{"id":"https://openalex.org/W7213758516","doi":"https://doi.org/10.64898/2026.09.18.26363386","title":"Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration","display_name":"Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration","publication_year":2026,"publication_date":"2026-09-20","ids":{"openalex":"https://openalex.org/W7213758516","doi":"https://doi.org/10.64898/2026.09.18.26363386"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.18.26363386","doi":"https://doi.org/10.64898/2026.09.18.26363386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363386","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/20/2026.09.18.26363386.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/20/2026.09.18.26363386.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152262211","display_name":"Sean YW Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sean YW Tan","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust","Department of Clinical Neurosciences, University of Cambridge","MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063197718","display_name":"Michelle Naessens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michelle Naessens","raw_affiliation_strings":["MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075493660","display_name":"Peter Simon Jones","orcid":"https://orcid.org/0000-0001-9695-0702","observed_orcids":["https://orcid.org/0000-0001-9695-0702"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Simon Jones","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012478494","display_name":"Emily G. Todd","orcid":"https://orcid.org/0000-0003-1551-5691","observed_orcids":["https://orcid.org/0000-0003-1551-5691"]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily G Todd","raw_affiliation_strings":["MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064215039","display_name":"Rebecca S. Williams","orcid":"https://orcid.org/0000-0001-7645-7398","observed_orcids":["https://orcid.org/0000-0001-7645-7398"]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca S. Williams","raw_affiliation_strings":["MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0001-7645-7398","affiliations":[{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000787488","display_name":"Christopher T. Rodgers","orcid":"https://orcid.org/0000-0003-1275-1197","observed_orcids":["https://orcid.org/0000-0003-1275-1197"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher T. Rodgers","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0003-1275-1197","affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062379252","display_name":"Laura E. Hughes","orcid":"https://orcid.org/0000-0002-1065-7175","observed_orcids":["https://orcid.org/0000-0002-1065-7175"]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura E. Hughes","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge","MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0002-1065-7175","affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053590404","display_name":"Noah Lorenz Shapiro","orcid":"https://orcid.org/0000-0002-7786-2747","observed_orcids":["https://orcid.org/0000-0002-7786-2747"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Noah L Shapiro","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge","UK Dementia Research Institute at Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"UK Dementia Research Institute at Cambridge","institution_ids":["https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029755532","display_name":"Julia Goddard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia Goddard","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge","UK Dementia Research Institute at Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"UK Dementia Research Institute at Cambridge","institution_ids":["https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152287771","display_name":"Meira van Schaik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Meira van Schaik","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge","UK Dementia Research Institute at Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"UK Dementia Research Institute at Cambridge","institution_ids":["https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073721007","display_name":"Amanda Heslegrave","orcid":"https://orcid.org/0000-0002-7290-6405","observed_orcids":["https://orcid.org/0000-0002-7290-6405"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda Heslegrave","raw_affiliation_strings":["Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL","UK Dementia Research Institute at University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"UK Dementia Research Institute at University College London","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079766290","display_name":"Henrik Zetterberg","orcid":"https://orcid.org/0000-0003-3930-4354","observed_orcids":["https://orcid.org/0000-0003-3930-4354","https://orcid.org/0000-0002-4671-6763"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE","US"],"is_corresponding":false,"raw_author_name":"Henrik Zetterberg","raw_affiliation_strings":["Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL","Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden","UK Dementia Research Institute at University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"UK Dementia Research Institute at University College London","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077445938","display_name":"Alexander G. Murley","orcid":"https://orcid.org/0000-0003-0813-0670","observed_orcids":["https://orcid.org/0000-0003-0813-0670"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander G Murley","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust","Department of Clinical Neurosciences, University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0003-0813-0670","affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007616574","display_name":"Maura Malpetti","orcid":"https://orcid.org/0000-0001-8923-9656","observed_orcids":["https://orcid.org/0000-0001-8923-9656"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maura Malpetti","raw_affiliation_strings":["Department of Clinical Neurosciences, University of Cambridge","UK Dementia Research Institute at Cambridge"],"raw_orcid":"https://orcid.org/0000-0001-8923-9656","affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"UK Dementia Research Institute at Cambridge","institution_ids":["https://openalex.org/I4210126463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025003387","display_name":"James Benedict Rowe","orcid":"https://orcid.org/0000-0001-7216-8679","observed_orcids":["https://orcid.org/0000-0001-7216-8679"]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James B Rowe","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust","Department of Clinical Neurosciences, University of Cambridge","MRC Cognition and Brain sciences Unit, University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0001-7216-8679","affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Department of Clinical Neurosciences, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Cognition and Brain sciences Unit, University of Cambridge","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5152262211"],"corresponding_institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I2802466933"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":1.0},{"id":"https://openalex.org/keywords/behavioral-variant-frontotemporal-dementia","display_name":"behavioral variant frontotemporal dementia","score":0.906000018119812},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":1.0},{"id":"https://openalex.org/keywords/1h-nmr-spectroscopy","display_name":"1H NMR","score":0.9399999976158142},{"id":"https://openalex.org/keywords/serum-inflammatory-markers","display_name":"serum inflammatory markers","score":0.765999972820282},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.5690000057220459},{"id":"https://openalex.org/keywords/inferior-frontal-gyrus","display_name":"inferior frontal gyrus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6769999861717224},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.6970000267028809},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6399999856948853},{"id":"https://openalex.org/keywords/csf2","display_name":"CSF2","score":0.6169999837875366},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.8338000178337097},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.6593999862670898},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6398000121116638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5551999807357788},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43560001254081726},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.43140000104904175},{"id":"https://openalex.org/C2776791281","wikidata":"https://www.wikidata.org/wiki/Q2385013","display_name":"Translocator protein","level":4,"score":0.4016000032424927},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.3628000020980835},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.33180001378059387},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.3296000063419342},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2969000041484833},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.2896000146865845},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.2766000032424927},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27219998836517334},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.26750001311302185},{"id":"https://openalex.org/C2778046553","wikidata":"https://www.wikidata.org/wiki/Q848340","display_name":"Occipital lobe","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2780749935","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive deficit","level":4,"score":0.25859999656677246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.18.26363386","doi":"https://doi.org/10.64898/2026.09.18.26363386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363386","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/20/2026.09.18.26363386.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.18.26363386","doi":"https://doi.org/10.64898/2026.09.18.26363386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.18.26363386","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/20/2026.09.18.26363386.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1227944200","display_name":"METAHEAD - Pioneering Multi-Site 7T Metabolic Imaging of the Human Brain","funder_award_id":"UKRI226","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1343867371","display_name":null,"funder_award_id":"-71320","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1802301745","display_name":null,"funder_award_id":"#101053962","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2493601830","display_name":null,"funder_award_id":"NIHR 203312","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G2537968379","display_name":null,"funder_award_id":"(NIHR203312","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2543812357","display_name":null,"funder_award_id":"UKDRI\u2010 1003","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G3260835310","display_name":"Fluid biomarkers for neurodegenerative dementias","funder_award_id":"2022-01018","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3914690605","display_name":null,"funder_award_id":"ALFGBG\u201071320","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4164855262","display_name":"Bridging the gap: biophysical models of human frontotemporal lobar degeneration","funder_award_id":"220258","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4260843567","display_name":null,"funder_award_id":"101,053,962","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4377393254","display_name":null,"funder_award_id":"UKDRI\u20101003","funder_id":"https://openalex.org/F4320320286","funder_display_name":"University College London"},{"id":"https://openalex.org/G4753630297","display_name":null,"funder_award_id":"NIHR203312","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5040492720","display_name":null,"funder_award_id":"ALFGBG-71320","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5048620333","display_name":"Parallel transmit 7T MRI to find epileptogenic lesions in patients with drug-resistant focal epilepsy","funder_award_id":"UKRI790","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5264190596","display_name":null,"funder_award_id":"UKDRI-1003","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5437517653","display_name":"Fluid biomarkers for neurodegenerative dementias","funder_award_id":"2023-00356","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5778058681","display_name":null,"funder_award_id":"UKDRI-1003","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6075061880","display_name":"CASCADE: CAuSe or Consequence in Alzheimer DiseasE?","funder_award_id":"2019-02397","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6158734006","display_name":null,"funder_award_id":"101053962","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G6211361385","display_name":"Decision making and dementia: from mechanisms to clinical trials","funder_award_id":"MC_UU_00030/14","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6361952146","display_name":null,"funder_award_id":"2019-02397","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G691914629","display_name":"MICA: Dementias Platform UK 2 - Integrated Dementia Experimental Medicine","funder_award_id":"MR/T033371/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7972240148","display_name":null,"funder_award_id":"2022-01018","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7998175682","display_name":null,"funder_award_id":"T033371/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8347284120","display_name":null,"funder_award_id":"NIHR203312","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8382260133","display_name":null,"funder_award_id":"220258","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"}],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213758516.pdf","grobid_xml":"https://content.openalex.org/works/W7213758516.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1895277992","https://openalex.org/W1895989725","https://openalex.org/W1907949022","https://openalex.org/W1908432422","https://openalex.org/W1973715974","https://openalex.org/W1988917755","https://openalex.org/W1990918805","https://openalex.org/W1992837035","https://openalex.org/W2008823687","https://openalex.org/W2010681077","https://openalex.org/W2025878623","https://openalex.org/W2040564926","https://openalex.org/W2057249855","https://openalex.org/W2059426479","https://openalex.org/W2063680739","https://openalex.org/W2067671215","https://openalex.org/W2073845553","https://openalex.org/W2086504454","https://openalex.org/W2089389165","https://openalex.org/W2120901401","https://openalex.org/W2128030851","https://openalex.org/W2139632888","https://openalex.org/W2148658155","https://openalex.org/W2150107812","https://openalex.org/W2152748843","https://openalex.org/W2172825401","https://openalex.org/W2189537077","https://openalex.org/W2721383701","https://openalex.org/W2750748451","https://openalex.org/W2765390900","https://openalex.org/W2767078245","https://openalex.org/W2783108014","https://openalex.org/W2799640243","https://openalex.org/W2813530246","https://openalex.org/W2885612171","https://openalex.org/W2904467105","https://openalex.org/W2945711076","https://openalex.org/W2952450428","https://openalex.org/W2958142957","https://openalex.org/W2963582013","https://openalex.org/W2999818394","https://openalex.org/W3004046311","https://openalex.org/W3011374615","https://openalex.org/W3037244022","https://openalex.org/W3048025713","https://openalex.org/W3048489258","https://openalex.org/W3074382982","https://openalex.org/W3091721457","https://openalex.org/W3091912339","https://openalex.org/W3095515993","https://openalex.org/W3097041920","https://openalex.org/W3102291668","https://openalex.org/W3110882068","https://openalex.org/W3134821755","https://openalex.org/W3164868648","https://openalex.org/W3189983597","https://openalex.org/W3210759110","https://openalex.org/W3212196891","https://openalex.org/W4295329051","https://openalex.org/W4312086105","https://openalex.org/W4321788949","https://openalex.org/W4323438786","https://openalex.org/W4361191211","https://openalex.org/W4386694446","https://openalex.org/W4388008063","https://openalex.org/W4388540430","https://openalex.org/W4398168498","https://openalex.org/W4401091830","https://openalex.org/W4401610044","https://openalex.org/W4401679451","https://openalex.org/W4402893657","https://openalex.org/W4403893143","https://openalex.org/W4404505700","https://openalex.org/W4406756877","https://openalex.org/W4407751177","https://openalex.org/W4408142186","https://openalex.org/W4408362064","https://openalex.org/W4408921885","https://openalex.org/W4415214015","https://openalex.org/W4416757388"],"related_works":["https://openalex.org/W2952450428","https://openalex.org/W1586197955","https://openalex.org/W1966516597","https://openalex.org/W4412957051","https://openalex.org/W7222116085","https://openalex.org/W4408835068","https://openalex.org/W4390195333","https://openalex.org/W4323544166","https://openalex.org/W7116978721","https://openalex.org/W4401679451"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,5,37,92,122,148,175,206,219,309,368,370],"Objectives":[3],"Cost-effective":[4],"mechanistically-informative":[6],"biomarkers":[7],"are":[8,54],"needed":[9],"to":[10,83,212],"advance":[11],"novel":[12],"therapeutics":[13],"for":[14],"dementia.":[15],"We":[16,95],"focus":[17],"on":[18],"neuroinflammation":[19],"in":[20,90,104,113,125,216,242,251,268,281,290,331,352,356],"disorders":[21,138],"associated":[22,296,327,360],"with":[23,118,130,136,198,222,235,283,297,328,361,371],"frontotemporal":[24,142],"lobar":[25],"degeneration":[26],"(FTLD).":[27],"Commonly":[28],"used":[29,211],"assays":[30,193],"include":[31],"positron":[32],"emission":[33],"tomography":[34],"(PET)":[35],"imaging":[36,80],"peripheral":[38,52,119,299,362],"blood":[39],"markers.":[40],"However,":[41],"PET":[42],"is":[43,102,345],"limited":[44],"by":[45,108,303],"radioactivity,":[46],"which":[47],"impedes":[48],"repeated":[49],"measurements,":[50],"while":[51],"markers":[53,186,363],"indirect":[55],"measures":[56],"of":[57,64,173,350,364],"neuropathology.":[58],"This":[59],"study":[60],"investigates":[61],"the":[62,97,163,199,252,269,291],"potential":[63],"proton":[65],"magnetic":[66],"resonance":[67],"spectroscopy":[68],"(MRS)":[69],"-":[70,82],"a":[71,170,181,298,346],"non-invasive":[72],"technique":[73],"that":[74,233],"can":[75],"be":[76],"deployed":[77],"alongside":[78],"structural":[79],"sequences":[81],"quantify":[84],"myo-inositol,":[85],"an":[86],"inflammatory":[87,185,231,300],"metabolite":[88],"found":[89],"astroglial":[91],"microglial":[93],"cells.":[94],"test":[96],"following":[98],"hypotheses":[99],"(1)":[100],"myo-inositol":[101,112,124,218,289,324,344],"elevated":[103,250],"brain":[105,115,127],"regions":[106,116,128,358],"affected":[107,114,126],"FTLD":[109,284],"disorders;":[110],"(2)":[111],"correlates":[117,129],"immune":[120],"markers;":[121],"(3)":[123],"cognitive":[131,372],"decline.":[132],"Methods":[133],"54":[134],"people":[135,282],"FTLD-associated":[137],"(29":[139],"behavioural":[140],"variant":[141],"dementia,":[143],"25":[144],"progressive":[145],"supranuclear":[146],"palsy)":[147],"73":[149],"age/sex-matched":[150],"controls":[151],"underwent":[152],"single-voxel":[153],"7":[154],"Tesla":[155],"MRS.":[156],"2cm":[157],"isotropic":[158],"voxels":[159],"were":[160,187,210,239,359],"placed":[161],"over":[162],"right":[164,176],"inferior":[165],"frontal":[166],"gyrus":[167],"(R":[168,179],"IFG,":[169],"disease-affected":[171,357],"region":[172],"interest),":[174],"occipital":[177],"lobe":[178],"OCC,":[180],"control":[182],"region).":[183],"Serum":[184],"measured":[188],"using":[189],"nucleic":[190],"acid-linked":[191],"immuno-sandwich":[192],"(NULISA).":[194],"Cognition":[195],"was":[196,249,294,325],"assessed":[197],"revised":[200],"Addenbrooke\u2019s":[201],"Cognitive":[202],"Examination":[203],"(ACE-R).":[204],"Mixed-effects":[205],"general":[207],"linear":[208,245],"models":[209],"evaluate":[213],"diagnostic":[214],"differences":[215],"regional":[217],"its":[220],"association":[221],"cognition.":[223],"Partial":[224],"least":[225],"squares":[226],"regression":[227],"identified":[228],"two":[229],"serum":[230],"components":[232,238],"covaried":[234],"myo-inositol;":[236],"these":[237],"subsequently":[240],"tested":[241],"confounder-adjusted":[243],"second-level":[244],"models.":[246],"Results":[247],"Myo-inositol":[248],"R":[253,270,292,322],"IFG":[254,293,323],"(\u03b2":[255,272,311,333],"=":[256,259,262,273,276,279,312,315,318,334,337,340],"0.20,":[257],"t":[258,275,314,336],"5.10,":[260],"p":[261,278,317,339],"8.8":[263],"\u00d7":[264,320],"10^-7)":[265],"but":[266],"not":[267],"OCC":[271],"0.05,":[274],"1.36,":[277],"0.18),":[280],"versus":[285],"controls.":[286],"In":[287],"FTLD,":[288],"positively":[295],"profile":[301],"characterised":[302],"IL-6,":[304],"IL-1\u03b2,":[305],"GFAP,":[306],"CSF2,":[307],"CRP,":[308],"CCL22":[310],"0.39,":[313],"5.12,":[316],"3.60":[319],"10^-6).":[321],"negatively":[326],"ACE-R":[329],"performance":[330],"patients":[332],"\u221244.59,":[335],"\u22124.12,":[338],"0.00016).":[341],"Conclusion":[342],"MRS-derived":[343],"promising":[347],"neuroimaging":[348],"biomarker":[349],"inflammation":[351,365],"FTLD.":[353],"Elevated":[354],"levels":[355],"(reflecting":[366],"astrocytosis":[367],"microgliosis)":[369],"impairment.":[373]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-21T00:00:00"}