,80,91,113,142,145,169,176],"the":[14,24,42,163],"recruitment":[15,66,164],"of":[16,31,44,128,165],"repair":[17,32,45,78,106,167],"factors.":[18],"Genome":[19],"maintenance":[20],"also":[21],"involves":[22],"regulating":[23],"assembly,":[25],"residence,":[27],"exchange,":[28],"disengagement":[30],"proteins":[33,168],"after":[34],"lesion":[35],"processing.":[36],"This":[37],"review":[38],"examines":[39],"PARylation":[40],"through":[41],"lens":[43],"protein":[46,59,129],"dynamics,":[47],"distinguishing":[48],"direct":[49],"poly(ADP-ribose)":[50],"(PAR)-dependent":[51],"regulation":[52],"from":[53],"PAR-associated":[54],"events":[55],"broader":[57],"nuclear":[58],"quality-control":[60,181],"pathways.":[61],"The":[62],"strongest":[63],"evidence":[64],"concerns":[65],"residence.":[69],"PAR":[70,160],"binding":[71],"drives":[72],"XRCC1":[73],"accumulation":[74],"at":[75],"base":[76],"excision":[77,105],"(BER)":[79],"single-strand":[81],"break":[82],"(SSB)":[83],"intermediates.":[84],"In":[85,103],"contrast,":[86],"auto-PARylation":[87],"PARP1":[89],"release,":[90],"PARP":[92],"inhibition":[93],"favors":[94],"persistent":[95],"PARP1-DNA":[96],"complexes":[97],"may":[99,123],"require":[100],"SUMO-RNF4-UFD1-p97/VCP-dependent":[101],"extraction.":[102],"nucleotide":[104],"(NER),":[107],"PARP1-associated":[108],"DDB2":[109],"regulation,":[110],"ALC1":[111],"recruitment,":[112],"intersect":[116],"with":[117],"ubiquitin-dependent":[118],"DDB2-XPC":[119],"exchange.":[120],"PAR-dependent":[121],"condensation":[122],"add":[124],"spatial":[126],"layer":[127],"organization,":[130],"although":[131],"its":[132],"contribution":[133],"remains":[134],"context-dependent.":[135],"We":[136],"further":[137],"discuss":[138],"implications":[139],"for":[140],"PARP-":[141],"PARG-directed":[143],"therapy":[144],"research-stage":[146],"functional":[147],"readouts.":[148],"Together,":[149],"these":[150],"observations":[151],"define":[152],"testable":[154],"proteostatic-rheostat":[155],"framework":[156],"in":[157],"which":[158],"variable":[159],"signals":[161],"influence":[162],"selected":[166],"subsequent":[170],"residence;":[172],"meanwhile,":[173],"later":[174],"extraction":[175],"turnover":[177],"involve":[178],"distinct,":[179],"intersecting":[180],"mechanisms.":[182]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-24T00:00:00"}