{"id":"https://openalex.org/W7214029262","doi":"https://doi.org/10.1172/jci206364","title":"KROX20 marks sebaceous gland stem cells and regulates their differentiation to maintain skin oil balance","display_name":"KROX20 marks sebaceous gland stem cells and regulates their differentiation to maintain skin oil balance","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214029262","doi":"https://doi.org/10.1172/jci206364","pmid":"https://pubmed.ncbi.nlm.nih.gov/42771469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722400"},"language":"en","primary_location":{"id":"doi:10.1172/jci206364","doi":"https://doi.org/10.1172/jci206364","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci206364","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1172/jci206364","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100718157","display_name":"Yumeng Zhang","orcid":"https://orcid.org/0000-0001-5220-0491","observed_orcids":["https://orcid.org/0000-0001-5220-0491"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yumeng Zhang","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":"https://orcid.org/0000-0001-5220-0491","affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012081623","display_name":"Pernelle Pulh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pernelle Pulh","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152472355","display_name":"Michelle F. Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle F. Pan","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160299432","display_name":"Yi He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi He","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041088097","display_name":"Juanzhu Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juanzhu Yan","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152450506","display_name":"Annie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Li","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055460395","display_name":"Ren\u00e9e M. McKay","orcid":"https://orcid.org/0000-0001-5976-1996","observed_orcids":["https://orcid.org/0000-0001-5976-1996"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e M. McKay","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064595278","display_name":"Lu Q. Le","orcid":"https://orcid.org/0000-0003-2817-5382","observed_orcids":["https://orcid.org/0000-0003-2817-5382"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu Q. Le","raw_affiliation_strings":["Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":"https://orcid.org/0000-0003-2817-5382","affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064595278"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74007882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/krox20","display_name":"Krox20","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sebaceous-gland-differentiation","display_name":"sebaceous gland differentiation","score":0.902999997138977},{"id":"https://openalex.org/keywords/dry-skin","display_name":"dry skin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7831000089645386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7476000189781189},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7466999888420105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6895999908447266},{"id":"https://openalex.org/C2777363609","wikidata":"https://www.wikidata.org/wiki/Q212328","display_name":"Sebaceous gland","level":2,"score":0.5685999989509583},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5408999919891357},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4781999886035919},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.4325000047683716},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4180999994277954},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37959998846054077},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C164794517","wikidata":"https://www.wikidata.org/wiki/Q16729831","display_name":"Stem cell niche","level":4,"score":0.32659998536109924},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.2985999882221222},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.296099990606308},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26330000162124634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25870001316070557},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2517000138759613},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.2517000138759613}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1172/jci206364","doi":"https://doi.org/10.1172/jci206364","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci206364","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:42771469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42771469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci206364","doi":"https://doi.org/10.1172/jci206364","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci206364","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2975657111","https://openalex.org/W4412516820","https://openalex.org/W4416551976","https://openalex.org/W7169875996","https://openalex.org/W3197444204","https://openalex.org/W4400454921","https://openalex.org/W4366184019","https://openalex.org/W2938118612","https://openalex.org/W4412516821","https://openalex.org/W4285984723"],"abstract_inverted_index":{"Oil-producing":[0],"sebaceous":[1,169],"glands":[2],"(SGs),":[3],"attached":[4],"to":[5,23,118,136,144,148],"the":[6,27,104,120,140],"upper/":[7],"middle":[8],"portion":[9],"of":[10,32,47,69,106,133,161],"hair":[11],"follicles,":[12],"are":[13],"indispensable":[14],"for":[15,102,168],"maintaining":[16],"skin":[17,150],"hydration,":[18],"and":[19,58,75,77,127],"their":[20,53],"dysfunction":[21],"leads":[22],"dry":[24,107],"skin.":[25,108],"However,":[26],"molecular":[28],"mechanisms":[29],"underlying":[30],"regulation":[31],"SG":[33,48,56,73,123,146],"stem":[34,49,124],"cells":[35,50,71],"remain":[36],"largely":[37],"unknown.":[38],"We":[39,60],"identified":[40],"transcription":[41,117],"factor":[42],"KROX20":[43,113],"as":[44],"a":[45,100,154],"marker":[46],"that":[51,112,156],"sustains":[52],"stemness":[54],"throughout":[55],"morphogenesis":[57],"homeostasis.":[59],"developed":[61],"an":[62],"inducible":[63],"mouse":[64],"model":[65],"in":[66],"which":[67],"ablation":[68],"KROX20-positive":[70],"causes":[72],"loss":[74],"rapidly":[76],"robustly":[78],"induces":[79],"dry,":[80],"flaky,":[81,95],"alopecia":[82],"symptoms":[83],"following":[84],"induction.":[85],"This":[86],"model,":[87],"termed":[88],"Xeroflacia":[89],"(Xero":[90],"=":[91,94,97],"xerosis,":[92],"fla":[93],"cia":[96],"alopecia),":[98],"provides":[99],"tool":[101],"studying":[103],"biology":[105],"Furthermore,":[109],"we":[110],"found":[111],"directly":[114],"regulates":[115],"Notch1":[116,134],"orchestrate":[119],"balance":[121],"between":[122],"cell":[125],"self-renewal":[126],"differentiation.":[128],"Small":[129],"molecule":[130],"drug":[131],"modulation":[132],"signaling":[135,158],"activate":[137],"or":[138],"inhibit":[139],"pathway":[141],"enabled":[142],"us":[143],"regulate":[145],"differentiation":[147],"maintain":[149],"oil":[151],"levels,":[152],"providing":[153],"proof-of-principle":[155],"other":[157],"pathways":[159],"downstream":[160],"Krox20":[162],"could":[163],"be":[164],"potential":[165],"therapeutic":[166],"targets":[167],"gland-related":[170],"diseases.":[171]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-09-23T00:00:00"}
