{"id":"https://openalex.org/W7213744403","doi":"https://doi.org/10.1016/j.cmp.2026.09.006","title":"Beyond CD19: Engineering next-generation CAR-T cell therapies for leukemia","display_name":"Beyond CD19: Engineering next-generation CAR-T cell therapies for leukemia","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7213744403","doi":"https://doi.org/10.1016/j.cmp.2026.09.006"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmp.2026.09.006","doi":"https://doi.org/10.1016/j.cmp.2026.09.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmp.2026.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S88161469","display_name":"Current Molecular Pharmacology","issn_l":"1874-4672","issn":["1874-4672","1874-4702"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cmp.2026.09.006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030393843","display_name":"Tejveer Singh","orcid":"https://orcid.org/0000-0003-2289-3287","observed_orcids":["https://orcid.org/0000-0003-2289-3287"]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Tejveer Singh","raw_affiliation_strings":["Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124694458","display_name":"Aadipoojya Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aadipoojya Jain","raw_affiliation_strings":["Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042783544","display_name":"Monica Bohot","orcid":"https://orcid.org/0009-0003-7310-8629","observed_orcids":["https://orcid.org/0009-0003-7310-8629"]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Monica Bohot","raw_affiliation_strings":["Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi-110 007, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085290172","display_name":"Hardeep Singh Tuli","orcid":"https://orcid.org/0000-0003-1155-0094","observed_orcids":["https://orcid.org/0000-0003-1155-0094"]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hardeep Singh Tuli","raw_affiliation_strings":["Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala-133 207, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala-133 207, India","institution_ids":["https://openalex.org/I155284866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088157291","display_name":"Sabyasachi Banerjee","orcid":"https://orcid.org/0000-0003-0983-4012","observed_orcids":["https://orcid.org/0000-0003-0983-4012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabyasachi Banerjee","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, Asansol 713 301, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, Asansol 713 301, West Bengal, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152280705","display_name":"Sandra Maria Barbalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3131263933","display_name":"S\u00e3o Paulo State Technological College","ror":"https://ror.org/04z64b609","country_code":"BR","type":"education","lineage":["https://openalex.org/I3131263933"]},{"id":"https://openalex.org/I4210112693","display_name":"Universidade de Mar\u00edlia","ror":"https://ror.org/01w96sp43","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112693"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sandra Maria Barbalho","raw_affiliation_strings":["Charitable Hospital, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","School of Food and Technology of Marilia (FATEC), Marilia 17500-000, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charitable Hospital, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210112693"]},{"raw_affiliation_string":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210112693"]},{"raw_affiliation_string":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Mar\u00edlia 17525-902, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210112693"]},{"raw_affiliation_string":"School of Food and Technology of Marilia (FATEC), Marilia 17500-000, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I3131263933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044366032","display_name":"Rosa Direito","orcid":"https://orcid.org/0000-0002-4143-4302","observed_orcids":["https://orcid.org/0000-0002-4143-4302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa Direito","raw_affiliation_strings":["Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science, Research"],"raw_orcid":"https://orcid.org/0000-0002-4143-4302","affiliations":[{"raw_affiliation_string":"Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science, Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035380808","display_name":"Nicolette Casarcia","orcid":"https://orcid.org/0000-0002-6280-7841","observed_orcids":["https://orcid.org/0000-0002-6280-7841"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nicolette Casarcia","raw_affiliation_strings":["Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-6280-7841","affiliations":[{"raw_affiliation_string":"Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019852381","display_name":"Anupam Bishayee","orcid":"https://orcid.org/0000-0001-9159-960X","observed_orcids":["https://orcid.org/0000-0001-9159-960X"]},"institutions":[{"id":"https://openalex.org/I18241798","display_name":"Lake Erie College of Osteopathic Medicine","ror":"https://ror.org/04679fh62","country_code":"US","type":"education","lineage":["https://openalex.org/I18241798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anupam Bishayee","raw_affiliation_strings":["Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA"],"raw_orcid":"https://orcid.org/0000-0001-9159-960X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA","institution_ids":["https://openalex.org/I18241798"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019852381","https://openalex.org/A5030393843"],"corresponding_institution_ids":["https://openalex.org/I110166357","https://openalex.org/I18241798"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67931385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"1","first_page":"319","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.8650000095367432},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7549999952316284},{"id":"https://openalex.org/keywords/t-cell-engineering","display_name":"T cell engineering","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6704999804496765},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5644999742507935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5200999975204468},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45809999108314514},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26080000400543213}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cmp.2026.09.006","doi":"https://doi.org/10.1016/j.cmp.2026.09.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmp.2026.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S88161469","display_name":"Current Molecular Pharmacology","issn_l":"1874-4672","issn":["1874-4672","1874-4702"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:comum.rcaap.pt:10400.26/65203","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmp.2026.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S4306401666","display_name":"Reposit\u00f3rio Comum (Reposit\u00f3rio Cient\u00edfico de Acesso Aberto de Portugal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"contribution to journal"}],"best_oa_location":{"id":"doi:10.1016/j.cmp.2026.09.006","doi":"https://doi.org/10.1016/j.cmp.2026.09.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmp.2026.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S88161469","display_name":"Current Molecular Pharmacology","issn_l":"1874-4672","issn":["1874-4672","1874-4702"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Molecular Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9001173780","display_name":null,"funder_award_id":"F. No.44 T 2O24-25l D9cCRH-/Tech./Standardization of pre-clinical Estd. of IC 50 for HM/10240","funder_id":"https://openalex.org/F4320334559","funder_display_name":"Central Council for Research in Homeopathy, Ministry of AYUSH, Government of India"},{"id":"https://openalex.org/G9001174416","display_name":null,"funder_award_id":"File no. HRC/RDC/2021/RP/13","funder_id":"https://openalex.org/F4320337504","funder_display_name":"Research and Development"}],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320334559","display_name":"Central Council for Research in Homeopathy, Ministry of AYUSH, Government of India","ror":"https://ror.org/04qawwn42"},{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":258,"referenced_works":["https://openalex.org/W1604141497","https://openalex.org/W1969179435","https://openalex.org/W1994554141","https://openalex.org/W2003424912","https://openalex.org/W2017142033","https://openalex.org/W2017838975","https://openalex.org/W2025459290","https://openalex.org/W2047205338","https://openalex.org/W2056150267","https://openalex.org/W2094541971","https://openalex.org/W2110375406","https://openalex.org/W2110820382","https://openalex.org/W2115492737","https://openalex.org/W2115695360","https://openalex.org/W2127564987","https://openalex.org/W2135132221","https://openalex.org/W2138919007","https://openalex.org/W2140672398","https://openalex.org/W2141316572","https://openalex.org/W2143222328","https://openalex.org/W2148644851","https://openalex.org/W2153230055","https://openalex.org/W2159884655","https://openalex.org/W2169579205","https://openalex.org/W2287846520","https://openalex.org/W2291095621","https://openalex.org/W2324071661","https://openalex.org/W2328999771","https://openalex.org/W2395845086","https://openalex.org/W2443085751","https://openalex.org/W2472600861","https://openalex.org/W2575217117","https://openalex.org/W2595282393","https://openalex.org/W2596050358","https://openalex.org/W2617763104","https://openalex.org/W2688905162","https://openalex.org/W2725970815","https://openalex.org/W2743378753","https://openalex.org/W2783304290","https://openalex.org/W2787301955","https://openalex.org/W2789597391","https://openalex.org/W2791923357","https://openalex.org/W2796132930","https://openalex.org/W2796911502","https://openalex.org/W2805378765","https://openalex.org/W2888063816","https://openalex.org/W2890560416","https://openalex.org/W2895568978","https://openalex.org/W2897977935","https://openalex.org/W2906628163","https://openalex.org/W2909926298","https://openalex.org/W2911924604","https://openalex.org/W2912741252","https://openalex.org/W2915860404","https://openalex.org/W2922798588","https://openalex.org/W2949232578","https://openalex.org/W2950001186","https://openalex.org/W2970303738","https://openalex.org/W2975666914","https://openalex.org/W2977459329","https://openalex.org/W2987601351","https://openalex.org/W2990377810","https://openalex.org/W2991173924","https://openalex.org/W2995900562","https://openalex.org/W3002455949","https://openalex.org/W3003422194","https://openalex.org/W3009044390","https://openalex.org/W3009220797","https://openalex.org/W3012307045","https://openalex.org/W3022543485","https://openalex.org/W3029732767","https://openalex.org/W3029779858","https://openalex.org/W3030364558","https://openalex.org/W3031546681","https://openalex.org/W3033405009","https://openalex.org/W3038790873","https://openalex.org/W3045082925","https://openalex.org/W3046025665","https://openalex.org/W3047493249","https://openalex.org/W3080764569","https://openalex.org/W3083550593","https://openalex.org/W3084578525","https://openalex.org/W3094579387","https://openalex.org/W3114785916","https://openalex.org/W3119125259","https://openalex.org/W3124631812","https://openalex.org/W3129647653","https://openalex.org/W3135480995","https://openalex.org/W3148729173","https://openalex.org/W3158771720","https://openalex.org/W3159397045","https://openalex.org/W3162374648","https://openalex.org/W3165125118","https://openalex.org/W3174944011","https://openalex.org/W3197491604","https://openalex.org/W3199293208","https://openalex.org/W3212255992","https://openalex.org/W3214170273","https://openalex.org/W4205382255","https://openalex.org/W4206359416","https://openalex.org/W4211240333","https://openalex.org/W4214543218","https://openalex.org/W4220766750","https://openalex.org/W4220841520","https://openalex.org/W4220844749","https://openalex.org/W4220859730","https://openalex.org/W4221025990","https://openalex.org/W4225371279","https://openalex.org/W4232414730","https://openalex.org/W4280488282","https://openalex.org/W4280509433","https://openalex.org/W4281298264","https://openalex.org/W4285594746","https://openalex.org/W4285818038","https://openalex.org/W4287009494","https://openalex.org/W4292707568","https://openalex.org/W4295222616","https://openalex.org/W4295886460","https://openalex.org/W4296299339","https://openalex.org/W4296628476","https://openalex.org/W4303645565","https://openalex.org/W4308416671","https://openalex.org/W4309889967","https://openalex.org/W4310710436","https://openalex.org/W4311871033","https://openalex.org/W4319823715","https://openalex.org/W4320489868","https://openalex.org/W4321004253","https://openalex.org/W4322489522","https://openalex.org/W4366463122","https://openalex.org/W4367185145","https://openalex.org/W4375955899","https://openalex.org/W4376111591","https://openalex.org/W4376279929","https://openalex.org/W4376609041","https://openalex.org/W4377263775","https://openalex.org/W4381053243","https://openalex.org/W4383105325","https://openalex.org/W4383534104","https://openalex.org/W4385383529","https://openalex.org/W4385971952","https://openalex.org/W4386437887","https://openalex.org/W4386726075","https://openalex.org/W4386988733","https://openalex.org/W4387258693","https://openalex.org/W4388629721","https://openalex.org/W4388665568","https://openalex.org/W4388817556","https://openalex.org/W4389247126","https://openalex.org/W4389992017","https://openalex.org/W4390768346","https://openalex.org/W4390909128","https://openalex.org/W4392023369","https://openalex.org/W4392086580","https://openalex.org/W4392094024","https://openalex.org/W4392139685","https://openalex.org/W4392512960","https://openalex.org/W4392752098","https://openalex.org/W4392752305","https://openalex.org/W4392857092","https://openalex.org/W4392878640","https://openalex.org/W4392883395","https://openalex.org/W4393316267","https://openalex.org/W4394810127","https://openalex.org/W4396645734","https://openalex.org/W4396866005","https://openalex.org/W4396904465","https://openalex.org/W4399089115","https://openalex.org/W4399178964","https://openalex.org/W4399248658","https://openalex.org/W4399823271","https://openalex.org/W4400496502","https://openalex.org/W4400805568","https://openalex.org/W4401002391","https://openalex.org/W4401218782","https://openalex.org/W4401284904","https://openalex.org/W4401372023","https://openalex.org/W4401643697","https://openalex.org/W4402549512","https://openalex.org/W4402746875","https://openalex.org/W4403077325","https://openalex.org/W4403625091","https://openalex.org/W4405015723","https://openalex.org/W4405698384","https://openalex.org/W4406229010","https://openalex.org/W4406403290","https://openalex.org/W4406407057","https://openalex.org/W4406827410","https://openalex.org/W4407142945","https://openalex.org/W4407410660","https://openalex.org/W4407873167","https://openalex.org/W4408026520","https://openalex.org/W4408040503","https://openalex.org/W4408283632","https://openalex.org/W4408731387","https://openalex.org/W4408732921","https://openalex.org/W4408937901","https://openalex.org/W4409150582","https://openalex.org/W4409245612","https://openalex.org/W4409253276","https://openalex.org/W4409516705","https://openalex.org/W4409856605","https://openalex.org/W4409963977","https://openalex.org/W4410005953","https://openalex.org/W4410247803","https://openalex.org/W4410879972","https://openalex.org/W4410893761","https://openalex.org/W4411694436","https://openalex.org/W4411854946","https://openalex.org/W4411987245","https://openalex.org/W4412098777","https://openalex.org/W4413010921","https://openalex.org/W4413048561","https://openalex.org/W4413102410","https://openalex.org/W4413148564","https://openalex.org/W4413218964","https://openalex.org/W4413814744","https://openalex.org/W4413969858","https://openalex.org/W4414128324","https://openalex.org/W4414164036","https://openalex.org/W4414822948","https://openalex.org/W4415026723","https://openalex.org/W4415070042","https://openalex.org/W4415466889","https://openalex.org/W4415495349","https://openalex.org/W4415648830","https://openalex.org/W4415738217","https://openalex.org/W4415756814","https://openalex.org/W4415838633","https://openalex.org/W4416094950","https://openalex.org/W4416748260","https://openalex.org/W4417354471","https://openalex.org/W7116089214","https://openalex.org/W7117699236","https://openalex.org/W7117736833","https://openalex.org/W7118336650","https://openalex.org/W7119478263","https://openalex.org/W7119520963","https://openalex.org/W7121214235","https://openalex.org/W7123344844","https://openalex.org/W7124281403","https://openalex.org/W7124319440","https://openalex.org/W7124547421","https://openalex.org/W7125283456","https://openalex.org/W7125404385","https://openalex.org/W7126222927","https://openalex.org/W7128074366","https://openalex.org/W7129035874","https://openalex.org/W7131777503","https://openalex.org/W7135027556","https://openalex.org/W7135052084","https://openalex.org/W7135386848","https://openalex.org/W7160135124","https://openalex.org/W7160898924","https://openalex.org/W7161491927","https://openalex.org/W7162214206","https://openalex.org/W7164800790","https://openalex.org/W7165173110"],"related_works":["https://openalex.org/W2784245609","https://openalex.org/W4242235289","https://openalex.org/W6940870308","https://openalex.org/W4247819838","https://openalex.org/W4294931083","https://openalex.org/W4245570430","https://openalex.org/W4239616658","https://openalex.org/W4366544236","https://openalex.org/W3170465535","https://openalex.org/W3205775385"],"abstract_inverted_index":{"Despite":[0],"the":[1,9,12,17,24,28,52,58,72,76,87,143,152,164,204,213,228],"advances":[2],"made":[3],"in":[4,197],"treating":[5],"leukemia,":[6],"relapse":[7],"of":[8,14,60,80,100,145,154,167,193,222,231],"disease":[10],"and":[11,78,129,180,219],"development":[13],"resistance":[15],"to":[16,94,185,202,207],"treatments":[18],"that":[19,90],"were":[20],"utilized":[21],"still":[22],"plague":[23],"field":[25],"today,":[26],"indicating":[27],"need":[29],"for":[30,65,102,150,227],"next-generation":[31,106,223],"immunotherapies.":[32],"Chimeric":[33],"antigen":[34,64,178],"receptor":[35],"T":[36],"cell":[37,55,108,195,225],"(CAR-T)":[38],"therapy":[39,196],"has":[40],"markedly":[41],"transformed":[42],"leukemia":[43,66,232],"treatment,":[44,67],"emerging":[45,146],"as":[46,171,210,212],"a":[47],"promising":[48],"therapeutic":[49],"approach.":[50],"Beyond":[51,83],"conventional":[53],"CAR-T":[54,107,118,121,124,127,130,155,168,194,224],"engineering":[56,88,205],"targeting":[57],"cluster":[59],"differentiation":[61],"19":[62],"(CD19)":[63],"this":[68,103,199],"review":[69,104,161,200],"also":[70,158,162],"investigates":[71],"biological":[73],"mechanisms":[74],"behind":[75],"efficacy":[77],"failure":[79],"these":[81,84,96,208],"treatments.":[82],"analyses":[85],"are":[86],"innovations":[89],"have":[91],"been":[92],"created":[93],"overcome":[95],"mentioned":[97],"issues.":[98],"Areas":[99],"focus":[101],"include":[105],"engineering,":[109],"including":[110],"developments":[111],"utilizing":[112],"dual":[113],"targeting,":[114],"logic":[115],"gates,":[116],"armored":[117],"cells,":[119,122,125,128],"switchable":[120],"universal":[123],"allogeneic":[126],"cells":[131,156],"engineered":[132],"with":[133],"clustered":[134],"regularly":[135],"interspaced":[136],"short":[137],"palindromic":[138],"repeats":[139],"(CRISPR)":[140],"technologies.":[141],"Additionally,":[142],"role":[144],"artificial":[147],"intelligence-driven":[148],"strategies":[149],"improving":[151],"design":[153],"is":[157],"discussed.":[159],"This":[160],"highlights":[163],"significant":[165],"limitations":[166],"therapy,":[169],"such":[170],"high":[172],"cost,":[173],"cytokine":[174],"release":[175],"syndrome,":[176],"neurotoxicity,":[177],"escape,":[179],"resistance,":[181],"which":[182],"can":[183],"contribute":[184],"cancer":[186],"relapse.":[187],"Rather":[188],"than":[189],"providing":[190],"an":[191],"overview":[192],"general,":[198],"aims":[201],"discuss":[203],"solutions":[206],"barriers,":[209],"well":[211],"considerations":[214],"regarding":[215],"manufacturing,":[216],"accessibility,":[217],"regulation,":[218],"clinical":[220],"translation":[221],"therapies":[226],"precision":[229],"treatment":[230],"patients.":[233]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-21T00:00:00"}