{"id":"https://openalex.org/W7213909029","doi":"https://doi.org/10.64898/2026.09.15.751411","title":"Coupling lysosomal polarity and purinergic signaling regulates B cell activation","display_name":"Coupling lysosomal polarity and purinergic signaling regulates B cell activation","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213909029","doi":"https://doi.org/10.64898/2026.09.15.751411"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.751411","doi":"https://doi.org/10.64898/2026.09.15.751411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751411.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001304711","display_name":"Martina Alamo","orcid":"https://orcid.org/0000-0002-4152-5618","observed_orcids":["https://orcid.org/0000-0002-4152-5618"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["CL","DE"],"is_corresponding":false,"raw_author_name":"M. Alamo Rollandi","raw_affiliation_strings":["Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0002-4152-5618","affiliations":[{"raw_affiliation_string":"Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028937576","display_name":"Juan Pablo Bozo","orcid":"https://orcid.org/0009-0006-5936-1531","observed_orcids":["https://orcid.org/0009-0006-5936-1531"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"J.P. Bozo","raw_affiliation_strings":["Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":"https://orcid.org/0009-0006-5936-1531","affiliations":[{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107761550","display_name":"Isidora Riob\u00f3","orcid":"https://orcid.org/0009-0008-0878-0650","observed_orcids":["https://orcid.org/0009-0008-0878-0650"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"I. Riob\u00f3","raw_affiliation_strings":["Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":"https://orcid.org/0009-0008-0878-0650","affiliations":[{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018336428","display_name":"Tamara L\u00f3pez-L\u00f3pez","orcid":"https://orcid.org/0009-0000-9345-907X","observed_orcids":["https://orcid.org/0009-0000-9345-907X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. L\u00f3pez-L\u00f3pez","raw_affiliation_strings":["Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0000-9345-907X","affiliations":[{"raw_affiliation_string":"Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093736837","display_name":"Johan M. Kux","orcid":"https://orcid.org/0009-0000-3734-2520","observed_orcids":["https://orcid.org/0009-0000-3734-2520"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.M. Kux","raw_affiliation_strings":["Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0000-3734-2520","affiliations":[{"raw_affiliation_string":"Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013264538","display_name":"Michelle Y. Jaeckstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.Y. Jaeckstein","raw_affiliation_strings":["Lipid Metabolism, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lipid Metabolism, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025732687","display_name":"Bj\u00f6rn Rissiek","orcid":"https://orcid.org/0000-0001-5327-5479","observed_orcids":["https://orcid.org/0000-0001-5327-5479"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Rissiek","raw_affiliation_strings":["Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5327-5479","affiliations":[{"raw_affiliation_string":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005653232","display_name":"J\u00f6erg Heeren","orcid":"https://orcid.org/0000-0002-5647-1034","observed_orcids":["https://orcid.org/0000-0002-5647-1034"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Heeren","raw_affiliation_strings":["Lipid Metabolism, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5647-1034","affiliations":[{"raw_affiliation_string":"Lipid Metabolism, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047031120","display_name":"Daniela Sauma","orcid":"https://orcid.org/0000-0001-8622-3245","observed_orcids":["https://orcid.org/0000-0001-8622-3245"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"D. Sauma","raw_affiliation_strings":["Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad de Chile, Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0001-8622-3245","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103074003","display_name":"Pablo Jos\u00e9 S\u00e1ez","orcid":"https://orcid.org/0000-0003-0521-9426","observed_orcids":["https://orcid.org/0000-0003-0521-9426"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"P.J. S\u00e1ez","raw_affiliation_strings":["Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0521-9426","affiliations":[{"raw_affiliation_string":"Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006392821","display_name":"Mar\u00eda-Isabel Yuseff","orcid":"https://orcid.org/0000-0001-8172-3785","observed_orcids":["https://orcid.org/0000-0001-8172-3785"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"M.I. Yuseff","raw_affiliation_strings":["Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0001-8172-3785","affiliations":[{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Department of Cellular and Molecular Biology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103074003"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":1.0},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.640999972820282},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pannexin-1-channels","display_name":"pannexin-1 channels","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.7250000238418579},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.8259999752044678},{"id":"https://openalex.org/keywords/rab6a","display_name":"Rab6A","score":0.8180000185966492},{"id":"https://openalex.org/keywords/vamp7","display_name":"VAMP7","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/b-cell-migration","display_name":"B cell migration","score":0.9110000133514404},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7796000242233276},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.7541999816894531},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.579800009727478},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4900999963283539},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.4772999882698059},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45320001244544983},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44699999690055847},{"id":"https://openalex.org/C172590197","wikidata":"https://www.wikidata.org/wiki/Q17165723","display_name":"Purinergic signalling","level":5,"score":0.4189999997615814},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.41760000586509705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3889000117778778},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.35839998722076416},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.34470000863075256},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.33480000495910645},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3244999945163727},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C103474210","wikidata":"https://www.wikidata.org/wiki/Q142851","display_name":"Immune receptor","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.3012000024318695},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C2909331102","wikidata":"https://www.wikidata.org/wiki/Q7278834","display_name":"Rac GTP-Binding Proteins","level":4,"score":0.29010000824928284},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C188810444","wikidata":"https://www.wikidata.org/wiki/Q3476415","display_name":"Phospholipid scramblase","level":5,"score":0.2660999894142151},{"id":"https://openalex.org/C64863464","wikidata":"https://www.wikidata.org/wiki/Q3190616","display_name":"Juxtacrine signalling","level":4,"score":0.26429998874664307}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.15.751411","doi":"https://doi.org/10.64898/2026.09.15.751411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.751411","doi":"https://doi.org/10.64898/2026.09.15.751411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/21/2026.09.15.751411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1434735576","display_name":null,"funder_award_id":"1221128","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G2413987741","display_name":"TUNING B CELL RESPONSES BY MECHANICAL CUES ROLE OF CYTOSKELETON REMODELING AND MEMBRANE TRAFFICKING","funder_award_id":"1221128","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3679234536","display_name":null,"funder_award_id":"RI_ 00489","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4158324185","display_name":"SFB 1328: Adeninnukleotide in Immunit\u00e4t und Entz\u00fcndung","funder_award_id":"335447717","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320325918","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":"https://ror.org/05btm5233"},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213909029.pdf","grobid_xml":"https://content.openalex.org/works/W7213909029.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2094312280","https://openalex.org/W2138420748","https://openalex.org/W2801022696","https://openalex.org/W3011632447","https://openalex.org/W4311818266"],"related_works":["https://openalex.org/W4402958296","https://openalex.org/W1581472592","https://openalex.org/W2133535940","https://openalex.org/W2915756396","https://openalex.org/W1481207011","https://openalex.org/W2791902410","https://openalex.org/W2808908229","https://openalex.org/W4412539086","https://openalex.org/W4291639848","https://openalex.org/W2003698173"],"abstract_inverted_index":{"Abstract":[0],"B":[1,10,51,73,82,180,192,206],"cell":[2,11,21,41,52,74,181,193,207],"activation":[3,53,155],"is":[4,31],"initiated":[5],"by":[6,34,81,106],"engagement":[7],"of":[8,26,46,61,94,99,156,179,191,199],"the":[9,24,37,44,59,95,110,125,133,137,153,159],"receptor":[12,173],"(BCR)":[13],"with":[14],"immobilized":[15,100],"antigens,":[16],"which":[17],"triggers":[18],"changes":[19],"in":[20,148],"polarity":[22,42],"promoting":[23],"establishment":[25],"an":[27,196],"immune":[28,111,126,160],"synapse":[29,112,161],"that":[30,78,171],"further":[32],"shaped":[33],"signals":[35],"from":[36,166],"microenvironment.":[38],"However,":[39],"how":[40],"coordinates":[43],"sensing":[45],"extracellular":[47],"cues":[48],"to":[49,70,120,132,168],"regulate":[50],"remains":[54],"unclear.":[55],"Here,":[56],"we":[57],"investigated":[58],"impact":[60],"adenosine":[62],"triphosphate":[63],"(ATP),":[64],"a":[65,92,145,163,176,188,202],"conventional":[66],"danger":[67],"signal":[68],"related":[69],"inflammation,":[71],"on":[72],"function.":[75],"We":[76,128],"found":[77],"ATP":[79,103,186],"released":[80,115],"cells,":[83],"as":[84,86,91,144,175,187,201],"well":[85],"exogenously":[87],"added":[88],"ATP,":[89],"acts":[90,174],"promoter":[93],"extraction":[96],"and":[97,113,141,195],"presentation":[98],"antigens.":[101],"Endogenous":[102],"was":[104],"produced":[105],"mitochondria":[107],"recruited":[108],"at":[109,124,158],"locally":[114],"via":[116],"Pannexin":[117],"1":[118],"channels":[119],"sustain":[121],"purinergic":[122],"signaling":[123],"synapse.":[127],"identified":[129],"P2RX4":[130,157,200],"trafficking":[131],"plasma":[134],"membrane":[135],"through":[136],"Rab6a+":[138],"trans-Golgi":[139],"network":[140],"VAMP7+/LAMP1+":[142],"lysosomes":[143],"key":[146],"step":[147],"this":[149,172],"response.":[150],"In":[151],"addition,":[152],"local":[154,189],"triggered":[162],"migratory":[164],"switch":[165,204],"motile":[167],"sessile,":[169],"suggesting":[170],"negative":[177],"regulator":[178],"migration.":[182],"These":[183],"findings":[184],"reveal":[185],"enhancer":[190],"function,":[194],"unexpected":[197],"role":[198],"molecular":[203],"for":[205],"activation.":[208]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-22T00:00:00"}
