{"id":"https://openalex.org/W7214010076","doi":"https://doi.org/10.1158/1538-7445.pediatric26-a013","title":"Abstract A013: Osteosarcoma metastases develop as neo-organs, creating distinct ecosystems with divergent therapeutic vulnerabilities","display_name":"Abstract A013: Osteosarcoma metastases develop as neo-organs, creating distinct ecosystems with divergent therapeutic vulnerabilities","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214010076","doi":"https://doi.org/10.1158/1538-7445.pediatric26-a013"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.pediatric26-a013","doi":"https://doi.org/10.1158/1538-7445.pediatric26-a013","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pediatric26-a013","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040476584","display_name":"Yogesh Budhathoki","orcid":"https://orcid.org/0009-0009-1278-6278","observed_orcids":["https://orcid.org/0009-0009-1278-6278"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogesh Budhathoki","raw_affiliation_strings":["1Nationwide Children's Hospital, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nationwide Children's Hospital, Columbus, OH,","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053959967","display_name":"Jeffrey P. Sheridan","orcid":"https://orcid.org/0009-0006-8486-7737","observed_orcids":["https://orcid.org/0009-0006-8486-7737"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey P. Sheridan","raw_affiliation_strings":["2Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085428143","display_name":"Veronica Jarzabek","orcid":"https://orcid.org/0009-0003-0043-8598","observed_orcids":["https://orcid.org/0009-0003-0043-8598"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Jarzabek","raw_affiliation_strings":["2Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123087662","display_name":"Matthew V. Cannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew V. Cannon","raw_affiliation_strings":["1Nationwide Children's Hospital, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nationwide Children's Hospital, Columbus, OH,","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072830005","display_name":"Troy A. McEachron","orcid":"https://orcid.org/0000-0003-0695-5783","observed_orcids":["https://orcid.org/0000-0003-0695-5783"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy A. McEachron","raw_affiliation_strings":["3National Institutes of Health, Bethesda, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Institutes of Health, Bethesda, MA,","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003472571","display_name":"Anand G. Patel","orcid":"https://orcid.org/0000-0002-1438-8275","observed_orcids":["https://orcid.org/0000-0002-1438-8275"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand G. Patel","raw_affiliation_strings":["4St. Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4St. Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094047930","display_name":"Matthew J. Gust","orcid":"https://orcid.org/0009-0009-3159-2559","observed_orcids":["https://orcid.org/0009-0009-3159-2559"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Gust","raw_affiliation_strings":["1Nationwide Children's Hospital, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nationwide Children's Hospital, Columbus, OH,","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032336330","display_name":"Daniel P. Regan","orcid":"https://orcid.org/0000-0002-3148-1332","observed_orcids":["https://orcid.org/0000-0002-3148-1332"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel P. Regan","raw_affiliation_strings":["5Colorado State University, Fort Collins, CO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Colorado State University, Fort Collins, CO,","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather L. Gardner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather L. Gardner","raw_affiliation_strings":["6Tufts University, North Grafton, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Tufts University, North Grafton, MA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000624568","display_name":"Ruben Dries","orcid":"https://orcid.org/0000-0001-7650-7754","observed_orcids":["https://orcid.org/0000-0001-7650-7754"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Dries","raw_affiliation_strings":["2Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129488755","display_name":"Ryan D. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Roberts","raw_affiliation_strings":["1Nationwide Children's Hospital, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nationwide Children's Hospital, Columbus, OH,","institution_ids":["https://openalex.org/I1314135232"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"18_Supplement_1","first_page":"A013","last_page":"A013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.6470000147819519},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/host-cell-reprogramming","display_name":"host cell reprogramming","score":0.7680000066757202},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.328000009059906},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.42399999499320984},{"id":"https://openalex.org/keywords/metastasis-progression","display_name":"metastasis progression","score":0.3140000104904175},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.5910000205039978},{"id":"https://openalex.org/keywords/rna-velocity","display_name":"RNA velocity","score":0.5630000233650208},{"id":"https://openalex.org/keywords/spatial-deconvolution","display_name":"spatial deconvolution","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7282999753952026},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6363000273704529},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6327000260353088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6207000017166138},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5246999859809875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4607999920845032},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.3968999981880188},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3612000048160553},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3578999936580658},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.34369999170303345},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33169999718666077},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3133000135421753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3125999867916107},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.pediatric26-a013","doi":"https://doi.org/10.1158/1538-7445.pediatric26-a013","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pediatric26-a013","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362545688","https://openalex.org/W7124290075","https://openalex.org/W7148731847","https://openalex.org/W4404451077","https://openalex.org/W3097034826","https://openalex.org/W4282938303","https://openalex.org/W3092841245","https://openalex.org/W4282944139","https://openalex.org/W4388742091","https://openalex.org/W6990999981"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Osteosarcoma":[2,114,277,372],"lung":[3,27,72],"metastases":[4,35,73,223,278,373],"are":[5,239],"the":[6,13,22,26,104,226,261,388],"principal":[7],"cause":[8],"of":[9,25,77,145,186,248,251,292,300,324,387],"osteosarcoma-related":[10],"death,":[11],"yet":[12],"processes":[14],"by":[15,193],"which":[16,189],"these":[17],"bone":[18],"tumor":[19],"cells":[20,115,196,296],"colonize":[21],"distinct":[23,48,132,207,257,378],"environment":[24],"remain":[28],"poorly":[29],"defined.":[30],"We":[31,56],"hypothesized":[32],"that":[33,42,180,297],"osteosarcoma":[34,71],"develop":[36,279,374],"through":[37,155],"an":[38,176],"organized,":[39],"organogenesis-like":[40],"process":[41],"produces":[43],"spatially":[44,281],"patterned":[45,157],"\"neo-organs\"":[46],"containing":[47],"cellular":[49,208,258],"ecosystems":[50,209,379],"with":[51,124,131,160,380],"divergent":[52,381],"therapeutic":[53,274,318,382],"vulnerabilities.":[54],"Methods:":[55],"integrated":[57],"single-cell":[58],"and":[59,66,69,85,96,126,134,137,169,184,197,203,260,269,282,294,311,322,326,330,397],"spatial":[60,86,97,178,202],"transcriptomic":[61],"data":[62],"from":[63,233,288],"human,":[64],"canine,":[65],"murine":[67],"(PDX":[68],"syngeneic)":[70],"spanning":[74],"multiple":[75],"stages":[76],"lesion":[78,242],"development.":[79],"Tumor":[80],"cell":[81],"states,":[82],"host-cell":[83],"reprogramming,":[84],"architecture":[87],"were":[88],"characterized":[89],"using":[90],"unsupervised":[91],"clustering,":[92],"RNA":[93],"velocity/regulon":[94],"inference,":[95],"deconvolution,":[98],"then":[99,164],"compared":[100],"lesions":[101,151],"arising":[102,224],"within":[103,210,225,310],"same":[105,227],"patients/animals,":[106],"as":[107,109,280,375],"well":[108,191],"comparing":[110],"between":[111,312],"animals/patients.":[112],"Results:":[113],"reproducibly":[116],"adopt":[117],"distinct,":[118],"conserved":[119,302],"transcriptional":[120],"states:":[121],"differentiated":[122,161],"phenotypes":[123,130,263],"fibroblast-like":[125],"immune-like":[127],"programs;":[128],"less-differentiated":[129,166],"proliferative":[133],"metabolic":[135],"signatures;":[136],"a":[138,156,200,249,289],"novel":[139],"phenotype":[140],"restricted":[141],"exclusively":[142],"to":[143,245,316],"regions":[144,173],"chondroid/osteoid":[146],"matrix":[147],"formation":[148],"(COMA).":[149],"As":[150],"develop,":[152],"they":[153,264],"progress":[154],"sequence,":[158],"beginning":[159],"\"edge\"":[162],"phenotypes,":[163,168],"incorporating":[165],"\"core\"":[167],"finally":[170],"acquiring":[171],"COMA":[172],"\u2014":[174],"establishing":[175],"inside-to-outside":[177],"hierarchy":[179],"mirrors":[181],"organogenesis.":[182],"Recruitment":[183],"reprogramming":[185],"host":[187,295],"cells,":[188],"is":[190,216],"illustrated":[192],"changes":[194],"epithelial":[195],"macrophages,":[198],"follows":[199,298],"parallel":[201],"temporal":[204],"pattern,":[205],"generating":[206],"each":[211,286],"region.":[212],"This":[213,305],"developmental":[214,254,303],"patterning":[215],"superimposed":[217],"on":[218],"substantial":[219],"inter-lesional":[220,262],"heterogeneity:":[221],"individual":[222],"patient":[228],"or":[229],"animal":[230],"diverge":[231],"markedly":[232],"one":[234,247,299],"another.":[235],"These":[236,256],"differences,":[237],"however,":[238],"not":[240],"random\u2014each":[241],"instead":[243],"appears":[244],"follow":[246],"handful":[250],"potential":[252],"neo-organ":[253],"pathways.":[255],"ecosystems,":[259],"compose,":[265],"exhibit":[266],"both":[267,309],"predicted":[268],"experimentally":[270],"observed":[271],"differences":[272],"in":[273,337,392,400],"sensitivity.":[275],"Conclusions:":[276],"temporally":[283],"organized":[284],"neo-organs,":[285,376],"built":[287],"reproducible":[290],"ecosystem":[291],"malignant":[293],"several":[301],"trajectories.":[304],"structured":[306],"heterogeneity,":[307],"occurring":[308],"lesions,":[313],"likely":[314],"contributes":[315],"mixed":[317],"responses,":[319,321],"incomplete":[320],"emergence":[323],"resistance,":[325],"points":[327],"toward":[328],"region-":[329],"lesion-specific":[331],"combinatorial":[332],"strategies":[333],"for":[334],"improving":[335],"outcomes":[336],"metastatic":[338],"osteosarcoma.":[339],"Citation":[340],"Format:":[341],"Yogesh":[342],"Budhathoki,":[343],"Jeffrey":[344],"P.":[345,362],"Sheridan,":[346],"Veronica":[347],"Jarzabek,":[348],"Matthew":[349,358],"V.":[350],"Cannon,":[351],"Troy":[352],"A.":[353],"McEachron,":[354],"Anand":[355],"G.":[356],"Patel,":[357],"J.":[359],"Gust,":[360],"Daniel":[361],"Regan,":[363],"Heather":[364],"L.":[365],"Gardner,":[366],"Ruben":[367],"Dries,":[368],"Ryan":[369],"D.":[370],"Roberts.":[371],"creating":[377],"vulnerabilities":[383],"[abstract].":[384],"In:":[385],"Proceedings":[386],"AACR":[389],"Special":[390],"Conference":[391],"Cancer":[393,411],"Research:":[394],"Bridging":[395],"Discovery":[396],"Clinical":[398],"Impact":[399],"Pediatric":[401],"Cancer;":[402],"2026":[403],"Sep":[404],"22-25;":[405],"Philadelphia,":[406],"PA.":[407],"Philadelphia":[408],"(PA):":[409],"AACR;":[410],"Res":[412],"2026;86(18_Suppl_1):Abstract":[413],"nr":[414],"A013.":[415]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-23T00:00:00"}
