{"id":"https://openalex.org/W7214005441","doi":"https://doi.org/10.64898/2026.09.20.752972","title":"Platelet-programmed circulating tumor cells signal to monocytes through a candidate CD40LG\u2013ITGA5:ITGB1 myeloid checkpoint axis in breast cancer","display_name":"Platelet-programmed circulating tumor cells signal to monocytes through a candidate CD40LG\u2013ITGA5:ITGB1 myeloid checkpoint axis in breast cancer","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7214005441","doi":"https://doi.org/10.64898/2026.09.20.752972"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.20.752972","doi":"https://doi.org/10.64898/2026.09.20.752972","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752972","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.752972.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.752972.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010834682","display_name":"Samane Khoshbakht","orcid":"https://orcid.org/0000-0003-3253-7577","observed_orcids":["https://orcid.org/0000-0003-3253-7577"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samane Khoshbakht","raw_affiliation_strings":["Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-3253-7577","affiliations":[{"raw_affiliation_string":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060157796","display_name":"Hojat Borna","orcid":"https://orcid.org/0000-0001-8711-6812","observed_orcids":["https://orcid.org/0000-0001-8711-6812"]},"institutions":[{"id":"https://openalex.org/I23946033","display_name":"University of Tehran","ror":"https://ror.org/05vf56z40","country_code":"IR","type":"education","lineage":["https://openalex.org/I23946033"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hojat Borna","raw_affiliation_strings":["Laboratory of Genomics and Epigenomics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genomics and Epigenomics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran","institution_ids":["https://openalex.org/I23946033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034078931","display_name":"Mehrnaz Zarei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehrnaz Zarei","raw_affiliation_strings":["Department of Biology, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080519063","display_name":"Zahra Salehi","orcid":"https://orcid.org/0000-0002-0839-2729","observed_orcids":["https://orcid.org/0000-0002-0839-2729"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Salehi","raw_affiliation_strings":["Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048583467","display_name":"Niloofar Hejazifar","orcid":"https://orcid.org/0009-0004-8628-2148","observed_orcids":["https://orcid.org/0009-0004-8628-2148"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Niloofar Hejazifar","raw_affiliation_strings":["Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy"],"raw_orcid":"https://orcid.org/0009-0004-8628-2148","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054856630","display_name":"Yasaman Setayeshpour","orcid":"https://orcid.org/0000-0002-3420-8841","observed_orcids":["https://orcid.org/0000-0002-3420-8841"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasaman Setayeshpour","raw_affiliation_strings":["Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27701, USA"],"raw_orcid":"https://orcid.org/0000-0002-3420-8841","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27701, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044646324","display_name":"Niroshana Anandasabapathy","orcid":"https://orcid.org/0000-0002-0473-8358","observed_orcids":["https://orcid.org/0000-0002-0473-8358"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niroshana Anandasabapathy","raw_affiliation_strings":["Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Meyer Cancer Center, Englander Institute for Precision Medicine, and Department of Dermatology, Weill Cornell Medical College, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-0473-8358","affiliations":[{"raw_affiliation_string":"Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Meyer Cancer Center, Englander Institute for Precision Medicine, and Department of Dermatology, Weill Cornell Medical College, New York, New York","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074081568","display_name":"Mayte Su\u00e1rez\u2010Fari\u00f1as","orcid":"https://orcid.org/0000-0001-8712-3553","observed_orcids":["https://orcid.org/0000-0001-8712-3553"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mayte Suarez-Farinas","raw_affiliation_strings":["Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5074081568"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.09369999915361404,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelet-indices","display_name":"platelet indices","score":0.6740000247955322},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.859000027179718},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.6940000057220459},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7630000114440918},{"id":"https://openalex.org/keywords/nk-cell-resistance","display_name":"NK cell resistance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.8389999866485596},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5734999775886536},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5719000101089478},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5626000165939331},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5333999991416931},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45489999651908875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.451200008392334},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3416000008583069},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3158000111579895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3061000108718872},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.257999986410141},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.20.752972","doi":"https://doi.org/10.64898/2026.09.20.752972","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752972","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.752972.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.20.752972","doi":"https://doi.org/10.64898/2026.09.20.752972","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752972","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.752972.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214005441.pdf","grobid_xml":"https://content.openalex.org/works/W7214005441.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322774661","https://openalex.org/W4407979379","https://openalex.org/W3150102637","https://openalex.org/W3006659366","https://openalex.org/W4404143864","https://openalex.org/W1824886871","https://openalex.org/W3083138793","https://openalex.org/W4412197734","https://openalex.org/W7168186555","https://openalex.org/W4409468295"],"abstract_inverted_index":{"ABSTRACT":[0],"Abstract":[1],"Figure":[2],"Circulating":[3],"tumor":[4,105,126],"cells":[5],"(CTCs)":[6],"are":[7],"key":[8],"drivers":[9],"of":[10,27,50,62,75,200,205],"distant":[11],"metastasis,":[12],"while":[13],"platelets":[14],"facilitate":[15],"this":[16,144],"process":[17],"by":[18,57,207],"protecting":[19],"them":[20],"from":[21,113],"immune":[22,169,202,212],"surveillance.":[23],"However,":[24,143,181],"the":[25,47,103,162,201],"detection":[26],"CTCs":[28,51,64,76,206],"exhibiting":[29],"platelet":[30,55,82,209],"markers":[31],"and":[32,65,84,129,152,158,184,223],"their":[33],"communication":[34,49,156],"with":[35,77],"monocytes":[36,173],"has":[37],"not":[38,147],"been":[39],"thoroughly":[40],"investigated.":[41],"This":[42,211],"study":[43],"seeks":[44],"to":[45,86,101,189],"identify":[46],"intercellular":[48],"that":[52],"have":[53],"acquired":[54],"traits":[56],"integrating":[58],"single-cell":[59],"RNA-seq":[60,111],"data":[61],"377":[63],"2,634":[66],"white":[67],"blood":[68],"cells.":[69],"Trajectory":[70],"analysis":[71],"identified":[72],"a":[73,167,216],"subpopulation":[74],"enhanced":[78],"platelet-related":[79],"functions,":[80],"including":[81],"aggregation":[83],"resistance":[85],"NK":[87],"cell\u2013mediated":[88],"cytotoxicity,":[89],"termed":[90],"Platelet-Programmed":[91],"CTCs.":[92],"The":[93],"Dampened":[94],"Weighted":[95],"Least":[96],"Squares":[97],"method":[98],"was":[99,122],"implemented":[100],"estimate":[102],"platelet-programmed":[104,125],"cell":[106,127],"proportion":[107,128],"in":[108,139,174],"1,102":[109],"bulk":[110],"samples":[112],"primary":[114],"breast":[115],"cancer":[116,175],"tumors.":[117],"A":[118],"strong":[119],"inverse":[120],"association":[121,145],"found":[123],"between":[124,150],"overall":[130],"survival":[131],"(Cox-PH":[132],"p-value":[133],"=0.00419,":[134],"HR=6":[135],"per":[136],"10%":[137],"increase":[138],"proportion,":[140],"95%":[141],"CI:1.76-20.7).":[142],"did":[146],"differ":[148],"significantly":[149],"early-":[151],"late-stage":[153],"patients.":[154],"Cell-cell":[155],"analyses":[157],"molecular":[159],"docking":[160],"revealed":[161],"CD40LG\u2013":[163],"ITGA5:ITGB1":[164],"pair":[165],"as":[166],"potential":[168],"checkpoint":[170,213],"candidate":[171],"for":[172,219],"(Hex":[176],"score=\u2212656.83;":[177],"TNF\u03b1\u2013TNFR":[178],"reference":[179],"complex=\u2212515).":[180],"further":[182,220],"experimental":[183,221],"clinical":[185],"validation":[186,222],"is":[187],"required":[188],"translate":[190],"these":[191,195],"findings.":[192],"In":[193],"conclusion,":[194],"findings":[196],"deepen":[197],"our":[198],"understanding":[199],"evasion":[203],"mechanisms":[204],"acquiring":[208],"characteristics.":[210],"axis":[214],"offers":[215],"novel":[217],"avenue":[218],"future":[224],"intervention.":[225]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-23T00:00:00"}
