{"id":"https://openalex.org/W7213890339","doi":"https://doi.org/10.64898/2026.09.18.26363400","title":"Promising prognostic factors in Cutaneous Leishmaniasis in regions of Leishmaniavirus 1 circulation","display_name":"Promising prognostic factors in Cutaneous Leishmaniasis in regions of Leishmaniavirus 1 circulation","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7213890339","doi":"https://doi.org/10.64898/2026.09.18.26363400"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.18.26363400","doi":"https://doi.org/10.64898/2026.09.18.26363400","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363400","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/21/2026.09.18.26363400.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/21/2026.09.18.26363400.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136239915","display_name":"Cipriano Ferreira da Silva J\u00fanior","orcid":"https://orcid.org/0000-0002-4058-9046","observed_orcids":["https://orcid.org/0000-0002-4058-9046"]},"institutions":[{"id":"https://openalex.org/I123001628","display_name":"Universidade Federal de Rond\u00f4nia","ror":"https://ror.org/02842cb31","country_code":"BR","type":"education","lineage":["https://openalex.org/I123001628"]},{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cipriano Ferreira da Silva-J\u00fanior","raw_affiliation_strings":["Centro de Medicina Tropical de Rond\u00f4nia (CEMETRON), Porto Velho, RO, Brazil","Departamento de Medicina, N\u00facleo de Sa\u00fade, Universidade Federal de Rond\u00f4nia, Porto Velho, RO, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Medicina Tropical de Rond\u00f4nia (CEMETRON), Porto Velho, RO, Brazil","institution_ids":[]},{"raw_affiliation_string":"Departamento de Medicina, N\u00facleo de Sa\u00fade, Universidade Federal de Rond\u00f4nia, Porto Velho, RO, Brazil","institution_ids":["https://openalex.org/I123001628"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102548535","display_name":"Sayonara Dos Reis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286055","display_name":"Fiocruz Rond\u00f4nia","ror":"https://ror.org/0120tkg95","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286055","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sayonara dos Reis","raw_affiliation_strings":["Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil","institution_ids":["https://openalex.org/I4405286055","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001231285","display_name":"Renata Bispo Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286055","display_name":"Fiocruz Rond\u00f4nia","ror":"https://ror.org/0120tkg95","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286055","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renata Bispo Santos","raw_affiliation_strings":["Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil","institution_ids":["https://openalex.org/I4405286055","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025274999","display_name":"Moreno Magalh\u00e3es de Souza Rodrigues","orcid":"https://orcid.org/0000-0002-1594-2311","observed_orcids":["https://orcid.org/0000-0002-1594-2311"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moreno Magalh\u00e3es de Souza Rodrigues","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102769052","display_name":"Juan Miguel Villalobos Salc\u00eado","orcid":"https://orcid.org/0000-0001-9107-0837","observed_orcids":["https://orcid.org/0000-0001-9107-0837"]},"institutions":[{"id":"https://openalex.org/I4405286055","display_name":"Fiocruz Rond\u00f4nia","ror":"https://ror.org/0120tkg95","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286055","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juan Miguel Villalobos Salcedo","raw_affiliation_strings":["Centro de Medicina Tropical de Rond\u00f4nia (CEMETRON), Porto Velho, RO, Brazil","Laborat\u00f3rio de Virologia Molecular, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9107-0837","affiliations":[{"raw_affiliation_string":"Centro de Medicina Tropical de Rond\u00f4nia (CEMETRON), Porto Velho, RO, Brazil","institution_ids":[]},{"raw_affiliation_string":"Laborat\u00f3rio de Virologia Molecular, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil","institution_ids":["https://openalex.org/I4405286055","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078790046","display_name":"Gabriel Eduardo Melim Ferreira","orcid":"https://orcid.org/0000-0002-3514-3031","observed_orcids":["https://orcid.org/0000-0002-3514-3031"]},"institutions":[{"id":"https://openalex.org/I4405286055","display_name":"Fiocruz Rond\u00f4nia","ror":"https://ror.org/0120tkg95","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286055","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel Eduardo Melim Ferreira","raw_affiliation_strings":["Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Vigil\u00e2ncia Integrada e Epidemiologia das Leishmanioses na Amaz\u00f4nia, Fiocruz Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Porto Velho, RO, Brazil","institution_ids":["https://openalex.org/I4405286055","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044013366","display_name":"Lilian Motta Cantanh\u00eade","orcid":"https://orcid.org/0000-0002-2376-4236","observed_orcids":["https://orcid.org/0000-0002-2376-4236"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lilian Motta Cantanh\u00eade","raw_affiliation_strings":["Laborat\u00f3rio de Pesquisa em Leishmanioses, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Pesquisa em Leishmanioses, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090746618","display_name":"Elisa Cupolillo","orcid":"https://orcid.org/0000-0002-0620-3250","observed_orcids":["https://orcid.org/0000-0002-0620-3250"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Elisa Cupolillo","raw_affiliation_strings":["Laborat\u00f3rio de Pesquisa em Leishmanioses, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0620-3250","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Pesquisa em Leishmanioses, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Tropical, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5090746618"],"corresponding_institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leishmania-viannia","display_name":"Leishmania (Viannia)","score":0.9139999747276306},{"id":"https://openalex.org/keywords/leishmania-rna-virus-1","display_name":"Leishmania RNA virus 1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/parasite-load","display_name":"infection intensity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.9120000004768372},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.6079999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.492000013589859},{"id":"https://openalex.org/keywords/rondonia","display_name":"Rond\u00f4nia","score":0.6859999895095825},{"id":"https://openalex.org/keywords/brazilian-amazon","display_name":"Brazilian Amazon","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neglected-tropical-diseases","display_name":"neglected tropical diseases","score":0.5479999780654907},{"id":"https://openalex.org/keywords/leishmania-dna-detection","display_name":"Leishmania DNA detection","score":0.48500001430511475},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.4350000023841858},{"id":"https://openalex.org/keywords/follow-up-monitoring","display_name":"follow-up monitoring","score":0.37299999594688416},{"id":"https://openalex.org/keywords/mucocutaneous-leishmaniasis","display_name":"mucocutaneous leishmaniasis","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.7608000040054321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.736299991607666},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6705999970436096},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.6582000255584717},{"id":"https://openalex.org/C2775993617","wikidata":"https://www.wikidata.org/wiki/Q7135939","display_name":"Parasite load","level":3,"score":0.6365000009536743},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5447999835014343},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.38519999384880066},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2780599195","wikidata":"https://www.wikidata.org/wiki/Q1950715","display_name":"Leishmania major","level":4,"score":0.27619999647140503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.26840001344680786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.18.26363400","doi":"https://doi.org/10.64898/2026.09.18.26363400","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363400","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/21/2026.09.18.26363400.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.18.26363400","doi":"https://doi.org/10.64898/2026.09.18.26363400","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363400","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/21/2026.09.18.26363400.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213890339.pdf","grobid_xml":"https://content.openalex.org/works/W7213890339.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W129693860","https://openalex.org/W1040641446","https://openalex.org/W1592307690","https://openalex.org/W1605146840","https://openalex.org/W1914885171","https://openalex.org/W1922907197","https://openalex.org/W1975590813","https://openalex.org/W1987969979","https://openalex.org/W1988148505","https://openalex.org/W2001373329","https://openalex.org/W2003628236","https://openalex.org/W2008384755","https://openalex.org/W2028780841","https://openalex.org/W2035691471","https://openalex.org/W2037047153","https://openalex.org/W2043513030","https://openalex.org/W2059816841","https://openalex.org/W2065773854","https://openalex.org/W2097748530","https://openalex.org/W2102328887","https://openalex.org/W2107581952","https://openalex.org/W2108562615","https://openalex.org/W2113282675","https://openalex.org/W2113402124","https://openalex.org/W2119665154","https://openalex.org/W2119787650","https://openalex.org/W2124817747","https://openalex.org/W2141740056","https://openalex.org/W2147933575","https://openalex.org/W2153804252","https://openalex.org/W2158240636","https://openalex.org/W2162623444","https://openalex.org/W2167717185","https://openalex.org/W2168106093","https://openalex.org/W2179298477","https://openalex.org/W2192701743","https://openalex.org/W2272568354","https://openalex.org/W2559780251","https://openalex.org/W2581364126","https://openalex.org/W2584100928","https://openalex.org/W2734640722","https://openalex.org/W2734933643","https://openalex.org/W2772151567","https://openalex.org/W2773343548","https://openalex.org/W2906683842","https://openalex.org/W2913193846","https://openalex.org/W2944966276","https://openalex.org/W2952837230","https://openalex.org/W2990037291","https://openalex.org/W3023287667","https://openalex.org/W3092151170","https://openalex.org/W3100517202","https://openalex.org/W3125301637","https://openalex.org/W3198179118","https://openalex.org/W4212881173","https://openalex.org/W4386793522","https://openalex.org/W4389131345","https://openalex.org/W4406419600","https://openalex.org/W4410614763"],"related_works":["https://openalex.org/W7133417998","https://openalex.org/W2906683842","https://openalex.org/W4406799637","https://openalex.org/W3007965038","https://openalex.org/W4412007505","https://openalex.org/W2561800644","https://openalex.org/W3083207109","https://openalex.org/W1040641446","https://openalex.org/W7095492590","https://openalex.org/W3205248247"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Cutaneous":[2,316],"leishmaniasis":[3,122,317],"(CL)":[4],"caused":[5],"by":[6,107],"Leishmania":[7,36,67,168,192,245,386,397,433],"(Viannia)":[8],"may":[9,301,333,364,470],"involve":[10],"parasite":[11,47,56,90,198,213,261,268,294,306,402,468,475],"dissemination":[12,262],"from":[13,117,415],"the":[14,28,85,134,184,194,224,252,341,354,375,383,416,422,425,465],"primary":[15],"skin":[16,62,110,156,185,326,380,428,450],"lesion":[17,186],"to":[18,27,457],"clinically":[19,69,113,173,247,405,436],"healthy":[20,70,114,174,248,406,437],"mucosal":[21,31,309,351],"sites,":[22,339],"a":[23,75,96,319,391],"process":[24,359],"potentially":[25],"relevant":[26],"development":[29],"of":[30,77,136,160,179,191,254,288,350,377,385,424,446],"leishmaniasis.":[32],"Parasite":[33,101],"burden":[34,269,469],"and":[35,50,58,89,103,112,139,162,222,257,293,311,360,382,409,467,480],"RNA":[37,387],"Virus":[38,388],"1":[39,389],"(LRV1)":[40],"have":[41],"been":[42],"proposed":[43],"as":[44],"factors":[45,355],"influencing":[46],"persistence,":[48],"dissemination,":[49],"treatment":[51,131,137,216,220,284,362,411,453,459,481],"response.":[52,313,482],"We":[53,82,94,372,419],"investigated":[54,373],"whether":[55,374],"load":[57,102,214,295],"LRV1":[59,88,104,152,181,237,292],"detection":[60,182,190,238,307,403,434],"in":[61,68,74,109,123,150,155,158,163,166,172,177,183,193,202,233,239,246,280,329,379,404,413,427,435,448],"lesions":[63,111,157,241,327,381,429,451],"were":[64,105,128,200,399,454],"associated":[65,188,218,228,243,271,356,400,431],"with":[66,79,119,189,219,229,244,260,272,275,357,361,401,410,432,443],"nasal":[71,115,164,175,195,249,342,407,438],"mucosa":[72,116,165,176,408],"and,":[73],"subset":[76],"patients,":[78,331],"therapeutic":[80,210,273,312],"outcome.":[81],"also":[83,334],"assessed":[84,106],"relationship":[86,259],"between":[87,291],"load.":[91],"Methodology/Principal":[92],"findings":[93,462],"conducted":[95],"prospective":[97],"observational":[98],"cohort":[99],"study.":[100],"qPCR":[108],"patients":[118,145,161,207,281,367,414,442],"localized":[120],"cutaneous":[121,240],"Rond\u00f4nia,":[124],"Brazilian":[125,417],"Amazon.":[126,418],"Samples":[127],"evaluated":[129,208],"before":[130,215,452],"(D0),":[132],"at":[133,308,337,477],"end":[135],"(D20),":[138],"during":[140],"follow-up":[141],"(D90\u2013180).":[142],"Among":[143,206],"178":[144],"screened,":[146],"CL":[147],"was":[148,153,170,187,217,223,242,270,430],"confirmed":[149],"113.":[151],"detected":[154,171],"34.51%":[159],"24.13%.":[167],"DNA":[169],"12.38%":[178],"patients.":[180],"mucosa.":[196,439],"Higher":[197],"loads":[199,278],"observed":[201,279],"more":[203,455],"recent":[204],"lesions.":[205],"for":[209],"outcome,":[211,274],"higher":[212,276,444],"failure":[221],"factor":[225],"most":[226],"strongly":[227],"an":[230,289],"unfavorable":[231],"response":[232,363],"multivariate":[234],"analysis.":[235],"Conclusions/Significance":[236],"mucosa,":[250,343],"although":[251],"significance":[253],"this":[255,358],"association":[256,290],"its":[258],"require":[263,369],"further":[264],"investigation.":[265],"In":[266,440],"contrast,":[267,441],"pre-treatment":[277],"who":[282,368],"experienced":[283],"failure.":[285,460],"The":[286],"absence":[287],"suggests":[296],"that":[297,323,393,421,464],"these":[298],"two":[299],"parameters":[300],"provide":[302,471],"distinct":[303],"information":[304,473],"regarding":[305],"sites":[310,479],"Author":[314],"Summary":[315],"is":[318],"neglected":[320],"tropical":[321],"disease":[322],"mainly":[324],"causes":[325],"but,":[328],"some":[330,396],"parasites":[332,378,447],"be":[335],"found":[336,420],"distant":[338,478],"including":[340],"even":[344],"when":[345],"there":[346],"are":[347],"no":[348],"signs":[349],"disease.":[352],"Understanding":[353],"help":[365],"identify":[366],"closer":[370],"follow-up.":[371],"amount":[376],"presence":[384,423,476],",":[390],"virus":[392,426,466],"naturally":[394],"infects":[395],"parasites,":[398],"outcome":[412],"amounts":[445],"their":[449],"likely":[456],"experience":[458],"These":[461],"suggest":[463],"different":[472],"about":[474]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-22T00:00:00"}