{"id":"https://openalex.org/W7214019682","doi":"https://doi.org/10.1038/s41568-026-00979-z","title":"Replication stress in cancer: origins, consequences and therapeutic opportunities","display_name":"Replication stress in cancer: origins, consequences and therapeutic opportunities","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214019682","doi":"https://doi.org/10.1038/s41568-026-00979-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42773173"},"language":"en","primary_location":{"id":"doi:10.1038/s41568-026-00979-z","doi":"https://doi.org/10.1038/s41568-026-00979-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41568-026-00979-z","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jchen8@mdanderson.org"],"raw_orcid":"https://orcid.org/0000-0002-1493-2189","affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jchen8@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026961383","display_name":"Lee Zou","orcid":"https://orcid.org/0000-0003-3094-1058","observed_orcids":["https://orcid.org/0000-0003-3094-1058"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee Zou","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. lee.zou@duke.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. lee.zou@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026961383","https://openalex.org/A5100365539"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":1.1907,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8087478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8230000138282776},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.7319999933242798},{"id":"https://openalex.org/keywords/transcription-replication-conflict","display_name":"transcription-replication conflict","score":0.8180000185966492},{"id":"https://openalex.org/keywords/atr-chk1-pathway","display_name":"ATR-Chk1 pathway","score":0.753000020980835},{"id":"https://openalex.org/keywords/replication-fork-restart","display_name":"replication fork restart","score":0.8209999799728394},{"id":"https://openalex.org/keywords/single-stranded-dna","display_name":"single-stranded DNA","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.699999988079071},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.843999981880188},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/brca1-2-deficiency","display_name":"BRCA1/2 deficiency","score":0.6679999828338623},{"id":"https://openalex.org/keywords/wrn-helicase","display_name":"WRN helicase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9789999723434448},{"id":"https://openalex.org/keywords/wee1-inhibitor","display_name":"WEE1 inhibitor","score":0.6909999847412109},{"id":"https://openalex.org/keywords/g2-checkpoint","display_name":"G2 checkpoint","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.460099995136261},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.357699990272522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3424000144004822},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.328900009393692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31200000643730164},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26910001039505005},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26030001044273376}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41568-026-00979-z","doi":"https://doi.org/10.1038/s41568-026-00979-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41568-026-00979-z","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:42773173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42773173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":221,"referenced_works":["https://openalex.org/W1522788044","https://openalex.org/W1531823089","https://openalex.org/W1717950015","https://openalex.org/W1848063234","https://openalex.org/W1855851918","https://openalex.org/W1965749659","https://openalex.org/W1968074226","https://openalex.org/W1970578083","https://openalex.org/W1973268287","https://openalex.org/W1974993967","https://openalex.org/W1979324654","https://openalex.org/W1981142961","https://openalex.org/W1981504084","https://openalex.org/W1983584570","https://openalex.org/W1984236815","https://openalex.org/W1984373702","https://openalex.org/W1986937402","https://openalex.org/W1987086578","https://openalex.org/W1992783176","https://openalex.org/W1993004107","https://openalex.org/W1993307543","https://openalex.org/W1993580403","https://openalex.org/W1994826332","https://openalex.org/W2003665515","https://openalex.org/W2008628928","https://openalex.org/W2009007206","https://openalex.org/W2011095025","https://openalex.org/W2012012836","https://openalex.org/W2018458310","https://openalex.org/W2020148863","https://openalex.org/W2022717702","https://openalex.org/W2029030998","https://openalex.org/W2033346972","https://openalex.org/W2038185005","https://openalex.org/W2040860750","https://openalex.org/W2041156660","https://openalex.org/W2042970469","https://openalex.org/W2043233135","https://openalex.org/W2043347159","https://openalex.org/W2043375872","https://openalex.org/W2043745733","https://openalex.org/W2043895957","https://openalex.org/W2046147149","https://openalex.org/W2050608484","https://openalex.org/W2053995121","https://openalex.org/W2056375209","https://openalex.org/W2059971436","https://openalex.org/W2065588235","https://openalex.org/W2066663722","https://openalex.org/W2067117419","https://openalex.org/W2067573570","https://openalex.org/W2075707444","https://openalex.org/W2082559623","https://openalex.org/W2082861064","https://openalex.org/W2083158919","https://openalex.org/W2084833108","https://openalex.org/W2092536432","https://openalex.org/W2094390470","https://openalex.org/W2098585738","https://openalex.org/W2098737737","https://openalex.org/W2103694115","https://openalex.org/W2104153021","https://openalex.org/W2106835088","https://openalex.org/W2106892764","https://openalex.org/W2107632586","https://openalex.org/W2110817748","https://openalex.org/W2111222453","https://openalex.org/W2112241575","https://openalex.org/W2119999819","https://openalex.org/W2121371748","https://openalex.org/W2127251317","https://openalex.org/W2129754926","https://openalex.org/W2132413371","https://openalex.org/W2136550941","https://openalex.org/W2138204634","https://openalex.org/W2141689006","https://openalex.org/W2149795092","https://openalex.org/W2152440925","https://openalex.org/W2152640619","https://openalex.org/W2154141161","https://openalex.org/W2155160595","https://openalex.org/W2157009184","https://openalex.org/W2165860917","https://openalex.org/W2167464044","https://openalex.org/W2187574279","https://openalex.org/W2207187217","https://openalex.org/W2219710908","https://openalex.org/W2335902060","https://openalex.org/W2344657883","https://openalex.org/W2346001051","https://openalex.org/W2346731093","https://openalex.org/W2476568892","https://openalex.org/W2530188477","https://openalex.org/W2531499154","https://openalex.org/W2531549933","https://openalex.org/W2540270174","https://openalex.org/W2548069873","https://openalex.org/W2563646853","https://openalex.org/W2597062310","https://openalex.org/W2609150653","https://openalex.org/W2609243345","https://openalex.org/W2610738034","https://openalex.org/W2623921962","https://openalex.org/W2625452721","https://openalex.org/W2727925085","https://openalex.org/W2733154631","https://openalex.org/W2736195686","https://openalex.org/W2738136165","https://openalex.org/W2739132742","https://openalex.org/W2743954317","https://openalex.org/W2745330422","https://openalex.org/W2749641460","https://openalex.org/W2783667606","https://openalex.org/W2784889917","https://openalex.org/W2786842416","https://openalex.org/W2788084906","https://openalex.org/W2788377084","https://openalex.org/W2789435487","https://openalex.org/W2792813139","https://openalex.org/W2800255316","https://openalex.org/W2884441656","https://openalex.org/W2888068269","https://openalex.org/W2896578193","https://openalex.org/W2898088739","https://openalex.org/W2905255940","https://openalex.org/W2905437169","https://openalex.org/W2911163118","https://openalex.org/W2912490696","https://openalex.org/W2912622559","https://openalex.org/W2912672694","https://openalex.org/W2921425880","https://openalex.org/W2921875691","https://openalex.org/W2936686072","https://openalex.org/W2948817675","https://openalex.org/W2949415937","https://openalex.org/W2950531883","https://openalex.org/W2952759348","https://openalex.org/W2968820602","https://openalex.org/W2970657071","https://openalex.org/W2972990570","https://openalex.org/W2982655986","https://openalex.org/W2983284890","https://openalex.org/W2984359187","https://openalex.org/W2985349530","https://openalex.org/W2994566149","https://openalex.org/W2994877203","https://openalex.org/W3006950991","https://openalex.org/W3015035400","https://openalex.org/W3042861529","https://openalex.org/W3047848114","https://openalex.org/W3089375288","https://openalex.org/W3091396062","https://openalex.org/W3097869202","https://openalex.org/W3110528877","https://openalex.org/W3121584400","https://openalex.org/W3137621387","https://openalex.org/W3148033431","https://openalex.org/W3154101159","https://openalex.org/W3154159901","https://openalex.org/W3156414413","https://openalex.org/W3161394630","https://openalex.org/W3176275742","https://openalex.org/W3183394989","https://openalex.org/W3184371487","https://openalex.org/W3185943155","https://openalex.org/W3187644677","https://openalex.org/W3187741617","https://openalex.org/W3198522767","https://openalex.org/W3200625607","https://openalex.org/W3203739989","https://openalex.org/W3206775306","https://openalex.org/W4220864127","https://openalex.org/W4220968648","https://openalex.org/W4224293621","https://openalex.org/W4225297234","https://openalex.org/W4225316996","https://openalex.org/W4280584055","https://openalex.org/W4281557609","https://openalex.org/W4283012954","https://openalex.org/W4286007893","https://openalex.org/W4289951438","https://openalex.org/W4307922066","https://openalex.org/W4310553414","https://openalex.org/W4312065951","https://openalex.org/W4315642125","https://openalex.org/W4322766156","https://openalex.org/W4323925836","https://openalex.org/W4361002324","https://openalex.org/W4366463919","https://openalex.org/W4380321939","https://openalex.org/W4382630855","https://openalex.org/W4383265707","https://openalex.org/W4384432207","https://openalex.org/W4385190996","https://openalex.org/W4385368280","https://openalex.org/W4387494986","https://openalex.org/W4389201763","https://openalex.org/W4389312596","https://openalex.org/W4389781403","https://openalex.org/W4391019487","https://openalex.org/W4391954183","https://openalex.org/W4392242533","https://openalex.org/W4396218881","https://openalex.org/W4399848807","https://openalex.org/W4403225491","https://openalex.org/W4404961497","https://openalex.org/W4409493866","https://openalex.org/W4410395542","https://openalex.org/W4410447694","https://openalex.org/W4411300972","https://openalex.org/W4415585962","https://openalex.org/W4415660301","https://openalex.org/W7117356706","https://openalex.org/W7125438842","https://openalex.org/W7125512984","https://openalex.org/W7127990058","https://openalex.org/W7135386970","https://openalex.org/W7158529444","https://openalex.org/W7162678486","https://openalex.org/W7162852969","https://openalex.org/W7170078189"],"related_works":["https://openalex.org/W2005115966","https://openalex.org/W3080325198","https://openalex.org/W7211905564","https://openalex.org/W2604115969","https://openalex.org/W4302424483","https://openalex.org/W3104539917","https://openalex.org/W2083158919","https://openalex.org/W2037352135","https://openalex.org/W4287836203","https://openalex.org/W2511137141"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-23T00:00:00"}