{"id":"https://openalex.org/W7213876846","doi":"https://doi.org/10.1177/03946320261472669","title":"Atypical cytokine release syndrome induced by carboplatin: The first described case report","display_name":"Atypical cytokine release syndrome induced by carboplatin: The first described case report","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7213876846","doi":"https://doi.org/10.1177/03946320261472669","pmid":"https://pubmed.ncbi.nlm.nih.gov/42765956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13731877"},"language":"en","primary_location":{"id":"doi:10.1177/03946320261472669","doi":"https://doi.org/10.1177/03946320261472669","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03946320261472669","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/03946320261472669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071860885","display_name":"Maria Cruz Torres G\u00f3rriz","orcid":"https://orcid.org/0009-0005-1859-143X","observed_orcids":["https://orcid.org/0009-0005-1859-143X"]},"institutions":[{"id":"https://openalex.org/I10902133","display_name":"Universitat Jaume I","ror":"https://ror.org/02ws1xc11","country_code":"ES","type":"education","lineage":["https://openalex.org/I10902133"]},{"id":"https://openalex.org/I4210097149","display_name":"Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana","ror":"https://ror.org/0116vew40","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210097149"]},{"id":"https://openalex.org/I4210125017","display_name":"Hospital General Universitari de Castell\u00f3","ror":"https://ror.org/02yp1e416","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125017"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria Cruz Torres G\u00f3rriz","raw_affiliation_strings":["FISABIO Foundation Research Group","General University Hospital of Castell\u00f3n","Jaume I University"],"raw_orcid":"https://orcid.org/0009-0005-1859-143X","affiliations":[{"raw_affiliation_string":"FISABIO Foundation Research Group","institution_ids":["https://openalex.org/I4210097149"]},{"raw_affiliation_string":"General University Hospital of Castell\u00f3n","institution_ids":["https://openalex.org/I4210125017"]},{"raw_affiliation_string":"Jaume I University","institution_ids":["https://openalex.org/I10902133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055299900","display_name":"Juli\u00e1n Borr\u00e1s Cuartero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096764","display_name":"Consorcio Hospitalario Provincial de Castell\u00f3n","ror":"https://ror.org/00t7jb983","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096764"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julian Borr\u00e1s Cuartero","raw_affiliation_strings":["Castellon Provincial Hospital Consortium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Castellon Provincial Hospital Consortium","institution_ids":["https://openalex.org/I4210096764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152362721","display_name":"Anna Bosh Requena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Bosh Requena","raw_affiliation_strings":["University Clinical Hospital of Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinical Hospital of Valencia","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048351112","display_name":"Dah Tay Jang","orcid":"https://orcid.org/0000-0002-3791-4389","observed_orcids":["https://orcid.org/0000-0002-3791-4389"]},"institutions":[{"id":"https://openalex.org/I4210125017","display_name":"Hospital General Universitari de Castell\u00f3","ror":"https://ror.org/02yp1e416","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125017"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Dah Tay Jang","raw_affiliation_strings":["General University Hospital of Castell\u00f3n"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital of Castell\u00f3n","institution_ids":["https://openalex.org/I4210125017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128016044","display_name":"Ernesto Enrique","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10902133","display_name":"Universitat Jaume I","ror":"https://ror.org/02ws1xc11","country_code":"ES","type":"education","lineage":["https://openalex.org/I10902133"]},{"id":"https://openalex.org/I4210097149","display_name":"Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana","ror":"https://ror.org/0116vew40","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210097149"]},{"id":"https://openalex.org/I4210125017","display_name":"Hospital General Universitari de Castell\u00f3","ror":"https://ror.org/02yp1e416","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125017"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ernesto Enrique","raw_affiliation_strings":["FISABIO Foundation Research Group","General University Hospital of Castell\u00f3n","Jaume I University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FISABIO Foundation Research Group","institution_ids":["https://openalex.org/I4210097149"]},{"raw_affiliation_string":"General University Hospital of Castell\u00f3n","institution_ids":["https://openalex.org/I4210125017"]},{"raw_affiliation_string":"Jaume I University","institution_ids":["https://openalex.org/I10902133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5071860885"],"corresponding_institution_ids":["https://openalex.org/I10902133","https://openalex.org/I4210097149","https://openalex.org/I4210125017"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":2.73,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.92748043,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"40","issue":null,"first_page":"3946320261472669","last_page":"3946320261472669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9169999957084656},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8700000047683716},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8820000290870667},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.9581999778747559},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8033999800682068},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7888000011444092},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.715399980545044},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5105000138282776},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.46619999408721924},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.40549999475479126},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39750000834465027},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3346000015735626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29490000009536743}],"mesh":[{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/03946320261472669","doi":"https://doi.org/10.1177/03946320261472669","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03946320261472669","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:42765956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42765956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of immunopathology and pharmacology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13731877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Immunopathol Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3dd9a8d9db7f46a09bb1df9a30f3d92a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3dd9a8d9db7f46a09bb1df9a30f3d92a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunopathology and Pharmacology, Vol 40 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/03946320261472669","doi":"https://doi.org/10.1177/03946320261472669","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03946320261472669","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2736017822","https://openalex.org/W2941541702","https://openalex.org/W3096103214","https://openalex.org/W3114347278","https://openalex.org/W3165252389","https://openalex.org/W4221087721","https://openalex.org/W4295564289","https://openalex.org/W4387516236","https://openalex.org/W4388223088","https://openalex.org/W4406400588","https://openalex.org/W4412005451"],"related_works":["https://openalex.org/W1910585037","https://openalex.org/W2131394403","https://openalex.org/W4411013935","https://openalex.org/W2057716223","https://openalex.org/W4210761406","https://openalex.org/W2051982165","https://openalex.org/W2003427988","https://openalex.org/W7098241036","https://openalex.org/W2000470790","https://openalex.org/W2108160031"],"abstract_inverted_index":{"IntroductionHypersensitivity":[0],"reactions":[1],"to":[2],"carboplatin":[3,25,48,75,97,106,156],"include":[4],"type":[5],"I":[6,124],"reactions,":[7,9],"mixed":[8,121,142],"and":[10,49,67,95,116,125],"delayed":[11,41,70,153],"reactions.Case":[12],"reportWe":[13],"report":[14],"a":[15,27,40,57,99,120,141,163],"case":[16],"of":[17,39,47,72,79,119,140,159,171],"an":[18,80,151],"atypical":[19],"cytokine":[20,42,82,126,130,172],"release":[21,43,83,102,131,146,173],"syndrome":[22,44,103,132,147],"induced":[23,133],"by":[24,134],"in":[26],"patient":[28,34,86],"with":[29,65,90,96,105],"breast":[30],"carcinoma.Management":[31],"&":[32],"outcomeThe":[33],"developed":[35],"clinical":[36],"manifestations":[37],"consisting":[38],"following":[45,155],"administration":[46],"paclitaxel.":[50],"To":[51],"establish":[52],"the":[53,77,138,169],"diagnosis,":[54],"she":[55],"underwent":[56],"double":[58],"desensitization":[59,100],"protocol":[60],"over":[61],"two":[62],"consecutive":[63],"days":[64],"paclitaxel":[66,91],"carboplatin.":[68],"A":[69,128],"elevation":[71],"interleukin-6":[73,160],"after":[74,114],"supported":[76],"diagnosis":[78,170],"isolated":[81],"syndrome.":[84,174],"The":[85],"subsequently":[87],"continued":[88],"treatment":[89],"through":[92],"standard":[93],"infusions":[94],"using":[98],"protocol.DiscussionCytokine":[101],"associated":[104],"has":[107],"been":[108],"previously":[109],"reported":[110],"as":[111,117,150],"occurring":[112,136],"immediately":[113],"infusion":[115],"part":[118],"phenotype":[122],"(type":[123],"release).":[127],"delayed-onset":[129],"carboplatin,":[135],"outside":[137],"context":[139],"reaction,":[143],"is":[144],"reported.ConclusionCytokine":[145],"may":[148,161],"present":[149],"isolated,":[152],"reaction":[154],"infusion.":[157],"Measurement":[158],"be":[162],"valuable":[164],"diagnostic":[165],"tool":[166],"for":[167],"confirming":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-22T00:00:00"}