{"id":"https://openalex.org/W7213895156","doi":"https://doi.org/10.2169/internalmedicine.7143-26","title":"Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report","display_name":"Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7213895156","doi":"https://doi.org/10.2169/internalmedicine.7143-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42778376"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.7143-26","doi":"https://doi.org/10.2169/internalmedicine.7143-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7143-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030826593","display_name":"Kohei Kiso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Kiso","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068585362","display_name":"Yusuke Shimoyama","orcid":"https://orcid.org/0009-0005-1133-7754","observed_orcids":["https://orcid.org/0009-0005-1133-7754"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Shimoyama","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107435014","display_name":"Saki Okuda-Hiwatashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saki Okuda-Hiwatashi","raw_affiliation_strings":["Department of Dermatology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031821817","display_name":"Taku Fujimura","orcid":"https://orcid.org/0000-0001-6809-5833","observed_orcids":["https://orcid.org/0000-0001-6809-5833"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Fujimura","raw_affiliation_strings":["Department of Dermatology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065382852","display_name":"Yoshihide Asano","orcid":"https://orcid.org/0000-0001-5560-9778","observed_orcids":["https://orcid.org/0000-0001-5560-9778"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide Asano","raw_affiliation_strings":["Department of Dermatology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008481324","display_name":"Rui Makino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rui Makino","raw_affiliation_strings":["Department of Nephrology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007057754","display_name":"Tetsuhiro Tanaka","orcid":"https://orcid.org/0000-0002-2238-4215","observed_orcids":["https://orcid.org/0000-0002-2238-4215"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuhiro Tanaka","raw_affiliation_strings":["Department of Nephrology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018880577","display_name":"Hideya Iwaki","orcid":"https://orcid.org/0009-0007-5498-9714","observed_orcids":["https://orcid.org/0009-0007-5498-9714"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideya Iwaki","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daisuke Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Okamoto","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153065615","display_name":"Hiroshi Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nagai","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038009665","display_name":"Takeo Naito","orcid":"https://orcid.org/0000-0002-9744-7946","observed_orcids":["https://orcid.org/0000-0002-9744-7946"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Naito","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063199955","display_name":"Rintaro Moroi","orcid":"https://orcid.org/0000-0002-6759-0135","observed_orcids":["https://orcid.org/0000-0002-6759-0135"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rintaro Moroi","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034412681","display_name":"Yoichi Kakuta","orcid":"https://orcid.org/0000-0002-7042-009X","observed_orcids":["https://orcid.org/0000-0002-7042-009X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Kakuta","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044706381","display_name":"Atsushi Masamune","orcid":"https://orcid.org/0000-0001-7184-7282","observed_orcids":["https://orcid.org/0000-0001-7184-7282"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Masamune","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72299933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cronkhite-canada-syndrome","display_name":"Cronkhite-Canada syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membranous-nephropathy","display_name":"membranous nephropathy","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-polyposis","display_name":"gastrointestinal polyposis","score":0.921999990940094},{"id":"https://openalex.org/keywords/ectodermal-abnormalities","display_name":"ectodermal abnormalities","score":0.9390000104904175},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9480000138282776},{"id":"https://openalex.org/keywords/phospholipase-a2-receptor","display_name":"phospholipase A2 receptor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9775999784469604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6712999939918518},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C2777891184","wikidata":"https://www.wikidata.org/wiki/Q7168693","display_name":"Peripheral T-cell lymphoma","level":4,"score":0.4713999927043915},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4438999891281128},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.38429999351501465},{"id":"https://openalex.org/C2777073666","wikidata":"https://www.wikidata.org/wiki/Q1592207","display_name":"Pseudolymphoma","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C2908761598","wikidata":"https://www.wikidata.org/wiki/Q3488638","display_name":"Positron Emission Tomography-Computed Tomography","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.7143-26","doi":"https://doi.org/10.2169/internalmedicine.7143-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7143-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:42778376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42778376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.7143-26","doi":"https://doi.org/10.2169/internalmedicine.7143-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7143-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213895156.pdf","grobid_xml":"https://content.openalex.org/works/W7213895156.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2902843033","https://openalex.org/W1969606187","https://openalex.org/W3042542374","https://openalex.org/W4400246392","https://openalex.org/W4397040394","https://openalex.org/W2809906838","https://openalex.org/W2052856748","https://openalex.org/W2379092286","https://openalex.org/W4389010814","https://openalex.org/W2337603581"],"abstract_inverted_index":{"Cronkhite-Canada":[0],"syndrome":[1],"(CCS)":[2],"is":[3],"a":[4,19,55,79],"rare":[5],"disorder":[6],"characterized":[7],"by":[8,25],"gastrointestinal":[9,72],"polyposis":[10],"and":[11,32,42,54,74,86],"ectodermal":[12],"abnormalities.":[13],"We":[14],"report":[15],"the":[16,45,50,71],"case":[17,77],"of":[18,48],"64-year-old":[20],"man":[21],"with":[22,61],"CCS":[23],"complicated":[24],"primary":[26],"cutaneous":[27],"peripheral":[28],"T-cell":[29],"lymphoma":[30,36],"(PC-PTCL)":[31],"membranous":[33,59,87],"nephropathy.":[34,88],"Cutaneous":[35],"was":[37],"controlled":[38],"using":[39],"topical":[40],"corticosteroids":[41],"phototherapy.":[43],"During":[44],"clinical":[46],"course":[47],"CCS,":[49,84],"patient":[51],"developed":[52],"proteinuria,":[53],"renal":[56],"biopsy":[57],"revealed":[58],"nephropathy":[60],"equivocal":[62],"phospholipase":[63],"A2":[64],"receptor":[65],"staining.":[66],"Corticosteroid":[67],"therapy":[68],"improved":[69],"both":[70],"manifestations":[73],"proteinuria.":[75],"This":[76],"suggests":[78],"possible":[80],"immune-mediated":[81],"association":[82],"among":[83],"PC-PTCL,":[85]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-22T00:00:00"}