{"id":"https://openalex.org/W7214074072","doi":"https://doi.org/10.1007/s00277-026-07346-w","title":"Clofarabine and intermediate-dose cytarabine after venetoclax failure in relapsed/refractory acute myeloid leukemia: a retrospective single-center experience","display_name":"Clofarabine and intermediate-dose cytarabine after venetoclax failure in relapsed/refractory acute myeloid leukemia: a retrospective single-center experience","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7214074072","doi":"https://doi.org/10.1007/s00277-026-07346-w"},"language":"en","primary_location":{"id":"doi:10.1007/s00277-026-07346-w","doi":"https://doi.org/10.1007/s00277-026-07346-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07346-w","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00277-026-07346-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038808770","display_name":"Gaia Ciolli","orcid":"https://orcid.org/0009-0004-9203-2698","observed_orcids":["https://orcid.org/0009-0004-9203-2698"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaia Ciolli","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089269897","display_name":"Matteo Piccini","orcid":"https://orcid.org/0000-0002-9653-4976","observed_orcids":["https://orcid.org/0000-0002-9653-4976"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Piccini","raw_affiliation_strings":["Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030706737","display_name":"Barbara Scappini","orcid":"https://orcid.org/0000-0002-4162-0009","observed_orcids":["https://orcid.org/0000-0002-4162-0009"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Scappini","raw_affiliation_strings":["Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071122576","display_name":"Francesca Crupi","orcid":"https://orcid.org/0000-0002-2689-4482","observed_orcids":["https://orcid.org/0000-0002-2689-4482"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Crupi","raw_affiliation_strings":["Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133877694","display_name":"Andrea Pasquini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Pasquini","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093396812","display_name":"Jessica Caroprese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jessica Caroprese","raw_affiliation_strings":["Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028078311","display_name":"Giorgio Cannetti","orcid":"https://orcid.org/0000-0002-3243-8213","observed_orcids":["https://orcid.org/0000-0002-3243-8213"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Cannetti","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chiara Lucarelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Lucarelli","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152546482","display_name":"Asia Machetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Asia Machetti","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013539196","display_name":"Paola Guglielmelli","orcid":"https://orcid.org/0000-0003-1809-284X","observed_orcids":["https://orcid.org/0000-0003-1809-284X"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Guglielmelli","raw_affiliation_strings":["Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111831311","display_name":"Alessandro M. Vannucchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro M. Vannucchi","raw_affiliation_strings":["Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032323700","display_name":"Francesco Mannelli","orcid":"https://orcid.org/0000-0003-4810-6501","observed_orcids":["https://orcid.org/0000-0003-4810-6501"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Mannelli","raw_affiliation_strings":["Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","Dipartimento di Medicina Sperimentale e Clinica, SOD Ematologia, Centro Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), Universit\u00e0 di Firenze, AOU Careggi, Largo Brambilla 3, Firenze, 50134, Italy","Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Dipartimento di Medicina Sperimentale e Clinica, SOD Ematologia, Centro Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), Universit\u00e0 di Firenze, AOU Careggi, Largo Brambilla 3, Firenze, 50134, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, 50134, Italy","institution_ids":["https://openalex.org/I4210115393"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032323700"],"corresponding_institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66453281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofarabine","display_name":"clofarabine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intermediate-dose-cytarabine","display_name":"intermediate-dose cytarabine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/venetoclax-resistance","display_name":"venetoclax resistance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/relapsed-refractory-acute-myeloid-leukemia","display_name":"relapsed/refractory acute myeloid leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6299999952316284},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7239999771118164},{"id":"https://openalex.org/keywords/early-mortality","display_name":"early mortality","score":0.859000027179718},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2777198975","wikidata":"https://www.wikidata.org/wiki/Q5134875","display_name":"Clofarabine","level":4,"score":0.9672999978065491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8654000163078308},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.8324999809265137},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7085999846458435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6883999705314636},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6693000197410583},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6399999856948853},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5737000107765198},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5525000095367432},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.4943000078201294},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.46639999747276306},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.36250001192092896},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3546000123023987},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3037000000476837},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2786000072956085},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.25850000977516174}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00277-026-07346-w","doi":"https://doi.org/10.1007/s00277-026-07346-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07346-w","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10962398/v1","doi":"https://doi.org/10.21203/rs.3.rs-10962398/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10962398/v1","pdf_url":"https://www.researchsquare.com/article/rs-10962398/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1007/s00277-026-07346-w","doi":"https://doi.org/10.1007/s00277-026-07346-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07346-w","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1165031887","display_name":null,"funder_award_id":"21267","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214074072.pdf","grobid_xml":"https://content.openalex.org/works/W7214074072.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1965658643","https://openalex.org/W2039694224","https://openalex.org/W2048591988","https://openalex.org/W2090466206","https://openalex.org/W2151121107","https://openalex.org/W2559537906","https://openalex.org/W2623089849","https://openalex.org/W2806682325","https://openalex.org/W2982353618","https://openalex.org/W3000515035","https://openalex.org/W3048827006","https://openalex.org/W4284884567","https://openalex.org/W4391738483","https://openalex.org/W4410158978"],"related_works":["https://openalex.org/W4220670263","https://openalex.org/W3003909887","https://openalex.org/W4226501601","https://openalex.org/W7203821381","https://openalex.org/W4389229421","https://openalex.org/W4392352581","https://openalex.org/W3213041369","https://openalex.org/W2951521563","https://openalex.org/W4417015708","https://openalex.org/W4394759173"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Resistance":[2],"to":[3],"venetoclax":[4],"(VEN)-based":[5],"therapies":[6],"is":[7],"a":[8,43,50],"therapeutic":[9],"challenge":[10],"in":[11,23,28,92,120,145],"acute":[12],"myeloid":[13],"leukemia":[14],"(AML).":[15],"Objectives":[16],"To":[17],"evaluate":[18],"the":[19,68,97],"efficacy":[20],"of":[21,37,72,94,101,122],"clofarabine":[22,58,131],"combination":[24],"with":[25,30],"intermediate-dose":[26,133],"cytarabine":[27,62,134],"patients":[29,73,102],"VEN-resistant":[31],"AML.":[32],"Methods":[33],"Two":[34],"real-world":[35],"cohorts":[36],"relapse/refractory":[38],"(R/R)":[39],"adult":[40],"AML":[41,148],"patients:":[42],"VEN-failure":[44,69],"cohort":[45,52,70,99],"(n":[46,53],"=":[47,54],"9)":[48],"and":[49,61,139],"pre-VEN":[51,98],"33).":[55],"Patients":[56],"received":[57],"22.5":[59],"mg/m\u00b2/day":[60],"1":[63],"g/m\u00b2/day":[64],"D1-5.":[65],"Results":[66],"In":[67,96,125],"11%":[71],"achieved":[74,103],"partial":[75],"response":[76],"(PR),":[77],"89%":[78],"were":[79],"refractory":[80],"(ORR":[81,108],"11%).":[82],"The":[83,110],"median":[84,111],"OS":[85,112],"was":[86,113,118],"2.0":[87],"months.":[88,115],"Early":[89,116],"mortality":[90,117],"occurred":[91],"33%":[93,100],"patients.":[95,123,149],"complete":[104],"remission,":[105],"6%":[106],"PR":[107],"39%).":[109],"4.0":[114],"recorded":[119],"3%":[121],"Conclusions":[124],"this":[126],"limited,":[127],"retrospective":[128],"single-center":[129],"experience,":[130],"plus":[132],"showed":[135],"minimal":[136],"clinical":[137],"activity":[138],"an":[140],"unfavorable":[141],"early":[142],"toxicity":[143],"profile":[144],"VEN-exposed":[146],"R/R":[147]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-24T00:00:00"}
