{"id":"https://openalex.org/W7213973178","doi":"https://doi.org/10.33393/jcb.2026.3797","title":"Circulating free and low-density lipoprotein-bound GD2 can compete in vitro with neuroblastoma cells for binding therapeutic anti-GD2 antibodies","display_name":"Circulating free and low-density lipoprotein-bound GD2 can compete in vitro with neuroblastoma cells for binding therapeutic anti-GD2 antibodies","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213973178","doi":"https://doi.org/10.33393/jcb.2026.3797","pmid":"https://pubmed.ncbi.nlm.nih.gov/42774998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13594967"},"language":"en","primary_location":{"id":"doi:10.33393/jcb.2026.3797","doi":"https://doi.org/10.33393/jcb.2026.3797","is_oa":true,"landing_page_url":"https://doi.org/10.33393/jcb.2026.3797","pdf_url":"https://journals.aboutscience.eu/index.php/jcb/article/download/3797/5311","source":{"id":"https://openalex.org/S4210183541","display_name":"Journal of Circulating Biomarkers","issn_l":"1849-4544","issn":["1849-4544"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Circulating Biomarkers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.aboutscience.eu/index.php/jcb/article/download/3797/5311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062915140","display_name":"Christina S. Turn","orcid":"https://orcid.org/0000-0003-3962-6740","observed_orcids":["https://orcid.org/0000-0003-3962-6740"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina Turn","raw_affiliation_strings":["Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA"],"raw_orcid":"https://orcid.org/0000-0003-3962-6740","affiliations":[{"raw_affiliation_string":"Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140126094","display_name":"Christine Busch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Busch","raw_affiliation_strings":["Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108500853","display_name":"Cara Toland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara Toland","raw_affiliation_strings":["Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037652877","display_name":"Hamid Bassiri","orcid":"https://orcid.org/0000-0001-6532-8478","observed_orcids":["https://orcid.org/0000-0001-6532-8478"]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid Bassiri","raw_affiliation_strings":["Division of Immunology, Johnson & Johnson Innovative Medicine, Spring House - USA","Division of Infectious Diseases and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Johnson & Johnson Innovative Medicine, Spring House - USA","institution_ids":["https://openalex.org/I1330063522"]},{"raw_affiliation_string":"Division of Infectious Diseases and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045426069","display_name":"Michael D. Hogarty","orcid":"https://orcid.org/0000-0002-9221-4852","observed_orcids":["https://orcid.org/0000-0002-9221-4852"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Hogarty","raw_affiliation_strings":["Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank M. Balis","raw_affiliation_strings":["Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA"],"raw_orcid":"https://orcid.org/0000-0002-8117-6926","affiliations":[{"raw_affiliation_string":"Division of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia - USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia - USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062915140"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":1500,"currency":"EUR","value_usd":1617},"apc_paid":{"value":1500,"currency":"EUR","value_usd":1617},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7195309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"69","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gd2","display_name":"GD2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gangliosides","display_name":"gangliosides","score":0.9100000262260437},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anti-gd2-antibody","display_name":"anti-GD2 antibody","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dinutuximab","display_name":"dinutuximab","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/adoptive-cellular-therapy","display_name":"adoptive cellular therapy","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8271999955177307},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7925999760627747},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6833000183105469},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6697999835014343},{"id":"https://openalex.org/C2777331542","wikidata":"https://www.wikidata.org/wiki/Q419287","display_name":"Ganglioside","level":2,"score":0.6218000054359436},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6212999820709229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5600000023841858},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4099000096321106},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40470001101493835},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36480000615119934},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.3222000002861023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31859999895095825},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C85196483","wikidata":"https://www.wikidata.org/wiki/Q6545857","display_name":"Ligand binding assay","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27230000495910645}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.33393/jcb.2026.3797","doi":"https://doi.org/10.33393/jcb.2026.3797","is_oa":true,"landing_page_url":"https://doi.org/10.33393/jcb.2026.3797","pdf_url":"https://journals.aboutscience.eu/index.php/jcb/article/download/3797/5311","source":{"id":"https://openalex.org/S4210183541","display_name":"Journal of Circulating Biomarkers","issn_l":"1849-4544","issn":["1849-4544"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Circulating Biomarkers","raw_type":"journal-article"},{"id":"pmid:42774998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42774998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of circulating biomarkers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13594967","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13594967/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Circ Biomark","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.33393/jcb.2026.3797","doi":"https://doi.org/10.33393/jcb.2026.3797","is_oa":true,"landing_page_url":"https://doi.org/10.33393/jcb.2026.3797","pdf_url":"https://journals.aboutscience.eu/index.php/jcb/article/download/3797/5311","source":{"id":"https://openalex.org/S4210183541","display_name":"Journal of Circulating Biomarkers","issn_l":"1849-4544","issn":["1849-4544"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Circulating Biomarkers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000875862","display_name":"NRSA Training Core","funder_award_id":"TL1TR001880","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306589","display_name":"Alex's Lemonade Stand Foundation for Childhood Cancer","ror":"https://ror.org/038ja4880"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213973178.pdf","grobid_xml":"https://content.openalex.org/works/W7213973178.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1884435079","https://openalex.org/W1965550919","https://openalex.org/W2061770965","https://openalex.org/W2130465135","https://openalex.org/W2162260323","https://openalex.org/W2527905628","https://openalex.org/W2618869560","https://openalex.org/W2757204525","https://openalex.org/W2895919137","https://openalex.org/W2911401252","https://openalex.org/W2980942118","https://openalex.org/W3091399767","https://openalex.org/W4200054353","https://openalex.org/W4200111418","https://openalex.org/W4200141042","https://openalex.org/W4200581012","https://openalex.org/W4281560777","https://openalex.org/W4309309594","https://openalex.org/W4389568793","https://openalex.org/W4390015907","https://openalex.org/W4407560509","https://openalex.org/W4412756479"],"related_works":["https://openalex.org/W4409668023","https://openalex.org/W2138147234","https://openalex.org/W2421915675","https://openalex.org/W4387119518","https://openalex.org/W4253753916","https://openalex.org/W7140288587","https://openalex.org/W4412756479","https://openalex.org/W2013431297","https://openalex.org/W2094409655","https://openalex.org/W3164659665"],"abstract_inverted_index":{"Introduction:":[0],"GD2":[1,28,83,108,127,148,159,175,192,195],"is":[2],"a":[3,119,134,144,221],"ganglioside":[4],"expressed":[5],"on":[6],"neuroblastoma":[7,42,46,201],"cell":[8,47],"membranes":[9],"and":[10,66,94,106,193,231],"shed":[11],"into":[12],"the":[13,32,61,90,170,211],"circulation,":[14],"where":[15],"it":[16],"primarily":[17],"circulates":[18],"bound":[19],"to":[20,41,79,97,113,131,133,163,167,200,218],"low-density":[21],"lipoprotein":[22],"(LDL).":[23],"We":[24],"questioned":[25],"whether":[26],"LDL-bound":[27,107,126,158,194],"could":[29,209],"interfere":[30],"with":[31,52,57,102,152,187,220],"binding":[33,112,130,162,179,199],"of":[34,92,173,213],"therapeutic":[35,214,234],"anti-GD2":[36,54,197,215],"monoclonal":[37],"antibodies":[38,101,216],"(like":[39],"dinutuximab)":[40],"cells.Methods:":[43],"The":[44],"GD2-expressing":[45,93],"line":[48],"IMR5":[49,103,114,132,164],"was":[50,70],"stained":[51],"an":[53],"antibody":[55,129,161,178,198],"tagged":[56],"allophycocyanin":[58],"(APC)":[59],"at":[60,84,141,229],"lowest":[62],"possible":[63],"saturating":[64],"concentration,":[65],"mean":[67],"fluorescence":[68],"intensity":[69],"measured":[71],"by":[72,165,180],"flow":[73],"cytometry":[74],"after":[75],"in":[76,116,118,150,185],"vitro":[77,117],"exposure":[78],"GD2-LDL":[80,208],"or":[81,228],"free":[82,138,174,191],"multiple":[85],"concentrations.":[86],"Control":[87],"experiments":[88],"assessed":[89],"ability":[91],"GD2-non-expressing":[95],"cells":[96,115],"compete":[98],"for":[99,236],"anti-GD2-APC":[100,110],"cells.Results:":[104],"Free":[105],"reduced":[109],"antibodies\u2019":[111],"concentration-dependent":[120],"manner.":[121],"At":[122,155,182],"physiologically":[123],"relevant":[124],"concentrations,":[125,157],"blocked":[128,196],"greater":[135],"extent":[136],"than":[137],"GD2,":[139],"including":[140],"100":[142],"nM,":[143],"concentration":[145,172],"below":[146],"median":[147],"concentrations":[149,183],"patients":[151,186,219],"high-risk":[153,188],"neuroblastoma.":[154],"higher":[156],"inhibited":[160],"up":[166],"92.6%,":[168],"whereas":[169],"same":[171],"only":[176],"decreased":[177],"56.6%Conclusions:":[181],"found":[184],"neuroblastoma,":[189],"both":[190],"cells.":[202],"These":[203],"data":[204],"suggest":[205],"that":[206],"circulating":[207],"impact":[210],"efficacy":[212],"administered":[217],"high":[222],"disease":[223],"burden":[224],"during":[225],"induction":[226],"therapy":[227],"relapse":[230],"may":[232],"have":[233],"implications":[235],"GD2-directed":[237],"adoptive":[238],"cellular":[239],"therapies.":[240]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-22T00:00:00"}
