{"id":"https://openalex.org/W7213972375","doi":"https://doi.org/10.64898/2026.09.18.752389","title":"Probing the interaction between the WDR41 7CD loop of the C9ORF72 complex and purified PQLC2","display_name":"Probing the interaction between the WDR41 7CD loop of the C9ORF72 complex and purified PQLC2","publication_year":2026,"publication_date":"2026-09-22","ids":{"openalex":"https://openalex.org/W7213972375","doi":"https://doi.org/10.64898/2026.09.18.752389"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.18.752389","doi":"https://doi.org/10.64898/2026.09.18.752389","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752389","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752389.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752389.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116066626","display_name":"Layal Jamal","orcid":"https://orcid.org/0009-0009-0550-0841","observed_orcids":["https://orcid.org/0009-0009-0550-0841"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4405258897","display_name":"Sant\u00e9 Orale","ror":"https://ror.org/01cgtm828","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091279","https://openalex.org/I4405258897"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Jamal","raw_affiliation_strings":["Faculty of Odontology, Universit\u00e9 Paris Cit\u00e9, Oral Health Research Unit, UMR1333, Montrouge, France","Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0009-0009-0550-0841","affiliations":[{"raw_affiliation_string":"Faculty of Odontology, Universit\u00e9 Paris Cit\u00e9, Oral Health Research Unit, UMR1333, Montrouge, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4405258897"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152415883","display_name":"Phil\u00e9mon von Gaudecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P von Gaudecker","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073246902","display_name":"Laura Pieri","orcid":"https://orcid.org/0000-0003-0779-9014","observed_orcids":["https://orcid.org/0000-0003-0779-9014"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Pieri","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-0779-9014","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006103299","display_name":"C\u00e9line Ransy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Ransy","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004790831","display_name":"Nodoka Nakamae","orcid":"https://orcid.org/0009-0003-4088-148X","observed_orcids":["https://orcid.org/0009-0003-4088-148X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N Nakamae","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0009-0003-4088-148X","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027704419","display_name":"Fran\u00e7ois Andr\u00e9","orcid":"https://orcid.org/0000-0003-1742-2800","observed_orcids":["https://orcid.org/0000-0003-1742-2800"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Andre","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-1742-2800","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067518832","display_name":"Igor Tasc\u00f3n","orcid":"https://orcid.org/0000-0003-2526-6238","observed_orcids":["https://orcid.org/0000-0003-2526-6238"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I Tascon","raw_affiliation_strings":["Ikerbasque Foundation for Science, Bilbao, Spain","Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2526-6238","affiliations":[{"raw_affiliation_string":"Ikerbasque Foundation for Science, Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539074","display_name":"Hanxing Jiang","orcid":"https://orcid.org/0009-0007-8359-8130","observed_orcids":["https://orcid.org/0009-0007-8359-8130"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"H Jiang","raw_affiliation_strings":["Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain"],"raw_orcid":"https://orcid.org/0009-0007-8359-8130","affiliations":[{"raw_affiliation_string":"Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742834","display_name":"Borja Ochoa-Lizarralde","orcid":"https://orcid.org/0000-0002-5532-0218","observed_orcids":["https://orcid.org/0000-0002-5532-0218"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B Ochoa-Lizarralde","raw_affiliation_strings":["Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5532-0218","affiliations":[{"raw_affiliation_string":"Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074737109","display_name":"Iban Ubarretxena\u2010Belandia","orcid":"https://orcid.org/0000-0003-4082-4349","observed_orcids":["https://orcid.org/0000-0003-4082-4349"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I Ubarretxena-Belandia","raw_affiliation_strings":["Ikerbasque Foundation for Science, Bilbao, Spain","Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4082-4349","affiliations":[{"raw_affiliation_string":"Ikerbasque Foundation for Science, Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210118072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058656295","display_name":"C\u00e9cile Debacker","orcid":"https://orcid.org/0009-0003-2401-7325","observed_orcids":["https://orcid.org/0009-0003-2401-7325"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387154016","display_name":"SPPIN - Saints-P\u00e8res Paris Institute for Neurosciences","ror":"https://ror.org/01a4enz31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Debacker","raw_affiliation_strings":["Saints-P\u00e8res Paris Institute for the Neurosciences, Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, F-75006 Paris, France"],"raw_orcid":"https://orcid.org/0009-0003-2401-7325","affiliations":[{"raw_affiliation_string":"Saints-P\u00e8res Paris Institute for the Neurosciences, Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, F-75006 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001810791","display_name":"Bruno Gasnier","orcid":"https://orcid.org/0000-0003-4458-6296","observed_orcids":["https://orcid.org/0000-0003-4458-6296"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387154016","display_name":"SPPIN - Saints-P\u00e8res Paris Institute for Neurosciences","ror":"https://ror.org/01a4enz31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Gasnier","raw_affiliation_strings":["Saints-P\u00e8res Paris Institute for the Neurosciences, Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, F-75006 Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-4458-6296","affiliations":[{"raw_affiliation_string":"Saints-P\u00e8res Paris Institute for the Neurosciences, Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, F-75006 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073451415","display_name":"Leandro C. Tabares","orcid":"https://orcid.org/0000-0002-8906-6430","observed_orcids":["https://orcid.org/0000-0002-8906-6430"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"LC Tabares","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0002-8906-6430","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101790931","display_name":"Jos\u00e9 Luis V\u00e1zquez-Ibar","orcid":"https://orcid.org/0000-0002-8314-3378","observed_orcids":["https://orcid.org/0000-0002-8314-3378"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"JL V\u00e1zquez-Ibar","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0002-8314-3378","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5101790931"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/disordered-loop","display_name":"disordered loop","score":0.5820000171661377},{"id":"https://openalex.org/keywords/aromatic-residues","display_name":"aromatic residues","score":0.7350000143051147},{"id":"https://openalex.org/keywords/homotrimer","display_name":"homotrimer","score":0.6970000267028809},{"id":"https://openalex.org/keywords/amino-acid-transport","display_name":"amino acid transport","score":0.593999981880188},{"id":"https://openalex.org/keywords/conformational-flexibility","display_name":"conformational flexibility","score":0.6209999918937683},{"id":"https://openalex.org/keywords/nitroxide-spin-labeling","display_name":"nitroxide spin labeling","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.7150999903678894},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.5586000084877014},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5432000160217285},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5146999955177307},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4666999876499176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4657000005245209},{"id":"https://openalex.org/C177462420","wikidata":"https://www.wikidata.org/wiki/Q7531731","display_name":"Site-directed spin labeling","level":3,"score":0.453900009393692},{"id":"https://openalex.org/C169912494","wikidata":"https://www.wikidata.org/wiki/Q1994007","display_name":"Nitroxide mediated radical polymerization","level":5,"score":0.367000013589859},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.362199991941452},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.33399999141693115},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C193812863","wikidata":"https://www.wikidata.org/wiki/Q7259688","display_name":"Pulsed EPR","level":4,"score":0.2953999936580658},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27970001101493835},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C139210041","wikidata":"https://www.wikidata.org/wiki/Q2145840","display_name":"Resonance (particle physics)","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.09.18.752389","doi":"https://doi.org/10.64898/2026.09.18.752389","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752389","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752389.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:HAL:hal-05846626v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05846626","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2026","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.09.18.752389","doi":"https://doi.org/10.64898/2026.09.18.752389","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.752389","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752389.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2247417377","display_name":null,"funder_award_id":"ANR- 10-INSB-05","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4212894969","display_name":null,"funder_award_id":"PID2022","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5022665926","display_name":null,"funder_award_id":"PID2022-143177NB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G502948375","display_name":null,"funder_award_id":"ANR-10- INSB-05","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G513542429","display_name":null,"funder_award_id":"ANR-10-INSB-05-05","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6092439753","display_name":null,"funder_award_id":"UAR2009","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G6694357955","display_name":null,"funder_award_id":"ANR-10-INSB-05-05","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G7237471465","display_name":null,"funder_award_id":"INSB-05","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8710043179","display_name":null,"funder_award_id":"05-05","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G8920660035","display_name":null,"funder_award_id":"PID2022","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G8928482289","display_name":"Mechanism of lysosomal signaling by an amino acid transceptor","funder_award_id":"ANR-22-CE11-0008","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320315862","display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie","ror":"https://ror.org/054q97b08"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321705","display_name":"Eusko Jaurlaritza","ror":"https://ror.org/00pz2fp31"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320324471","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17"},{"id":"https://openalex.org/F4320327185","display_name":"French Infrastructure for Integrated Structural Biology","ror":"https://ror.org/045sst074"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213972375.pdf","grobid_xml":"https://content.openalex.org/works/W7213972375.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1493142940","https://openalex.org/W1515404266","https://openalex.org/W1532176344","https://openalex.org/W1534985842","https://openalex.org/W1940906693","https://openalex.org/W1966311581","https://openalex.org/W1999474474","https://openalex.org/W2004582874","https://openalex.org/W2019991237","https://openalex.org/W2021520922","https://openalex.org/W2023468367","https://openalex.org/W2025176940","https://openalex.org/W2046216903","https://openalex.org/W2047439787","https://openalex.org/W2054981831","https://openalex.org/W2060194574","https://openalex.org/W2060273164","https://openalex.org/W2064697628","https://openalex.org/W2069957357","https://openalex.org/W2077878341","https://openalex.org/W2079362486","https://openalex.org/W2093154482","https://openalex.org/W2105738527","https://openalex.org/W2132262459","https://openalex.org/W2133678277","https://openalex.org/W2138207816","https://openalex.org/W2146051607","https://openalex.org/W2153188271","https://openalex.org/W2154945114","https://openalex.org/W2166434963","https://openalex.org/W2166467743","https://openalex.org/W2206954826","https://openalex.org/W2234076653","https://openalex.org/W2257572427","https://openalex.org/W2311186916","https://openalex.org/W2336528486","https://openalex.org/W2406553940","https://openalex.org/W2518003787","https://openalex.org/W2593803283","https://openalex.org/W2593816418","https://openalex.org/W2597549071","https://openalex.org/W2605540202","https://openalex.org/W2753604846","https://openalex.org/W2765934351","https://openalex.org/W2785714783","https://openalex.org/W2802223982","https://openalex.org/W2805414276","https://openalex.org/W2815343175","https://openalex.org/W2896532438","https://openalex.org/W2900551238","https://openalex.org/W2920955434","https://openalex.org/W2952521211","https://openalex.org/W2982942741","https://openalex.org/W2991456852","https://openalex.org/W2996031468","https://openalex.org/W3016970018","https://openalex.org/W3048679663","https://openalex.org/W3081042567","https://openalex.org/W3081868833","https://openalex.org/W3090557866","https://openalex.org/W3111971324","https://openalex.org/W3114895015","https://openalex.org/W3129948148","https://openalex.org/W3190208935","https://openalex.org/W4280560201","https://openalex.org/W4292117557","https://openalex.org/W4295960241","https://openalex.org/W4318817988","https://openalex.org/W4327575311","https://openalex.org/W4396721167","https://openalex.org/W7125984418"],"related_works":["https://openalex.org/W3129948148","https://openalex.org/W7151954832","https://openalex.org/W4406925485","https://openalex.org/W7205124728","https://openalex.org/W2166467743","https://openalex.org/W4392501631","https://openalex.org/W7223421347","https://openalex.org/W4400801157","https://openalex.org/W4393057657","https://openalex.org/W7147652639"],"abstract_inverted_index":{"Abstract":[0],"The":[1,176],"lysosomal":[2],"cationic":[3,24],"amino":[4,25,63],"acid":[5,26,64],"transceptor":[6,228],"PQLC2":[7,35,60,84,106,174],"integrates":[8],"transport":[9],"with":[10,36,132],"receptor-like":[11],"signaling":[12],"roles":[13],"by":[14],"recruiting":[15],"the":[16,32,44,48,80,123,129,136,140,141,145,170,183,187,192,198,227],"C9ORF72/SMCR8/WDR41":[17],"(CSW)":[18],"complex":[19],"in":[20,181],"response":[21],"to":[22,66,78,116,148],"cellular":[23,62],"depletion.":[27],"CSW":[28],"recruitment":[29],"depends":[30],"on":[31],"interaction":[33,53,81,151],"of":[34,51,128,139,144,169,186,195,230],"a":[37,86,93,99,113,179,213,222],"disordered":[38],"loop":[39,90,131,147,172,188,220],"(7CD":[40],"loop)":[41],"extending":[42],"from":[43],"WDR41":[45,88],"\u03b2-propeller.":[46],"Defining":[47],"molecular":[49],"basis":[50],"this":[52,150],"is":[54,189],"therefore":[55],"essential":[56],"for":[57,204,217],"understanding":[58,226],"how":[59],"connects":[61],"availability":[65],"downstream":[67],"signaling.":[68],"Here,":[69],"we":[70,103,211],"used":[71],"site-directed":[72],"electron":[73],"paramagnetic":[74],"resonance":[75],"(EPR)":[76],"spectroscopy":[77],"characterize":[79],"between":[82],"purified":[83],"and":[85,107,125,134,166],"synthetic":[87],"7CD":[89,130,146,171,219],"peptide":[91],"containing":[92],"site-specific":[94],"nitroxide":[95],"spin":[96],"label.":[97],"Using":[98],"consensus":[100],"mutagenesis":[101],"strategy,":[102],"stabilized":[104],"detergent-purified":[105],"found":[108],"that":[109],"it":[110],"assembles":[111],"as":[112],"homotrimer,":[114],"similar":[115],"other":[117],"PQ-loop":[118],"transporters.":[119],"EPR":[120],"experiments":[121],"demonstrated":[122],"direct":[124,214],"specific":[126],"association":[127],"PQLC2,":[133,196],"highlighted":[135],"key":[137],"role":[138],"central":[142,184],"region":[143,185],"establish":[149],"via":[152],"conserved":[153],"aromatic":[154],"residues.":[155],"Spin":[156],"labels":[157],"introduced":[158],"at":[159],"different":[160],"positions":[161],"further":[162],"provided":[163],"local":[164],"structural":[165],"dynamic":[167],"information":[168],"upon":[173],"binding.":[175],"data":[177],"supports":[178],"model":[180],"which":[182,201],"anchored":[190],"within":[191],"cytosolic":[193],"cavity":[194],"whereas":[197],"flanking":[199],"regions,":[200],"are":[202],"dispensable":[203],"binding,":[205],"retain":[206],"substantial":[207],"conformational":[208],"flexibility.":[209],"Together,":[210],"provide":[212],"biochemical":[215],"evidence":[216],"PQLC2/WDR41":[218],"recognition,":[221],"step":[223],"forward":[224],"towards":[225],"mechanism":[229],"PQLC2.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-22T00:00:00"}