{"id":"https://openalex.org/W7214016208","doi":"https://doi.org/10.64898/2026.09.22.753493","title":"Comprehensive analysis of ammonia and biogenic amines in ecologically diverse systems with high-resolution mass spectrometry","display_name":"Comprehensive analysis of ammonia and biogenic amines in ecologically diverse systems with high-resolution mass spectrometry","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214016208","doi":"https://doi.org/10.64898/2026.09.22.753493"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.753493","doi":"https://doi.org/10.64898/2026.09.22.753493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753493.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106163942","display_name":"Mateusz Fido","orcid":"https://orcid.org/0009-0002-0878-5968","observed_orcids":["https://orcid.org/0009-0002-0878-5968"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mateusz Fido","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0002-0878-5968","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107973065","display_name":"Elisa Cappio Barazzone","orcid":"https://orcid.org/0000-0003-1295-4672","observed_orcids":["https://orcid.org/0000-0003-1295-4672"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elisa Cappio Barazzone","raw_affiliation_strings":["Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1295-4672","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117397691","display_name":"Etienne Hoesli","orcid":"https://orcid.org/0009-0008-4163-9106","observed_orcids":["https://orcid.org/0009-0008-4163-9106"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Etienne Hoesli","raw_affiliation_strings":["Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0008-4163-9106","affiliations":[{"raw_affiliation_string":"Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117325202","display_name":"Jens Scheidegger","orcid":"https://orcid.org/0009-0000-8900-9789","observed_orcids":["https://orcid.org/0009-0000-8900-9789"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jens Scheidegger","raw_affiliation_strings":["Department of Quantitative Biomedicine, University of Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0000-8900-9789","affiliations":[{"raw_affiliation_string":"Department of Quantitative Biomedicine, University of Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030273906","display_name":"Nimisha Khurana","orcid":"https://orcid.org/0000-0002-5823-4956","observed_orcids":["https://orcid.org/0000-0002-5823-4956"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nimisha Khurana","raw_affiliation_strings":["Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5823-4956","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152446456","display_name":"Jeongmin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jeongmin Kim","raw_affiliation_strings":["Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014507176","display_name":"Markus Arnoldini","orcid":"https://orcid.org/0000-0003-3770-1348","observed_orcids":["https://orcid.org/0000-0003-3770-1348"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Markus Arnoldini","raw_affiliation_strings":["Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3770-1348","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022888783","display_name":"Martin Sperfeld","orcid":"https://orcid.org/0000-0001-8707-7761","observed_orcids":["https://orcid.org/0000-0001-8707-7761"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Sperfeld","raw_affiliation_strings":["Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8707-7761","affiliations":[{"raw_affiliation_string":"Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134192152","display_name":"Raffael Luca Schumann","orcid":"https://orcid.org/0000-0001-8401-4036","observed_orcids":["https://orcid.org/0000-0001-8401-4036"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raffael Luca Schumann","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0001-8401-4036","affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027144722","display_name":"Shinichi Sunagawa","orcid":"https://orcid.org/0000-0003-3065-0314","observed_orcids":["https://orcid.org/0000-0003-3065-0314"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Shinichi Sunagawa","raw_affiliation_strings":["Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3065-0314","affiliations":[{"raw_affiliation_string":"Department of Biology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090245763","display_name":"Annika Hausmann","orcid":"https://orcid.org/0000-0001-8852-3444","observed_orcids":["https://orcid.org/0000-0001-8852-3444"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Annika Hausmann","raw_affiliation_strings":["Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8852-3444","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001571695","display_name":"Renato Zenobi","orcid":"https://orcid.org/0000-0001-5211-4358","observed_orcids":["https://orcid.org/0000-0001-5211-4358"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Renato Zenobi","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5211-4358","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064708056","display_name":"Emma Marie Caroline Slack","orcid":"https://orcid.org/0000-0002-2473-1145","observed_orcids":["https://orcid.org/0000-0002-2473-1145"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["CH","GB"],"is_corresponding":true,"raw_author_name":"Emma Slack","raw_affiliation_strings":["Basel Research Center for Child Health, Basel, Switzerland","Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","Sir William Dunn School of Pathology, University of Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-2473-1145","affiliations":[{"raw_affiliation_string":"Basel Research Center for Child Health, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064708056"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.23770000040531158,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/biogenic-amines","display_name":"biogenic amines","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitrogen-compounds","display_name":"nitrogen compounds","score":0.906000018119812},{"id":"https://openalex.org/keywords/nitrogen-metabolism","display_name":"nitrogen metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gnotobiotic-mice","display_name":"gnotobiotic mice","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nitrogen-assimilation","display_name":"nitrogen assimilation","score":0.593999981880188},{"id":"https://openalex.org/keywords/cnidarian-algal-symbiosis","display_name":"cnidarian-algal symbiosis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/freshwater-ecosystems","display_name":"freshwater ecosystems","score":0.6230000257492065},{"id":"https://openalex.org/keywords/bacterial-culture","display_name":"bacterial culture","score":0.6480000019073486},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6362000107765198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5949000120162964},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.5799999833106995},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5789999961853027},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C94061648","wikidata":"https://www.wikidata.org/wiki/Q336191","display_name":"Wastewater","level":2,"score":0.4708999991416931},{"id":"https://openalex.org/C2780428219","wikidata":"https://www.wikidata.org/wiki/Q16952335","display_name":"Cover (algebra)","level":2,"score":0.4580000042915344},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.4472000002861023},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C90195498","wikidata":"https://www.wikidata.org/wiki/Q183129","display_name":"Water pollution","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C57442070","wikidata":"https://www.wikidata.org/wiki/Q221275","display_name":"Sewage treatment","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.22.753493","doi":"https://doi.org/10.64898/2026.09.22.753493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.5281/zenodo.22881184","doi":"https://doi.org/10.5281/zenodo.22881184","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22881184","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ComputationalNotebook"},{"id":"doi:10.5281/zenodo.22881185","doi":"https://doi.org/10.5281/zenodo.22881185","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22881185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ComputationalNotebook"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753493","doi":"https://doi.org/10.64898/2026.09.22.753493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214016208.pdf","grobid_xml":"https://content.openalex.org/works/W7214016208.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W1531128","https://openalex.org/W44824495","https://openalex.org/W134636542","https://openalex.org/W1479687496","https://openalex.org/W1551543102","https://openalex.org/W1605848926","https://openalex.org/W1797274876","https://openalex.org/W1799585027","https://openalex.org/W1924395043","https://openalex.org/W1964934351","https://openalex.org/W1970318669","https://openalex.org/W1971999272","https://openalex.org/W1972912664","https://openalex.org/W1981842847","https://openalex.org/W1983320630","https://openalex.org/W1990784869","https://openalex.org/W2004235182","https://openalex.org/W2006071359","https://openalex.org/W2007791111","https://openalex.org/W2033880775","https://openalex.org/W2039904409","https://openalex.org/W2051915627","https://openalex.org/W2065713403","https://openalex.org/W2067010551","https://openalex.org/W2069069647","https://openalex.org/W2072386808","https://openalex.org/W2076920984","https://openalex.org/W2081465448","https://openalex.org/W2084441023","https://openalex.org/W2086298274","https://openalex.org/W2087931725","https://openalex.org/W2089691332","https://openalex.org/W2112931540","https://openalex.org/W2124112424","https://openalex.org/W2128367977","https://openalex.org/W2136903430","https://openalex.org/W2142515723","https://openalex.org/W2205815921","https://openalex.org/W2271322073","https://openalex.org/W2343086455","https://openalex.org/W2397480150","https://openalex.org/W2435882090","https://openalex.org/W2506977319","https://openalex.org/W2526966274","https://openalex.org/W2549269050","https://openalex.org/W2557254277","https://openalex.org/W2569134411","https://openalex.org/W2584082995","https://openalex.org/W2734683753","https://openalex.org/W2761955769","https://openalex.org/W2762591668","https://openalex.org/W2790597252","https://openalex.org/W2803318850","https://openalex.org/W2809483588","https://openalex.org/W2892979128","https://openalex.org/W2922522932","https://openalex.org/W2950770972","https://openalex.org/W2965483714","https://openalex.org/W2972815970","https://openalex.org/W2979930753","https://openalex.org/W3000639611","https://openalex.org/W3008115082","https://openalex.org/W3015189532","https://openalex.org/W3034512976","https://openalex.org/W3135388544","https://openalex.org/W3154060361","https://openalex.org/W3201370879","https://openalex.org/W3201617548","https://openalex.org/W3215297819","https://openalex.org/W4214886240","https://openalex.org/W4281646699","https://openalex.org/W4285012482","https://openalex.org/W4288691577","https://openalex.org/W4294012083","https://openalex.org/W4296796970","https://openalex.org/W4310266649","https://openalex.org/W4311425368","https://openalex.org/W4317517312","https://openalex.org/W4319655586","https://openalex.org/W4321104218","https://openalex.org/W4379536604","https://openalex.org/W4382011223","https://openalex.org/W4385271178","https://openalex.org/W4386089829","https://openalex.org/W4387873873","https://openalex.org/W4387967266","https://openalex.org/W4388130645","https://openalex.org/W4391124335","https://openalex.org/W4391486856","https://openalex.org/W4399173593","https://openalex.org/W4399725773","https://openalex.org/W4402123515","https://openalex.org/W4402358307","https://openalex.org/W4403665086","https://openalex.org/W4410910305","https://openalex.org/W4410954996","https://openalex.org/W4412750642","https://openalex.org/W4412950297","https://openalex.org/W4417427536","https://openalex.org/W6949497256","https://openalex.org/W7138099495"],"related_works":["https://openalex.org/W7162681216","https://openalex.org/W1967993506","https://openalex.org/W7098233750","https://openalex.org/W3132886946","https://openalex.org/W7142212246","https://openalex.org/W7037094418","https://openalex.org/W2082337826","https://openalex.org/W7204214558","https://openalex.org/W4323663321","https://openalex.org/W2143703939"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"acquisition":[2],"of":[3,13,43,47,68,94,98,107,143,162,200],"sufficient":[4],"nitrogen":[5,149,201],"for":[6,90],"growth,":[7],"as":[8,10],"well":[9],"the":[11,41,91,105,137,141,144,174,198],"disposal":[12],"highly":[14],"toxic":[15],"nitrogen-containing":[16,52,113],"degradation":[17],"products,":[18],"represent":[19],"serious":[20],"metabolic":[21],"challenges":[22],"in":[23,110,115,125,151,173],"all":[24],"multicellular":[25],"organisms":[26],"and":[27,50,81,117,128,170,204],"microbial":[28,190],"ecosystems.":[29],"Understanding":[30],"these":[31,99],"processes":[32],"requires":[33],"a":[34,44,73,126,133,159,181],"broadly":[35,182],"applicable":[36,183],"system":[37],"to":[38,61,139,193],"accurately":[39],"quantify":[40],"concentration":[42],"wide":[45],"spectrum":[46],"biological":[48],"amines":[49],"inorganic":[51],"compounds.":[53],"To":[54],"date,":[55],"this":[56,108],"has":[57],"been":[58],"challenging":[59],"due":[60],"limited":[62],"specificity,":[63],"selectivity,":[64],"breadth":[65],"and/or":[66],"sensitivity":[67],"assays.":[69],"Here":[70],"we":[71,135,179],"present":[72],"simple,":[74],"optimized":[75],"method":[76,109,138],"based":[77],"on":[78,147,166],"liquid":[79],"chromatography":[80],"high-resolution":[82],"mass":[83],"spectrometry,":[84],"with":[85,153],"an":[86],"accompanying":[87],"analysis":[88],"pipeline,":[89],"accurate":[92],"quantification":[93],"more":[95],"than":[96],"30":[97],"compounds,":[100],"including":[101],"ammonia.":[102],"We":[103],"demonstrate":[104],"effectiveness":[106],"quantifying":[111],"relevant":[112],"compounds":[114],"mouse":[116],"human":[118],"gut":[119,145,163],"content,":[120],"bacterial":[121],"cultures,":[122],"algal":[123],"symbiosis":[124],"cnidarian":[127],"freshwater":[129],"ecosystem":[130],"samples.":[131],"As":[132],"proof-of-concept,":[134],"applied":[136],"study":[140],"influence":[142,161],"microbiome":[146],"cecal":[148],"distribution":[150],"mice":[152],"different":[154],"gnotobiotic":[155],"microbiomes.":[156],"This":[157],"revealed":[158],"profound":[160],"microbiota":[164],"composition":[165],"amino":[167],"acid,":[168],"ammonia,":[169],"amine":[171],"concentrations":[172],"upper":[175],"large":[176],"intestine.":[177],"Overall,":[178],"provide":[180],"approach":[184],"that":[185],"can":[186],"be":[187],"used":[188],"across":[189],"ecology":[191],"fields":[192],"generate":[194],"novel":[195],"insights":[196],"into":[197],"biology":[199],"assimilation,":[202],"exchange,":[203],"disposal.":[205]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-23T00:00:00"}