{"id":"https://openalex.org/W7213778683","doi":"https://doi.org/10.3390/ijms27219632","title":"Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk","display_name":"Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7213778683","doi":"https://doi.org/10.3390/ijms27219632","pmid":"https://pubmed.ncbi.nlm.nih.gov/42780028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596684"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27219632","doi":"https://doi.org/10.3390/ijms27219632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219632","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27219632","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049259251","display_name":"Tianying Zhao","orcid":"https://orcid.org/0000-0002-0103-1867","observed_orcids":["https://orcid.org/0000-0002-0103-1867"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210162197","display_name":"Vanderbilt Health","ror":"https://ror.org/05grhsk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162197"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianying Zhao","raw_affiliation_strings":["Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA","Vanderbilt School of Medicine, Vanderbilt University, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-0103-1867","affiliations":[{"raw_affiliation_string":"Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt School of Medicine, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048065612","display_name":"Mariah Hoffman","orcid":"https://orcid.org/0000-0002-0509-3408","observed_orcids":["https://orcid.org/0000-0002-0509-3408"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210162197","display_name":"Vanderbilt Health","ror":"https://ror.org/05grhsk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162197"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariah M. Hoffman","raw_affiliation_strings":["Department of Neurology, Vanderbilt Health, Nashville, TN 37232, USA","Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vanderbilt Health, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197"]},{"raw_affiliation_string":"Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030319840","display_name":"Gang Wu","orcid":"https://orcid.org/0000-0002-1678-5864","observed_orcids":["https://orcid.org/0000-0002-1678-5864"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Wu","raw_affiliation_strings":["Center for Applied Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-1678-5864","affiliations":[{"raw_affiliation_string":"Center for Applied Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040220531","display_name":"V\u00e9ronique Belzil","orcid":"https://orcid.org/0000-0003-4450-5396","observed_orcids":["https://orcid.org/0000-0003-4450-5396"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210162197","display_name":"Vanderbilt Health","ror":"https://ror.org/05grhsk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162197"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Veronique V. Belzil","raw_affiliation_strings":["Department of Medicine, Vanderbilt Health, Nashville, TN 37232, USA","Department of Neurology, Vanderbilt Health, Nashville, TN 37232, USA","Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA","Vanderbilt School of Medicine, Vanderbilt University, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0003-4450-5396","affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt Health, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197"]},{"raw_affiliation_string":"Department of Neurology, Vanderbilt Health, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197"]},{"raw_affiliation_string":"Vanderbilt ALS Research Center, Vanderbilt Health, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt School of Medicine, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040220531"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210162197","https://openalex.org/I901861585"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67364888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"9632","last_page":"9632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/blood-dna-methylation","display_name":"blood DNA methylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/methylome-wide-association-study","display_name":"methylome-wide association study","score":0.9039999842643738},{"id":"https://openalex.org/keywords/predixcan","display_name":"PrediXcan","score":0.8849999904632568},{"id":"https://openalex.org/keywords/c9orf72","display_name":"C9orf72","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gene-expression-prediction","display_name":"gene expression prediction","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6998000144958496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.699400007724762},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.6962000131607056},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6302000284194946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6116999983787537},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.5764999985694885},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.524399995803833},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4921000003814697},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4830999970436096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4796999990940094},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.37040001153945923},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.3637000024318695},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.323199987411499},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2948000133037567},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2615000009536743}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms27219632","doi":"https://doi.org/10.3390/ijms27219632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219632","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.64898/2026.09.17.26363319","doi":"https://doi.org/10.64898/2026.09.17.26363319","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.17.26363319","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/20/2026.09.17.26363319.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596684","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596684/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596684/pdf/nihpp-2026.09.17.26363319v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv","raw_type":"Text"},{"id":"pmid:42780028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42780028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27219632","doi":"https://doi.org/10.3390/ijms27219632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219632","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213778683.pdf","grobid_xml":"https://content.openalex.org/works/W7213778683.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1989424501","https://openalex.org/W1993273815","https://openalex.org/W2047028564","https://openalex.org/W2066828509","https://openalex.org/W2098798042","https://openalex.org/W2122825543","https://openalex.org/W2127027434","https://openalex.org/W2132295371","https://openalex.org/W2135046866","https://openalex.org/W2136691282","https://openalex.org/W2150523249","https://openalex.org/W2154945114","https://openalex.org/W2160357890","https://openalex.org/W2209106767","https://openalex.org/W2292330705","https://openalex.org/W2316537321","https://openalex.org/W2334107927","https://openalex.org/W2460114159","https://openalex.org/W2517281723","https://openalex.org/W2592387132","https://openalex.org/W2593282276","https://openalex.org/W2600206677","https://openalex.org/W2796081119","https://openalex.org/W2797975136","https://openalex.org/W2887847409","https://openalex.org/W2889728125","https://openalex.org/W2952346218","https://openalex.org/W3022946221","https://openalex.org/W3024541627","https://openalex.org/W3029634481","https://openalex.org/W3081033880","https://openalex.org/W3088778932","https://openalex.org/W3114107609","https://openalex.org/W3123589318","https://openalex.org/W3133859624","https://openalex.org/W3207362495","https://openalex.org/W3209174880","https://openalex.org/W4213246082","https://openalex.org/W4220676470","https://openalex.org/W4226286160","https://openalex.org/W4283012307","https://openalex.org/W4289957736","https://openalex.org/W4294541781","https://openalex.org/W4295896242","https://openalex.org/W4308745457","https://openalex.org/W4365135317","https://openalex.org/W4372349506","https://openalex.org/W4377940133","https://openalex.org/W4387142713","https://openalex.org/W4404283194","https://openalex.org/W4407830848","https://openalex.org/W4408845344","https://openalex.org/W4410001468","https://openalex.org/W4410373653","https://openalex.org/W7134073962"],"related_works":["https://openalex.org/W4392473781","https://openalex.org/W3137053129","https://openalex.org/W4213246082","https://openalex.org/W4224241649","https://openalex.org/W4401073565","https://openalex.org/W4399922686","https://openalex.org/W2721897171","https://openalex.org/W4417212764","https://openalex.org/W4404689979","https://openalex.org/W3041952276"],"abstract_inverted_index":{"Abstract":[0],"Amyotrophic":[1],"lateral":[2],"sclerosis":[3],"(ALS)":[4],"is":[5],"a":[6,38,98,168,226,253],"fatal":[7],"neurodegenerative":[8],"disorder":[9],"whose":[10],"genetic":[11,231,258],"architecture":[12],"and":[13,60,77,115,142,146,155,188,217,238,265],"underlying":[14],"molecular":[15],"mechanisms":[16,268],"remain":[17],"incompletely":[18],"understood,":[19],"particularly":[20],"in":[21,57,173],"sporadic":[22],"disease.":[23],"To":[24],"investigate":[25],"whether":[26],"genetically":[27,44,85],"regulated":[28],"DNA":[29,47],"methylation":[30,48,87,178,216],"may":[31,245],"help":[32],"interpret":[33],"ALS":[34,67,110,134,141,174,183,209,230],"susceptibility,":[35],"we":[36],"conducted":[37],"methylome-wide":[39],"association":[40,69,195,259],"study":[41,70],"(MWAS)":[42],"of":[43,80,101],"predicted":[45,86],"blood":[46],"using":[49,95,112,117,197],"the":[50,58],"PrediXcan":[51],"framework.":[52],"CpG-specific":[53],"prediction":[54,202],"models":[55,114,203],"developed":[56],"ARIES":[59,113],"Understanding":[61,118],"Society":[62,119],"cohorts":[63],"were":[64,107],"applied":[65],"to":[66,164,229],"genome-wide":[68],"(GWAS)":[71],"summary":[72],"statistics":[73],"from":[74],"27,205":[75],"cases":[76],"110,881":[78],"controls":[79],"European":[81],"ancestry.":[82],"In":[83],"total,":[84],"at":[88,166,185,191,220],"192,378":[89],"unique":[90],"CpG":[91,235],"sites":[92],"was":[93,179],"evaluated":[94],"S-PrediXcan.":[96],"At":[97],"nominal":[99],"threshold":[100],"p":[102],"<":[103],"0.05,":[104],"3,741":[105],"CpGs":[106,125,162,187],"associated":[108,132,181,190,207],"with":[109,133,182,208],"risk":[111,184,210],"13,127":[116],"models.":[120],"After":[121],"Bonferroni":[122,212],"correction,":[123,213],"25":[124],"across":[126],"eight":[127],"genomic":[128,239],"regions":[129,240],"remained":[130],"significantly":[131],"risk.":[135],"These":[136,223],"included":[137],"signals":[138,219,260],"near":[139],"established":[140],"ALS-frontotemporal":[143],"dementia":[144],"genes":[145,206],"loci,":[147],"including":[148,214],"C9orf72":[149,221],",":[150,152,154,157],"TBK1":[151],"SCFD1":[153],"MOB3B":[156],"as":[158,160],"well":[159],"three":[161],"mapping":[163],"WHAMM":[165],"15q25.2,":[167],"region":[169],"not":[170],"previously":[171],"implicated":[172],"by":[175,233],"GWAS.":[176],"Predicted":[177],"positively":[180],"18":[186],"inversely":[189],"seven.":[192],"Complementary":[193],"transcriptome-wide":[194],"analyses":[196],"GTEx":[198],"v8":[199],"whole-blood":[200],"gene-expression":[201],"identified":[204],"11":[205],"after":[211],"convergent":[215],"expression":[218],".":[222],"findings":[224],"add":[225],"regulatory":[227,267],"dimension":[228],"studies":[232],"prioritizing":[234],"sites,":[236],"genes,":[237],"through":[241],"which":[242],"inherited":[243],"variation":[244],"influence":[246],"disease":[247],"susceptibility.":[248],"PrediXcan-based":[249],"MWAS":[250],"therefore":[251],"provides":[252],"complementary":[254],"strategy":[255],"for":[256,269],"refining":[257],"into":[261],"biologically":[262],"testable":[263],"candidates":[264],"identifying":[266],"further":[270],"functional":[271],"investigation.":[272]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-21T00:00:00"}