{"id":"https://openalex.org/W7213986904","doi":"https://doi.org/10.1111/pace.70450","title":"Loss of Septal Q Waves Is Associated With QRS Widening After Transcatheter Aortic Valve Implantation","display_name":"Loss of Septal Q Waves Is Associated With QRS Widening After Transcatheter Aortic Valve Implantation","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213986904","doi":"https://doi.org/10.1111/pace.70450","pmid":"https://pubmed.ncbi.nlm.nih.gov/42768299"},"language":"en","primary_location":{"id":"doi:10.1111/pace.70450","doi":"https://doi.org/10.1111/pace.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pace.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pace.70450","source":{"id":"https://openalex.org/S128634829","display_name":"Pacing and Clinical Electrophysiology","issn_l":"0147-8389","issn":["0147-8389","1540-8159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and Clinical Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pace.70450","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075730328","display_name":"Samah Alkharji","orcid":"https://orcid.org/0000-0002-0061-960X","observed_orcids":["https://orcid.org/0000-0002-0061-960X"]},"institutions":[{"id":"https://openalex.org/I2799949964","display_name":"Adan Hospital","ror":"https://ror.org/01mtpwn71","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2799949964"]},{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Samah AlKharji","raw_affiliation_strings":["Cardiac Electrophysiology division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait","Faculty of Medicine Kuwait University  Kuwait City Kuwait"],"raw_orcid":"https://orcid.org/0000-0002-0061-960X","affiliations":[{"raw_affiliation_string":"Cardiac Electrophysiology division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait","institution_ids":["https://openalex.org/I2799949964","https://openalex.org/I4210129520"]},{"raw_affiliation_string":"Faculty of Medicine Kuwait University  Kuwait City Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019604021","display_name":"Krishna Kumar Mohanan Nair","orcid":"https://orcid.org/0000-0002-3313-3462","observed_orcids":["https://orcid.org/0000-0002-3313-3462"]},"institutions":[{"id":"https://openalex.org/I2799949964","display_name":"Adan Hospital","ror":"https://ror.org/01mtpwn71","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2799949964"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Krishna Kumar","raw_affiliation_strings":["Cardiac Electrophysiology division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait"],"raw_orcid":"https://orcid.org/0000-0002-3313-3462","affiliations":[{"raw_affiliation_string":"Cardiac Electrophysiology division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait","institution_ids":["https://openalex.org/I2799949964","https://openalex.org/I4210129520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152437675","display_name":"Abdullah Esmaeil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800519576","display_name":"Mubarak Al Kabeer Hospital","ror":"https://ror.org/05nkffb74","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2800519576"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Abdullah Esmaeil","raw_affiliation_strings":["Interventional and structural heart disease, Department of Cardiology Mubarak Al Kabeer Hospital, Ministry of Health  Kuwait City Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional and structural heart disease, Department of Cardiology Mubarak Al Kabeer Hospital, Ministry of Health  Kuwait City Kuwait","institution_ids":["https://openalex.org/I2800519576","https://openalex.org/I4210129520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027936852","display_name":"Ahmed Alshatti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799949964","display_name":"Adan Hospital","ror":"https://ror.org/01mtpwn71","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2799949964"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Ahmed AlShatti","raw_affiliation_strings":["Interventional and Structural Heart Disease Division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional and Structural Heart Disease Division, Department of Cardiology, Al Dabbous Cardiac Center Adan Hospital, Ministry of Health  Kuwait City Kuwait","institution_ids":["https://openalex.org/I2799949964","https://openalex.org/I4210129520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075730328"],"corresponding_institution_ids":["https://openalex.org/I2799949964","https://openalex.org/I36721946","https://openalex.org/I4210129520"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/qrs-widening","display_name":"QRS widening","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cardiac-conduction-disorders","display_name":"cardiac conduction disorders","score":0.8429999947547913},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9279999732971191},{"id":"https://openalex.org/keywords/post-procedural-monitoring","display_name":"post-procedural monitoring","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9222999811172485},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.8711000084877014},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7699000239372253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7411999702453613},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.47369998693466187},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4311000108718872},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C2909456097","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Conduction abnormalities","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.30820000171661377},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C178697064","wikidata":"https://www.wikidata.org/wiki/Q3800650","display_name":"PR interval","level":4,"score":0.2678999900817871},{"id":"https://openalex.org/C2777385415","wikidata":"https://www.wikidata.org/wiki/Q1615191","display_name":"Cardiac catheterization","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.251800000667572},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/pace.70450","doi":"https://doi.org/10.1111/pace.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pace.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pace.70450","source":{"id":"https://openalex.org/S128634829","display_name":"Pacing and Clinical Electrophysiology","issn_l":"0147-8389","issn":["0147-8389","1540-8159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and Clinical Electrophysiology","raw_type":"journal-article"},{"id":"pmid:42768299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42768299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and clinical electrophysiology : PACE","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/pace.70450","doi":"https://doi.org/10.1111/pace.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pace.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pace.70450","source":{"id":"https://openalex.org/S128634829","display_name":"Pacing and Clinical Electrophysiology","issn_l":"0147-8389","issn":["0147-8389","1540-8159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and Clinical Electrophysiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213986904.pdf","grobid_xml":"https://content.openalex.org/works/W7213986904.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W107933927","https://openalex.org/W1150726894","https://openalex.org/W1559104772","https://openalex.org/W1967847641","https://openalex.org/W2041802295","https://openalex.org/W2048212542","https://openalex.org/W2130951671","https://openalex.org/W2142929577","https://openalex.org/W2897559105","https://openalex.org/W3093603655","https://openalex.org/W3110972146","https://openalex.org/W3121851336","https://openalex.org/W3184554206","https://openalex.org/W4229024036","https://openalex.org/W4280510733","https://openalex.org/W4385803803","https://openalex.org/W4392888904","https://openalex.org/W4404687801","https://openalex.org/W4407219124","https://openalex.org/W4415593313","https://openalex.org/W7129000770","https://openalex.org/W7140462886"],"related_works":["https://openalex.org/W7164208285","https://openalex.org/W4390919982","https://openalex.org/W4380716246","https://openalex.org/W2566390715","https://openalex.org/W2799698034","https://openalex.org/W2803398595","https://openalex.org/W2155640452","https://openalex.org/W4233806190","https://openalex.org/W2316919165","https://openalex.org/W3094028647"],"abstract_inverted_index":{"BACKGROUND:":[0],"Conduction":[1],"disturbances":[2],"remain":[3],"a":[4,64,74,234],"common":[5],"complication":[6],"following":[7],"transcatheter":[8],"aortic":[9],"valve":[10],"implantation":[11],"(TAVI).":[12],"While":[13],"baseline":[14,33,84,123,225],"conduction":[15,22,49,239],"abnormalities":[16],"are":[17,253],"well-established":[18],"predictors":[19],"of":[20,41,68,97,150,158,238],"post-procedural":[21,217,249],"disease":[23],"or":[24,35,86,125,227],"permanent":[25],"pacemaker":[26],"implantation,":[27],"risk":[28,246],"stratification":[29,247],"in":[30,58,100,112,141,148,161,220,245,259],"patients":[31,70,121,143,221],"without":[32,83,122,224],"PR":[34,85,124,226],"QRS":[36,87,113,126,136,159,197,218,228],"prolongation":[37,88],"remains":[38],"limited.":[39],"Loss":[40],"septal":[42],"Q":[43,98],"waves":[44,99],"(LSQ)":[45],"may":[46,231],"reflect":[47],"underlying":[48],"system":[50,240],"vulnerability":[51,241],"but":[52],"has":[53],"not":[54],"been":[55],"systematically":[56],"evaluated":[57],"this":[59],"setting.":[60],"METHODS:":[61],"We":[62],"conducted":[63],"retrospective":[65],"observational":[66],"study":[67],"consecutive":[69],"undergoing":[71,222],"TAVI":[72,223],"at":[73],"single":[75],"tertiary":[76],"center":[77],"between":[78],"2018":[79],"and":[80,104,135,248,256],"2024.":[81],"Patients":[82],"were":[89,129],"included.":[90],"LSQ":[91,145,152,209,230],"was":[92,109,146,153,192,213],"defined":[93],"as":[94,233],"the":[95,132],"absence":[96],"leads":[101],"I,":[102],"V5,":[103],"V6.":[105],"The":[106,172],"primary":[107,133],"outcome":[108,134],"an":[110],"increase":[111],"duration":[114],"\u2265":[115],"20":[116],"ms.":[117],"RESULTS:":[118],"Among":[119],"87":[120],"prolongation,":[127],"86":[128],"evaluable":[130],"for":[131,178],"widening":[137,160,198,219],"\u226520":[138],"ms":[139],"occurred":[140],"31":[142],"(36.0%).":[144],"present":[147],"40.2%":[149],"patients.":[151],"associated":[154,195,215],"with":[155,196,216,242],"increased":[156],"odds":[157],"unadjusted":[162],"analysis":[163],"(OR":[164],"2.71,":[165],"95%":[166,183,202],"CI":[167,184,203],"1.09-6.74;":[168],"p":[169,186,205],"=":[170,187,206],"0.031).":[171],"association":[173],"remained":[174],"significant":[175],"after":[176],"adjustment":[177],"AF":[179,191],"(adjusted":[180,199],"OR":[181,200],"2.76,":[182],"1.07-7.11;":[185],"0.035)":[188],"(Table":[189],"2).":[190],"also":[193],"independently":[194,214],"3.79,":[201],"1.10-13.08;":[204],"0.035).":[207],"CONCLUSION:":[208],"on":[210],"pre-procedural":[211],"ECG":[212],"prolongation.":[229],"serve":[232],"simple,":[235],"non-invasive":[236],"marker":[237],"potential":[243],"utility":[244],"monitoring.":[250],"These":[251],"findings":[252],"hypothesis":[254],"generating":[255],"warrant":[257],"validation":[258],"larger":[260],"prospective":[261],"cohorts.":[262]},"counts_by_year":[],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2026-09-22T00:00:00"}