{"id":"https://openalex.org/W7214083591","doi":"https://doi.org/10.1073/pnas.2608599123","title":"Adaptability of the GroEL/GroES chaperonin to proteostatic challenge revealed by directed evolution","display_name":"Adaptability of the GroEL/GroES chaperonin to proteostatic challenge revealed by directed evolution","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214083591","doi":"https://doi.org/10.1073/pnas.2608599123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42776757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13624683"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2608599123","doi":"https://doi.org/10.1073/pnas.2608599123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2608599123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2608599123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032663886","display_name":"Marie\u2010Pierre Castani\u00e9\u2010Cornet","orcid":"https://orcid.org/0000-0001-9889-1101","observed_orcids":["https://orcid.org/0000-0001-9889-1101"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210149702","display_name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires","ror":"https://ror.org/04rrj3a80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210149702","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie-Pierre Castani\u00e9-Cornet","raw_affiliation_strings":["Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS"],"raw_orcid":"https://orcid.org/0000-0001-9889-1101","affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210149702","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039886706","display_name":"Tatsuya Niwa","orcid":"https://orcid.org/0000-0002-1330-8974","observed_orcids":["https://orcid.org/0000-0002-1330-8974"]},"institutions":[{"id":"https://openalex.org/I4405286735","display_name":"Cell Biology Center","ror":"https://ror.org/02yce3669","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4400009020","https://openalex.org/I4405286735"]},{"id":"https://openalex.org/I4405286842","display_name":"Institute of Integrated Research, Institute of Science Tokyo","ror":"https://ror.org/038jk9m46","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4400009020","https://openalex.org/I4405286842"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Niwa","raw_affiliation_strings":["Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo"],"raw_orcid":"https://orcid.org/0000-0002-1330-8974","affiliations":[{"raw_affiliation_string":"Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo","institution_ids":["https://openalex.org/I4405286735","https://openalex.org/I4405286842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073717088","display_name":"\u00c9mile Dupuy","orcid":"https://orcid.org/0000-0001-8177-681X","observed_orcids":["https://orcid.org/0000-0001-8177-681X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210149702","display_name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires","ror":"https://ror.org/04rrj3a80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210149702","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"\u00c9mile Dupuy","raw_affiliation_strings":["Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS"],"raw_orcid":"https://orcid.org/0000-0001-8177-681X","affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210149702","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108108198","display_name":"Anne-Marie Cirinesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210149702","display_name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires","ror":"https://ror.org/04rrj3a80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210149702","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Marie Cirinesi","raw_affiliation_strings":["Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210149702","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053437073","display_name":"Manajit K. Hayer-Hartl","orcid":"https://orcid.org/0000-0001-8213-6742","observed_orcids":["https://orcid.org/0000-0001-8213-6742"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manajit Hayer-Hartl","raw_affiliation_strings":["Department of Cellular Biochemistry, Max Planck Institute of Biochemistry"],"raw_orcid":"https://orcid.org/0000-0001-8213-6742","affiliations":[{"raw_affiliation_string":"Department of Cellular Biochemistry, Max Planck Institute of Biochemistry","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065881832","display_name":"Hideki Taguchi","orcid":"https://orcid.org/0000-0002-6612-9339","observed_orcids":["https://orcid.org/0000-0002-6612-9339"]},"institutions":[{"id":"https://openalex.org/I4405286735","display_name":"Cell Biology Center","ror":"https://ror.org/02yce3669","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4400009020","https://openalex.org/I4405286735"]},{"id":"https://openalex.org/I4405286842","display_name":"Institute of Integrated Research, Institute of Science Tokyo","ror":"https://ror.org/038jk9m46","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4400009020","https://openalex.org/I4405286842"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Taguchi","raw_affiliation_strings":["Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo"],"raw_orcid":"https://orcid.org/0000-0002-6612-9339","affiliations":[{"raw_affiliation_string":"Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo","institution_ids":["https://openalex.org/I4405286735","https://openalex.org/I4405286842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086048712","display_name":"F. Ulrich Hartl","orcid":"https://orcid.org/0000-0002-7941-135X","observed_orcids":["https://orcid.org/0000-0002-7941-135X"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Ulrich Hartl","raw_affiliation_strings":["Department of Cellular Biochemistry, Max Planck Institute of Biochemistry"],"raw_orcid":"https://orcid.org/0000-0002-7941-135X","affiliations":[{"raw_affiliation_string":"Department of Cellular Biochemistry, Max Planck Institute of Biochemistry","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078468797","display_name":"Pierre Genevaux","orcid":"https://orcid.org/0000-0001-7539-3126","observed_orcids":["https://orcid.org/0000-0001-7539-3126"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210149702","display_name":"Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaires","ror":"https://ror.org/04rrj3a80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210149702","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pierre Genevaux","raw_affiliation_strings":["Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS"],"raw_orcid":"https://orcid.org/0000-0001-7539-3126","affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie et de G\u00e9n\u00e9tique Mol\u00e9culaires, Centre de Biologie Int\u00e9grative, Universit\u00e9 de Toulouse, CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210149702","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5032663886","https://openalex.org/A5078468797"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210149702","https://openalex.org/I4405258862","https://openalex.org/I4405266242"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57528461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"39","first_page":"e2608599123","last_page":"e2608599123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.8090000152587891},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.7730000019073486},{"id":"https://openalex.org/keywords/precipitating-factors","display_name":"precipitating factors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/substrate-preference","display_name":"substrate preference","score":0.6809999942779541},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.7559999823570251},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C87190427","wikidata":"https://www.wikidata.org/wiki/Q14864994","display_name":"GroEL","level":4,"score":0.9404000043869019},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.8622999787330627},{"id":"https://openalex.org/C85755625","wikidata":"https://www.wikidata.org/wiki/Q24771589","display_name":"Chaperonin","level":3,"score":0.8338000178337097},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.7653999924659729},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6672999858856201},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.618399977684021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5672000050544739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5259000062942505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5098999738693237},{"id":"https://openalex.org/C98924942","wikidata":"https://www.wikidata.org/wiki/Q16886584","display_name":"Foldase","level":5,"score":0.4902999997138977},{"id":"https://openalex.org/C61397870","wikidata":"https://www.wikidata.org/wiki/Q1069458","display_name":"Chemical chaperone","level":4,"score":0.48579999804496765},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4668999910354614},{"id":"https://openalex.org/C2777174735","wikidata":"https://www.wikidata.org/wiki/Q18047040","display_name":"CLPB","level":4,"score":0.44909998774528503},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.40779998898506165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3637000024318695},{"id":"https://openalex.org/C46522908","wikidata":"https://www.wikidata.org/wiki/Q14865007","display_name":"GroES","level":5,"score":0.3596999943256378},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018835","descriptor_name":"Chaperonin 10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018835","descriptor_name":"Chaperonin 10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018835","descriptor_name":"Chaperonin 10","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050956","descriptor_name":"HSP40 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2608599123","doi":"https://doi.org/10.1073/pnas.2608599123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2608599123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:42776757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42776757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13624683","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13624683/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05772584v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05772584","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2026, 123 (39), &#x27E8;10.1073/pnas.2608599123&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2608599123","doi":"https://doi.org/10.1073/pnas.2608599123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2608599123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2348257463","display_name":null,"funder_award_id":"JP26116002","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G251409016","display_name":null,"funder_award_id":"JP21wm0425004","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4813974774","display_name":null,"funder_award_id":"JP20H05925","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5153399625","display_name":null,"funder_award_id":"57210259","funder_id":"https://openalex.org/F4320320875","funder_display_name":"Deutscher Akademischer Austauschdienst"},{"id":"https://openalex.org/G5702708062","display_name":"Translation-coupled protein folding analyses","funder_award_id":"21H04763","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7744001544","display_name":"Development and application of a comprehensive method for proteome-wide protein conformational state analysis","funder_award_id":"24K09392","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000379230","display_name":null,"funder_award_id":"JP23ek0109642","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W93719713","https://openalex.org/W1498099361","https://openalex.org/W1861216951","https://openalex.org/W1923570112","https://openalex.org/W1959680805","https://openalex.org/W1963842416","https://openalex.org/W1980656534","https://openalex.org/W1987209219","https://openalex.org/W1988404150","https://openalex.org/W1992256434","https://openalex.org/W1993674986","https://openalex.org/W1994709137","https://openalex.org/W2003409413","https://openalex.org/W2013582991","https://openalex.org/W2021901995","https://openalex.org/W2025501168","https://openalex.org/W2028173143","https://openalex.org/W2032629970","https://openalex.org/W2042180447","https://openalex.org/W2042814467","https://openalex.org/W2050887062","https://openalex.org/W2055926450","https://openalex.org/W2062205636","https://openalex.org/W2065248572","https://openalex.org/W2065504621","https://openalex.org/W2066118700","https://openalex.org/W2074179726","https://openalex.org/W2078010704","https://openalex.org/W2084164517","https://openalex.org/W2084560720","https://openalex.org/W2090411283","https://openalex.org/W2093498871","https://openalex.org/W2098665638","https://openalex.org/W2104438148","https://openalex.org/W2105463652","https://openalex.org/W2107370157","https://openalex.org/W2108385415","https://openalex.org/W2109356676","https://openalex.org/W2109553859","https://openalex.org/W2116137883","https://openalex.org/W2122881249","https://openalex.org/W2136670217","https://openalex.org/W2138749342","https://openalex.org/W2140536590","https://openalex.org/W2142338805","https://openalex.org/W2147289825","https://openalex.org/W2151982140","https://openalex.org/W2160595750","https://openalex.org/W2171533950","https://openalex.org/W2172170548","https://openalex.org/W2238452763","https://openalex.org/W2333318116","https://openalex.org/W2473711714","https://openalex.org/W2580446384","https://openalex.org/W2767673696","https://openalex.org/W2782804945","https://openalex.org/W3063299260","https://openalex.org/W3165617216","https://openalex.org/W3166378752","https://openalex.org/W4319728571","https://openalex.org/W4401793614","https://openalex.org/W4409493926","https://openalex.org/W4410253938","https://openalex.org/W4416183001","https://openalex.org/W4416774872"],"related_works":["https://openalex.org/W4847159","https://openalex.org/W7095891342","https://openalex.org/W1987209219","https://openalex.org/W2336387921","https://openalex.org/W2768145124","https://openalex.org/W2036552407","https://openalex.org/W136040147","https://openalex.org/W2117929060","https://openalex.org/W4319924167","https://openalex.org/W2147289825"],"abstract_inverted_index":{"The":[0],"folding":[1,124],"of":[2,12,56,93,100,118,152],"newly":[3],"synthesized":[4],"proteins":[5,13],"is":[6],"assisted":[7],"by":[8,52],"an":[9,122],"essential":[10],"network":[11,51],"known":[14],"as":[15],"molecular":[16],"chaperones.":[17],"In":[18,106],"bacteria,":[19],"the":[20,42,48,91,136],"chaperones":[21,163,178],"Trigger":[22],"Factor":[23],"(TF),":[24],"DnaK/DnaJ":[25],"(Hsp70":[26],"system),":[27],"and":[28,44,64,95,121,149,181],"GroEL/GroES":[29,57],"(chaperonin":[30],"system)":[31],"are":[32],"key":[33],"players":[34],"in":[35,58,75,85,90,139,143,145,157],"proteostasis":[36],"maintenance.":[37],"Here,":[38],"we":[39],"further":[40,103],"explore":[41],"cooperation":[43,175],"substrate":[45],"preference":[46],"within":[47],"bacterial":[49],"chaperone":[50,66,83],"performing":[53],"directed":[54],"evolution":[55],"Escherichia":[59],"coli":[60],"lacking":[61,147],"both":[62],"TF":[63,94,148,180],"DnaK":[65],"pathways.":[67],"We":[68],"found":[69],"that":[70,110,160],"single":[71],"amino":[72],"acid":[73],"substitutions":[74],"GroEL":[76,112,156,168],"were":[77],"sufficient":[78],"to":[79,155],"significantly":[80],"improve":[81],"its":[82],"activity":[84],"vivo":[86,144,158],"at":[87,129],"high":[88],"temperature":[89],"absence":[92],"DnaKJ,":[96],"with":[97,170,176],"a":[98,115],"combination":[99],"selected":[101],"mutations":[102],"enhancing":[104],"functionality.":[105],"vitro":[107],"analysis":[108],"showed":[109,159],"high-performing":[111],"variants":[113],"have":[114],"higher":[116],"rate":[117,125],"ATP":[119,131,140],"hydrolysis":[120],"increased":[123],"for":[126,135],"certain":[127],"substrates":[128,153,169],"low":[130,171],"concentration,":[132],"thereby":[133],"compensating":[134],"significant":[137],"drop":[138],"level":[141],"observed":[142],"cells":[146],"DnaKJ.":[150,182],"Analysis":[151],"bound":[154],"experimentally":[161],"evolved":[162],"likely":[164],"adapted":[165],"toward":[166],"obligate":[167],"solubility,":[172],"thus":[173],"bypassing":[174],"upstream":[177],"like":[179]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-24T00:00:00"}
