{"id":"https://openalex.org/W7213755161","doi":"https://doi.org/10.7759/cureus.116592","title":"Prenatal Diagnosis of Alobar Holoprosencephaly With Cyclopia and Proboscis: A Case Report","display_name":"Prenatal Diagnosis of Alobar Holoprosencephaly With Cyclopia and Proboscis: A Case Report","publication_year":2026,"publication_date":"2026-09-20","ids":{"openalex":"https://openalex.org/W7213755161","doi":"https://doi.org/10.7759/cureus.116592","pmid":"https://pubmed.ncbi.nlm.nih.gov/42904174","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682412"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.116592","doi":"https://doi.org/10.7759/cureus.116592","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116592","pdf_url":"https://www.cureus.com/articles/529346-prenatal-diagnosis-of-alobar-holoprosencephaly-with-cyclopia-and-proboscis-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/529346-prenatal-diagnosis-of-alobar-holoprosencephaly-with-cyclopia-and-proboscis-a-case-report.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152290627","display_name":"Manisha Mahajan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manisha Mahajan","raw_affiliation_strings":["Department of Radiology, Government Medical College, Udhampur, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Government Medical College, Udhampur, IND","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146114546","display_name":"Varun Mahajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164371","display_name":"Government Medical College","ror":"https://ror.org/04y908s98","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164371"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Varun Mahajan","raw_affiliation_strings":["Department of General Surgery, Government Medical College, Jammu, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Government Medical College, Jammu, IND","institution_ids":["https://openalex.org/I4210164371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5146074336","display_name":"Chandla Nikita Kishore Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164371","display_name":"Government Medical College","ror":"https://ror.org/04y908s98","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164371"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandla Nikita Kishor Singh","raw_affiliation_strings":["Department of Anesthesia and Critical Care, Government Medical College, Jammu, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Government Medical College, Jammu, IND","institution_ids":["https://openalex.org/I4210164371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5146114546"],"corresponding_institution_ids":["https://openalex.org/I4210164371"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67425557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e116592","last_page":"e116592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alobar-holoprosencephaly","display_name":"alobar holoprosencephaly","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclopia","display_name":"cyclopia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proboscis","display_name":"proboscis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prenatal-ultrasound","display_name":"prenatal ultrasound","score":0.7210000157356262},{"id":"https://openalex.org/keywords/single-ventricle","display_name":"single ventricle","score":0.7879999876022339},{"id":"https://openalex.org/keywords/facial-anomalies","display_name":"facial anomalies","score":0.5820000171661377},{"id":"https://openalex.org/keywords/abortion","display_name":"abortion","score":0.7089999914169312},{"id":"https://openalex.org/keywords/fetal-brain-malformations","display_name":"fetal brain malformations","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2779491988","wikidata":"https://www.wikidata.org/wiki/Q1153284","display_name":"Cyclopia","level":5,"score":0.9659000039100647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9628999829292297},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.8108999729156494},{"id":"https://openalex.org/C2781374659","wikidata":"https://www.wikidata.org/wiki/Q1459821","display_name":"Holoprosencephaly","level":4,"score":0.8019999861717224},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.47530001401901245},{"id":"https://openalex.org/C2992981700","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital disease","level":2,"score":0.39969998598098755},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3950999975204468},{"id":"https://openalex.org/C2993153387","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic diagnosis","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.28360000252723694}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.116592","doi":"https://doi.org/10.7759/cureus.116592","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116592","pdf_url":"https://www.cureus.com/articles/529346-prenatal-diagnosis-of-alobar-holoprosencephaly-with-cyclopia-and-proboscis-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:42904174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42904174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682412","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682412/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.116592","doi":"https://doi.org/10.7759/cureus.116592","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116592","pdf_url":"https://www.cureus.com/articles/529346-prenatal-diagnosis-of-alobar-holoprosencephaly-with-cyclopia-and-proboscis-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213755161.pdf","grobid_xml":"https://content.openalex.org/works/W7213755161.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1965726990","https://openalex.org/W2002686561","https://openalex.org/W2015720648","https://openalex.org/W2083467596","https://openalex.org/W2087285048","https://openalex.org/W2135387476","https://openalex.org/W2160084771","https://openalex.org/W2269171550","https://openalex.org/W2803673148"],"related_works":["https://openalex.org/W7127110167","https://openalex.org/W2780283837","https://openalex.org/W1996099803","https://openalex.org/W3024294990","https://openalex.org/W4205455896","https://openalex.org/W3195583754","https://openalex.org/W6968234384","https://openalex.org/W2414288807","https://openalex.org/W7215915668","https://openalex.org/W3022151800"],"abstract_inverted_index":{"Alobar":[0],"holoprosencephaly":[1],"(HPE)":[2],"is":[3,109],"a":[4,23,27,37,43,60,65],"severe":[5,81],"developmental":[6],"abnormality":[7],"of":[8,34,86,101],"the":[9,80,87,89,99,103],"fetal":[10,104],"brain.":[11],"It":[12],"can":[13],"also":[14],"be":[15],"associated":[16],"with":[17,69],"major":[18],"facial":[19],"abnormalities.":[20],"We":[21],"report":[22],"case":[24,97],"diagnosed":[25],"during":[26],"routine":[28],"ultrasound":[29],"scan":[30],"at":[31,93],"22":[32],"weeks":[33],"pregnancy":[35,90],"in":[36],"26-year-old":[38],"G2P1L1":[39],"woman.":[40],"Ultrasound":[41],"showed":[42,59],"single":[44,61],"ventricular":[45],"cavity,":[46],"an":[47],"absent":[48],"interhemispheric":[49],"fissure":[50],"and":[51,54,64,83],"falx":[52],"cerebri,":[53],"fused":[55],"thalami.":[56],"Facial":[57],"examination":[58],"median":[62],"orbit":[63],"midline":[66],"proboscis,":[67],"consistent":[68],"cyclopia.":[70],"No":[71],"other":[72],"structural":[73],"abnormalities":[74],"were":[75],"seen.":[76],"After":[77],"counseling":[78],"about":[79],"nature":[82],"poor":[84],"prognosis":[85],"condition,":[88],"was":[91],"terminated":[92],"23":[94],"weeks.":[95],"This":[96],"highlights":[98],"importance":[100],"examining":[102],"face":[105],"when":[106],"alobar":[107],"HPE":[108],"suspected":[110],"on":[111],"ultrasound.":[112]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-21T00:00:00"}