{"id":"https://openalex.org/W7214034955","doi":"https://doi.org/10.64898/2026.09.21.26363555","title":"Motor cortex pain compensation is modifiable: allostatic load degrades its analgesic efficiency and rehabilitation restores it","display_name":"Motor cortex pain compensation is modifiable: allostatic load degrades its analgesic efficiency and rehabilitation restores it","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214034955","doi":"https://doi.org/10.64898/2026.09.21.26363555","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622370"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.21.26363555","doi":"https://doi.org/10.64898/2026.09.21.26363555","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363555","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/22/2026.09.21.26363555.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/22/2026.09.21.26363555.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062615661","display_name":"Felipe Fregni","orcid":"https://orcid.org/0000-0002-1703-7526","observed_orcids":["https://orcid.org/0000-0002-1703-7526","https://orcid.org/0000-0003-1307-9355","https://orcid.org/0000-0001-9359-8643"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felipe Fregni","raw_affiliation_strings":["Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":"https://orcid.org/0000-0003-1307-9355","affiliations":[{"raw_affiliation_string":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050723577","display_name":"Marta Imamura","orcid":"https://orcid.org/0000-0003-0355-9697","observed_orcids":["https://orcid.org/0000-0003-0355-9697"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]},{"id":"https://openalex.org/I4405266836","display_name":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o","ror":"https://ror.org/05ygb7j78","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405266836"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marta Imamura","raw_affiliation_strings":["Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (IMREA HCFMUSP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (IMREA HCFMUSP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210145268","https://openalex.org/I4405266836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079733959","display_name":"Lucas Camargo","orcid":"https://orcid.org/0000-0002-4112-6473","observed_orcids":["https://orcid.org/0000-0002-4112-6473"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas Camargo","raw_affiliation_strings":["Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062024820","display_name":"Kevin Pacheco\u2010Barrios","orcid":"https://orcid.org/0000-0002-7166-2816","observed_orcids":["https://orcid.org/0000-0002-7166-2816"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I271457894","display_name":"Universidad San Ignacio de Loyola","ror":"https://ror.org/03vgk3f90","country_code":"PE","type":"education","lineage":["https://openalex.org/I271457894"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["PE","US"],"is_corresponding":false,"raw_author_name":"Kevin Pacheco-Barrios","raw_affiliation_strings":["Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA","Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencias en Salud, Vicerrectorado de Investigaci\u00f3n, Universidad San Ignacio de Loyola, Lima 15023, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencias en Salud, Vicerrectorado de Investigaci\u00f3n, Universidad San Ignacio de Loyola, Lima 15023, Peru","institution_ids":["https://openalex.org/I271457894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139113718","display_name":"Anna Lepesteur Gianlorenco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Carolyna Lepesteur Gianloren\u00e7o","raw_affiliation_strings":["Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000751419","display_name":"Linamara Rizzo Battistella","orcid":"https://orcid.org/0000-0001-5275-0733","observed_orcids":["https://orcid.org/0000-0001-5275-0733"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]},{"id":"https://openalex.org/I4405266836","display_name":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o","ror":"https://ror.org/05ygb7j78","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405266836"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Linamara Battistella","raw_affiliation_strings":["Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (IMREA HCFMUSP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (IMREA HCFMUSP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210145268","https://openalex.org/I4405266836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048887475","display_name":"Wolnei Caumo","orcid":"https://orcid.org/0000-0002-5083-4658","observed_orcids":["https://orcid.org/0000-0002-5083-4658"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wolnei Caumo","raw_affiliation_strings":["Laboratory of Pain and Neuromodulation, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pain and Neuromodulation, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210097146"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5062615661"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.18870000541210175,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-motor-cortex","display_name":"primary motor cortex","score":0.8140000104904175},{"id":"https://openalex.org/keywords/allostatic-load","display_name":"allostatic load","score":0.9710000157356262},{"id":"https://openalex.org/keywords/intracortical-inhibition","display_name":"intracortical inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fibromyalgia","display_name":"fibromyalgia","score":0.949999988079071},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/rehabilitation-response","display_name":"rehabilitation response","score":0.6510000228881836},{"id":"https://openalex.org/keywords/homa","display_name":"HOMA","score":0.8349999785423279},{"id":"https://openalex.org/keywords/transcranial-magnetic-stimulation","display_name":"transcranial magnetic stimulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.5329999923706055},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.6503999829292297},{"id":"https://openalex.org/C187150481","wikidata":"https://www.wikidata.org/wiki/Q4733156","display_name":"Allostatic load","level":2,"score":0.60589998960495},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.6050999760627747},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5685999989509583},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5315999984741211},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.5026999711990356},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.45980000495910645},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.42329999804496765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3937999904155731},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3921000063419342},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.3896999955177307},{"id":"https://openalex.org/C2780307956","wikidata":"https://www.wikidata.org/wiki/Q18707","display_name":"Primary motor cortex","level":4,"score":0.3666999936103821},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35040000081062317},{"id":"https://openalex.org/C2777831278","wikidata":"https://www.wikidata.org/wiki/Q540571","display_name":"Fibromyalgia","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C2780023022","wikidata":"https://www.wikidata.org/wiki/Q1338171","display_name":"Compensation (psychology)","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2778535154","wikidata":"https://www.wikidata.org/wiki/Q5889863","display_name":"Homeostatic model assessment","level":4,"score":0.26420000195503235},{"id":"https://openalex.org/C2434490","wikidata":"https://www.wikidata.org/wiki/Q1306920","display_name":"Neurofeedback","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C113062710","wikidata":"https://www.wikidata.org/wiki/Q2463100","display_name":"Motor coordination","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.25949999690055847}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.21.26363555","doi":"https://doi.org/10.64898/2026.09.21.26363555","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363555","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/22/2026.09.21.26363555.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42818155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622370","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622370/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.21.26363555","doi":"https://doi.org/10.64898/2026.09.21.26363555","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363555","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/22/2026.09.21.26363555.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6019612608","display_name":"Inhibitory deficit as a marker of neuroplasticity in rehabilitation","funder_award_id":"17/12943-8","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6035685618","display_name":"Optimized tDCS for fibromyalgia: targeting the endogenous pain control system","funder_award_id":"R01AT009491","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320323339","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214034955.pdf","grobid_xml":"https://content.openalex.org/works/W7214034955.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2127730691","https://openalex.org/W4200317974","https://openalex.org/W7098355847","https://openalex.org/W2094765298","https://openalex.org/W3091716235","https://openalex.org/W2952536699","https://openalex.org/W80508816","https://openalex.org/W1969212774","https://openalex.org/W2003540603","https://openalex.org/W2950220826"],"abstract_inverted_index":{"The":[0,27],"primary":[1],"motor":[2,54],"cortex":[3,55,180],"is":[4,58,182],"a":[5,37,60,71,75,87],"critical":[6],"hub":[7],"for":[8],"pain":[9,32,56],"control,":[10],"yet":[11],"its":[12,119],"few":[13],"identified":[14],"regulatory":[15],"mechanisms":[16],"-":[17,23,129],"intracortical":[18,94],"inhibition":[19,45,95],"and":[20,74,83,93,118,161,188],"oscillatory":[21],"markers":[22],"predict":[24],"symptoms":[25],"inconsistently.":[26],"prevailing":[28],"view":[29],"holds":[30],"that":[31,46,53],"results":[33],"from":[34,42],"reduced":[35],"inhibition,":[36],"fixed":[38],"deficit,":[39],"rather":[40],"than":[41],"resistance":[43,148],"to":[44,101,111],"rehabilitation":[47,157],"can":[48],"reverse.":[49],"Here":[50],"we":[51],"show":[52],"compensation":[57,181],"instead":[59],"modifiable":[61],"state":[62],"whose":[63],"analgesic":[64],"efficiency":[65],"depends":[66],"on":[67,141],"allostatic":[68,106,186],"load.":[69],"In":[70],"fibromyalgia":[72],"trial":[73],"knee":[76],"osteoarthritis":[77,128],"cohort":[78],"assessed":[79],"with":[80,177],"parallel":[81],"EEG":[82],"transcranial":[84],"magnetic":[85],"stimulation,":[86],"signature":[88],"combining":[89],"central":[90],"theta":[91],"asymmetry":[92],"was":[96,122,149],"unrelated":[97],"or":[98],"inversely":[99],"related":[100,110],"symptom":[102],"burden":[103],"under":[104,113,124,151],"low":[105],"load":[107,115,126,187],"but":[108,165],"positively":[109],"it":[112],"high":[114,125,152],"in":[116,127,163,167,169],"fibromyalgia,":[117],"protective":[120],"association":[121],"attenuated":[123],"the":[130,142,172],"same":[131],"signal":[132],"carrying":[133],"different":[134],"clinical":[135],"meaning.":[136],"A":[137],"burden-adjusted":[138],"index":[139],"modelled":[140],"homeostatic":[143],"model":[144],"assessment":[145],"of":[146],"insulin":[147],"elevated":[150],"load,":[153],"predicted":[154],"improvement":[155],"after":[156],"beyond":[158],"baseline":[159],"severity,":[160],"fell":[162],"responders":[164],"not":[166],"non-responders;":[168],"both":[170],"cohorts":[171],"neurophysiological":[173],"component":[174],"itself":[175],"recalibrated":[176],"response.":[178],"Motor":[179],"thus":[183],"degraded":[184],"by":[185,190],"restored":[189],"rehabilitation.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-23T00:00:00"}