{"id":"https://openalex.org/W7214038728","doi":"https://doi.org/10.64898/2026.09.18.752746","title":"Single residues within the YTHDF intrinsically disordered region control m 6 A-dependent mRNA decay","display_name":"Single residues within the YTHDF intrinsically disordered region control m 6 A-dependent mRNA decay","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214038728","doi":"https://doi.org/10.64898/2026.09.18.752746","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818126","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622065"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.18.752746","doi":"https://doi.org/10.64898/2026.09.18.752746","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752746","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752746.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752746.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050213527","display_name":"Benedetta Ricci","orcid":"https://orcid.org/0000-0002-5213-0531","observed_orcids":["https://orcid.org/0000-0002-5213-0531"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedetta Ricci","raw_affiliation_strings":["Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-5213-0531","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050207664","display_name":"Danika Sommer","orcid":"https://orcid.org/0000-0001-6466-8323","observed_orcids":["https://orcid.org/0000-0001-6466-8323"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danika Sommer","raw_affiliation_strings":["Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035518942","display_name":"Daymieri Narvaez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daymieri Narvaez","raw_affiliation_strings":["Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152475227","display_name":"Ruqi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruqi Zhang","raw_affiliation_strings":["Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080271854","display_name":"Jacob B. Geri","orcid":"https://orcid.org/0000-0002-9215-5610","observed_orcids":["https://orcid.org/0000-0002-9215-5610"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Geri","raw_affiliation_strings":["Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008569712","display_name":"Sara Zaccara","orcid":"https://orcid.org/0000-0002-6569-2015","observed_orcids":["https://orcid.org/0000-0002-6569-2015"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sara Zaccara","raw_affiliation_strings":["Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-6569-2015","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008569712"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.75,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.75,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.20800000429153442,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9210000038146973},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.906000018119812},{"id":"https://openalex.org/keywords/rna-granules","display_name":"RNA granules","score":0.906000018119812},{"id":"https://openalex.org/keywords/cellular-fitness","display_name":"cell fitness","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6766999959945679},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5784000158309937},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.5612999796867371},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5547000169754028},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5478000044822693},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.5382999777793884},{"id":"https://openalex.org/C2780887552","wikidata":"https://www.wikidata.org/wiki/Q7226087","display_name":"Poly(A)-binding protein","level":5,"score":0.48989999294281006},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4733000099658966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4496999979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44369998574256897},{"id":"https://openalex.org/C162419368","wikidata":"https://www.wikidata.org/wiki/Q14864908","display_name":"P-bodies","level":5,"score":0.4237000048160553},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.39640000462532043},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3885999917984009},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30309998989105225},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.29350000619888306},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2799000144004822},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C117838200","wikidata":"https://www.wikidata.org/wiki/Q14592582","display_name":"Stress granule","level":5,"score":0.25839999318122864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2578999996185303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.18.752746","doi":"https://doi.org/10.64898/2026.09.18.752746","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752746","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752746.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622065","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818126/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.18.752746","doi":"https://doi.org/10.64898/2026.09.18.752746","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752746","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752746.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214038728.pdf","grobid_xml":"https://content.openalex.org/works/W7214038728.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1976260744","https://openalex.org/W1987981719","https://openalex.org/W1991807334","https://openalex.org/W1992672580","https://openalex.org/W2001858363","https://openalex.org/W2003911773","https://openalex.org/W2011852020","https://openalex.org/W2023333666","https://openalex.org/W2065847836","https://openalex.org/W2078964320","https://openalex.org/W2128420974","https://openalex.org/W2138267133","https://openalex.org/W2139995722","https://openalex.org/W2157658519","https://openalex.org/W2336828812","https://openalex.org/W2507685096","https://openalex.org/W2568226856","https://openalex.org/W2605361745","https://openalex.org/W2627064270","https://openalex.org/W2766599608","https://openalex.org/W2767613320","https://openalex.org/W2773925504","https://openalex.org/W2784370070","https://openalex.org/W2784500348","https://openalex.org/W2793785833","https://openalex.org/W2806884808","https://openalex.org/W2808587407","https://openalex.org/W2885321095","https://openalex.org/W2888618670","https://openalex.org/W2889513238","https://openalex.org/W2906593639","https://openalex.org/W2914907359","https://openalex.org/W2928211142","https://openalex.org/W2960264922","https://openalex.org/W3010320439","https://openalex.org/W3026751717","https://openalex.org/W3029046617","https://openalex.org/W3083008290","https://openalex.org/W3087500438","https://openalex.org/W3092757562","https://openalex.org/W3093053585","https://openalex.org/W3131839988","https://openalex.org/W3132864675","https://openalex.org/W3165179041","https://openalex.org/W4220795729","https://openalex.org/W4281391717","https://openalex.org/W4281558719","https://openalex.org/W4307500724","https://openalex.org/W4317830667","https://openalex.org/W4318985524","https://openalex.org/W4382542460","https://openalex.org/W4384936518","https://openalex.org/W4387742328","https://openalex.org/W4388540721","https://openalex.org/W4388541090","https://openalex.org/W4388636313","https://openalex.org/W4392243629","https://openalex.org/W4401014965","https://openalex.org/W4404400020","https://openalex.org/W4404595805","https://openalex.org/W4406452416","https://openalex.org/W4410081364","https://openalex.org/W4411807640","https://openalex.org/W4411985457","https://openalex.org/W4415503346","https://openalex.org/W7130522902","https://openalex.org/W7135013631","https://openalex.org/W7172535697"],"related_works":["https://openalex.org/W7172535697","https://openalex.org/W7097584582","https://openalex.org/W1992672580","https://openalex.org/W2507685096","https://openalex.org/W1991807334","https://openalex.org/W4393364040","https://openalex.org/W3029046617","https://openalex.org/W1987981719","https://openalex.org/W2579378735","https://openalex.org/W2575691519"],"abstract_inverted_index":{"SUMMARY":[0],"Intrinsically":[1],"disordered":[2,49],"regions":[3],"(IDRs)":[4],"mediate":[5],"protein":[6,125],"interactions,":[7],"condensate":[8],"partitioning,":[9],"and":[10,31,38,98,110,138],"regulatory":[11,132],"control":[12],"in":[13,70],"RNA-binding":[14],"proteins,":[15],"yet":[16],"the":[17,47,130,135],"residue-level":[18,44,131],"logic":[19,133],"underlying":[20],"IDR":[21,76,137,151],"function":[22],"has":[23],"remained":[24],"difficult":[25],"to":[26,42,61,113,145],"define":[27,129],"using":[28],"conventional":[29],"fragment-":[30],"truncation-based":[32],"approaches.":[33],"Here,":[34],"we":[35,74,84],"apply":[36],"cytosine":[37],"adenine":[39],"base-editor":[40,140],"screens":[41],"map":[43],"regulation":[45],"within":[46,150],"intrinsically":[48],"region":[50],"of":[51,134],"YTHDF2,":[52],"a":[53,71,143],"cytoplasmic":[54,114],"reader":[55],"that":[56,78,87,103],"couples":[57],"m":[58,105,120],"6":[59,106,121],"A":[60,122],"mRNA":[62,108],"decay.":[63],"By":[64],"tiling":[65],"base":[66],"edits":[67],"across":[68],"YTHDF2":[69,89,101,136],"YTHDF1/YTHDF3-null":[72],"background,":[73],"identify":[75],"residues":[77,86],"regulate":[79],"YTHDF2-dependent":[80],"cellular":[81],"fitness.":[82],"Interestingly,":[83],"identified":[85],"limit":[88],"decay":[90,109],"activity.":[91],"Their":[92],"mutation":[93],"disrupts":[94],"endogenous":[95],"protein-protein":[96],"interactions":[97],"generates":[99],"hyperactive":[100],"variants":[102],"promote":[104],"A-dependent":[107],"alter":[111],"recruitment":[112],"RNA":[115],"granules,":[116],"without":[117],"affecting":[118],"intrinsic":[119],"binding":[123],"or":[124],"stability.":[126],"These":[127],"findings":[128],"establish":[139],"screening":[141],"as":[142],"strategy":[144],"uncover":[146],"functional":[147],"mechanisms":[148],"encoded":[149],"regions.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-23T00:00:00"}
