{"id":"https://openalex.org/W7213880522","doi":"https://doi.org/10.2169/internalmedicine.7712-26","title":"Prevalence of Intestinal Methanogen Overgrowth in Progressive Supranuclear Palsy: A Case-Control Study","display_name":"Prevalence of Intestinal Methanogen Overgrowth in Progressive Supranuclear Palsy: A Case-Control Study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7213880522","doi":"https://doi.org/10.2169/internalmedicine.7712-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42778379"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.7712-26","doi":"https://doi.org/10.2169/internalmedicine.7712-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7712-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7712-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7712-26/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074932994","display_name":"Shun Yamazaki","orcid":"https://orcid.org/0000-0003-2861-5675","observed_orcids":["https://orcid.org/0000-0003-2861-5675"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun Yamazaki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055854164","display_name":"Kentaro Tominaga","orcid":"https://orcid.org/0000-0001-6792-1005","observed_orcids":["https://orcid.org/0000-0001-6792-1005"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Tominaga","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041527882","display_name":"Kotaro Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Watanabe","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152320261","display_name":"Tsuyoshi Matsubara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Matsubara","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takanori Igarashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Igarashi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028538104","display_name":"Takuya Wakabayashi","orcid":"https://orcid.org/0000-0002-5616-1802","observed_orcids":["https://orcid.org/0000-0002-5616-1802"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Wakabayashi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015456190","display_name":"Hanako Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hanako Yamazaki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kunihiko Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiko Yokoyama","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001539195","display_name":"Yuichi Kojima","orcid":"https://orcid.org/0000-0001-8337-884X","observed_orcids":["https://orcid.org/0000-0001-8337-884X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Kojima","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110611270","display_name":"Yuzo Kawata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuzo Kawata","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152367970","display_name":"Kazuya Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Takahashi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016240303","display_name":"Hiroyuki Ab\u00e9","orcid":"https://orcid.org/0000-0003-2618-7494","observed_orcids":["https://orcid.org/0000-0003-2618-7494"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Abe","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044165971","display_name":"Akira Sakamaki","orcid":"https://orcid.org/0000-0002-9368-7272","observed_orcids":["https://orcid.org/0000-0002-9368-7272"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Sakamaki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039282643","display_name":"Takanobu Ishiguro","orcid":"https://orcid.org/0000-0002-8205-4912","observed_orcids":["https://orcid.org/0000-0002-8205-4912"]},"institutions":[{"id":"https://openalex.org/I4405285868","display_name":"Brain Research Institute, Niigata University","ror":"https://ror.org/00hy9c257","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285868","https://openalex.org/I71395657"]},{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanobu Ishiguro","raw_affiliation_strings":["Department of Neurology, Brain Research Institute, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brain Research Institute, Niigata University, Japan","institution_ids":["https://openalex.org/I4405285868","https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088062381","display_name":"Osamu Onodera","orcid":"https://orcid.org/0000-0003-3354-5472","observed_orcids":["https://orcid.org/0000-0003-3354-5472"]},"institutions":[{"id":"https://openalex.org/I4405285868","display_name":"Brain Research Institute, Niigata University","ror":"https://ror.org/00hy9c257","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285868","https://openalex.org/I71395657"]},{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Onodera","raw_affiliation_strings":["Department of Neurology, Brain Research Institute, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brain Research Institute, Niigata University, Japan","institution_ids":["https://openalex.org/I4405285868","https://openalex.org/I71395657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394925","display_name":"Shuji Terai","orcid":"https://orcid.org/0000-0002-5439-635X","observed_orcids":["https://orcid.org/0000-0002-5439-635X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Terai","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70587487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.4269999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":1.0},{"id":"https://openalex.org/keywords/small-intestinal-bacterial-overgrowth","display_name":"small intestinal bacterial overgrowth","score":0.9559999704360962},{"id":"https://openalex.org/keywords/methane","display_name":"methane","score":0.33399999141693115},{"id":"https://openalex.org/keywords/breath-test","display_name":"breath test","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gastrointestinal-dysfunction","display_name":"gastrointestinal dysfunction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7200000286102295},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.883400022983551},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4675999879837036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40290001034736633},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39169999957084656},{"id":"https://openalex.org/C2777438225","wikidata":"https://www.wikidata.org/wiki/Q1169785","display_name":"Methanogen","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.7712-26","doi":"https://doi.org/10.2169/internalmedicine.7712-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7712-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7712-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:42778379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42778379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.7712-26","doi":"https://doi.org/10.2169/internalmedicine.7712-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7712-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7712-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213880522.pdf","grobid_xml":"https://content.openalex.org/works/W7213880522.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3093626432","https://openalex.org/W1970710489","https://openalex.org/W2510141755","https://openalex.org/W4205729881","https://openalex.org/W3041592717","https://openalex.org/W1983564695","https://openalex.org/W4414905773","https://openalex.org/W2072544053","https://openalex.org/W3156408757","https://openalex.org/W2553062798"],"abstract_inverted_index":{"Objective":[0],"Progressive":[1],"supranuclear":[2],"palsy":[3],"(PSP)":[4],"is":[5],"a":[6,64,183],"rare":[7],"neurodegenerative":[8],"disorder":[9],"frequently":[10,122],"accompanied":[11],"by":[12,189,198],"severe":[13],"gastrointestinal":[14,171,232],"dysfunction,":[15],"particularly":[16],"constipation.":[17],"Although":[18,196],"small":[19,200,223],"intestinal":[20,31,51,185,224],"bacterial":[21],"overgrowth":[22,53],"(SIBO)":[23],"has":[24],"been":[25,40],"reported":[26],"in":[27,34,58,76,84,123,128,144,221],"several":[28],"neurological":[29],"diseases,":[30],"microbial":[32,186,212],"phenotypes":[33],"patients":[35,59,77,102,109,124,156],"with":[36,60,78,86,103,110,125,157,180],"PSP":[37,104,111,126,158,181,215],"have":[38],"not":[39,142],"systematically":[41],"evaluated.":[42],"This":[43],"study":[44,67,205],"aimed":[45],"to":[46,68,230],"assess":[47],"the":[48,87,175,199,210,222],"prevalence":[49,93],"of":[50,94,177,214],"methanogen":[52,190],"(IMO)":[54],"and":[55,71,97,105,112,161,170,216,226],"hydrogen-type":[56,95,139,194],"SIBO":[57,96,140],"PSP.Methods":[61],"We":[62],"conducted":[63],"cross-sectional":[65],"case-control":[66],"evaluate":[69],"hydrogen-":[70],"methane-based":[72],"breath":[73],"test":[74],"profiles":[75],"PSP.":[79],"Breath":[80],"testing":[81],"was":[82,99,119,141,159,165],"performed":[83],"accordance":[85],"North":[88],"American":[89],"Consensus":[90],"criteria.":[91],"The":[92,147],"IMO":[98,118,168],"compared":[100],"between":[101,167],"healthy":[106,114,129],"controls.Results":[107],"Five":[108],"33":[113],"controls":[115,130],"were":[116],"included.":[117],"identified":[120],"more":[121],"than":[127,193],"(40.0%":[131],"vs.":[132],"3.0%;":[133],"P":[134],"=":[135],"0.040).":[136],"In":[137],"contrast,":[138],"observed":[143,166],"either":[145],"group.":[146],"mean":[148],"Gastrointestinal":[149],"Symptom":[150],"Rating":[151],"Scale":[152],"(GSRS)":[153],"score":[154],"among":[155],"29.4\u00b15.9,":[160],"no":[162],"clear":[163],"association":[164],"positivity":[169],"symptom":[172],"severity":[173],"or":[174],"presence":[176],"constipation.Conclusions":[178],"Patients":[179],"exhibited":[182],"distinct":[184],"phenotype":[187],"characterized":[188],"predominance":[191],"rather":[192],"SIBO.":[195],"limited":[197],"sample":[201],"size,":[202],"this":[203],"pilot":[204],"provides":[206],"novel":[207],"insights":[208],"into":[209],"gut":[211],"characteristics":[213],"suggests":[217],"that":[218],"qualitative":[219],"alterations":[220],"microbiota":[225],"motility":[227],"may":[228],"contribute":[229],"PSP-associated":[231],"dysfunction.":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-22T00:00:00"}