{"id":"https://openalex.org/W7213944833","doi":"https://doi.org/10.64898/2026.09.15.751737","title":"Prefrontal control of hippocampal map reorganization during sleep","display_name":"Prefrontal control of hippocampal map reorganization during sleep","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213944833","doi":"https://doi.org/10.64898/2026.09.15.751737"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.751737","doi":"https://doi.org/10.64898/2026.09.15.751737","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751737","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751737.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751737.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038223442","display_name":"Ruoyu Huang","orcid":"https://orcid.org/0000-0002-9496-688X","observed_orcids":["https://orcid.org/0000-0002-9496-688X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruoyu Huang","raw_affiliation_strings":["Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9496-688X","affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146593498","display_name":"Masahiro Nakano","orcid":"https://orcid.org/0009-0004-4069-047X","observed_orcids":["https://orcid.org/0009-0004-4069-047X"]},"institutions":[{"id":"https://openalex.org/I4396570676","display_name":"Sainsbury Wellcome Centre","ror":"https://ror.org/04kjqkz56","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4396570676","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Masahiro Nakano","raw_affiliation_strings":["Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4396570676","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039497694","display_name":"Claudia Clopath","orcid":"https://orcid.org/0000-0003-4507-8648","observed_orcids":["https://orcid.org/0000-0003-4507-8648"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Clopath","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036040037","display_name":"Jan Born A","orcid":"https://orcid.org/0000-0002-1847-6248","observed_orcids":["https://orcid.org/0000-0002-1847-6248"]},"institutions":[{"id":"https://openalex.org/I4210160326","display_name":"German Center for Diabetes Research","ror":"https://ror.org/04qq88z54","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160326","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Born","raw_affiliation_strings":["German Center for Diabetes Research (DZD), Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University T\u00fcbingen (IDM), T\u00fcbingen, Germany","Institute of Medical Psychology and Behavioral Neurobiology, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Diabetes Research (DZD), Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University T\u00fcbingen (IDM), T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210160326","https://openalex.org/I8087733"]},{"raw_affiliation_string":"Institute of Medical Psychology and Behavioral Neurobiology, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064701185","display_name":"Thorsten Bartsch","orcid":"https://orcid.org/0000-0001-8387-5731","observed_orcids":["https://orcid.org/0000-0001-8387-5731"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Bartsch","raw_affiliation_strings":["Memory Disorders and Plasticity Group, Department of Neurology, University Hospital Schleswig-Holstein, Kiel 24105, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memory Disorders and Plasticity Group, Department of Neurology, University Hospital Schleswig-Holstein, Kiel 24105, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021541206","display_name":"Martin Both","orcid":"https://orcid.org/0000-0003-1847-9796","observed_orcids":["https://orcid.org/0000-0003-1847-9796"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Both","raw_affiliation_strings":["Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Germany","Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072597997","display_name":"Eduardo Blanco-Hern\u00e1ndez","orcid":"https://orcid.org/0009-0007-0000-6882","observed_orcids":["https://orcid.org/0009-0007-0000-6882"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eduardo Blanco-Hern\u00e1ndez","raw_affiliation_strings":["Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048169959","display_name":"Andrea Burgalossi","orcid":"https://orcid.org/0000-0003-0039-3599","observed_orcids":["https://orcid.org/0000-0003-0039-3599"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andrea Burgalossi","raw_affiliation_strings":["Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of T\u00fcbingen, T\u00fcbingen 72076, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Werner-Reichardt Centre for Integrative Neuroscience, Otfried-M\u00fcller-Str. 25, 72076 T\u00fcbingen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048169959"],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-dependent-memory-consolidation","display_name":"sleep-dependent memory consolidation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8880000114440918},{"id":"https://openalex.org/keywords/memory-generalization","display_name":"memory generalization","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hippocampal-reactivation","display_name":"hippocampal reactivation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/novel-environment-exploration","display_name":"novel environment exploration","score":0.5180000066757202},{"id":"https://openalex.org/keywords/familiarity","display_name":"familiarity","score":0.36000001430511475},{"id":"https://openalex.org/keywords/chemogenetic-inactivation","display_name":"chemogenetic inactivation","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.9218000173568726},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7968000173568726},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6840000152587891},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5968999862670898},{"id":"https://openalex.org/C2781369091","wikidata":"https://www.wikidata.org/wiki/Q2303730","display_name":"Place cell","level":3,"score":0.557699978351593},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.5285999774932861},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43639999628067017},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.4115000069141388},{"id":"https://openalex.org/C29993825","wikidata":"https://www.wikidata.org/wiki/Q7002656","display_name":"Neuroscience of sleep","level":4,"score":0.3686999976634979},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.36010000109672546},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.15.751737","doi":"https://doi.org/10.64898/2026.09.15.751737","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751737","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751737.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.751737","doi":"https://doi.org/10.64898/2026.09.15.751737","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751737","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751737.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213944833.pdf","grobid_xml":"https://content.openalex.org/works/W7213944833.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W4399466484","https://openalex.org/W4413780186","https://openalex.org/W7141868356"],"related_works":["https://openalex.org/W2071290167","https://openalex.org/W2034379782","https://openalex.org/W81224128","https://openalex.org/W2949306816","https://openalex.org/W4408789517","https://openalex.org/W7119310964","https://openalex.org/W2962305511","https://openalex.org/W4362638468","https://openalex.org/W2161473801","https://openalex.org/W2053308210"],"abstract_inverted_index":{"Abstract":[0],"During":[1],"wakefulness,":[2],"exposure":[3],"to":[4,16,41],"novel":[5,75,84,108,151],"experiences":[6],"induces":[7],"hippocampal":[8,50,63,152,168,173],"remapping,":[9],"in":[10,82,106,116],"which":[11],"place":[12,59,79,103],"cell":[13,104],"ensembles":[14],"reorganize":[15],"form":[17],"distinct":[18],"representations":[19,35,105],"of":[20,25,57,90,101,128,137],"new":[21],"information.":[22],"Classical":[23],"models":[24,159],"systems":[26],"consolidation":[27],"posit":[28],"that":[29,113,162],"subsequent":[30],"sleep":[31,92,142,163],"stabilizes":[32],"these":[33],"wake-formed":[34],"and":[36,133,147],"supports":[37],"their":[38],"gradual":[39],"transfer":[40],"medial":[42],"prefrontal":[43,176],"cortex":[44],"(mPFC)":[45],"networks":[46],"primarily":[47],"via":[48,175],"bottom-up":[49],"reactivations.":[51],"Using":[52],"miniscope":[53],"Ca":[54],"2+":[55],"imaging":[56],"CA1":[58],"cells,":[60],"we":[61],"monitored":[62],"activity":[64],"as":[65],"mice":[66],"explored":[67],"a":[68,73,87],"familiar":[69,102],"environment":[70,109],"followed":[71],"by":[72,97,125,160],"similar":[74],"one.":[76],"As":[77],"expected,":[78],"cells":[80],"remapped":[81],"the":[83,99,107,117,138,150],"context.":[85],"However,":[86],"single":[88],"episode":[89],"post-encoding":[91,141],"selectively":[93],"reversed":[94],"remapping":[95],"dynamics":[96],"promoting":[98],"reinstatement":[100,122],"\u2013":[110],"an":[111],"effect":[112],"was":[114,123],"absent":[115],"wake":[118],"condition.":[119],"This":[120],"neural":[121],"accompanied":[124],"behavioral":[126],"indicators":[127],"familiarity,":[129],"including":[130],"reduced":[131],"exploration":[132],"rearing.":[134],"Chemogenetic":[135],"inactivation":[136],"mPFC":[139],"during":[140],"abolished":[143],"this":[144],"generalization":[145],"effect,":[146],"instead":[148],"preserved":[149],"map.":[153],"Thus,":[154],"our":[155],"results":[156],"extend":[157],"current":[158],"showing":[161],"not":[164],"only":[165],"consolidates":[166],"wake-established":[167],"patterns,":[169],"but":[170],"actively":[171],"shapes":[172],"maps":[174],"control,":[177],"thereby":[178],"supporting":[179],"memory":[180],"generalization.":[181]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-22T00:00:00"}
