{"id":"https://openalex.org/W7213779487","doi":"https://doi.org/10.1038/s41598-026-67436-7","title":"Divergent HIF isoform association is linked to hypoxia responses in Mesenchymal stromal cells and human dermal fibroblasts","display_name":"Divergent HIF isoform association is linked to hypoxia responses in Mesenchymal stromal cells and human dermal fibroblasts","publication_year":2026,"publication_date":"2026-09-20","ids":{"openalex":"https://openalex.org/W7213779487","doi":"https://doi.org/10.1038/s41598-026-67436-7"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-67436-7","doi":"https://doi.org/10.1038/s41598-026-67436-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67436-7","pdf_url":"https://www.nature.com/articles/s41598-026-67436-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-67436-7_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152287859","display_name":"Li Liu","orcid":"https://orcid.org/0009-0000-4177-0798","observed_orcids":["https://orcid.org/0009-0000-4177-0798"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK"],"raw_orcid":"https://orcid.org/0009-0000-4177-0798","affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5152262811","display_name":"Zhanfeng Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zhanfeng Cui","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5152262811"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60088194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.10159999877214432,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-response","display_name":"hypoxia response","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hif1a","display_name":"HIF1A","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hif-3alpha","display_name":"HIF-3\u03b1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-type-specific-gene-expression","display_name":"cell type-specific gene expression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/transcriptomic-remodeling","display_name":"transcriptomic remodeling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7993999719619751},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7842000126838684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6930999755859375},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6730999946594238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6344000101089478},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6082000136375427},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5726000070571899},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.45100000500679016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43470001220703125},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.414000004529953},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4083999991416931},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.40299999713897705},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3783999979496002},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3684999942779541},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36250001192092896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.3327000141143799},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.29820001125335693},{"id":"https://openalex.org/C31194975","wikidata":"https://www.wikidata.org/wiki/Q20970095","display_name":"HIF1A","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28519999980926514},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.27639999985694885},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25119999051094055},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-67436-7","doi":"https://doi.org/10.1038/s41598-026-67436-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67436-7","pdf_url":"https://www.nature.com/articles/s41598-026-67436-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-67436-7","doi":"https://doi.org/10.1038/s41598-026-67436-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67436-7","pdf_url":"https://www.nature.com/articles/s41598-026-67436-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213779487.pdf","grobid_xml":"https://content.openalex.org/works/W7213779487.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2071227792"],"related_works":["https://openalex.org/W2005408022","https://openalex.org/W2968140460","https://openalex.org/W2041552691","https://openalex.org/W263902195","https://openalex.org/W2100207849","https://openalex.org/W2171833305","https://openalex.org/W2093784756","https://openalex.org/W2012309077","https://openalex.org/W2164620699","https://openalex.org/W1990000527"],"abstract_inverted_index":{"Abstract":[0],"Hypoxia":[1],"is":[2],"a":[3,89,169,191],"fundamental":[4],"microenvironmental":[5],"signal":[6],"that":[7,163],"shapes":[8],"stromal":[9,20,137,171,204],"cell":[10,65,150,218],"behavior":[11],"in":[12,57,147],"tissue":[13],"repair,":[14],"fibrosis,":[15],"and":[16,23,53,59,107,143,184,209,217],"regenerative":[17,213],"medicine.":[18],"Mesenchymal":[19],"cells":[21],"(MSCs)":[22],"fibroblasts":[24,62,189],"share":[25],"overlapping":[26,135],"phenotypic":[27,156],"features":[28],"under":[29,40,206],"standard":[30],"culture":[31],"conditions,":[32],"yet":[33],"whether":[34],"they":[35],"engage":[36],"equivalent":[37],"adaptive":[38,104],"programs":[39],"hypoxic":[41],"stress":[42,207],"remains":[43],"unclear.":[44],"Here,":[45],"we":[46],"performed":[47],"comparative":[48],"transcriptomic":[49,76],"analyses":[50,109],"to":[51,80,155],"define":[52],"contrast":[54],"hypoxia":[55,140,164],"responses":[56,117,128],"MSCs":[58,72,181],"human":[60],"dermal":[61],"(HDFs).":[63],"Both":[64],"types":[66],"mounted":[67],"robust":[68],"hypoxia-responsive":[69,93],"programs;":[70],"however,":[71],"exhibited":[73],"substantially":[74],"broader":[75,183],"remodeling,":[77,187],"with":[78,122],"two-":[79],"four-fold":[81],"more":[82,119,185],"differentially":[83],"expressed":[84],"genes":[85,94],"than":[86],"HDFs.":[87],"Although":[88],"conserved":[90],"subset":[91],"of":[92,179,203],"was":[95],"shared,":[96],"most":[97],"regulated":[98],"transcripts":[99],"were":[100,118],"cell-type-specific,":[101],"indicating":[102],"distinct":[103,195],"architectures.":[105],"Pathway":[106],"co-expression":[108],"further":[110],"revealed":[111],"divergent":[112],"HIF-associated":[113],"signaling":[114],"structure:":[115],"MSC":[116],"strongly":[120],"aligned":[121],"HIF1A-centered":[123],"regulatory":[124,153,196],"networks,":[125],"whereas":[126,188],"HDF":[127],"showed":[129],"relatively":[130],"stronger":[131],"HIF2A/HIF3A-associated":[132],"organization.":[133],"Despite":[134],"baseline":[136],"marker":[138],"profiles,":[139],"induced":[141],"pronounced":[142],"non-overlapping":[144],"surface-marker":[145],"remodeling":[146],"the":[148,201],"two":[149],"types,":[151],"linking":[152],"divergence":[154],"state":[157],"changes.":[158],"Collectively,":[159],"these":[160],"findings":[161],"demonstrate":[162],"does":[165],"not":[166],"simply":[167],"amplify":[168],"common":[170],"program,":[172],"but":[173,194],"instead":[174],"exposes":[175],"latent":[176],"cell-type-specific":[177],"strategies":[178],"adaptation.":[180],"undergo":[182],"plastic":[186],"adopt":[190],"comparatively":[192],"restrained":[193],"state.":[197],"These":[198],"results":[199],"refine":[200],"interpretation":[202],"identity":[205],"conditions":[208],"have":[210],"implications":[211],"for":[212],"medicine,":[214],"fibrosis":[215],"biology,":[216],"manufacturing.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-21T00:00:00"}
