{"id":"https://openalex.org/W7213909700","doi":"https://doi.org/10.3390/cells15181697","title":"UBQLN4 Is a Prognostic Biomarker in Intrahepatic Cholangiocarcinoma That Is Associated with Cisplatin Resistance","display_name":"UBQLN4 Is a Prognostic Biomarker in Intrahepatic Cholangiocarcinoma That Is Associated with Cisplatin Resistance","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213909700","doi":"https://doi.org/10.3390/cells15181697","pmid":"https://pubmed.ncbi.nlm.nih.gov/42782797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13605264"},"language":"en","primary_location":{"id":"doi:10.3390/cells15181697","doi":"https://doi.org/10.3390/cells15181697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15181697","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cells15181697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033109001","display_name":"Kodai Abe","orcid":"https://orcid.org/0000-0002-1138-7437","observed_orcids":["https://orcid.org/0000-0002-1138-7437","https://orcid.org/0009-0008-2482-7690"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Kodai Abe","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137104588","display_name":"Kelly Chong","orcid":"https://orcid.org/0009-0001-6219-4088","observed_orcids":["https://orcid.org/0009-0001-6219-4088"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Chong","raw_affiliation_strings":["Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA"],"raw_orcid":"https://orcid.org/0009-0001-6219-4088","affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101498190","display_name":"Yuta Abe","orcid":"https://orcid.org/0000-0002-5840-8901","observed_orcids":["https://orcid.org/0000-0002-5840-8901"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Abe","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5840-8901","affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014273795","display_name":"Minoru Kitago","orcid":"https://orcid.org/0000-0002-4909-1199","observed_orcids":["https://orcid.org/0000-0002-4909-1199"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Kitago","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4909-1199","affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041286008","display_name":"Motonori Edanami","orcid":"https://orcid.org/0000-0002-7169-1860","observed_orcids":["https://orcid.org/0000-0002-7169-1860"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motonori Edanami","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014784355","display_name":"Yosuke Uematsu","orcid":"https://orcid.org/0009-0004-8694-6549","observed_orcids":["https://orcid.org/0009-0004-8694-6549"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Uematsu","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124027249","display_name":"Yohei Masugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Masugi","raw_affiliation_strings":["Department of Pathology, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","Department of Pathology, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Department of Pathology, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063415866","display_name":"Akihisa Ueno","orcid":"https://orcid.org/0000-0001-9428-4128","observed_orcids":["https://orcid.org/0000-0001-9428-4128"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihisa Ueno","raw_affiliation_strings":["Department of Pathology, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan","Division of Diagnostic Pathology, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9428-4128","affiliations":[{"raw_affiliation_string":"Department of Pathology, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]},{"raw_affiliation_string":"Division of Diagnostic Pathology, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080547240","display_name":"Matias Alberto Bustos","orcid":"https://orcid.org/0000-0001-9625-1127","observed_orcids":["https://orcid.org/0000-0001-9625-1127"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matias A. Bustos","raw_affiliation_strings":["Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","Department of Translational and Precision Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA"],"raw_orcid":"https://orcid.org/0000-0001-9625-1127","affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]},{"raw_affiliation_string":"Department of Translational and Precision Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008106546","display_name":"Anton J. Bilchik","orcid":"https://orcid.org/0000-0002-7251-2828","observed_orcids":["https://orcid.org/0000-0002-7251-2828"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton J. Bilchik","raw_affiliation_strings":["Department of Gastrointestinal and Hepatobiliary Surgery, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA"],"raw_orcid":"https://orcid.org/0000-0002-7251-2828","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal and Hepatobiliary Surgery, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086398854","display_name":"Yosef Shiloh","orcid":"https://orcid.org/0000-0002-1538-6060","observed_orcids":["https://orcid.org/0000-0002-1538-6060"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yosef Shiloh","raw_affiliation_strings":["David and Inez Myers Laboratory for Cancer Genetics, Department of Human Genetics and Computational Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":"https://orcid.org/0000-0002-1538-6060","affiliations":[{"raw_affiliation_string":"David and Inez Myers Laboratory for Cancer Genetics, Department of Human Genetics and Computational Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521231","display_name":"Yuko Kitagawa","orcid":"https://orcid.org/0000-0002-0271-5670","observed_orcids":["https://orcid.org/0000-0002-0271-5670"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Kitagawa","raw_affiliation_strings":["Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Keio University School of Medicine, Shinjuku 160-8582, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120989760","display_name":"Dave S. B. Hoon","orcid":"https://orcid.org/0000-0003-1915-3683","observed_orcids":["https://orcid.org/0000-0003-1915-3683"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dave S. B. Hoon","raw_affiliation_strings":["Advanced Therapeutics and Biomedical Technologies, The Lundquist Institute of Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA 90504, USA","Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Therapeutics and Biomedical Technologies, The Lundquist Institute of Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA 90504, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Department of Translational Molecular Medicine, Saint John\u2019s Cancer Institute (SJCI), Saint John\u2019s Health Center (SJHC), Providence Health System (PHS), Santa Monica, CA 90404, USA","institution_ids":["https://openalex.org/I4210104056"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033109001"],"corresponding_institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210104056"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7288586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"18","first_page":"1697","last_page":"1697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/copy-number-amplification","display_name":"copy number amplification","score":0.9100000262260437},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy-response","display_name":"neoadjuvant chemotherapy response","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ubiquitin-binding-proteins","display_name":"ubiquitin-binding protein","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7720000147819519},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.7660999894142151},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7544000148773193},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6087999939918518},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5828999876976013},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5530999898910522},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5418000221252441},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5353999733924866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5350000262260437},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.461899995803833},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4325999915599823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42669999599456787},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4099000096321106},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4032999873161316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34290000796318054},{"id":"https://openalex.org/C3017919176","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Biliary tract cancer","level":4,"score":0.34209999442100525},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.32670000195503235},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2759999930858612},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.2615000009536743},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25769999623298645}],"mesh":[{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells15181697","doi":"https://doi.org/10.3390/cells15181697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15181697","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmid:42782797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42782797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13605264","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42782797/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f5dfc235bd554286b837f22aca7345c8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f5dfc235bd554286b837f22aca7345c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 15, Iss 18, p 1697 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells15181697","doi":"https://doi.org/10.3390/cells15181697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15181697","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1974693247","https://openalex.org/W2063190884","https://openalex.org/W2077003423","https://openalex.org/W2083960841","https://openalex.org/W2089027570","https://openalex.org/W2130410032","https://openalex.org/W2157852151","https://openalex.org/W2214074259","https://openalex.org/W2883615837","https://openalex.org/W2897926526","https://openalex.org/W2908226200","https://openalex.org/W2924865280","https://openalex.org/W2952658308","https://openalex.org/W3005388847","https://openalex.org/W3039360174","https://openalex.org/W3124058635","https://openalex.org/W3133033797","https://openalex.org/W3178537870","https://openalex.org/W3199253355","https://openalex.org/W3209610915","https://openalex.org/W4200608537","https://openalex.org/W4281793936","https://openalex.org/W4285499710","https://openalex.org/W4295141431","https://openalex.org/W4307327519","https://openalex.org/W4308904392","https://openalex.org/W4317355154","https://openalex.org/W4317885425","https://openalex.org/W4365998338","https://openalex.org/W4366490166","https://openalex.org/W4385261201","https://openalex.org/W4391055736","https://openalex.org/W4400382510","https://openalex.org/W4404029001","https://openalex.org/W4410384052","https://openalex.org/W4415484362","https://openalex.org/W4416146471","https://openalex.org/W4416424198","https://openalex.org/W7166189255"],"related_works":["https://openalex.org/W7148652278","https://openalex.org/W7116903253","https://openalex.org/W7162498909","https://openalex.org/W3133033797","https://openalex.org/W3005388847","https://openalex.org/W4285499710","https://openalex.org/W3179714564","https://openalex.org/W7163959014","https://openalex.org/W4221129186","https://openalex.org/W2621075446"],"abstract_inverted_index":{"Background:":[0],"Intrahepatic":[1],"cholangiocarcinoma":[2],"(iCCA)":[3],"is":[4,45,225],"an":[5,91],"aggressive":[6],"biliary":[7],"tract":[8],"malignancy":[9],"with":[10,97,135,163,173,197,227],"limited":[11],"treatment":[12],"options":[13],"and":[14,41,61,72,80,95,106,139,170,231,260,267],"poor":[15],"prognosis.":[16],"Platinum-based":[17],"drugs":[18],"are":[19],"one":[20],"of":[21,64,113],"the":[22,59,111,125,154],"major":[23,29],"therapies;":[24],"however,":[25],"resistance":[26],"remains":[27],"a":[28,34,50,243,257],"therapeutic":[30,261],"challenge.":[31],"Ubiquilin-4":[32],"(UBQLN4),":[33],"ubiquitin-binding":[35],"protein":[36],"implicated":[37],"in":[38,54,66,83,90,115,129,143,146,150,237,248],"cancer":[39],"progression":[40],"DNA":[42],"damage":[43],"responses,":[44],"located":[46],"at":[47],"chromosome":[48],"1q22,":[49,120],"region":[51],"recurrently":[52,126],"amplified":[53,127],"several":[55],"cancers.":[56],"We":[57],"investigated":[58],"clinical":[60,93,229],"functional":[62,240],"relevance":[63],"UBQLN4":[65,81,85,114,131,158,192,209,219,223,247,255],"iCCA.":[67,84],"Methods:":[68],"Public":[69],"datasets":[70],"(TCGA-CHOL":[71],"GSE107943)":[73],"were":[74],"analyzed":[75],"to":[76,201,234],"identify":[77,254],"genomic":[78],"alterations":[79],"expression":[82,87,133,160,193,224],"mRNA":[86,132,159],"was":[88,123,140,161,194],"evaluated":[89],"independent":[92,266],"cohort":[94],"correlated":[96,134],"patient":[98],"outcomes.":[99],"Functional":[100],"studies":[101,241],"using":[102],"iCCA":[103,144,206],"cell":[104,207],"lines":[105],"three-dimensional":[107],"spheroid":[108],"models":[109],"examined":[110],"role":[112,245],"cisplatin":[116,212,250],"resistance.":[117],"Results:":[118],"Chromosome":[119],"containing":[121],"UBQLN4,":[122],"among":[124],"regions":[128],"TCGA-CHOL.":[130],"copy":[136],"number":[137],"amplification":[138],"significantly":[141],"higher":[142,157],"than":[145],"normal":[147],"liver":[148],"tissue":[149],"both":[151],"datasets.":[152],"In":[153,205],"validation":[155],"cohort,":[156],"associated":[162,172,196,226],"shorter":[164,174],"recurrence-free":[165,175],"survival":[166,176],"(p":[167],"=":[168,183,189],"0.025)":[169],"remained":[171],"after":[177],"adjustment":[178],"for":[179,246],"clinicopathological":[180],"factors":[181],"(HR":[182],"2.44;":[184],"95%":[185],"CI":[186],"1.14\u20135.20;":[187],"p":[188],"0.022).":[190],"Higher":[191],"also":[195],"poorer":[198],"pathological":[199],"response":[200,233],"cisplatin-containing":[202,235],"neoadjuvant":[203],"chemotherapy.":[204],"lines,":[208],"knockdown":[210],"increased":[211,218],"sensitivity,":[213],"whereas":[214],"cisplatin-resistant":[215],"derivatives":[216],"showed":[217],"expression.":[220],"Conclusions:":[221],"Elevated":[222],"adverse":[228],"outcomes":[230],"reduced":[232],"chemotherapy":[236],"iCCA,":[238],"while":[239],"support":[242],"potential":[244,258],"modulating":[249],"sensitivity.":[251],"These":[252],"findings":[253],"as":[256],"biomarker":[259],"candidate":[262],"that":[263],"warrants":[264],"further":[265],"prospective":[268],"validation.":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-22T00:00:00"}
