{"id":"https://openalex.org/W7213979653","doi":"https://doi.org/10.7759/cureus.116712","title":"Postoperative Hemothorax in an Adult With RIT1-Associated Noonan Syndrome and Reduced Factor XIII Antigen Despite Preserved Activity","display_name":"Postoperative Hemothorax in an Adult With RIT1-Associated Noonan Syndrome and Reduced Factor XIII Antigen Despite Preserved Activity","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7213979653","doi":"https://doi.org/10.7759/cureus.116712","pmid":"https://pubmed.ncbi.nlm.nih.gov/42923906","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13688289"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.116712","doi":"https://doi.org/10.7759/cureus.116712","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116712","pdf_url":"https://www.cureus.com/articles/533164-postoperative-hemothorax-in-an-adult-with-rit1-associated-noonan-syndrome-and-reduced-factor-xiii-antigen-despite-preserved-activity.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/533164-postoperative-hemothorax-in-an-adult-with-rit1-associated-noonan-syndrome-and-reduced-factor-xiii-antigen-despite-preserved-activity.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152421547","display_name":"Bastien Sylvester Claeys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124719","display_name":"Solothurner Spit\u00e4ler","ror":"https://ror.org/02swf6979","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124719"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Bastien Sylvester Claeys","raw_affiliation_strings":["Internal Medicine, Solothurner Spit\u00e4ler, Solothurn, CHE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Solothurner Spit\u00e4ler, Solothurn, CHE","institution_ids":["https://openalex.org/I4210124719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5152421547"],"corresponding_institution_ids":["https://openalex.org/I4210124719"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57095665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e116712","last_page":"e116712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12830","display_name":"Pectus Deformity Diagnosis and Treatment","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noonan-syndrome","display_name":"Noonan syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rasopathies","display_name":"RASopathies","score":0.8429999947547913},{"id":"https://openalex.org/keywords/factor-xiii-activity","display_name":"factor XIII activity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hemostatic-disorders","display_name":"hemostatic disorders","score":0.8109999895095825},{"id":"https://openalex.org/keywords/congenital-diaphragmatic-hernia","display_name":"congenital diaphragmatic hernia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pleurectomy","display_name":"pleurectomy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/chronic-pleuritis","display_name":"chronic pleuritis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/wolff-parkinson-white-syndrome","display_name":"Wolff-Parkinson-White syndrome","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9890999794006348},{"id":"https://openalex.org/C2776149932","wikidata":"https://www.wikidata.org/wiki/Q1543446","display_name":"Noonan syndrome","level":2,"score":0.8671000003814697},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5630000233650208},{"id":"https://openalex.org/C2779630960","wikidata":"https://www.wikidata.org/wiki/Q369073","display_name":"Hemothorax","level":3,"score":0.4830000102519989},{"id":"https://openalex.org/C2779672106","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIII","level":3,"score":0.4255000054836273},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4172999858856201},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37529999017715454},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36489999294281006},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.116712","doi":"https://doi.org/10.7759/cureus.116712","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116712","pdf_url":"https://www.cureus.com/articles/533164-postoperative-hemothorax-in-an-adult-with-rit1-associated-noonan-syndrome-and-reduced-factor-xiii-antigen-despite-preserved-activity.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13688289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13688289/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13688289/pdf/cureus-0018-00000116712.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42923906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42923906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.116712","doi":"https://doi.org/10.7759/cureus.116712","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116712","pdf_url":"https://www.cureus.com/articles/533164-postoperative-hemothorax-in-an-adult-with-rit1-associated-noonan-syndrome-and-reduced-factor-xiii-antigen-despite-preserved-activity.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213979653.pdf","grobid_xml":"https://content.openalex.org/works/W7213979653.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2200911078","https://openalex.org/W2338493213","https://openalex.org/W2343590051","https://openalex.org/W2896407975","https://openalex.org/W3142323159"],"related_works":["https://openalex.org/W2942824107","https://openalex.org/W2412939641","https://openalex.org/W2052622924","https://openalex.org/W2094355616","https://openalex.org/W3142323159","https://openalex.org/W2023591596","https://openalex.org/W1990659432","https://openalex.org/W3192021385","https://openalex.org/W7055999000","https://openalex.org/W2886961979"],"abstract_inverted_index":{"Noonan":[0,43,142,168],"syndrome":[1,44,169],"is":[2],"a":[3,13,39,49,136],"genetically":[4],"heterogeneous":[5,164],"RASopathy":[6],"associated":[7],"with":[8,26,77],"congenital":[9,27],"cardiovascular":[10],"abnormalities":[11],"and":[12,38,64,67,72,74,80,88,95,108,170],"broad":[14],"spectrum":[15],"of":[16,22,42,48,69,104,157,167,173],"hemostatic":[17,165],"abnormalities.We":[18],"report":[19],"the":[20,58,70,105,149,155,158,163,171],"case":[21,161],"an":[23],"adult":[24],"man":[25],"pulmonary":[28],"valve":[29],"disease,":[30],"previous":[31],"radiofrequency":[32],"ablation":[33],"for":[34,112],"Wolff-Parkinson-White":[35],"syndrome,":[36],"hepatosplenomegaly,":[37],"clinical":[40],"suspicion":[41],"who":[45],"underwent":[46],"repair":[47],"previously":[50],"unrecognized":[51],"large":[52],"left-sided":[53],"diaphragmatic":[54],"rupture.The":[55],"defect":[56],"contained":[57],"left":[59,62,85],"colonic":[60],"flexure,":[61],"kidney":[63],"adrenal":[65],"gland,":[66],"parts":[68],"stomach":[71],"spleen,":[73],"was":[75,110],"repaired":[76],"primary":[78],"closure":[79],"mesh":[81],"reinforcement.A":[82],"substantial":[83],"postoperative":[84,159],"hemothorax":[86],"developed":[87],"required":[89],"thoracic":[90],"drainage,":[91],"followed":[92],"by":[93],"persistent":[94],"recurrent":[96],"pleural":[97],"collections.Subsequent":[98],"thoracoscopy":[99],"demonstrated":[100,116],"marked":[101],"inflammatory":[102],"thickening":[103],"parietal":[106],"pleura,":[107],"pleurectomy":[109],"performed":[111],"chronic":[113],"pleuritis.Hematological":[114],"evaluation":[115,180],"mildly":[117],"reduced":[118,150],"factor":[119,127,151],"XIII":[120,128,152],"antigen":[121,153],"levels":[122],"on":[123],"repeat":[124],"testing,":[125],"while":[126],"activity":[129],"remained":[130],"preserved.Molecular":[131],"genetic":[132],"testing":[133],"subsequently":[134],"identified":[135],"heterozygous":[137],"pathogenic":[138],"RIT1":[139],"variant,":[140],"confirming":[141],"syndrome.The":[143],"available":[144],"findings":[145],"do":[146],"not":[147],"establish":[148],"as":[154],"cause":[156],"hemothorax.This":[160],"highlights":[162],"phenotype":[166],"importance":[172],"comprehensive":[174],"perioperative":[175],"bleeding":[176,184],"assessment,":[177],"including":[178],"targeted":[179],"when":[181],"clinically":[182],"significant":[183],"occurs.":[185]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-22T00:00:00"}