{"id":"https://openalex.org/W7214028545","doi":"https://doi.org/10.7554/elife.112455.1","title":"A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription","display_name":"A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214028545","doi":"https://doi.org/10.7554/elife.112455.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.112455.1","doi":"https://doi.org/10.7554/elife.112455.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.112455.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.112455.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076741150","display_name":"Ahmed Emam Abdelnaby","orcid":"https://orcid.org/0000-0003-4775-3643","observed_orcids":["https://orcid.org/0000-0003-4775-3643"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Emam Abdelnaby","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077890752","display_name":"Yin\u2010Hu Wang","orcid":"https://orcid.org/0000-0002-3637-8852","observed_orcids":["https://orcid.org/0000-0002-3637-8852"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yin-Hu Wang","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152475189","display_name":"J Cory Benson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Cory Benson","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121401563","display_name":"Isagani Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isagani Perez","raw_affiliation_strings":["Department of Medicine, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065089220","display_name":"Shen Mark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Shen","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031811063","display_name":"Maxwell McDermott","orcid":"https://orcid.org/0009-0005-9503-0556","observed_orcids":["https://orcid.org/0009-0005-9503-0556"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell McDermott","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035850116","display_name":"Miki Jishage","orcid":"https://orcid.org/0000-0002-2835-2564","observed_orcids":["https://orcid.org/0000-0002-2835-2564"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miki Jishage","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013099273","display_name":"Amal Taher Elhaw","orcid":"https://orcid.org/0000-0001-6547-3018","observed_orcids":["https://orcid.org/0000-0001-6547-3018"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amal T Elhaw","raw_affiliation_strings":["Department of Medicine, Division of Malignant Hematology and Medical Oncology, University of Pittsburgh School of Medicine","UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Malignant Hematology and Medical Oncology, University of Pittsburgh School of Medicine","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050810489","display_name":"Silvia Cruz\u2010Rangel","orcid":"https://orcid.org/0000-0001-6433-1640","observed_orcids":["https://orcid.org/0000-0001-6433-1640"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia Cruz-Rangel","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002693624","display_name":"Raphael J Courjaret","orcid":"https://orcid.org/0000-0002-0042-0377","observed_orcids":["https://orcid.org/0000-0002-0042-0377"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Raphael Courjaret","raw_affiliation_strings":["Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","Department of Systems and Computational Biomedicine, Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","institution_ids":["https://openalex.org/I4210152471","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Systems and Computational Biomedicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114160674","display_name":"Abdelaziz Belkadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Abdelaziz Belkadi","raw_affiliation_strings":["Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","Department of Systems and Computational Biomedicine, Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","institution_ids":["https://openalex.org/I4210152471","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Systems and Computational Biomedicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152444450","display_name":"Fang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Fang Yu","raw_affiliation_strings":["Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","Department of Systems and Computational Biomedicine, Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","institution_ids":["https://openalex.org/I4210152471","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Systems and Computational Biomedicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152449808","display_name":"Douglas S Prado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas S Prado","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101517275","display_name":"Shuai Yuan","orcid":"https://orcid.org/0009-0006-6153-194X","observed_orcids":["https://orcid.org/0009-0006-6153-194X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuai Yuan","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109953026","display_name":"Ping Xin","orcid":"https://orcid.org/0000-0002-2721-5218","observed_orcids":["https://orcid.org/0000-0002-2721-5218"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Xin","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079581156","display_name":"Adam C. Straub","orcid":"https://orcid.org/0000-0003-0542-9466","observed_orcids":["https://orcid.org/0000-0003-0542-9466"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam C Straub","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140571421","display_name":"Francisco F Schopfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco F Schopfer","raw_affiliation_strings":["University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024845751","display_name":"Nadine Hempel","orcid":"https://orcid.org/0000-0002-5574-8783","observed_orcids":["https://orcid.org/0000-0002-5574-8783"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Hempel","raw_affiliation_strings":["Department of Medicine, Division of Malignant Hematology and Medical Oncology, University of Pittsburgh School of Medicine","UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-5574-8783","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Malignant Hematology and Medical Oncology, University of Pittsburgh School of Medicine","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042180155","display_name":"William F. Hawse","orcid":"https://orcid.org/0000-0001-8371-3345","observed_orcids":["https://orcid.org/0000-0001-8371-3345"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William F Hawse","raw_affiliation_strings":["Center for Systems Immunology, University of Pittsburgh","Department of Immunology, University of Pittsburgh"],"raw_orcid":"https://orcid.org/0000-0001-8371-3345","affiliations":[{"raw_affiliation_string":"Center for Systems Immunology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053075978","display_name":"David B. Beck","orcid":"https://orcid.org/0000-0002-5884-6231","observed_orcids":["https://orcid.org/0000-0002-5884-6231"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B Beck","raw_affiliation_strings":["Department of Medicine, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037292","display_name":"Khaled Machaca","orcid":"https://orcid.org/0000-0001-6215-2411","observed_orcids":["https://orcid.org/0000-0001-6215-2411"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Khaled Machaca","raw_affiliation_strings":["Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","Department of Systems and Computational Biomedicine, Weill Cornell Medicine"],"raw_orcid":"https://orcid.org/0000-0001-6215-2411","affiliations":[{"raw_affiliation_string":"Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation","institution_ids":["https://openalex.org/I4210152471","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Systems and Computational Biomedicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091404565","display_name":"Stefan Feske","orcid":"https://orcid.org/0000-0001-5431-8178","observed_orcids":["https://orcid.org/0000-0001-5431-8178"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Feske","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061372270","display_name":"Mohamed Trebak","orcid":"https://orcid.org/0000-0001-6759-864X","observed_orcids":["https://orcid.org/0000-0001-6759-864X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Trebak","raw_affiliation_strings":["UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine","University of Pittsburgh, Department of Pharmacology and Chemical Biology"],"raw_orcid":"https://orcid.org/0000-0001-6759-864X","affiliations":[{"raw_affiliation_string":"UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"University of Pittsburgh, Department of Pharmacology and Chemical Biology","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.6679999828338623},{"id":"https://openalex.org/keywords/orai2","display_name":"Orai2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/orai3","display_name":"Orai3","score":1.0},{"id":"https://openalex.org/keywords/crac-channels","display_name":"CRAC channels","score":0.753000020980835},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nfat-activation","display_name":"NFAT activation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.5839999914169312},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C189938988","wikidata":"https://www.wikidata.org/wiki/Q24744925","display_name":"NFAT","level":4,"score":0.941100001335144},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7572000026702881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6991000175476074},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.5995000004768372},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5181000232696533},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.46810001134872437},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4546000063419342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.453900009393692},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.42750000953674316},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.41839998960494995},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.3953999876976013},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3898000121116638},{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.387800008058548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.383899986743927},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3400000035762787},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.29989999532699585},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.27950000762939453},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2709999978542328},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.2529999911785126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.112455.1","doi":"https://doi.org/10.7554/elife.112455.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.112455.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.112455.1","doi":"https://doi.org/10.7554/elife.112455.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.112455.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000901418","display_name":"Ca2+ signaling Networks in Health and Disease","funder_award_id":"R35HL150778","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000911603","display_name":"Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and Disease","funder_award_id":"R35HL161177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309815","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320334416","display_name":"Weill Cornell Medicine - Qatar","ror":"https://ror.org/05v5hg569"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W42959858","https://openalex.org/W1595570385","https://openalex.org/W1670760110","https://openalex.org/W1882452859","https://openalex.org/W1900274922","https://openalex.org/W1934528477","https://openalex.org/W1935830997","https://openalex.org/W1963703355","https://openalex.org/W1977030391","https://openalex.org/W1977201959","https://openalex.org/W1978593035","https://openalex.org/W1985924867","https://openalex.org/W1995110654","https://openalex.org/W2003829187","https://openalex.org/W2012302730","https://openalex.org/W2015480034","https://openalex.org/W2019904725","https://openalex.org/W2038600671","https://openalex.org/W2039846615","https://openalex.org/W2041383551","https://openalex.org/W2046196975","https://openalex.org/W2058622754","https://openalex.org/W2059038663","https://openalex.org/W2059989081","https://openalex.org/W2063048358","https://openalex.org/W2066603202","https://openalex.org/W2067110557","https://openalex.org/W2068592712","https://openalex.org/W2070832223","https://openalex.org/W2080970129","https://openalex.org/W2082338288","https://openalex.org/W2083786196","https://openalex.org/W2088729275","https://openalex.org/W2095594166","https://openalex.org/W2097439505","https://openalex.org/W2101586949","https://openalex.org/W2110801754","https://openalex.org/W2113130311","https://openalex.org/W2134304136","https://openalex.org/W2140707292","https://openalex.org/W2144003637","https://openalex.org/W2144543766","https://openalex.org/W2157973267","https://openalex.org/W2163789582","https://openalex.org/W2164156889","https://openalex.org/W2164819852","https://openalex.org/W2167279371","https://openalex.org/W2229423562","https://openalex.org/W2409804531","https://openalex.org/W2467159710","https://openalex.org/W2495550846","https://openalex.org/W2549673184","https://openalex.org/W2582158726","https://openalex.org/W2605821164","https://openalex.org/W2625835005","https://openalex.org/W2755287478","https://openalex.org/W2763526200","https://openalex.org/W2770227510","https://openalex.org/W2791358733","https://openalex.org/W2884255979","https://openalex.org/W2908770791","https://openalex.org/W2913485995","https://openalex.org/W2913681907","https://openalex.org/W2914840597","https://openalex.org/W2921789782","https://openalex.org/W2942151678","https://openalex.org/W3000544553","https://openalex.org/W3024569254","https://openalex.org/W3044421432","https://openalex.org/W3045267509","https://openalex.org/W3067209413","https://openalex.org/W3134190116","https://openalex.org/W3158722482","https://openalex.org/W3198444904","https://openalex.org/W3206934744","https://openalex.org/W4255760236","https://openalex.org/W4289525177","https://openalex.org/W4303453498","https://openalex.org/W4309335807","https://openalex.org/W4391925485","https://openalex.org/W4401544074","https://openalex.org/W4406115872","https://openalex.org/W4407813550","https://openalex.org/W4410950161","https://openalex.org/W4411504209","https://openalex.org/W4415596065"],"related_works":["https://openalex.org/W7168221703","https://openalex.org/W4321453125","https://openalex.org/W2084897495","https://openalex.org/W2144003637","https://openalex.org/W2059989081","https://openalex.org/W2083786196","https://openalex.org/W2039846615","https://openalex.org/W4410950161","https://openalex.org/W3183826230","https://openalex.org/W4251087957"],"abstract_inverted_index":{"The":[0,130],"Ca\u00b2\u207a":[1,3,96],"release-activated":[2],"(CRAC)":[4],"channel":[5],"mediates":[6],"store-operated":[7],"calcium":[8],"entry":[9],"(SOCE),":[10],"a":[11],"ubiquitous":[12],"pathway":[13],"essential":[14],"for":[15,135,175,213],"many":[16],"cell":[17],"types,":[18],"including":[19],"immune":[20,176],"cells.":[21],"Three":[22],"Orai":[23,118,124,137,251],"(Orai1/2/3)":[24],"proteins":[25,45],"constitute":[26],"the":[27,39,79,144,240,250],"plasma":[28],"membrane":[29],"pore-forming":[30],"units":[31],"of":[32,132,141,150,181,186,243,249],"CRAC":[33,203],"channels":[34],"that":[35,98,122,140,190,230],"are":[36,50,53,197,236],"activated":[37],"by":[38,239,246],"endoplasmic":[40],"reticulum":[41],"(ER)":[42],"Ca2+-sensing":[43],"STIM1/2":[44],"when":[46],"ER":[47],"Ca2+":[48],"stores":[49],"depleted.":[51],"Orai1/2/3":[52],"differentially":[54],"expressed":[55],"across":[56,89],"primary":[57,156],"cells":[58,112,161,207],"with":[59,143,200],"discernible":[60],"differences":[61],"in":[62,155],"their":[63],"structures":[64],"and":[65,78,87,120,168,183,224,233],"biophysical":[66],"properties.":[67],"Further,":[68],"Orai1":[69],"has":[70],"two":[71],"alternatively":[72],"translated":[73],"isoforms:":[74],"long":[75],"mammalian-specific":[76],"Orai1\u03b1":[77,152,196,215],"63-residue":[80],"shorter":[81],"Orai1\u03b2,":[82],"which":[83],"is":[84,106],"evolutionarily":[85],"older":[86],"conserved":[88],"vertebrates.":[90],"Whether":[91],"Orai1\u03b1/1\u03b2/2/3":[92],"produce":[93],"unique":[94],"cytosolic":[95],"signatures":[97],"bias":[99],"transcriptional":[100,172,234],"responses":[101,173],"through":[102],"effectors":[103],"like":[104],"NFAT":[105,164,225,231],"unclear.":[107],"Here,":[108],"we":[109],"used":[110],"HEK293":[111],"engineered":[113],"to":[114,127],"express":[115],"one":[116],"native":[117],"isoform":[119,138,248],"show":[121],"all":[123],"isoforms":[125],"couple":[126],"NFAT1/4":[128,133],"induction.":[129,226],"magnitude":[131],"induction":[134],"each":[136,247],"matches":[139],"SOCE,":[142,163],"following":[145],"profile:":[146],"Orai1\u03b2>Orai1\u03b1>>Orai2>Orai3.":[147],"Near-native":[148],"re-expression":[149],"either":[151],"or":[153,211],"Orai1\u03b2":[154],"murine":[157],"Orai1\u2212/\u2212":[158],"CD4\u207a":[159],"T":[160,206],"restored":[162],"activation,":[165],"cytokine":[166],"production":[167],"promoted":[169],"near":[170],"identical":[171],"enriched":[174],"activation":[177,232],"pathways.":[178],"An":[179],"analysis":[180],"genetic":[182],"clinical":[184],"data":[185,228],"human":[187],"individuals":[188,209],"showed":[189,218],"homozygous":[191,210],"null":[192,216],"mutations":[193],"selectively":[194],"abolishing":[195],"not":[198],"associated":[199],"disease":[201],"resembling":[202],"channelopathy.":[204],"Primary":[205],"from":[208],"heterozygous":[212],"an":[214],"mutation":[217],"enhanced,":[219],"rather":[220],"than":[221],"impaired,":[222],"SOCE":[223,244],"Our":[227],"indicate":[229],"outputs":[235],"primarily":[237],"driven":[238],"graded":[241],"strength":[242],"mediated":[245],"quartet.":[252]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-23T00:00:00"}
