{"id":"https://openalex.org/W7213947754","doi":"https://doi.org/10.1016/s2152-2650(26)03687-6","title":"PA-324 Optimized Computationally Engineered CD70-Targeting Virus-Free CRISPR Knock-in CAR T Cells for High-Risk Multiple Myeloma","display_name":"PA-324 Optimized Computationally Engineered CD70-Targeting Virus-Free CRISPR Knock-in CAR T Cells for High-Risk Multiple Myeloma","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7213947754","doi":"https://doi.org/10.1016/s2152-2650(26)03687-6"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(26)03687-6","doi":"https://doi.org/10.1016/s2152-2650(26)03687-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)03687-6","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023528069","display_name":"Bonell Pati\u00f1o-Escobar","orcid":"https://orcid.org/0000-0003-2622-4822","observed_orcids":["https://orcid.org/0000-0003-2622-4822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonell Patino-Escobar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031061959","display_name":"Daniel Dirck Waller","orcid":"https://orcid.org/0000-0002-8291-2630","observed_orcids":["https://orcid.org/0000-0002-8291-2630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel D. Waller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015810033","display_name":"Corynn Kasap","orcid":"https://orcid.org/0000-0002-3667-8097","observed_orcids":["https://orcid.org/0000-0002-3667-8097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corynn Kasap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152352818","display_name":"Amrik Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amrik Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088152553","display_name":"Sham Rampersaud","orcid":"https://orcid.org/0000-0001-7473-4144","observed_orcids":["https://orcid.org/0000-0001-7473-4144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sham Rampersaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152401983","display_name":"Ke Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058176725","display_name":"Radhika Dalal","orcid":"https://orcid.org/0000-0002-7128-5635","observed_orcids":["https://orcid.org/0000-0002-7128-5635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radhika Dalal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030991521","display_name":"Fernando Salangsang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Salangsang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126175626","display_name":"Juan Antonio Camara Serrano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Antonio Camara Serrano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152369129","display_name":"Yan Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030364434","display_name":"Veronica Steri","orcid":"https://orcid.org/0000-0003-2499-6618","observed_orcids":["https://orcid.org/0000-0003-2499-6618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronica Steri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906927","display_name":"Tanja Kortemme","orcid":"https://orcid.org/0000-0002-8494-680X","observed_orcids":["https://orcid.org/0000-0002-8494-680X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanja Kortemme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040998041","display_name":"Justin Eyquem","orcid":"https://orcid.org/0000-0001-8262-1190","observed_orcids":["https://orcid.org/0000-0001-8262-1190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin Eyquem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054844413","display_name":"Brian Rudolph Shy","orcid":"https://orcid.org/0000-0001-9569-3708","observed_orcids":["https://orcid.org/0000-0001-9569-3708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Shy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055852791","display_name":"Arun P. Wiita","orcid":"https://orcid.org/0000-0002-7465-6964","observed_orcids":["https://orcid.org/0000-0002-7465-6964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun P. Wiita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"S230","last_page":"S230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd70","display_name":"CD70","score":0.8460000157356262},{"id":"https://openalex.org/keywords/crispr-knock-in","display_name":"CRISPR knock-in","score":0.781000018119812},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/high-risk-multiple-myeloma","display_name":"high-risk myeloma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/engineered-t-cells","display_name":"engineered T cells","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.7642999887466431},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7394999861717224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6861000061035156},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5963000059127808},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3506999909877777},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C2994499388","wikidata":"https://www.wikidata.org/wiki/Q656732","display_name":"Gene deletion","level":4,"score":0.266400009393692},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2402999997138977},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.22849999368190765},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2232999950647354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(26)03687-6","doi":"https://doi.org/10.1016/s2152-2650(26)03687-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)03687-6","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402735866","https://openalex.org/W7213905397","https://openalex.org/W7213861918","https://openalex.org/W4413137558","https://openalex.org/W7213957594","https://openalex.org/W7213936649","https://openalex.org/W7213924657","https://openalex.org/W7213955749","https://openalex.org/W7034698254","https://openalex.org/W4293087882"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-22T00:00:00"}