{"id":"https://openalex.org/W7213909256","doi":"https://doi.org/10.1016/j.crphar.2026.100261","title":"Advances in mucoadhesive drug delivery systems: Mechanistic insights, pharmacological performance, and translational pathways","display_name":"Advances in mucoadhesive drug delivery systems: Mechanistic insights, pharmacological performance, and translational pathways","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7213909256","doi":"https://doi.org/10.1016/j.crphar.2026.100261","pmid":"https://pubmed.ncbi.nlm.nih.gov/42923958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13688460"},"language":"en","primary_location":{"id":"doi:10.1016/j.crphar.2026.100261","doi":"https://doi.org/10.1016/j.crphar.2026.100261","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crphar.2026.100261","pdf_url":"https://www.sciencedirect.com/science/article/pii/S259025712600012X/pdf","source":{"id":"https://openalex.org/S4210225866","display_name":"Current Research in Pharmacology and Drug Discovery","issn_l":"2590-2571","issn":["2590-2571"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Pharmacology and Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S259025712600012X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025818785","display_name":"Farwa Zahra","orcid":"https://orcid.org/0009-0006-5998-4392","observed_orcids":["https://orcid.org/0009-0006-5998-4392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farwa Zahra","raw_affiliation_strings":["Department of Pharmacy, Superior University Sargodha Campus, Sargodha, Punjab, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Superior University Sargodha Campus, Sargodha, Punjab, Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007102303","display_name":"Ahmed Raza Hashmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11662577","display_name":"Monash University Malaysia","ror":"https://ror.org/00yncr324","country_code":"MY","type":"education","lineage":["https://openalex.org/I11662577","https://openalex.org/I56590836"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ahmed Raza Hashmi","raw_affiliation_strings":["School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia","institution_ids":["https://openalex.org/I11662577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134489141","display_name":"Ram Narayanan Ravi","orcid":"https://orcid.org/0000-0003-0483-1621","observed_orcids":["https://orcid.org/0000-0003-0483-1621"]},"institutions":[{"id":"https://openalex.org/I11662577","display_name":"Monash University Malaysia","ror":"https://ror.org/00yncr324","country_code":"MY","type":"education","lineage":["https://openalex.org/I11662577","https://openalex.org/I56590836"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ram Narayanan Ravi","raw_affiliation_strings":["Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia","institution_ids":["https://openalex.org/I11662577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069693365","display_name":"Mahendran Sekar","orcid":"https://orcid.org/0000-0002-3022-6137","observed_orcids":["https://orcid.org/0000-0002-3022-6137"]},"institutions":[{"id":"https://openalex.org/I11662577","display_name":"Monash University Malaysia","ror":"https://ror.org/00yncr324","country_code":"MY","type":"education","lineage":["https://openalex.org/I11662577","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I2802910988","display_name":"University of Cyberjaya","ror":"https://ror.org/04f1eek20","country_code":"MY","type":"education","lineage":["https://openalex.org/I2802910988"]},{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Mahendran Sekar","raw_affiliation_strings":["Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya, Selangor, 63000, Malaysia","Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia","School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-3022-6137","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya, Selangor, 63000, Malaysia","institution_ids":["https://openalex.org/I2802910988"]},{"raw_affiliation_string":"Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia","institution_ids":["https://openalex.org/I4528857"]},{"raw_affiliation_string":"School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia","institution_ids":["https://openalex.org/I11662577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152361451","display_name":"Ling Shing Wong","orcid":"https://orcid.org/0000-0002-5869-0804","observed_orcids":["https://orcid.org/0000-0002-5869-0804"]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ling Shing Wong","raw_affiliation_strings":["Faculty of Health and Life Sciences, INTI International University, Nilai, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035096535","display_name":"Ravindran Jaganathan","orcid":"https://orcid.org/0000-0002-2654-1855","observed_orcids":["https://orcid.org/0000-0002-2654-1855"]},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ravindran Jaganathan","raw_affiliation_strings":["Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033355309","display_name":"Rajeswari Ravindran","orcid":"https://orcid.org/0000-0001-7844-5243","observed_orcids":["https://orcid.org/0000-0001-7844-5243"]},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Rajeswari Ravindran","raw_affiliation_strings":["Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Perak, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069693365"],"corresponding_institution_ids":["https://openalex.org/I11662577","https://openalex.org/I2802910988","https://openalex.org/I4528857"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":0.5448,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66135458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"11","issue":null,"first_page":"100261","last_page":"100261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucoadhesive-drug-delivery-systems","display_name":"mucoadhesive drug delivery systems","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mucus-penetration","display_name":"mucus penetration","score":0.777999997138977},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mucoadhesive-polymers","display_name":"mucoadhesive polymers","score":0.8690000176429749},{"id":"https://openalex.org/keywords/surface-functionalization","display_name":"surface functionalization","score":0.7540000081062317},{"id":"https://openalex.org/keywords/thiolation","display_name":"thiolation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/stimuli-responsive-hydrogels","display_name":"stimuli-responsive hydrogels","score":0.8479999899864197},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.699999988079071},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vaginal-drug-delivery","display_name":"vaginal drug delivery","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.746999979019165},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.7599999904632568},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.7360000014305115},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/drug-residence-time","display_name":"drug residence time","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46299999952316284},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4408000111579895},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41119998693466187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3684999942779541},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2802000045776367},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.crphar.2026.100261","doi":"https://doi.org/10.1016/j.crphar.2026.100261","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crphar.2026.100261","pdf_url":"https://www.sciencedirect.com/science/article/pii/S259025712600012X/pdf","source":{"id":"https://openalex.org/S4210225866","display_name":"Current Research in Pharmacology and Drug Discovery","issn_l":"2590-2571","issn":["2590-2571"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Pharmacology and Drug Discovery","raw_type":"journal-article"},{"id":"pmid:42923958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42923958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current research in pharmacology and drug discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13688460","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13688460/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Res Pharmacol Drug Discov","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:30cefb5b5c93483da68c14e8d13eabc1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/30cefb5b5c93483da68c14e8d13eabc1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Research in Pharmacology and Drug Discovery, Vol 11, Iss , Pp 100261-","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.crphar.2026.100261","doi":"https://doi.org/10.1016/j.crphar.2026.100261","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crphar.2026.100261","pdf_url":"https://www.sciencedirect.com/science/article/pii/S259025712600012X/pdf","source":{"id":"https://openalex.org/S4210225866","display_name":"Current Research in Pharmacology and Drug Discovery","issn_l":"2590-2571","issn":["2590-2571"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Pharmacology and Drug Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320971","display_name":"Monash University","ror":"https://ror.org/02bfwt286"},{"id":"https://openalex.org/F4320326583","display_name":"Monash University Malaysia","ror":"https://ror.org/00yncr324"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213909256.pdf","grobid_xml":"https://content.openalex.org/works/W7213909256.grobid-xml"},"referenced_works_count":379,"referenced_works":["https://openalex.org/W59104685","https://openalex.org/W285598011","https://openalex.org/W1546874946","https://openalex.org/W1568674147","https://openalex.org/W1591566813","https://openalex.org/W1846371116","https://openalex.org/W1913547133","https://openalex.org/W1961169379","https://openalex.org/W1963681285","https://openalex.org/W1965876265","https://openalex.org/W1965948300","https://openalex.org/W1966781049","https://openalex.org/W1968261348","https://openalex.org/W1970823414","https://openalex.org/W1971219227","https://openalex.org/W1973360557","https://openalex.org/W1973447487","https://openalex.org/W1973546785","https://openalex.org/W1975350613","https://openalex.org/W1977847814","https://openalex.org/W1983814066","https://openalex.org/W1989513078","https://openalex.org/W1991184420","https://openalex.org/W1994294415","https://openalex.org/W1995519098","https://openalex.org/W1996878412","https://openalex.org/W1996920490","https://openalex.org/W1998624966","https://openalex.org/W2001776145","https://openalex.org/W2001895546","https://openalex.org/W2006406939","https://openalex.org/W2011850720","https://openalex.org/W2013637675","https://openalex.org/W2015301858","https://openalex.org/W2016602599","https://openalex.org/W2017998764","https://openalex.org/W2019914376","https://openalex.org/W2020965737","https://openalex.org/W2021978496","https://openalex.org/W2024481699","https://openalex.org/W2024966194","https://openalex.org/W2024994244","https://openalex.org/W2026075419","https://openalex.org/W2027344717","https://openalex.org/W2028389376","https://openalex.org/W2032344062","https://openalex.org/W2032952768","https://openalex.org/W2035082393","https://openalex.org/W2035101826","https://openalex.org/W2041880062","https://openalex.org/W2043701990","https://openalex.org/W2045115635","https://openalex.org/W2046886904","https://openalex.org/W2049826959","https://openalex.org/W2051992458","https://openalex.org/W2057313485","https://openalex.org/W2059280897","https://openalex.org/W2059763085","https://openalex.org/W2059855607","https://openalex.org/W2061932684","https://openalex.org/W2064001005","https://openalex.org/W2068513992","https://openalex.org/W2074645731","https://openalex.org/W2077440292","https://openalex.org/W2077474882","https://openalex.org/W2082527026","https://openalex.org/W2084273288","https://openalex.org/W2085250824","https://openalex.org/W2091577738","https://openalex.org/W2095267646","https://openalex.org/W2096595821","https://openalex.org/W2097211405","https://openalex.org/W2098984295","https://openalex.org/W2099592724","https://openalex.org/W2099734999","https://openalex.org/W2099930528","https://openalex.org/W2101059745","https://openalex.org/W2109547735","https://openalex.org/W2111529217","https://openalex.org/W2126146585","https://openalex.org/W2131181234","https://openalex.org/W2139887779","https://openalex.org/W2140491816","https://openalex.org/W2146185088","https://openalex.org/W2148634121","https://openalex.org/W2149695969","https://openalex.org/W2150565654","https://openalex.org/W2161336836","https://openalex.org/W2164361905","https://openalex.org/W2165511881","https://openalex.org/W2208537272","https://openalex.org/W2282629511","https://openalex.org/W2282679090","https://openalex.org/W2289527278","https://openalex.org/W2292488580","https://openalex.org/W2342942413","https://openalex.org/W2414192172","https://openalex.org/W2418390375","https://openalex.org/W2436581275","https://openalex.org/W2472266396","https://openalex.org/W2475154681","https://openalex.org/W2494308878","https://openalex.org/W2509178858","https://openalex.org/W2517182458","https://openalex.org/W2532188293","https://openalex.org/W2540164560","https://openalex.org/W2554975910","https://openalex.org/W2555090309","https://openalex.org/W2580582776","https://openalex.org/W2588997868","https://openalex.org/W2589081434","https://openalex.org/W2594525290","https://openalex.org/W2600670030","https://openalex.org/W2610683705","https://openalex.org/W2611818005","https://openalex.org/W2618707963","https://openalex.org/W2625669596","https://openalex.org/W2752517723","https://openalex.org/W2754189939","https://openalex.org/W2754709330","https://openalex.org/W2768214444","https://openalex.org/W2770462120","https://openalex.org/W2790608253","https://openalex.org/W2791639731","https://openalex.org/W2804312444","https://openalex.org/W2809087003","https://openalex.org/W2809449491","https://openalex.org/W2810618571","https://openalex.org/W2810871613","https://openalex.org/W2884167302","https://openalex.org/W2886127819","https://openalex.org/W2892357729","https://openalex.org/W2900823108","https://openalex.org/W2909678312","https://openalex.org/W2912061036","https://openalex.org/W2940707756","https://openalex.org/W2941262033","https://openalex.org/W2943121315","https://openalex.org/W2953510302","https://openalex.org/W2964253094","https://openalex.org/W2964648755","https://openalex.org/W2969014584","https://openalex.org/W2971513758","https://openalex.org/W2979591769","https://openalex.org/W2980518880","https://openalex.org/W2981287651","https://openalex.org/W2984444873","https://openalex.org/W2987099528","https://openalex.org/W2987932370","https://openalex.org/W2997760038","https://openalex.org/W3005713586","https://openalex.org/W3007207274","https://openalex.org/W3007614905","https://openalex.org/W3011214583","https://openalex.org/W3012203377","https://openalex.org/W3014207261","https://openalex.org/W3016686600","https://openalex.org/W3028047631","https://openalex.org/W3028269073","https://openalex.org/W3031520405","https://openalex.org/W3037803258","https://openalex.org/W3043265151","https://openalex.org/W3046828722","https://openalex.org/W3095485661","https://openalex.org/W3110055320","https://openalex.org/W3115263824","https://openalex.org/W3123364893","https://openalex.org/W3129729380","https://openalex.org/W3131147110","https://openalex.org/W3134958929","https://openalex.org/W3135501099","https://openalex.org/W3137624007","https://openalex.org/W3138816562","https://openalex.org/W3163575089","https://openalex.org/W3167975027","https://openalex.org/W3170326935","https://openalex.org/W3172698712","https://openalex.org/W3176265002","https://openalex.org/W3180619770","https://openalex.org/W3187148062","https://openalex.org/W3196807555","https://openalex.org/W3202286872","https://openalex.org/W3203381395","https://openalex.org/W3209711646","https://openalex.org/W3209971466","https://openalex.org/W3210682390","https://openalex.org/W4200055263","https://openalex.org/W4200515163","https://openalex.org/W4206139807","https://openalex.org/W4206379701","https://openalex.org/W4210728618","https://openalex.org/W4211169164","https://openalex.org/W4213117238","https://openalex.org/W4220653036","https://openalex.org/W4220812920","https://openalex.org/W4220949814","https://openalex.org/W4224324386","https://openalex.org/W4226352671","https://openalex.org/W4229333532","https://openalex.org/W4246351114","https://openalex.org/W4248590941","https://openalex.org/W4280621424","https://openalex.org/W4281294706","https://openalex.org/W4282979273","https://openalex.org/W4285205855","https://openalex.org/W4285733464","https://openalex.org/W4286716785","https://openalex.org/W4290705197","https://openalex.org/W4291916139","https://openalex.org/W4294794246","https://openalex.org/W4295931451","https://openalex.org/W4296280836","https://openalex.org/W4296330995","https://openalex.org/W4297231530","https://openalex.org/W4303962153","https://openalex.org/W4308684335","https://openalex.org/W4309457365","https://openalex.org/W4309828215","https://openalex.org/W4310153972","https://openalex.org/W4311377637","https://openalex.org/W4311755269","https://openalex.org/W4312094347","https://openalex.org/W4312210108","https://openalex.org/W4313244978","https://openalex.org/W4315619790","https://openalex.org/W4317206951","https://openalex.org/W4319317978","https://openalex.org/W4319759219","https://openalex.org/W4321374330","https://openalex.org/W4321599256","https://openalex.org/W4322743006","https://openalex.org/W4322743842","https://openalex.org/W4323350844","https://openalex.org/W4362733348","https://openalex.org/W4366778904","https://openalex.org/W4377103064","https://openalex.org/W4379230814","https://openalex.org/W4380358680","https://openalex.org/W4380758638","https://openalex.org/W4380991375","https://openalex.org/W4381429810","https://openalex.org/W4381572190","https://openalex.org/W4381853411","https://openalex.org/W4382657565","https://openalex.org/W4384406161","https://openalex.org/W4385268460","https://openalex.org/W4385274547","https://openalex.org/W4385580250","https://openalex.org/W4385613280","https://openalex.org/W4386216237","https://openalex.org/W4386514412","https://openalex.org/W4386934726","https://openalex.org/W4386996786","https://openalex.org/W4387310707","https://openalex.org/W4387344109","https://openalex.org/W4387598724","https://openalex.org/W4387616821","https://openalex.org/W4387802714","https://openalex.org/W4387945515","https://openalex.org/W4388016258","https://openalex.org/W4388019346","https://openalex.org/W4388334057","https://openalex.org/W4389333811","https://openalex.org/W4389547140","https://openalex.org/W4389792686","https://openalex.org/W4389814978","https://openalex.org/W4390616626","https://openalex.org/W4391512766","https://openalex.org/W4391540402","https://openalex.org/W4391578321","https://openalex.org/W4391813239","https://openalex.org/W4392190921","https://openalex.org/W4393178934","https://openalex.org/W4393393880","https://openalex.org/W4393942950","https://openalex.org/W4394010185","https://openalex.org/W4394727542","https://openalex.org/W4395116063","https://openalex.org/W4396621159","https://openalex.org/W4396719885","https://openalex.org/W4396904428","https://openalex.org/W4396920657","https://openalex.org/W4396985608","https://openalex.org/W4398201833","https://openalex.org/W4398763231","https://openalex.org/W4399264491","https://openalex.org/W4399591774","https://openalex.org/W4399889667","https://openalex.org/W4400098916","https://openalex.org/W4401070411","https://openalex.org/W4401124245","https://openalex.org/W4401222351","https://openalex.org/W4401284206","https://openalex.org/W4401485069","https://openalex.org/W4401553519","https://openalex.org/W4401669434","https://openalex.org/W4401694629","https://openalex.org/W4401728359","https://openalex.org/W4401911151","https://openalex.org/W4402255142","https://openalex.org/W4402307787","https://openalex.org/W4402421577","https://openalex.org/W4402510213","https://openalex.org/W4402637916","https://openalex.org/W4403051813","https://openalex.org/W4403224376","https://openalex.org/W4403225520","https://openalex.org/W4403230064","https://openalex.org/W4403335267","https://openalex.org/W4403708893","https://openalex.org/W4403990641","https://openalex.org/W4404324724","https://openalex.org/W4404638999","https://openalex.org/W4404721446","https://openalex.org/W4404905927","https://openalex.org/W4405048643","https://openalex.org/W4405371097","https://openalex.org/W4405608237","https://openalex.org/W4405700450","https://openalex.org/W4405947653","https://openalex.org/W4406051911","https://openalex.org/W4406334624","https://openalex.org/W4406472437","https://openalex.org/W4406526186","https://openalex.org/W4406586516","https://openalex.org/W4406687341","https://openalex.org/W4406706593","https://openalex.org/W4406714797","https://openalex.org/W4407338543","https://openalex.org/W4407675607","https://openalex.org/W4407790780","https://openalex.org/W4407798415","https://openalex.org/W4409108888","https://openalex.org/W4409116964","https://openalex.org/W4409202265","https://openalex.org/W4409248068","https://openalex.org/W4409259428","https://openalex.org/W4409446613","https://openalex.org/W4409811770","https://openalex.org/W4410015600","https://openalex.org/W4410321851","https://openalex.org/W4410472964","https://openalex.org/W4410777588","https://openalex.org/W4410796289","https://openalex.org/W4410815954","https://openalex.org/W4411149028","https://openalex.org/W4411211852","https://openalex.org/W4411279149","https://openalex.org/W4411459673","https://openalex.org/W4411779134","https://openalex.org/W4411930322","https://openalex.org/W4411962234","https://openalex.org/W4412085795","https://openalex.org/W4412095900","https://openalex.org/W4412151509","https://openalex.org/W4412190003","https://openalex.org/W4412464977","https://openalex.org/W4412717633","https://openalex.org/W4412860525","https://openalex.org/W4412987474","https://openalex.org/W4413116932","https://openalex.org/W4413307436","https://openalex.org/W4413358754","https://openalex.org/W4413496659","https://openalex.org/W4413846239","https://openalex.org/W4414071381","https://openalex.org/W4414284461","https://openalex.org/W4415211085","https://openalex.org/W4415380358","https://openalex.org/W4415514742","https://openalex.org/W4415991128","https://openalex.org/W7116933635","https://openalex.org/W7128599360","https://openalex.org/W7128978966","https://openalex.org/W7155609347","https://openalex.org/W7160188449","https://openalex.org/W7160195036","https://openalex.org/W7167519614","https://openalex.org/W7171988737"],"related_works":["https://openalex.org/W7104366237","https://openalex.org/W7118118636","https://openalex.org/W7170162149","https://openalex.org/W7203664945","https://openalex.org/W7081948147","https://openalex.org/W6949697910","https://openalex.org/W4413878328","https://openalex.org/W7160395094","https://openalex.org/W4403638375","https://openalex.org/W7167901911"],"abstract_inverted_index":{"Mucoadhesive":[0],"drug":[1,16,50,113,195,268],"delivery":[2,120,269],"systems":[3],"(MDDS)":[4],"have":[5,62],"emerged":[6],"as":[7,166,258],"an":[8],"important":[9],"strategy":[10],"in":[11,54,133,236],"modern":[12],"pharmacology":[13,250],"to":[14,69,135,180,232,240,277],"enhance":[15],"residence":[17],"time,":[18],"improve":[19],"mucosal":[20,37],"absorption,":[21],"and":[22,33,43,59,73,87,100,103,111,128,139,149,157,172,184,194,206,209,212,214,222,227,239,251,261,271],"optimize":[23],"therapeutic":[24,185],"performance":[25,141],"across":[26,142],"diverse":[27],"administration":[28],"routes.":[29,151],"By":[30,244],"enabling":[31],"intimate":[32],"prolonged":[34],"interactions":[35],"with":[36,78,161,178,248],"tissues,":[38],"MDDS":[39,68,257],"directly":[40],"influence":[41],"pharmacokinetic":[42],"pharmacodynamic":[44],"outcomes":[45],"while":[46],"supporting":[47],"patient-centric,":[48],"non-invasive":[49],"delivery.":[51],"Recent":[52],"advances":[53],"polymer":[55],"engineering,":[56],"surface":[57],"functionalization,":[58],"formulation":[60,188],"design":[61],"further":[63],"expanded":[64],"the":[65,95,101,190],"capability":[66],"of":[67,91,98,118,154,225],"overcome":[70],"biological":[71,104],"barriers":[72],"address":[74],"key":[75,234],"limitations":[76],"associated":[77],"conventional":[79],"dosage":[80],"forms.":[81],"This":[82],"review":[83,191,255],"provides":[84],"a":[85,259],"comprehensive":[86],"mechanistically":[88],"driven":[89],"analysis":[90],"MDDS,":[92],"focusing":[93],"on":[94],"fundamental":[96],"principles":[97],"mucoadhesion":[99],"physicochemical":[102],"factors":[105],"governing":[106],"adhesive":[107],"strength,":[108],"mucus":[109],"penetration,":[110],"controlled":[112],"release.":[114],"A":[115],"wide":[116],"range":[117],"mucoadhesive":[119,217],"platforms,":[121],"including":[122,198],"films,":[123],"gels,":[124],"tablets,":[125],"patches,":[126],"hydrogels,":[127],"particulate":[129],"systems,":[130],"are":[131,230],"discussed":[132],"relation":[134],"their":[136,273],"structure-property-function":[137],"relationships":[138],"pharmacological":[140],"oral,":[143],"nasal,":[144],"ocular,":[145],"gastrointestinal,":[146],"vaginal,":[147],"rectal,":[148],"pulmonary":[150],"The":[152],"role":[153],"natural,":[155],"semi-synthetic,":[156],"synthetic":[158],"polymers,":[159],"together":[160],"advanced":[162],"functionalization":[163],"strategies":[164,270],"such":[165],"thiolation,":[167],"ligand":[168],"incorporation,":[169],"stimuli-responsive":[170],"networks,":[171],"nanotechnology":[173],"integration,":[174],"is":[175],"critically":[176],"evaluated":[177,211],"respect":[179],"enhancing":[181],"adhesion,":[182],"permeability,":[183],"efficacy.":[186],"Beyond":[187],"design,":[189],"emphasizes":[192],"translational":[193,252],"discovery-relevant":[196],"considerations,":[197],"Quality":[199],"by":[200],"Design":[201],"(QbD),":[202],"manufacturing":[203],"scalability,":[204],"regulatory":[205],"safety":[207],"expectations,":[208],"clinically":[210,262],"Food":[213],"Drug":[215],"Administration-approved":[216],"products.":[218],"Selected":[219],"clinical":[220,237],"trials":[221],"case":[223],"studies":[224],"successful":[226],"unsuccessful":[228],"formulations":[229],"examined":[231],"highlight":[233],"challenges":[235],"translation":[238],"identify":[241],"emerging":[242],"opportunities.":[243],"bridging":[245],"mechanistic":[246],"understanding":[247],"applied":[249],"development,":[253],"this":[254],"positions":[256],"versatile":[260],"viable":[263],"platform":[264],"for":[265],"advancing":[266],"next-generation":[267],"accelerating":[272],"progression":[274],"from":[275],"discovery":[276],"patient":[278],"care.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-22T00:00:00"}