{"id":"https://openalex.org/W7213986262","doi":"https://doi.org/10.64898/2026.09.18.752493","title":"TFE3 fusions drive expression of CD44 and SPP1 in Translocation Renal Cell Carcinoma","display_name":"TFE3 fusions drive expression of CD44 and SPP1 in Translocation Renal Cell Carcinoma","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7213986262","doi":"https://doi.org/10.64898/2026.09.18.752493"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.18.752493","doi":"https://doi.org/10.64898/2026.09.18.752493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752493.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014074616","display_name":"Kaushal V. Asrani","orcid":"https://orcid.org/0000-0002-9777-5296","observed_orcids":["https://orcid.org/0000-0002-9777-5296"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kaushal Asrani","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-9777-5296","affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040241785","display_name":"Juhyung Woo","orcid":"https://orcid.org/0000-0001-6262-8088","observed_orcids":["https://orcid.org/0000-0001-6262-8088"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juhyung Woo","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047383259","display_name":"Thiago Vidotto","orcid":"https://orcid.org/0000-0002-7268-4494","observed_orcids":["https://orcid.org/0000-0002-7268-4494"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thiago Vidotto","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034988901","display_name":"Kewen Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kewen Feng","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152409325","display_name":"Alan Lorenzetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Lorenzetti","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027111342","display_name":"Eddie L. Imada","orcid":"https://orcid.org/0000-0001-9527-3703","observed_orcids":["https://orcid.org/0000-0001-9527-3703"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddie Imada","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149109781","display_name":"Huili Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huili Li","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019196752","display_name":"Rajan Singh","orcid":"https://orcid.org/0000-0001-5500-1949","observed_orcids":["https://orcid.org/0000-0001-5500-1949"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajan Singh","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108333089","display_name":"Anand K Thotakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand Thotakura","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112803385","display_name":"Sangeeta Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangeeta Ray","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152437501","display_name":"Lia Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lia Oliveira","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123181931","display_name":"Adrianna Amaral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrianna Amaral","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073692717","display_name":"Vikrant Palande","orcid":"https://orcid.org/0000-0002-3062-2105","observed_orcids":["https://orcid.org/0000-0002-3062-2105"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikrant Palande","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079019104","display_name":"Ravi Kumar Anchoori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Anchoori","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011318024","display_name":"Jayaprakash Mandal","orcid":"https://orcid.org/0000-0003-2003-9757","observed_orcids":["https://orcid.org/0000-0003-2003-9757"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayaprakash Mandal","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139674698","display_name":"Roy Elias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Elias","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028661200","display_name":"Christopher J. Thoburn","orcid":"https://orcid.org/0000-0001-7743-9183","observed_orcids":["https://orcid.org/0000-0001-7743-9183"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Thoburn","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152412449","display_name":"Md. Masud Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md. Masud Rana","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135015536","display_name":"Hrishikesh Nagbhushan Gangule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hrishikesh Gangule","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152424086","display_name":"Alexander Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Gao","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087756231","display_name":"Pornima Phatak","orcid":"https://orcid.org/0000-0002-3675-7051","observed_orcids":["https://orcid.org/0000-0002-3675-7051"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pornima Phatak","raw_affiliation_strings":["Birmingham Veterans Affairs Medical Center, UAB, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham Veterans Affairs Medical Center, UAB, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110904052","display_name":"James Donahue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Donahue","raw_affiliation_strings":["Birmingham Veterans Affairs Medical Center, UAB, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham Veterans Affairs Medical Center, UAB, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070461373","display_name":"Yasser M. A. Ged","orcid":"https://orcid.org/0000-0001-6671-7002","observed_orcids":["https://orcid.org/0000-0001-6671-7002"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasser Ged","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030962772","display_name":"Nirmish Singla","orcid":"https://orcid.org/0000-0001-9495-6983","observed_orcids":["https://orcid.org/0000-0001-9495-6983"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nirmish Singla","raw_affiliation_strings":["Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148944428","display_name":"John Copland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Copland","raw_affiliation_strings":["Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129096361","display_name":"Laura Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Schmidt","raw_affiliation_strings":["Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107963543","display_name":"William Marston Linehan","orcid":"https://orcid.org/0000-0001-7983-3109","observed_orcids":["https://orcid.org/0000-0001-7983-3109"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Marston Linehan","raw_affiliation_strings":["Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005154278","display_name":"Pedram Argani","orcid":"https://orcid.org/0000-0001-8797-9474","observed_orcids":["https://orcid.org/0000-0001-8797-9474"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedram Argani","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054652534","display_name":"Tamara Lotan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Lotan","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland","Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5014074616"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tfe3-fusion","display_name":"TFE3 fusion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9660000205039978},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5070000290870667},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.6669999957084656},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7781000137329102},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6395999789237976},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6128000020980835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6097999811172485},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4724999964237213},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4334999918937683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41130000352859497},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3686000108718872},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36320000886917114},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.35850000381469727},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.33559998869895935},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3301999866962433},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2563999891281128},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.2551000118255615},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.18.752493","doi":"https://doi.org/10.64898/2026.09.18.752493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.18.752493","doi":"https://doi.org/10.64898/2026.09.18.752493","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752493","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752493.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1459558516","display_name":null,"funder_award_id":"5P30CA006973-52","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2671596539","display_name":"Targeting Lysosomal Biogenesis in Renal Tumors with TSC1/2 Loss","funder_award_id":"W81XWH-20-1-0843","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G4054003021","display_name":"Exploring and Leveraging Therapeutic Vulnerabilities in Renal Tumors with TSC1/2 Loss","funder_award_id":"W81XWH-22-1-0264","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G5536966411","display_name":null,"funder_award_id":"W81XWH-20-1-0843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6012682559","display_name":null,"funder_award_id":"HHSN261201500003I","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6336093431","display_name":null,"funder_award_id":"HHSN261201500003I","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8882569155","display_name":null,"funder_award_id":"HHSN261201500003I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213986262.pdf","grobid_xml":"https://content.openalex.org/works/W7213986262.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2002583936","https://openalex.org/W2037632318","https://openalex.org/W2047902687","https://openalex.org/W2064505748","https://openalex.org/W2082745326","https://openalex.org/W2112056046","https://openalex.org/W2135269189","https://openalex.org/W2137059411","https://openalex.org/W2140484012","https://openalex.org/W2169500410","https://openalex.org/W2264092661","https://openalex.org/W2626522201","https://openalex.org/W2800392236","https://openalex.org/W2888951867","https://openalex.org/W2897249806","https://openalex.org/W2898701133","https://openalex.org/W2899184640","https://openalex.org/W2942509924","https://openalex.org/W2947839897","https://openalex.org/W2949177718","https://openalex.org/W2980967819","https://openalex.org/W2984472267","https://openalex.org/W2988223295","https://openalex.org/W3025663994","https://openalex.org/W3134354266","https://openalex.org/W3196083918","https://openalex.org/W4206899650","https://openalex.org/W4225993798","https://openalex.org/W4285678402","https://openalex.org/W4292489664","https://openalex.org/W4309076562","https://openalex.org/W4311025761","https://openalex.org/W4366824437","https://openalex.org/W4377023457","https://openalex.org/W4384816663","https://openalex.org/W4385638791","https://openalex.org/W4387420341","https://openalex.org/W4388843329","https://openalex.org/W4390732769","https://openalex.org/W4392032909","https://openalex.org/W4414779353","https://openalex.org/W4415782414"],"related_works":["https://openalex.org/W7204987519","https://openalex.org/W7135212359","https://openalex.org/W7204990611","https://openalex.org/W2740762379","https://openalex.org/W2567180948","https://openalex.org/W2791919267","https://openalex.org/W4232180297","https://openalex.org/W2795991551","https://openalex.org/W2943624288","https://openalex.org/W4408073184"],"abstract_inverted_index":{"Summary":[0],"Xp11.2":[1],"translocation":[2],"RCC":[3,13],"[Xp11.2":[4],"tRCC])":[5],"is":[6,24,40],"an":[7,25],"underdiagnosed":[8],"and":[9,32,49,64,74,81,86,107,113,129],"aggressive":[10],"subtype":[11],"of":[12,44,72,103,123,132],"with":[14,33,69,127,137],"few":[15],"specific":[16,130],"or":[17],"targeted":[18],"therapies.":[19],"The":[20],"transmembrane":[21],"glycoprotein":[22],"CD44":[23,73,92,124,145],"emerging":[26],"target":[27],"in":[28,78,100,152],"many":[29],"advanced":[30],"malignancies,":[31],"its":[34],"ligand":[35],"OPN":[36],"(":[37],"SPP1":[38,94,147],"),":[39],"a":[41,87],"crucial":[42],"driver":[43],"cancer":[45],"progression,":[46],"stemness,":[47],"metastasis,":[48],"immune":[50],"suppression.":[51],"Here":[52],"we":[53],"show":[54],"that":[55,144],"common":[56],"TFE3":[57],"-fusions":[58],"[including":[59],"SFPQ-TFE3,":[60],"PRCC-TFE3,":[61],"ASPSCR1-TFE3":[62],",":[63],"NONO-TFE3":[65],"]":[66],"are":[67],"associated":[68,126],"upregulated":[70,99],"expression":[71,96],"SPP1,":[75],"as":[76],"observed":[77],"multiple":[79],"human":[80,114],"murine":[82,88,101],"bulk":[83],"transcriptomic":[84],"studies":[85],"tRCC":[89,105,115,133],"snRNA-Seq":[90],"dataset.":[91],"and/or":[93,119,146],"protein":[95],"were":[97],"also":[98],"models":[102],"transgenic":[104],"kidneys":[106],"urine":[108],"specimens,":[109],"patient-derived":[110],"cell":[111,134],"lines":[112],"cases,":[116],"by":[117],"immunoblotting":[118],"IHC.":[120],"Transient":[121],"deletion":[122],"was":[125],"profound":[128],"suppression":[131],"line":[135],"growth,":[136],"decreased":[138],"mTOR":[139],"signaling.":[140],"These":[141],"data":[142],"suggest":[143],"may":[148],"potentially":[149],"drive":[150],"tumorigenesis":[151],"tRCC.":[153]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-22T00:00:00"}
