{"id":"https://openalex.org/W7214083549","doi":"https://doi.org/10.3389/fphar.2026.1884091","title":"Research progress in clinical utilization of H2 as a pleiotropic agent","display_name":"Research progress in clinical utilization of H2 as a pleiotropic agent","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214083549","doi":"https://doi.org/10.3389/fphar.2026.1884091","pmid":"https://pubmed.ncbi.nlm.nih.gov/42846842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13643697"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1884091","doi":"https://doi.org/10.3389/fphar.2026.1884091","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1884091","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2026.1884091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152536971","display_name":"Qinghui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131125","display_name":"Huanghuai University","ror":"https://ror.org/02k92ks68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131125"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghui Zhao","raw_affiliation_strings":["Institute of Physical Culture, Huanghuai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Culture, Huanghuai University","institution_ids":["https://openalex.org/I4210131125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152545062","display_name":"Tengchong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131125","display_name":"Huanghuai University","ror":"https://ror.org/02k92ks68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131125"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengchong Li","raw_affiliation_strings":["Institute of Physical Culture, Huanghuai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Culture, Huanghuai University","institution_ids":["https://openalex.org/I4210131125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021730871","display_name":"Rongke Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131125","display_name":"Huanghuai University","ror":"https://ror.org/02k92ks68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131125"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongke Lv","raw_affiliation_strings":["Institute of Physical Culture, Huanghuai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Culture, Huanghuai University","institution_ids":["https://openalex.org/I4210131125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407480","display_name":"Dong Li","orcid":"https://orcid.org/0000-0002-7527-5645","observed_orcids":["https://orcid.org/0000-0002-7527-5645"]},"institutions":[{"id":"https://openalex.org/I4210131125","display_name":"Huanghuai University","ror":"https://ror.org/02k92ks68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131125"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Li","raw_affiliation_strings":["Institute of Physical Culture, Huanghuai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Culture, Huanghuai University","institution_ids":["https://openalex.org/I4210131125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602276","display_name":"Hongru Li","orcid":"https://orcid.org/0000-0003-4700-962X","observed_orcids":["https://orcid.org/0000-0003-4700-962X","https://orcid.org/0009-0001-1071-5531"]},"institutions":[{"id":"https://openalex.org/I4210091296","display_name":"Zhumadian Central Hospital","ror":"https://ror.org/00h4nzs54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091296"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongru Li","raw_affiliation_strings":["Zhumadian Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhumadian Central Hospital","institution_ids":["https://openalex.org/I4210091296"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100407480","https://openalex.org/A5100602276"],"corresponding_institution_ids":["https://openalex.org/I4210091296","https://openalex.org/I4210131125"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62722405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1884091","last_page":"1884091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cell-signaling-regulation","display_name":"cell signaling regulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/clinical-application","display_name":"clinical application","score":0.5040000081062317},{"id":"https://openalex.org/keywords/disease-models","display_name":"disease models","score":0.6470000147819519},{"id":"https://openalex.org/keywords/translational-medicine","display_name":"translational medicine","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5286999940872192},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.513700008392334},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.5022000074386597},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4555000066757202},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4422999918460846},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42899999022483826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3479999899864197},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C2986762682","wikidata":"https://www.wikidata.org/wiki/Q964754","display_name":"Basic research","level":2,"score":0.3287000060081482},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3167000114917755},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.303600013256073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1884091","doi":"https://doi.org/10.3389/fphar.2026.1884091","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1884091","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13643697","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42846842/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13643697/pdf/fphar-17-1884091.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42846842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42846842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e0f891b5f9bd4f8d8d7d8bb46274607e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e0f891b5f9bd4f8d8d7d8bb46274607e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1884091","doi":"https://doi.org/10.3389/fphar.2026.1884091","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1884091","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329524","display_name":"Huanghuai University","ror":"https://ror.org/02k92ks68"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":224,"referenced_works":["https://openalex.org/W1506720526","https://openalex.org/W1605504568","https://openalex.org/W1965517089","https://openalex.org/W1971665258","https://openalex.org/W1991900694","https://openalex.org/W2043897070","https://openalex.org/W2062212261","https://openalex.org/W2074862395","https://openalex.org/W2077113765","https://openalex.org/W2080251957","https://openalex.org/W2084316653","https://openalex.org/W2084829587","https://openalex.org/W2086810938","https://openalex.org/W2099576434","https://openalex.org/W2101106843","https://openalex.org/W2101526447","https://openalex.org/W2108132563","https://openalex.org/W2110826367","https://openalex.org/W2111649022","https://openalex.org/W2125948531","https://openalex.org/W2128526521","https://openalex.org/W2131700094","https://openalex.org/W2138812470","https://openalex.org/W2159054927","https://openalex.org/W2159293191","https://openalex.org/W2162995588","https://openalex.org/W2163272174","https://openalex.org/W2168795718","https://openalex.org/W2169657429","https://openalex.org/W2230204591","https://openalex.org/W2235682587","https://openalex.org/W2324450935","https://openalex.org/W2342734712","https://openalex.org/W2397977415","https://openalex.org/W2466448612","https://openalex.org/W2605891804","https://openalex.org/W2617779226","https://openalex.org/W2733994766","https://openalex.org/W2750534773","https://openalex.org/W2750885285","https://openalex.org/W2752602281","https://openalex.org/W2755894657","https://openalex.org/W2765663928","https://openalex.org/W2767845378","https://openalex.org/W2781897408","https://openalex.org/W2791525628","https://openalex.org/W2805667071","https://openalex.org/W2807845832","https://openalex.org/W2808863657","https://openalex.org/W2885006502","https://openalex.org/W2891582021","https://openalex.org/W2892633620","https://openalex.org/W2894866383","https://openalex.org/W2898785855","https://openalex.org/W2910542236","https://openalex.org/W2911255870","https://openalex.org/W2912714652","https://openalex.org/W2921207990","https://openalex.org/W2936155417","https://openalex.org/W2936595416","https://openalex.org/W2944473633","https://openalex.org/W2945912206","https://openalex.org/W2953544727","https://openalex.org/W2959728234","https://openalex.org/W2960761646","https://openalex.org/W2963032626","https://openalex.org/W2963171906","https://openalex.org/W2965781007","https://openalex.org/W2973509862","https://openalex.org/W2973733841","https://openalex.org/W2980390034","https://openalex.org/W2981939858","https://openalex.org/W2987502704","https://openalex.org/W2987587716","https://openalex.org/W2995680970","https://openalex.org/W3002853676","https://openalex.org/W3005254896","https://openalex.org/W3006241683","https://openalex.org/W3009595715","https://openalex.org/W3012790024","https://openalex.org/W3025925610","https://openalex.org/W3033825698","https://openalex.org/W3037277607","https://openalex.org/W3047695545","https://openalex.org/W3084277555","https://openalex.org/W3087588976","https://openalex.org/W3089111196","https://openalex.org/W3097007803","https://openalex.org/W3100367398","https://openalex.org/W3115477054","https://openalex.org/W3115968256","https://openalex.org/W3129323983","https://openalex.org/W3134467225","https://openalex.org/W3157108517","https://openalex.org/W3161718576","https://openalex.org/W3181495359","https://openalex.org/W3186757216","https://openalex.org/W3194312798","https://openalex.org/W3194824775","https://openalex.org/W3196589757","https://openalex.org/W3200548603","https://openalex.org/W3203014445","https://openalex.org/W3203282372","https://openalex.org/W3203691717","https://openalex.org/W4200061023","https://openalex.org/W4206158113","https://openalex.org/W4210593463","https://openalex.org/W4211184994","https://openalex.org/W4214863771","https://openalex.org/W4220740164","https://openalex.org/W4220892878","https://openalex.org/W4221086891","https://openalex.org/W4224923132","https://openalex.org/W4225002645","https://openalex.org/W4225007563","https://openalex.org/W4229014969","https://openalex.org/W4281615131","https://openalex.org/W4283312951","https://openalex.org/W4285109245","https://openalex.org/W4285742728","https://openalex.org/W4295962805","https://openalex.org/W4297464550","https://openalex.org/W4306391355","https://openalex.org/W4307552376","https://openalex.org/W4307757262","https://openalex.org/W4312142122","https://openalex.org/W4313260746","https://openalex.org/W4313454195","https://openalex.org/W4313558017","https://openalex.org/W4313654682","https://openalex.org/W4315642182","https://openalex.org/W4318387550","https://openalex.org/W4318406775","https://openalex.org/W4324095516","https://openalex.org/W4362635234","https://openalex.org/W4365141009","https://openalex.org/W4376131650","https://openalex.org/W4378903065","https://openalex.org/W4388459693","https://openalex.org/W4388511331","https://openalex.org/W4389056287","https://openalex.org/W4389549916","https://openalex.org/W4389888819","https://openalex.org/W4390140059","https://openalex.org/W4390450570","https://openalex.org/W4390829995","https://openalex.org/W4391151589","https://openalex.org/W4391166743","https://openalex.org/W4392905873","https://openalex.org/W4393053694","https://openalex.org/W4393192604","https://openalex.org/W4393356154","https://openalex.org/W4394743840","https://openalex.org/W4394769730","https://openalex.org/W4394958781","https://openalex.org/W4396619353","https://openalex.org/W4397010472","https://openalex.org/W4398784823","https://openalex.org/W4399980992","https://openalex.org/W4400039039","https://openalex.org/W4400722236","https://openalex.org/W4400903140","https://openalex.org/W4401514087","https://openalex.org/W4401611773","https://openalex.org/W4401754064","https://openalex.org/W4402630518","https://openalex.org/W4402630553","https://openalex.org/W4403276066","https://openalex.org/W4404763727","https://openalex.org/W4405086778","https://openalex.org/W4405454278","https://openalex.org/W4406598684","https://openalex.org/W4406817970","https://openalex.org/W4407183451","https://openalex.org/W4407279643","https://openalex.org/W4408120973","https://openalex.org/W4408160571","https://openalex.org/W4408291082","https://openalex.org/W4408740245","https://openalex.org/W4408949817","https://openalex.org/W4409239106","https://openalex.org/W4409285400","https://openalex.org/W4409475856","https://openalex.org/W4409533117","https://openalex.org/W4409885963","https://openalex.org/W4409893045","https://openalex.org/W4410099992","https://openalex.org/W4410377072","https://openalex.org/W4410380850","https://openalex.org/W4410827332","https://openalex.org/W4411078466","https://openalex.org/W4411095856","https://openalex.org/W4411189439","https://openalex.org/W4411326251","https://openalex.org/W4411329518","https://openalex.org/W4411441580","https://openalex.org/W4411583208","https://openalex.org/W4411623001","https://openalex.org/W4412425726","https://openalex.org/W4412544786","https://openalex.org/W4412684171","https://openalex.org/W4412687370","https://openalex.org/W4412700432","https://openalex.org/W4412784652","https://openalex.org/W4413027576","https://openalex.org/W4413099227","https://openalex.org/W4413133320","https://openalex.org/W4413253251","https://openalex.org/W4413296990","https://openalex.org/W4413305174","https://openalex.org/W4413378370","https://openalex.org/W4413757611","https://openalex.org/W4413803691","https://openalex.org/W4413902565","https://openalex.org/W4414153062","https://openalex.org/W4414190098","https://openalex.org/W4414531480","https://openalex.org/W4415687423","https://openalex.org/W4415710954","https://openalex.org/W4417452397","https://openalex.org/W7116108389","https://openalex.org/W7125592979","https://openalex.org/W7127120561","https://openalex.org/W7134047574"],"related_works":["https://openalex.org/W4391892298","https://openalex.org/W4403358098","https://openalex.org/W2135082935","https://openalex.org/W7101161585","https://openalex.org/W3175804637","https://openalex.org/W2109179624","https://openalex.org/W1503565493","https://openalex.org/W2143692885","https://openalex.org/W3004133553","https://openalex.org/W2759847566"],"abstract_inverted_index":{"H":[0,43,108,119,142],"2":[1,44,109,120,143],"is":[2],"a":[3,53,96],"fundamental":[4],"environmental":[5],"factor":[6],"for":[7,16,85],"the":[8,17,82,103,113,127,138],"origin":[9],"of":[10,19,68,88,107,115,123,129,141],"life,":[11],"providing":[12],"an":[13],"energetic":[14],"basis":[15],"emergence":[18],"primitive":[20],"life.":[21],"Through":[22],"its":[23,33],"selective":[24],"antioxidant,":[25],"anti-inflammatory,":[26],"and":[27,40,49,110,136],"anti-apoptotic":[28],"activities,":[29],"as":[30,32,52],"well":[31],"regulatory":[34],"effects":[35,48],"on":[36,118],"cell":[37],"signaling":[38],"pathways":[39],"gene":[41],"expression,":[42],"exerts":[45],"broad":[46],"biological":[47],"has":[50,63,93],"emerged":[51],"favorable":[54],"pleiotropic":[55],"therapeutic":[56],"agent.":[57],"To":[58],"date,":[59],"hydrogen":[60,89],"medicine":[61],"research":[62,92,97],"covered":[64],"almost":[65],"all":[66],"types":[67],"diseases":[69,122],"across":[70],"organ":[71],"systems,":[72,125],"with":[73,126],"more":[74],"than":[75],"170":[76],"disease":[77],"models":[78],"under":[79],"investigation.":[80],"Amid":[81],"growing":[83],"demand":[84],"translational":[86],"applications":[87],"medicine,":[90],"clinical":[91,116,134],"gradually":[94],"become":[95],"hotspot.":[98],"Here,":[99],"we":[100],"extensively":[101],"reviewed":[102],"latest":[104],"mechanistic":[105],"understanding":[106],"comprehensively":[111],"summarized":[112],"progress":[114],"studies":[117],"in":[121],"different":[124],"goal":[128],"informing":[130],"future":[131],"large-scale,":[132],"multi-center":[133],"trials":[135],"supporting":[137],"multidisciplinary":[139],"development":[140],"medicine.":[144]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-24T00:00:00"}