{"id":"https://openalex.org/W7213668987","doi":"https://doi.org/10.64898/2026.09.16.752071","title":"An Artificial Intelligence Model for Longitudinal Assessment of TCR Repertoires in SARS-CoV-2 Vaccine Recipients","display_name":"An Artificial Intelligence Model for Longitudinal Assessment of TCR Repertoires in SARS-CoV-2 Vaccine Recipients","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213668987","doi":"https://doi.org/10.64898/2026.09.16.752071"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.16.752071","doi":"https://doi.org/10.64898/2026.09.16.752071","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752071","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752071.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752071.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022291659","display_name":"Zhonghuang Wang","orcid":"https://orcid.org/0000-0002-1268-883X","observed_orcids":["https://orcid.org/0000-0002-1268-883X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4405272711","display_name":"Changping Laboratory","ror":"https://ror.org/04kf84k17","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhonghuang Wang","raw_affiliation_strings":["AI for life sciences lab, Tencent, Shenzhen, China","Changping Laboratory, Beijing, P. R. China","National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI for life sciences lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]},{"raw_affiliation_string":"Changping Laboratory, Beijing, P. R. China","institution_ids":["https://openalex.org/I4405272711"]},{"raw_affiliation_string":"National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080161214","display_name":"Yu Shan Zhao","orcid":"https://orcid.org/0000-0001-8179-4903","observed_orcids":["https://orcid.org/0000-0001-8179-4903"]},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhao","raw_affiliation_strings":["AI for life sciences lab, Tencent, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI for life sciences lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152210570","display_name":"Xiao Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Xiao","raw_affiliation_strings":["Geneplus-Beijing Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing Institute, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129956315","display_name":"Bing He","orcid":"https://orcid.org/0000-0003-1719-9290","observed_orcids":["https://orcid.org/0000-0003-1719-9290"]},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing He","raw_affiliation_strings":["AI for life sciences lab, Tencent, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI for life sciences lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015529287","display_name":"Yanling Sun","orcid":"https://orcid.org/0000-0002-3175-3625","observed_orcids":["https://orcid.org/0000-0002-3175-3625"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Sun","raw_affiliation_strings":["National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102760391","display_name":"Shan Xiong","orcid":"https://orcid.org/0000-0001-5271-2825","observed_orcids":["https://orcid.org/0000-0001-5271-2825"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Xiong","raw_affiliation_strings":["Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056461668","display_name":"Chenchen Qin","orcid":"https://orcid.org/0009-0002-8663-1657","observed_orcids":["https://orcid.org/0009-0002-8663-1657"]},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenchen Qin","raw_affiliation_strings":["AI for life sciences lab, Tencent, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI for life sciences lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152241122","display_name":"Zhipeng Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhipeng Zhou","raw_affiliation_strings":["Geneplus-Beijing Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing Institute, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069064247","display_name":"Lianpeng Chang","orcid":"https://orcid.org/0000-0002-7649-2748","observed_orcids":["https://orcid.org/0000-0002-7649-2748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lianpeng Chang","raw_affiliation_strings":["Geneplus-Beijing Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing Institute, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152220390","display_name":"Jing Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Bai","raw_affiliation_strings":["Geneplus-Beijing Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing Institute, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152168306","display_name":"Wenming Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4405272711","display_name":"Changping Laboratory","ror":"https://ror.org/04kf84k17","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenming Zhao","raw_affiliation_strings":["Changping Laboratory, Beijing, P. R. China","National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changping Laboratory, Beijing, P. R. China","institution_ids":["https://openalex.org/I4405272711"]},{"raw_affiliation_string":"National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128823668","display_name":"Wenhua Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhua Liang","raw_affiliation_strings":["Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5152249514","display_name":"Jianhua Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Yao","raw_affiliation_strings":["AI for life sciences lab, Tencent, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI for life sciences lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022291659"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2250653659","https://openalex.org/I2801577699","https://openalex.org/I4405272711"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.578000009059906},{"id":"https://openalex.org/keywords/large-language-models","display_name":"large language models","score":0.640999972820282},{"id":"https://openalex.org/keywords/v-gene-usage","display_name":"V gene usage","score":0.6660000085830688},{"id":"https://openalex.org/keywords/antibody-levels","display_name":"antibody levels","score":0.5659999847412109},{"id":"https://openalex.org/keywords/longitudinal-immune-response","display_name":"longitudinal immune response","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.8672000169754028},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.701200008392334},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6481999754905701},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6438000202178955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5773000121116638},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5332000255584717},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.516700029373169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4480000138282776},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.37720000743865967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36000001430511475},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.3188000023365021},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.16.752071","doi":"https://doi.org/10.64898/2026.09.16.752071","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752071","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752071.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.16.752071","doi":"https://doi.org/10.64898/2026.09.16.752071","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752071","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752071.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1010740573","display_name":null,"funder_award_id":"32170678","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3564989049","display_name":null,"funder_award_id":"XDA0460203","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213668987.pdf","grobid_xml":"https://content.openalex.org/works/W7213668987.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W1989223689"],"related_works":["https://openalex.org/W4393222104","https://openalex.org/W7141509870","https://openalex.org/W4412111126","https://openalex.org/W4224232618","https://openalex.org/W7126122900","https://openalex.org/W4386446176","https://openalex.org/W4378906594","https://openalex.org/W4414742851","https://openalex.org/W4200463430","https://openalex.org/W4200087343"],"abstract_inverted_index":{"Abstract":[0],"T":[1,196],"cells":[2,197],"play":[3],"a":[4,58,149,158,178],"crucial":[5],"role":[6],"in":[7,15,71,113,172,200],"reducing":[8],"disease":[9],"severity":[10],"during":[11],"SARS-CoV-2":[12],"infection":[13],"and":[14,36,67,77,81,110,132,176,185,192,198,216],"shaping":[16],"long-term":[17],"immune":[18,24,87],"memory.":[19],"However,":[20],"the":[21,37,54,72,86,95,107,166,169,190,210,218],"precise":[22],"molecular":[23],"responses,":[25],"particularly":[26],"involving":[27],"T-cell":[28],"receptor":[29],"(TCR)":[30],"repertoire":[31],"changes":[32],"after":[33,82,106],"full":[34],"vaccination,":[35,83],"use":[38],"of":[39,89,97,161,168,195,213],"TCR":[40,73,183,228],"analysis":[41],"to":[42,63,103,117],"evaluate":[43],"vaccine":[44,150],"efficacy,":[45],"remain":[46],"incompletely":[47],"understood.":[48],"In":[49],"this":[50],"study,":[51],"we":[52,122,147],"developed":[53,148],"DeepAir-Cov19":[55],"model":[56,61,152,171],"(AUC=0.94),":[57],"large":[59,170],"language":[60],"tailored":[62],"identify":[64],"SARS-CoV-2-specific":[65,100,174,182,214],"TCRs,":[66],"observed":[68],"significant":[69],"differences":[70],"profiles":[74],"between":[75,181],"antibody-negative":[76],"antibody-positive":[78],"populations":[79],"before":[80],"indicating":[84],"that":[85,153],"status":[88],"pre-vaccine":[90],"recipients":[91],"can":[92],"directly":[93],"assess":[94],"efficacy":[96,151],"vaccination.":[98],"Notably,":[99],"TCRs":[101,143,175,215],"expanded":[102],"peak":[104],"levels":[105,156],"second":[108],"dose":[109],"remained":[111],"detectable":[112],"most":[114],"subjects":[115],"up":[116],"10":[118],"months":[119],"post-vaccination.":[120],"Meanwhile,":[121],"also":[123],"identified":[124],"three":[125],"specific":[126],"V":[127],"genes,":[128],"20":[129],"V-J":[130],"combinations,":[131],"3":[133],"epitopes":[134],"associated":[135],"with":[136,157],"these":[137,227],"responses.":[138],"Finally,":[139],"by":[140],"leveraging":[141],"vaccine-specific":[142],"as":[144],"novel":[145],"biomarkers,":[146],"predicts":[154],"antibody":[155,186],"mean":[159],"AUC":[160],"0.96.":[162],"These":[163],"findings":[164],"underscore":[165],"accuracy":[167],"predicting":[173],"reveal":[177],"strong":[179],"correlation":[180],"responses":[184],"levels.":[187],"This":[188],"highlights":[189],"complementary":[191],"synergistic":[193],"roles":[194],"antibodies":[199],"providing":[201],"vaccine-mediated":[202],"protection.":[203],"Our":[204],"results":[205],"offer":[206],"valuable":[207],"insights":[208],"into":[209],"longitudinal":[211],"dynamics":[212],"illustrate":[217],"potential":[219],"for":[220],"developing":[221],"potency":[222],"evaluation":[223],"models":[224],"based":[225],"on":[226],"insights.":[229]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-20T00:00:00"}