{"id":"https://openalex.org/W7214040784","doi":"https://doi.org/10.64898/2026.09.20.750311","title":"Aged-associated changes in active YAP staining during impaired skin wound healing in aged mice and delayed wound closure in ICE mice","display_name":"Aged-associated changes in active YAP staining during impaired skin wound healing in aged mice and delayed wound closure in ICE mice","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214040784","doi":"https://doi.org/10.64898/2026.09.20.750311"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.20.750311","doi":"https://doi.org/10.64898/2026.09.20.750311","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.750311","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.750311.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.750311.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006979030","display_name":"Masayuki Tokunaga","orcid":"https://orcid.org/0000-0001-6092-9629","observed_orcids":["https://orcid.org/0000-0001-6092-9629","https://orcid.org/0009-0001-4774-9225"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I4405285712","display_name":"Research Institute for Cell Design Medical Science, Yamaguchi University","ror":"https://ror.org/000pr5j65","country_code":"JP","type":"facility","lineage":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Tokunaga","raw_affiliation_strings":["Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6092-9629","affiliations":[{"raw_affiliation_string":"Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060484970","display_name":"Nao Kitamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I4405285712","display_name":"Research Institute for Cell Design Medical Science, Yamaguchi University","ror":"https://ror.org/000pr5j65","country_code":"JP","type":"facility","lineage":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nao Kitamura","raw_affiliation_strings":["Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152478683","display_name":"Mai Hamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Hamamoto","raw_affiliation_strings":["Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041205933","display_name":"Motoshi Hayano","orcid":"https://orcid.org/0000-0001-6453-2741","observed_orcids":["https://orcid.org/0000-0001-6453-2741"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210107168","display_name":"Keio University Hospital","ror":"https://ror.org/01k8ej563","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107168"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoshi Hayano","raw_affiliation_strings":["Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6453-2741","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210107168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059704901","display_name":"Kazuhiro Kimura","orcid":"https://orcid.org/0000-0002-2502-6149","observed_orcids":["https://orcid.org/0000-0002-2502-6149"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I4405285712","display_name":"Research Institute for Cell Design Medical Science, Yamaguchi University","ror":"https://ror.org/000pr5j65","country_code":"JP","type":"facility","lineage":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Kimura","raw_affiliation_strings":["Department of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009495120","display_name":"Makoto Furutani\u2010Seiki","orcid":"https://orcid.org/0000-0002-0885-4778","observed_orcids":["https://orcid.org/0000-0002-0885-4778"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I4405285712","display_name":"Research Institute for Cell Design Medical Science, Yamaguchi University","ror":"https://ror.org/000pr5j65","country_code":"JP","type":"facility","lineage":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Furutani-Seiki","raw_affiliation_strings":["Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0885-4778","affiliations":[{"raw_affiliation_string":"Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068268225","display_name":"Yoichi Asaoka","orcid":"https://orcid.org/0000-0003-0802-4106","observed_orcids":["https://orcid.org/0000-0003-0802-4106"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I4405285712","display_name":"Research Institute for Cell Design Medical Science, Yamaguchi University","ror":"https://ror.org/000pr5j65","country_code":"JP","type":"facility","lineage":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Asaoka","raw_affiliation_strings":["Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0802-4106","affiliations":[{"raw_affiliation_string":"Department of Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Sciences, Yamaguchi University, Ube, Yamaguchi, 755-8505, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068268225"],"corresponding_institution_ids":["https://openalex.org/I173915773","https://openalex.org/I4405285712"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.11129999905824661,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.9340000152587891},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9850000143051147},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mechanosensitive-signaling","display_name":"mechanosensitive signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ankrd1","display_name":"ANKRD1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/delayed-wound-closure","display_name":"delayed wound closure","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7049999833106995},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/col3a1","display_name":"COL3A1","score":0.984000027179718},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ccn1","display_name":"CYR61","score":0.9789999723434448},{"id":"https://openalex.org/keywords/arhgap18","display_name":"ARHGAP18","score":0.9390000104904175},{"id":"https://openalex.org/keywords/full-thickness-excisional-wounds","display_name":"full-thickness excisional wounds","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.9703999757766724},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7800999879837036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47999998927116394},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4242999851703644},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34540000557899475},{"id":"https://openalex.org/C2993873987","wikidata":"https://www.wikidata.org/wiki/Q184753","display_name":"Wound closure","level":3,"score":0.33980000019073486},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C2776716733","wikidata":"https://www.wikidata.org/wiki/Q1890226","display_name":"Adventitia","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2671999931335449},{"id":"https://openalex.org/C2776413796","wikidata":"https://www.wikidata.org/wiki/Q6452285","display_name":"Skin ulcer","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2644999921321869}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.20.750311","doi":"https://doi.org/10.64898/2026.09.20.750311","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.750311","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.750311.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.20.750311","doi":"https://doi.org/10.64898/2026.09.20.750311","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.750311","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.750311.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214040784.pdf","grobid_xml":"https://content.openalex.org/works/W7214040784.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1581119831","https://openalex.org/W1966228205","https://openalex.org/W1979581862","https://openalex.org/W1987292598","https://openalex.org/W2011806880","https://openalex.org/W2126525177","https://openalex.org/W2139160260","https://openalex.org/W2146337514","https://openalex.org/W2299859137","https://openalex.org/W2353982544","https://openalex.org/W2904492726","https://openalex.org/W3155386417","https://openalex.org/W4312210563","https://openalex.org/W4313531093","https://openalex.org/W4315705280","https://openalex.org/W4382930889","https://openalex.org/W4398180946","https://openalex.org/W7139008323"],"related_works":["https://openalex.org/W7118064043","https://openalex.org/W7160640594","https://openalex.org/W4411157420","https://openalex.org/W7100297141","https://openalex.org/W6912890240","https://openalex.org/W4385651451","https://openalex.org/W7212210176","https://openalex.org/W2022269012","https://openalex.org/W2344333895","https://openalex.org/W4394583900"],"abstract_inverted_index":{"Abstract":[0],"Aging":[1],"is":[2,33,210],"associated":[3],"with":[4,47,177,187,230],"impaired":[5],"skin":[6],"wound":[7,45,71,86,101,169,184,208,248],"healing,":[8,46,170],"but":[9,221],"the":[10,24,105,112,123,142],"molecular":[11],"mechanisms":[12],"underlying":[13],"this":[14,37],"decline":[15],"remain":[16],"incompletely":[17],"understood.":[18,35],"In":[19,36,146],"particular,":[20],"how":[21],"aging":[22],"affects":[23],"temporal":[25,224],"regulation":[26,173,225],"of":[27,64,108,111,174,207,218,226],"mechanosensitive":[28,54,175,227],"signaling":[29,176],"during":[30,104,168],"tissue":[31],"repair":[32],"poorly":[34],"study,":[38],"we":[39],"investigated":[40],"age-associated":[41,68,163,205,244],"changes":[42],"in":[43,70,79,152,165,197,246],"cutaneous":[44,247],"a":[48,192,238],"focus":[49],"on":[50],"Yes-associated":[51],"protein":[52],"(YAP)-associated":[53],"responses,":[55],"and":[56,81,85,90,119,122,130,138],"examined":[57,143],"whether":[58],"ICE":[59,180,234],"mice,":[60,84,190],"an":[61],"inducible":[62],"model":[63,241],"epigenetic":[65],"aging,":[66],"reproduce":[67],"impairment":[69,206],"repair.":[72,109],"Splinted":[73],"full-thickness":[74],"excisional":[75],"wounds":[76,140,154],"were":[77,93],"generated":[78],"young":[80,137],"naturally":[82,198],"aged":[83,139,153,199],"closure,":[87,102],"gene":[88],"expression,":[89],"active":[91],"YAP":[92,160],"evaluated":[94],"over":[95],"time.":[96],"Aged":[97],"mice":[98,181,235],"exhibited":[99,182],"delayed":[100,183],"particularly":[103],"mid-to-late":[106],"phases":[107],"Expression":[110],"fibrosis-related":[113],"genes":[114,125],"Tgfb1":[115],",":[116,118,121,127,129],"Col1a1":[117],"Col3a1":[120],"YAP-associated":[124],"Ctgf":[126],"Cyr61":[128],"Arhgap18":[131],"did":[132],"not":[133,212],"differ":[134],"significantly":[135],"between":[136],"at":[141,155],"time":[144],"points.":[145],"contrast,":[147],"Ankrd1":[148,232],"was":[149],"selectively":[150],"elevated":[151],"postoperative":[156],"day":[157],"14.":[158],"Active":[159],"immunofluorescence":[161],"showed":[162],"differences":[164],"staining":[166],"patterns":[167],"indicating":[171],"altered":[172,223],"aging.":[178],"Furthermore,":[179],"closure":[185],"compared":[186],"Cre":[188],"control":[189],"reproducing":[191],"major":[193],"functional":[194],"feature":[195],"observed":[196],"mice.":[200],"These":[201],"findings":[202],"suggest":[203],"that":[204],"healing":[209],"characterized":[211],"by":[213,222],"uniform":[214],"activation":[215],"or":[216],"suppression":[217],"YAP-related":[219],"signaling,":[220],"responses":[228],"together":[229],"selective":[231],"elevation.":[233],"could":[236],"provide":[237],"useful":[239],"experimental":[240],"for":[242],"investigating":[243],"defects":[245],"healing.":[249]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-23T00:00:00"}