{"id":"https://openalex.org/W7214066563","doi":"https://doi.org/10.64898/2026.09.22.753145","title":"Multimodal 3D imaging reveals a central role for lysosomes in dissolution of cholesterol crystals by macrophages","display_name":"Multimodal 3D imaging reveals a central role for lysosomes in dissolution of cholesterol crystals by macrophages","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214066563","doi":"https://doi.org/10.64898/2026.09.22.753145"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.753145","doi":"https://doi.org/10.64898/2026.09.22.753145","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753145","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.22.753145","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092695940","display_name":"Vibeke Akkerman","orcid":"https://orcid.org/0000-0002-5103-1240","observed_orcids":["https://orcid.org/0000-0002-5103-1240"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Vibeke Akkerman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5103-1240","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046296228","display_name":"Alice Dupont Juhl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Alice Dupont Juhl","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009045593","display_name":"Jacob Marcus Egebjerg","orcid":"https://orcid.org/0009-0001-1451-9116","observed_orcids":["https://orcid.org/0009-0001-1451-9116"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob M. Egebjerg","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark"],"raw_orcid":"https://orcid.org/0009-0001-1451-9116","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070570938","display_name":"Christoph Pratsch","orcid":"https://orcid.org/0000-0003-4315-4854","observed_orcids":["https://orcid.org/0000-0003-4315-4854"]},"institutions":[{"id":"https://openalex.org/I2800795503","display_name":"Helmholtz-Zentrum Berlin f\u00fcr Materialien und Energie","ror":"https://ror.org/02aj13c28","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2800795503"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Pratsch","raw_affiliation_strings":["Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany","institution_ids":["https://openalex.org/I2800795503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074987930","display_name":"Stephan Werner","orcid":"https://orcid.org/0000-0002-9041-1967","observed_orcids":["https://orcid.org/0000-0002-9041-1967"]},"institutions":[{"id":"https://openalex.org/I2800795503","display_name":"Helmholtz-Zentrum Berlin f\u00fcr Materialien und Energie","ror":"https://ror.org/02aj13c28","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2800795503"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Werner","raw_affiliation_strings":["Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany","institution_ids":["https://openalex.org/I2800795503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059108216","display_name":"Gerd Schneider","orcid":"https://orcid.org/0000-0001-9448-0524","observed_orcids":["https://orcid.org/0000-0001-9448-0524"]},"institutions":[{"id":"https://openalex.org/I2800795503","display_name":"Helmholtz-Zentrum Berlin f\u00fcr Materialien und Energie","ror":"https://ror.org/02aj13c28","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2800795503"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Schneider","raw_affiliation_strings":["Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of X-Ray Microscopy, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin, Germany","institution_ids":["https://openalex.org/I2800795503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114068772","display_name":"Tido Willms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tido Willms","raw_affiliation_strings":["Department of Biology, Humboldt University Berlin, Invalidenstr. 42, 10115 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Humboldt University Berlin, Invalidenstr. 42, 10115 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128552222","display_name":"Peter  (1791 - 1877) Mu\u0308ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter M\u00fcller","raw_affiliation_strings":["Department of Biology, Humboldt University Berlin, Invalidenstr. 42, 10115 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Humboldt University Berlin, Invalidenstr. 42, 10115 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078784635","display_name":"Sergey Kapishnikov","orcid":"https://orcid.org/0000-0003-2560-054X","observed_orcids":["https://orcid.org/0000-0003-2560-054X"]},"institutions":[{"id":"https://openalex.org/I4405261776","display_name":"SiriusXT Ltd (Ireland)","ror":"https://ror.org/05twbtq26","country_code":"IE","type":"company","lineage":["https://openalex.org/I4405261776"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sergey Kapishnikov","raw_affiliation_strings":["SiriusXT Limited, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SiriusXT Limited, Dublin, Ireland","institution_ids":["https://openalex.org/I4405261776"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090901298","display_name":"Daniel W\u00fcstner","orcid":"https://orcid.org/0000-0003-4995-9709","observed_orcids":["https://orcid.org/0000-0003-4995-9709"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Daniel W\u00fcstner","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-4995-9709","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK\u20135230 Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090901298"],"corresponding_institution_ids":["https://openalex.org/I177969490"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol-crystals","display_name":"cholesterol crystals","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.722000002861023},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.6899999976158142},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8130000233650208},{"id":"https://openalex.org/keywords/late-endosomes","display_name":"late endosomes","score":0.781000018119812},{"id":"https://openalex.org/keywords/lysosomal-acidification","display_name":"lysosomal acidification","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lysosomal-exocytosis","display_name":"lysosomal exocytosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cholesterol-transport","display_name":"cholesterol transport","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cyclodextrins","display_name":"cyclodextrins","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dehydroergosterol","display_name":"dehydroergosterol","score":0.902999997138977},{"id":"https://openalex.org/keywords/u18666a","display_name":"U18666A","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/crystal-dissolution","display_name":"crystal dissolution","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7745000123977661},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7161999940872192},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6819000244140625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6743000149726868},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6122000217437744},{"id":"https://openalex.org/C2779934242","wikidata":"https://www.wikidata.org/wiki/Q7187520","display_name":"Phospholipidosis","level":4,"score":0.6031000018119812},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5763999819755554},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5590999722480774},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5562000274658203},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.5228000283241272},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5175999999046326},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.4982999861240387},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.49219998717308044},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.49219998717308044},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.4717000126838684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4675999879837036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.43299999833106995},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.41269999742507935},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.4097000062465668},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.3596999943256378},{"id":"https://openalex.org/C2777722557","wikidata":"https://www.wikidata.org/wiki/Q4841341","display_name":"Bafilomycin","level":4,"score":0.34209999442100525},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.3391000032424927},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.2757999897003174},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.26109999418258667},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.22.753145","doi":"https://doi.org/10.64898/2026.09.22.753145","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753145","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753145","doi":"https://doi.org/10.64898/2026.09.22.753145","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753145","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W144567121","https://openalex.org/W1499811594","https://openalex.org/W1972483153","https://openalex.org/W1983619827","https://openalex.org/W1988826338","https://openalex.org/W1998249296","https://openalex.org/W2032146255","https://openalex.org/W2033206973","https://openalex.org/W2034029712","https://openalex.org/W2043890963","https://openalex.org/W2072056790","https://openalex.org/W2077276315","https://openalex.org/W2078583436","https://openalex.org/W2101504230","https://openalex.org/W2121946692","https://openalex.org/W2122573744","https://openalex.org/W2131894828","https://openalex.org/W2284163092","https://openalex.org/W2316823580","https://openalex.org/W2330691955","https://openalex.org/W2341412675","https://openalex.org/W2401470133","https://openalex.org/W2555780791","https://openalex.org/W2562351185","https://openalex.org/W2751026635","https://openalex.org/W2769534854","https://openalex.org/W2811390012","https://openalex.org/W2949649294","https://openalex.org/W3003296071","https://openalex.org/W3084231116","https://openalex.org/W3111521801","https://openalex.org/W3164704875","https://openalex.org/W4214667590","https://openalex.org/W4214891622","https://openalex.org/W4290725087","https://openalex.org/W4309570245","https://openalex.org/W4322715840","https://openalex.org/W4385145536","https://openalex.org/W4388127467","https://openalex.org/W4388133499","https://openalex.org/W4391026761","https://openalex.org/W4404466178","https://openalex.org/W4407876251","https://openalex.org/W4408098270","https://openalex.org/W4408244292","https://openalex.org/W4410356589","https://openalex.org/W4414039870","https://openalex.org/W4416769883","https://openalex.org/W4417427260","https://openalex.org/W6891933225","https://openalex.org/W7128432945"],"related_works":["https://openalex.org/W4385145536","https://openalex.org/W2089652415","https://openalex.org/W2121946692","https://openalex.org/W2184705469","https://openalex.org/W2084069102","https://openalex.org/W2048595675","https://openalex.org/W7096547382","https://openalex.org/W4400185552","https://openalex.org/W2606491058","https://openalex.org/W1983619827"],"abstract_inverted_index":{"Abstract":[0],"Formation":[1],"of":[2,13,19,44,75,84,92,98,108,140,148,154,160,167,190,205,233,252,262],"cholesterol":[3,31,254],"crystals":[4,235],"(CCs)":[5],"is":[6,194,208],"a":[7,112,145,172],"key":[8],"event":[9],"during":[10,176],"the":[11,16,29,42,109,152,158,188,201,231,245],"development":[12],"atherosclerosis,":[14],"but":[15],"molecular":[17],"mechanisms":[18],"their":[20],"degradation":[21,139],"within":[22],"cells":[23],"are":[24,64,129],"poorly":[25],"understood.":[26],"By":[27],"incorporating":[28],"fluorescent":[30,146,168,197],"analogue":[32],"TopFluor-Cholesterol":[33],"(TF-Chol)":[34],"into":[35,212],"CCs,":[36,253],"we":[37,60,120,226],"were":[38],"able":[39],"to":[40,105,183,187,210],"visualize":[41],"uptake":[43],"CCs":[45,63,124,155],"in":[46,66,73,94,125,236,239,258],"macrophages":[47,128,143],"using":[48,218],"correlative":[49],"fluorescence":[50,219],"and":[51,69,96,137,156,203,214,216,221,238,256],"soft":[52],"X-ray":[53],"microscopy.":[54],"Using":[55,111],"quantitative":[56],"3D":[57,117],"live-cell":[58],"imaging,":[59],"show":[61,121],"that":[62,122,180,228],"processed":[65,130],"late":[67],"endosomes":[68],"lysosomes":[70],"(LE/Lys),":[71],"resulting":[72],"formation":[74,159],"TF-Chol":[76,93],"containing":[77],"lipid":[78],"droplets":[79],"(LDs)":[80],"over":[81],"time.":[82],"Inhibition":[83],"lysosomal":[85,99,132,246],"sterol":[86,198],"export":[87],"with":[88,101,116,127,144,163,171],"U18666A":[89],"caused":[90],"accumulation":[91],"LE/Lys,":[95],"inhibition":[97],"acidification":[100],"bafilomycin":[102],"A1":[103],"led":[104],"reduced":[106],"dissolution":[107,153,189,232,251],"CCs.":[110,141,191],"novel":[113],"assay":[114],"combined":[115],"image":[118],"processing,":[119],"large":[123],"contact":[126],"via":[131],"exocytosis":[133],"followed":[134],"by":[135,217],"extracellular":[136],"intracellular":[138,181],"Treating":[142],"version":[147],"cyclodextrin":[149],"(CD)":[150],"promoted":[151],"enhanced":[157],"LDs":[161],"enriched":[162],"TF-Chol.":[164],"The":[165],"majority":[166],"CD":[169,229],"co-localized":[170],"marker":[173],"for":[174,250],"LE/Lys":[175,184],"this":[177],"process,":[178],"suggesting":[179],"delivery":[182],"may":[185],"contribute":[186],"Dehydroergosterol":[192],"(DHE)":[193],"an":[195],"intrinsically":[196],"closely":[199],"mimicking":[200],"properties":[202],"behavior":[204],"cholesterol.":[206],"DHE":[207,234],"known":[209],"self-associate":[211],"aggregates":[213],"crystals,":[215],"spectroscopy":[220],"specialized":[222],"ultraviolet":[223],"(UV)":[224],"microscopy,":[225],"found":[227],"enhances":[230],"vitro":[237],"cells.":[240],"Together,":[241],"our":[242],"findings":[243],"highlight":[244],"pathway":[247],"as":[248],"responsible":[249],"trafficking,":[255],"efflux":[257],"macrophages.":[259],"For":[260],"Table":[261],"contents":[263],"only":[264]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-24T00:00:00"}
