{"id":"https://openalex.org/W7214049647","doi":"https://doi.org/10.64898/2026.09.21.753151","title":"A Wolbachia pipientis protein confers resistance to virus infection in Drosophila melanogaster","display_name":"A Wolbachia pipientis protein confers resistance to virus infection in Drosophila melanogaster","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214049647","doi":"https://doi.org/10.64898/2026.09.21.753151"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.21.753151","doi":"https://doi.org/10.64898/2026.09.21.753151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753151","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.21.753151.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.21.753151.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026710627","display_name":"Thomas Leech","orcid":"https://orcid.org/0000-0002-9504-0739","observed_orcids":["https://orcid.org/0000-0002-9504-0739"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Leech","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082554682","display_name":"Bruno Taschke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bruno Taschke","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055224183","display_name":"Ralf Leslie Meilenbrock","orcid":"https://orcid.org/0000-0001-9864-0257","observed_orcids":["https://orcid.org/0000-0001-9864-0257"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Leslie Meilenbrock","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028665639","display_name":"Luke Stephen Tain","orcid":"https://orcid.org/0000-0002-5845-7383","observed_orcids":["https://orcid.org/0000-0002-5845-7383"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luke Stephen Tain","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028977824","display_name":"Pingze Zhang","orcid":"https://orcid.org/0000-0002-6156-9722","observed_orcids":["https://orcid.org/0000-0002-6156-9722"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pingze Zhang","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054480882","display_name":"Sebastian Gr\u00f6nke","orcid":"https://orcid.org/0000-0002-1539-5346","observed_orcids":["https://orcid.org/0000-0002-1539-5346"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Gr\u00f6nke","raw_affiliation_strings":["Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1539-5346","affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059311261","display_name":"Linda Partridge","orcid":"https://orcid.org/0000-0001-9615-0094","observed_orcids":["https://orcid.org/0000-0001-9615-0094"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Linda Partridge","raw_affiliation_strings":["Institute of Healthy Ageing, and GEE, UCL, United Kingdom","Max-Planck Institute for Biology of Ageing, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9615-0094","affiliations":[{"raw_affiliation_string":"Institute of Healthy Ageing, and GEE, UCL, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Max-Planck Institute for Biology of Ageing, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059311261"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210153965","https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wolbachia-pipientis","display_name":"Wolbachia pipientis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8640000224113464},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drosophila-c-virus","display_name":"Drosophila C virus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/imd-pathway","display_name":"Imd pathway","score":0.6940000057220459},{"id":"https://openalex.org/keywords/relish","display_name":"Relish","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.593999981880188},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.777999997138977},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.6019999980926514},{"id":"https://openalex.org/keywords/rna-viruses","display_name":"RNA viruses","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2779356413","wikidata":"https://www.wikidata.org/wiki/Q283526","display_name":"Wolbachia","level":3,"score":0.957099974155426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8981000185012817},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7950999736785889},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7142999768257141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5841000080108643},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.574400007724762},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5098999738693237},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46630001068115234},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42899999022483826},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.413100004196167},{"id":"https://openalex.org/C136961756","wikidata":"https://www.wikidata.org/wiki/Q7431879","display_name":"Schneider 2 cells","level":5,"score":0.4027000069618225},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.40049999952316284},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3995000123977661},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.38940000534057617},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.36250001192092896},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.33869999647140503},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2915000021457672},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.28360000252723694},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.27559998631477356}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.21.753151","doi":"https://doi.org/10.64898/2026.09.21.753151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753151","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.21.753151.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.21.753151","doi":"https://doi.org/10.64898/2026.09.21.753151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753151","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.21.753151.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000095838","display_name":null,"funder_award_id":"NIH-P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214049647.pdf","grobid_xml":"https://content.openalex.org/works/W7214049647.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1580426270","https://openalex.org/W1755844030","https://openalex.org/W1968219928","https://openalex.org/W1970985601","https://openalex.org/W1995972219","https://openalex.org/W1999574084","https://openalex.org/W1999966127","https://openalex.org/W2009246694","https://openalex.org/W2013749723","https://openalex.org/W2020003088","https://openalex.org/W2025476226","https://openalex.org/W2028012273","https://openalex.org/W2030942380","https://openalex.org/W2038357425","https://openalex.org/W2041602338","https://openalex.org/W2043283675","https://openalex.org/W2047526274","https://openalex.org/W2052112605","https://openalex.org/W2052636440","https://openalex.org/W2053685560","https://openalex.org/W2056558785","https://openalex.org/W2062202124","https://openalex.org/W2064274440","https://openalex.org/W2066490392","https://openalex.org/W2070156683","https://openalex.org/W2071560595","https://openalex.org/W2075519966","https://openalex.org/W2075570572","https://openalex.org/W2081730917","https://openalex.org/W2102549002","https://openalex.org/W2102902375","https://openalex.org/W2108077860","https://openalex.org/W2109975664","https://openalex.org/W2114570000","https://openalex.org/W2115882842","https://openalex.org/W2116661167","https://openalex.org/W2120996994","https://openalex.org/W2121172114","https://openalex.org/W2126419817","https://openalex.org/W2128655116","https://openalex.org/W2132329761","https://openalex.org/W2133250947","https://openalex.org/W2137039075","https://openalex.org/W2146512944","https://openalex.org/W2146758165","https://openalex.org/W2147294427","https://openalex.org/W2150650344","https://openalex.org/W2151223000","https://openalex.org/W2157725915","https://openalex.org/W2161620412","https://openalex.org/W2222379602","https://openalex.org/W2229090536","https://openalex.org/W2296845215","https://openalex.org/W2471535861","https://openalex.org/W2579326722","https://openalex.org/W2584730025","https://openalex.org/W2592348331","https://openalex.org/W2622026032","https://openalex.org/W2739052000","https://openalex.org/W2753808184","https://openalex.org/W2791412679","https://openalex.org/W2791722385","https://openalex.org/W2809089210","https://openalex.org/W2887158367","https://openalex.org/W2887568208","https://openalex.org/W2889565365","https://openalex.org/W2910698406","https://openalex.org/W2942169161","https://openalex.org/W2951029237","https://openalex.org/W2952146885","https://openalex.org/W2988053505","https://openalex.org/W2997022986","https://openalex.org/W3008705497","https://openalex.org/W3155813597","https://openalex.org/W3172070999","https://openalex.org/W3173724788","https://openalex.org/W3178766860","https://openalex.org/W4313411560","https://openalex.org/W4392192855","https://openalex.org/W4407378632","https://openalex.org/W7095786534"],"related_works":["https://openalex.org/W2108077860","https://openalex.org/W7097391030","https://openalex.org/W186270442","https://openalex.org/W7099907181","https://openalex.org/W7099851671","https://openalex.org/W1985921629","https://openalex.org/W2625871672","https://openalex.org/W4409278199","https://openalex.org/W2075519966","https://openalex.org/W2030984826"],"abstract_inverted_index":{"Abstract":[0],"The":[1,122],"intracellular":[2,305],"bacterium":[3,306],"Wolbachia":[4,28,58,82,90,111,120,128,139,143,286,302,337,358,387,392,466],"pipientis":[5],"alters":[6],"the":[7,53,79,87,93,96,138,158,224,227,245,254,276,297,355,367,384,397,408,419,472],"biology":[8],"of":[9,37,45,81,89,95,137,188,196,198,207,221,226,253,257,269,279,317,357,366,386,391,415,435,474,487],"its":[10,38,318,324,328],"arthropod":[11],"hosts":[12],"in":[13,23,78,150,312,354,383,396,423,464,471],"many":[14,313],"ways,":[15],"and":[16,26,112,118,162,243,432,446],"can":[17],"increase":[18],"resistance":[19,62,94,225],"to":[20,40,84,99,108,113,166,229,310,323,326],"RNA":[21,50,333,485],"viruses":[22,486],"both":[24,107],"Drosophila":[25,71,102,342,368,376,398,454],"mosquitoes.":[27],"-induced":[29,467],"pathogen":[30,468],"blocking":[31],"has":[32],"generated":[33,179],"much":[34],"interest":[35],"because":[36],"potential":[39,251],"restrict":[41],"insect":[42,314],"vector":[43],"transmission":[44],"human":[46],"diseases":[47],"caused":[48],"by":[49,56,375],"viruses.":[51],"However,":[52],"molecular":[54],"mechanisms":[55],"which":[57,73],"affects":[59],"host":[60,176,294,329],"viral":[61],"are":[63,74,164,344,349],"still":[64],"mostly":[65],"elusive.":[66],"We":[67,360,439],"used":[68],"dilp2-3,5":[69,151],"mutant":[70,97,124,152,345],",":[72,83],"long-lived,":[75,351],"but":[76,205,335,352,380],"only":[77,353,382],"presence":[80,88,356,385],"show":[85],"that":[86,145,292,307,343,362,402,448],"also":[91],"increased":[92,223],"flies":[98,116,125,228,363,424],"infection":[100,331,374,431],"with":[101,117,185,332],"C":[103,377],"virus":[104,378],"(DCV),":[105,379],"relative":[106],"mutants":[109],"lacking":[110,364],"wild":[114,131],"type":[115,132],"without":[119],".":[121,359,388],"insulin":[123,347,369,399],"had":[126],"higher":[127],"titres":[129],"than":[130],"flies.":[133,153],"By":[134],"RNA-seq":[135],"analysis":[136,233],"transcriptome,":[140],"we":[141,178,283,412],"identified":[142,244,284],"genes":[144,191,393],"were":[146,156,371,394],"more":[147],"strongly":[148,160],"expressed":[149,413],"Ankyrin-domain-containing":[154],"proteins":[155],"among":[157],"most":[159],"up-regulated":[161],"they":[163,403],"predicted":[165],"be":[167,405],"secreted":[168],"effector":[169],"proteins.":[170,194,438],"To":[171],"address":[172],"their":[173],"effect":[174,278],"on":[175],"physiology,":[177],"4":[180],"transgenic":[181],"fly":[182,214],"lines":[183],"each":[184],"inducible":[186],"expression":[187,206,261],"a":[189,235,250,264,285,452,478],"different":[190],"encoding":[192],"ankyrin-domain-containing":[193,420],"Expression":[195],"3":[197],"these":[199,416],"did":[200],"not":[201],"cause":[202],"obvious":[203],"effects,":[204],"WD0754":[208,222,241,260],"at":[209],"high":[210],"levels":[211],"severely":[212],"shortened":[213],"survival.":[215],"Interestingly,":[216],"however,":[217],"chronic":[218],"low-level":[219],"induction":[220],"DCV":[230,430],"infection.":[231],"Proteomics":[232],"showed":[234],"robust,":[236],"tissue-specific,":[237],"anti-viral":[238,409,436,444],"response":[239],"upon":[240],"induction,":[242],"NFkB-like":[246],"IMD":[247,270,298],"pathway":[248],"as":[249,477],"mediator":[252,268],"antiviral":[255,277],"activity":[256],"WD0754.":[258,280],"Consistently,":[259],"activated":[262],"Relish,":[263,451],"key":[265],"downstream":[266],"transcriptional":[267],"signalling,":[271],"while":[272],"loss-of":[273],"Relish":[274],"blocked":[275],"In":[281],"summary,":[282],"-derived":[287],"ankyrin":[288],"domain":[289],"containing":[290],"protein":[291,421],"modulates":[293],"immunity":[295,437,445],"through":[296],"pathway.":[299],"Authors\u2019":[300],"summary":[301],"is":[303,308,321,340],"an":[304,461],"able":[309],"proliferate":[311],"species.":[315],"Part":[316],"evolutionary":[319],"success":[320],"due":[322],"ability":[325],"protect":[327],"from":[330,429],"viruses,":[334],"how":[336],"does":[338],"this":[339,442],"unknown.":[341],"for":[346,407,482],"signaling":[348],"often":[350],"found":[361,447],"several":[365],"ligands":[370],"protected":[372],"against":[373],"again":[381],"A":[389],"group":[390],"upregulated":[395],"mutants,":[400],"suggesting":[401],"could":[404,426],"responsible":[406],"protection.":[410],"When":[411],"one":[414],"possible":[417],"effectors,":[418],"WD0754,":[422],"it":[425,449],"provide":[427],"protection":[428],"induced":[433],"upregulation":[434],"further":[440],"characterised":[441],"WD0754-induced":[443],"required":[450],"well-known":[453],"immune":[455],"transcription":[456],"factor.":[457],"This":[458],"work":[459],"marks":[460],"important":[462],"step":[463],"understanding":[465],"blocking,":[469],"especially":[470],"context":[473],"Wolbachia\u2019s":[475],"use":[476],"biological":[479],"control":[480],"agent":[481],"vector-borne,":[483],"pathogenic":[484],"humans.":[488]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-23T00:00:00"}
