{"id":"https://openalex.org/W7213974150","doi":"https://doi.org/10.64898/2026.09.19.749544","title":"The RNA modification N 6 -methyladenosine restrains SIRP\u03b1 to license myeloid efferocytosis in atherosclerosis","display_name":"The RNA modification N 6 -methyladenosine restrains SIRP\u03b1 to license myeloid efferocytosis in atherosclerosis","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213974150","doi":"https://doi.org/10.64898/2026.09.19.749544"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.19.749544","doi":"https://doi.org/10.64898/2026.09.19.749544","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.19.749544","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.19.749544.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.19.749544.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061976414","display_name":"Aneesh S. Kallapur","orcid":"https://orcid.org/0000-0001-7886-3699","observed_orcids":["https://orcid.org/0000-0001-7886-3699"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aneesh Kallapur","raw_affiliation_strings":["Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA","Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7886-3699","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152410925","display_name":"Xiang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Li","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083020535","display_name":"Elena Rodr\u00edguez\u2010S\u00e1nchez","orcid":"https://orcid.org/0000-0002-5020-949X","observed_orcids":["https://orcid.org/0000-0002-5020-949X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Rodriguez-Sanchez","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681479","display_name":"Zhengyi Zhang","orcid":"https://orcid.org/0000-0001-9094-1223","observed_orcids":["https://orcid.org/0000-0001-9094-1223"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengyi Zhang","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017852382","display_name":"Aniketa Sinha","orcid":"https://orcid.org/0000-0003-3039-9369","observed_orcids":["https://orcid.org/0000-0003-3039-9369"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniketa Sinha","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125754050","display_name":"Lijing Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijing Cheng","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411866","display_name":"Dan Wang","orcid":"https://orcid.org/0000-0003-0313-5528","observed_orcids":["https://orcid.org/0000-0003-0313-5528"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Wang","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152410759","display_name":"Jing Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Gu","raw_affiliation_strings":["Department of Human Genetics, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125699487","display_name":"Jason Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Kim","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121047800","display_name":"Xiaohui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Wu","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152421133","display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Division of Computational Biomedicine, Biological Chemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Biological Chemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152420171","display_name":"Ya Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya Cui","raw_affiliation_strings":["Division of Computational Biomedicine, Biological Chemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Biological Chemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152434187","display_name":"Xin He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin He","raw_affiliation_strings":["Department of Human Genetics, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091114864","display_name":"Chuan He","orcid":"https://orcid.org/0000-0003-4319-7424","observed_orcids":["https://orcid.org/0000-0003-4319-7424","https://orcid.org/0000-0002-9983-7526","https://orcid.org/0000-0002-6171-810X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan He","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA","Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015408928","display_name":"Tamer Sallam","orcid":"https://orcid.org/0000-0001-7144-7393","observed_orcids":["https://orcid.org/0000-0001-7144-7393"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tamer Sallam","raw_affiliation_strings":["Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA","Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015408928"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mettl14","display_name":"METTL14","score":0.9629999995231628},{"id":"https://openalex.org/keywords/epitranscriptomic-regulation","display_name":"epitranscriptomic regulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-stability","display_name":"atherosclerotic plaque stability","score":0.7179999947547913},{"id":"https://openalex.org/keywords/necrotic-core","display_name":"necrotic core","score":0.6209999918937683},{"id":"https://openalex.org/keywords/thymic-apoptosis","display_name":"thymic apoptosis","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7095000147819519},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5601999759674072},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.557200014591217},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5259000062942505},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4982999861240387},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4700999855995178},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.44119998812675476},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4309999942779541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4140999913215637},{"id":"https://openalex.org/C2777408375","wikidata":"https://www.wikidata.org/wiki/Q707810","display_name":"Arteriogenesis","level":3,"score":0.41260001063346863},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3910999894142151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35830000042915344},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.3529999852180481},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3418000042438507},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.3407999873161316},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28940001130104065},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2754000127315521},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C168261976","wikidata":"https://www.wikidata.org/wiki/Q5347407","display_name":"Efferocytosis","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.25279998779296875},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.19.749544","doi":"https://doi.org/10.64898/2026.09.19.749544","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.19.749544","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.19.749544.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.19.749544","doi":"https://doi.org/10.64898/2026.09.19.749544","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.19.749544","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.19.749544.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213974150.pdf","grobid_xml":"https://content.openalex.org/works/W7213974150.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1986256219","https://openalex.org/W1988376074","https://openalex.org/W1995892391","https://openalex.org/W2014863678","https://openalex.org/W2025696553","https://openalex.org/W2032159795","https://openalex.org/W2039999701","https://openalex.org/W2064393764","https://openalex.org/W2065847836","https://openalex.org/W2073751205","https://openalex.org/W2078964320","https://openalex.org/W2079724669","https://openalex.org/W2095474336","https://openalex.org/W2110153407","https://openalex.org/W2116505573","https://openalex.org/W2122693935","https://openalex.org/W2131110587","https://openalex.org/W2401656403","https://openalex.org/W2497350880","https://openalex.org/W2759443181","https://openalex.org/W2776540408","https://openalex.org/W2790187710","https://openalex.org/W2905137116","https://openalex.org/W2945926178","https://openalex.org/W2950063384","https://openalex.org/W2999012956","https://openalex.org/W3001475210","https://openalex.org/W3016950990","https://openalex.org/W3026033619","https://openalex.org/W3037464909","https://openalex.org/W3037791176","https://openalex.org/W3103567189","https://openalex.org/W3112986012","https://openalex.org/W3121941032","https://openalex.org/W3122002269","https://openalex.org/W3127283963","https://openalex.org/W3131735436","https://openalex.org/W3157295498","https://openalex.org/W3159494124","https://openalex.org/W3183307215","https://openalex.org/W3186377298","https://openalex.org/W3214068706","https://openalex.org/W4200164950","https://openalex.org/W4221074781","https://openalex.org/W4225011946","https://openalex.org/W4307500724","https://openalex.org/W4310766578","https://openalex.org/W4312118929","https://openalex.org/W4321597820","https://openalex.org/W4360600689","https://openalex.org/W4366210400","https://openalex.org/W4390571027","https://openalex.org/W4391258649","https://openalex.org/W4394805727","https://openalex.org/W4396938847","https://openalex.org/W4407953944","https://openalex.org/W4407982800","https://openalex.org/W4409145269","https://openalex.org/W4409472664","https://openalex.org/W7118425839","https://openalex.org/W7121648459","https://openalex.org/W7125829397","https://openalex.org/W7140204386"],"related_works":["https://openalex.org/W4221130122","https://openalex.org/W4281259453","https://openalex.org/W4308524169","https://openalex.org/W4389793212","https://openalex.org/W4307548076","https://openalex.org/W4411324498","https://openalex.org/W3089789954","https://openalex.org/W3200264607","https://openalex.org/W7116788371","https://openalex.org/W4313312784"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Macrophages":[2],"participate":[3],"in":[4,28,56,66,111,173,193,208,218,236,244,301,304,308,362],"atherosclerotic":[5,273,302],"plaque":[6],"development,":[7],"progression":[8],"and":[9,13,20,98,144,164,200,271,311,351],"resolution,":[10,228],"integrating":[11],"lipid":[12,201],"inflammatory":[14],"cues":[15],"to":[16,38,198,241],"balance":[17],"tissue":[18],"damage":[19],"repair.":[21],"Despite":[22],"considerable":[23],"understanding":[24],"of":[25,58,106,118,134,231,255,267,295,319,349,359],"macrophage":[26,242,299,360],"function":[27],"atherosclerosis,":[29],"the":[30,47,115,256,265,309,320,336],"underlying":[31],"regulatory":[32],"mechanisms":[33],"governing":[34],"these":[35],"responses":[36],"continue":[37],"evolve.":[39],"Emerging":[40],"evidence":[41],"implicates":[42],"epitranscriptomic":[43,353],"gene":[44],"regulation":[45,207,361],"by":[46],"RNA":[48,96,216,327],"modification":[49,235],"N":[50],"6":[51,54,75,81,108,121,136,182,188,205,233,249,258,292,316,339],"-methyladenosine":[52],"(m":[53,80,187],"A)":[55],"control":[57],"context":[59],"specific":[60,253],"immune":[61,199],"responses,":[62],"but":[63],"its":[64,329],"role":[65,288],"atherosclerosis":[67,146,245],"is":[68],"not":[69],"well-defined.":[70],"Methods":[71],"We":[72],"integrated":[73],"m":[74,107,120,135,181,204,232,248,257,291,315,338],"A":[76,82,109,122,137,183,189,206,234,250,259,317,340],"quantitative":[77,184],"trait":[78,185],"loci":[79,186,196],"QTLs)":[83],"with":[84,167,220,281],"Coronary":[85],"Artery":[86],"Disease":[87],"(CAD)":[88],"GWAS":[89,195],"summary":[90],"statistics.":[91],"Using":[92,212],"Oxford":[93,213],"Nanopore":[94,214],"direct":[95,215],"sequencing":[97,217],"MeRIP-":[99],"seq,":[100],"we":[101,126,224],"constructed":[102],"a":[103,128,226,305,345,356],"high-resolution":[104],"map":[105,230],"modifications":[110],"macrophages.":[112],"To":[113],"determine":[114],"functional":[116],"consequences":[117],"myeloid":[119,290,296,337],"loss":[123],"in-vivo":[124],",":[125],"generated":[127,225],"myeloid-specific":[129],"loss-":[130],"of-function":[131],"mouse":[132],"model":[133],"(":[138],"Mettl14":[139,263,282,297],"f/f":[140,283],"LysM":[141],"Cre":[142],")":[143],"performed":[145,172],"studies":[147,171],"using":[148,161],"bone":[149,175],"marrow":[150,176],"transplantation":[151],"into":[152],"irradiated":[153],"Ldlr":[154,277],"--/-":[155,278],"mice.":[156],"Atherosclerosis":[157],"lesions":[158],"were":[159,191],"analyzed":[160],"light":[162],"microscopy":[163],"immunofluorescence":[165],"imaging,":[166],"complementary":[168],"in-vitro":[169,312],"mechanistic":[170],"murine":[174],"derived":[177],"macrophages":[178],"(BMDMs).":[179],"Results":[180],"-QTLs)":[190],"enriched":[192],"CAD":[194,210],"relevant":[197],"function,":[202],"implicating":[203],"human":[209],"genetics.":[211],"conjunction":[219],"public":[221],"MeRIP-sequencing":[222],"data,":[223],"single-base":[227],"stoichiometric":[229],"macrophages,":[237],"nominating":[238],"genes":[239],"central":[240],"biology":[243],"as":[246,344,355],"high-confidence":[247],"targets.":[251],"Myeloid":[252],"deletion":[254],"\u201cwriter\u201d":[260],"complex":[261],"subunit":[262],"drove":[264],"development":[266],"larger,":[268],"more":[269],"necrotic":[270],"unstable":[272],"plaques":[274],"on":[275],"an":[276,286],"background":[279],"compared":[280],"controls,":[284],"establishing":[285],"atheroprotective":[287],"for":[289],"A.":[293],"Loss":[294],"impaired":[298],"efferocytosis":[300,350],"plaques,":[303],"dexamethasone-induced":[306],"apoptosis":[307],"thymus":[310],".":[313],"Molecularly,":[314],"methylation":[318],"\u201cdon\u2019t":[321],"eat":[322],"me\u201d":[323],"antiphagocytic":[324],"receptor":[325],"SIRP\u03b1":[326,342],"suppressed":[328],"protein":[330],"expression.":[331],"Conclusions":[332],"These":[333],"findings":[334],"identify":[335],"-":[341],"axis":[343],"novel":[346],"homeostatic":[347],"regulator":[348],"establish":[352],"remodeling":[354],"crucial":[357],"layer":[358],"atherosclerosis.":[363]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-22T00:00:00"}
