{"id":"https://openalex.org/W7213986335","doi":"https://doi.org/10.64898/2026.09.20.753066","title":"Breaking Pore Symmetry to Prolong DNA Residence in Solid-State Nanopores","display_name":"Breaking Pore Symmetry to Prolong DNA Residence in Solid-State Nanopores","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7213986335","doi":"https://doi.org/10.64898/2026.09.20.753066"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.20.753066","doi":"https://doi.org/10.64898/2026.09.20.753066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.753066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.753066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.753066.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103246638","display_name":"Simran Nasa","orcid":"https://orcid.org/0000-0002-6471-6038","observed_orcids":["https://orcid.org/0000-0002-6471-6038"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Simran Nasa","raw_affiliation_strings":["Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036141401","display_name":"Pranjal Sur","orcid":"https://orcid.org/0009-0007-5307-0116","observed_orcids":["https://orcid.org/0009-0007-5307-0116"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pranjal Sur","raw_affiliation_strings":["Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102780622","display_name":"Prabal Kumar Maiti","orcid":"https://orcid.org/0000-0002-9956-1136","observed_orcids":["https://orcid.org/0000-0002-9956-1136"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabal K. Maiti","raw_affiliation_strings":["Department of Physics, Indian Institute of Science, Bengaluru 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Indian Institute of Science, Bengaluru 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089685445","display_name":"Manoj M. Varma","orcid":"https://orcid.org/0000-0002-1218-1422","observed_orcids":["https://orcid.org/0000-0002-1218-1422"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manoj M. Varma","raw_affiliation_strings":["Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India"],"raw_orcid":"https://orcid.org/0000-0002-1218-1422","affiliations":[{"raw_affiliation_string":"Centre for Nano Science and Engineering, Indian Institute of Science, Bengaluru 560012, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089685445"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-state-nanopores","display_name":"solid-state nanopores","score":0.9750000238418579},{"id":"https://openalex.org/keywords/dna-transport","display_name":"DNA transport","score":0.4580000042915344},{"id":"https://openalex.org/keywords/single-molecule-detection","display_name":"single-molecule detection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/electric-field-redistribution","display_name":"electric field redistribution","score":0.7070000171661377},{"id":"https://openalex.org/keywords/ionic-strength-effects","display_name":"ionic strength effects","score":0.7879999876022339},{"id":"https://openalex.org/keywords/membrane-thickness","display_name":"membrane thickness","score":0.39100000262260437},{"id":"https://openalex.org/keywords/atomistic-simulation","display_name":"atomistic simulation","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.894599974155426},{"id":"https://openalex.org/C151637689","wikidata":"https://www.wikidata.org/wiki/Q5318064","display_name":"Dwell time","level":2,"score":0.6193000078201294},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5982999801635742},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5971999764442444},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5705000162124634},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5677000284194946},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.4788999855518341},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4668999910354614},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.43389999866485596},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4052000045776367},{"id":"https://openalex.org/C41999313","wikidata":"https://www.wikidata.org/wiki/Q489328","display_name":"Molecular physics","level":1,"score":0.40369999408721924},{"id":"https://openalex.org/C99895341","wikidata":"https://www.wikidata.org/wiki/Q366058","display_name":"Persistence length","level":3,"score":0.38119998574256897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36039999127388},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3529999852180481},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C2775913793","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Residence time (fluid dynamics)","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C204795200","wikidata":"https://www.wikidata.org/wiki/Q903282","display_name":"Symmetry breaking","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C2779886137","wikidata":"https://www.wikidata.org/wiki/Q21030012","display_name":"Symmetry (geometry)","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.2842999994754791},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C74080474","wikidata":"https://www.wikidata.org/wiki/Q7305975","display_name":"Redistribution (election)","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C105569014","wikidata":"https://www.wikidata.org/wiki/Q3271208","display_name":"Porous medium","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.2567000091075897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.20.753066","doi":"https://doi.org/10.64898/2026.09.20.753066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.753066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.753066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.20.753066","doi":"https://doi.org/10.64898/2026.09.20.753066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.753066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.20.753066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320318581","display_name":"Indian Institute of Technology Gandhinagar","ror":"https://ror.org/0036p5w23"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320336895","display_name":"National NanoFab Center","ror":"https://ror.org/05k1va520"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213986335.pdf","grobid_xml":"https://content.openalex.org/works/W7213986335.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W160347429","https://openalex.org/W1031578623","https://openalex.org/W1538258919","https://openalex.org/W1944872933","https://openalex.org/W1963982927","https://openalex.org/W1976499671","https://openalex.org/W1982898268","https://openalex.org/W1993527536","https://openalex.org/W1997647778","https://openalex.org/W2009886994","https://openalex.org/W2010936313","https://openalex.org/W2015359849","https://openalex.org/W2025583382","https://openalex.org/W2025618463","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2057477511","https://openalex.org/W2059648430","https://openalex.org/W2067174909","https://openalex.org/W2081693079","https://openalex.org/W2089675977","https://openalex.org/W2094537242","https://openalex.org/W2094879588","https://openalex.org/W2103945336","https://openalex.org/W2113231874","https://openalex.org/W2127407003","https://openalex.org/W2170711116","https://openalex.org/W2233819953","https://openalex.org/W2293393117","https://openalex.org/W2296475169","https://openalex.org/W2321940188","https://openalex.org/W2510475640","https://openalex.org/W2557322836","https://openalex.org/W2884157655","https://openalex.org/W2936177448","https://openalex.org/W2949224026","https://openalex.org/W2992752060","https://openalex.org/W2998199734","https://openalex.org/W3006545642","https://openalex.org/W3017297538","https://openalex.org/W3198767362","https://openalex.org/W4211132533","https://openalex.org/W4392105836","https://openalex.org/W4409368642","https://openalex.org/W4415968219"],"related_works":["https://openalex.org/W3124921490","https://openalex.org/W3119673031","https://openalex.org/W2127143588","https://openalex.org/W2920330030","https://openalex.org/W2050174467","https://openalex.org/W2016042758","https://openalex.org/W2312050492","https://openalex.org/W2766654929","https://openalex.org/W2142962840","https://openalex.org/W2607919103"],"abstract_inverted_index":{"Abstract":[0],"Rapid":[1],"DNA":[2,25,113],"transport":[3],"limits":[4],"the":[5,79],"temporal":[6],"resolution":[7],"of":[8,56,73,81],"solid-state":[9,137],"nanopore":[10],"sensing.":[11,149],"Here":[12],"we":[13],"show":[14],"that":[15],"breaking":[16],"pore":[17,76],"symmetry":[18],"through":[19],"geometric":[20,125],"inclination":[21,126],"produces":[22],"exceptionally":[23],"prolonged":[24,82],"residence":[26,135],"without":[27],"surface":[28],"functionalization":[29],"or":[30],"external":[31],"trapping.":[32],"For":[33],"500-base-pair":[34],"double-stranded":[35],"(ds)":[36],"DNA,":[37],"13":[38],"nm":[39],"diameter":[40],"SiNx":[41],"pores":[42],"in":[43,136],"tilted":[44],"membranes":[45],"exhibit":[46],"a":[47,52,106,128,141],"distinct":[48],"long-lived":[49],"population":[50,80],"with":[51],"mean":[53],"dwell":[54,67],"time":[55],"11.1":[57],"seconds":[58],"at":[59],"600":[60],"mV":[61],"bias,":[62],"exceeding":[63],"previously":[64],"reported":[65],"dsDNA":[66],"times":[68],"by":[69],"at-least":[70],"4":[71],"orders":[72],"magnitude.":[74],"Controlled":[75],"tilting":[77],"reproduces":[78],"events,":[83],"whose":[84],"prevalence":[85],"and":[86,102,118,139],"duration":[87],"depend":[88],"on":[89],"ionic":[90],"strength.":[91],"TEM-EELS":[92],"based":[93],"thickness":[94],"measurements":[95],"exclude":[96],"substantial":[97],"membrane-thickness":[98],"differences,":[99],"while":[100],"continuum":[101],"atomistic":[103],"simulations":[104],"support":[105],"mechanism":[107],"coupling":[108],"electric-field":[109],"redistribution":[110],"to":[111],"off-axis":[112],"motion,":[114],"increased":[115],"pore-wall":[116],"contact":[117],"suppressed":[119],"axial":[120],"mobility.":[121],"These":[122],"findings":[123],"establish":[124],"as":[127],"passive":[129],"design":[130],"variable":[131],"for":[132,147],"engineering":[133],"molecular":[134],"nanopores":[138],"provide":[140],"route":[142],"towards":[143],"longer":[144],"observation":[145],"windows":[146],"single-molecule":[148]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-22T00:00:00"}