{"id":"https://openalex.org/W7213658286","doi":"https://doi.org/10.64898/2026.09.16.752086","title":"Polyamines control inorganic polyphosphate levels during bacterial nitrogen starvation","display_name":"Polyamines control inorganic polyphosphate levels during bacterial nitrogen starvation","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213658286","doi":"https://doi.org/10.64898/2026.09.16.752086","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596347"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.16.752086","doi":"https://doi.org/10.64898/2026.09.16.752086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752086.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049299641","display_name":"Jian Guan","orcid":"https://orcid.org/0000-0002-4671-7432","observed_orcids":["https://orcid.org/0000-0002-4671-7432"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Guan","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052091521","display_name":"Pavithra Mahadevan","orcid":"https://orcid.org/0000-0002-5459-5551","observed_orcids":["https://orcid.org/0000-0002-5459-5551"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavithra Mahadevan","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046177432","display_name":"Ursula Jakob","orcid":"https://orcid.org/0000-0002-4020-4572","observed_orcids":["https://orcid.org/0000-0002-4020-4572"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ursula Jakob","raw_affiliation_strings":["Department of Biological Chemistry, Michigan Medicine, Ann Arbor, MI, 48109","Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Michigan Medicine, Ann Arbor, MI, 48109","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 49109","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046177432"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.13619999587535858,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/inorganic-polyphosphate","display_name":"inorganic polyphosphate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nitrogen-starvation","display_name":"nitrogen starvation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":1.0},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polyamine-catabolism","display_name":"polyamine catabolism","score":0.847000002861023},{"id":"https://openalex.org/keywords/exopolyphosphatase","display_name":"exopolyphosphatase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bacterial-survival","display_name":"bacterial survival","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.754800021648407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.753600001335144},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5777999758720398},{"id":"https://openalex.org/C2780282346","wikidata":"https://www.wikidata.org/wiki/Q24774081","display_name":"Glycerol kinase","level":3,"score":0.555899977684021},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5503000020980835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5407000184059143},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.4668999910354614},{"id":"https://openalex.org/C2778038992","wikidata":"https://www.wikidata.org/wiki/Q420783","display_name":"Polyphosphate","level":3,"score":0.4535999894142151},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.439300000667572},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.42500001192092896},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.3921000063419342},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3666999936103821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3580999970436096},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.34940001368522644},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.3440999984741211},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.336899995803833},{"id":"https://openalex.org/C138463869","wikidata":"https://www.wikidata.org/wiki/Q14901436","display_name":"Starvation response","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C26628138","wikidata":"https://www.wikidata.org/wiki/Q22272147","display_name":"Stringent response","level":4,"score":0.3084000051021576},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2777008805","wikidata":"https://www.wikidata.org/wiki/Q2063923","display_name":"Inorganic pyrophosphatase","level":4,"score":0.2809000015258789},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.16.752086","doi":"https://doi.org/10.64898/2026.09.16.752086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596347","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779857/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.16.752086","doi":"https://doi.org/10.64898/2026.09.16.752086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000867079","display_name":"Exploring New Players in Proteostasis","funder_award_id":"R35GM122506","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213658286.pdf","grobid_xml":"https://content.openalex.org/works/W7213658286.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416402749","https://openalex.org/W4224999637","https://openalex.org/W2041166198","https://openalex.org/W3205455072","https://openalex.org/W2341696976","https://openalex.org/W2594398579","https://openalex.org/W2414981052","https://openalex.org/W2122225327","https://openalex.org/W7163386284","https://openalex.org/W2064199521"],"abstract_inverted_index":{"rapidly":[0],"accumulates":[1],"polyP,":[2],"which":[3,69,86],"drives":[4],"the":[5,75,94,112,119,124,129,161,169],"formation":[6],"of":[7,28,93,114,122,137],"RNA-protein":[8],"granules":[9],"that":[10,24,42,79,111,160],"sustain":[11],"long-term":[12],"survival.":[13],"What":[14],"triggers":[15],"this":[16],"upregulation":[17],"has":[18],"remained":[19],"unknown.":[20],"Here":[21],"we":[22,72],"show":[23],"polyamines,":[25,97],"a":[26,83,148],"group":[27],"highly":[29],"conserved,":[30],"amino":[31],"acid-derived":[32],"polycations,":[33],"regulate":[34],"polyP":[35,50,104,171],"accumulation":[36],"during":[37,51,106],"N":[38,60,107,165],"starvation.":[39,108],"We":[40,109],"found":[41,110],"deleting":[43],"all":[44],"nine":[45],"polyamine":[46,70,162],"biosynthesis":[47],"genes":[48],"elevates":[49],"exponential":[52],"growth":[53],"and":[54,158],"by":[55],"more":[56],"than":[57],"5-fold":[58],"under":[59],"starvation,":[61],"with":[62],"shorter":[63],"chains":[64],"preferentially":[65],"accumulating.":[66],"To":[67],"dissect":[68],"matters,":[71],"further":[73],"deleted":[74],"three":[76,95],"catabolic":[77],"enzymes":[78],"consume":[80],"polyamines":[81,115],"as":[82],"nitrogen":[84],"source,":[85],"enabled":[87],"complementation":[88],"assays.":[89],"Supplying":[90],"any":[91],"one":[92],"physiological":[96],"putrescine,":[98],"spermidine,":[99],"or":[100,128,140],"cadaverine,":[101],"restored":[102],"wild-type":[103],"levels":[105,121],"absence":[113],"did":[116],"not":[117],"affect":[118],"steady-state":[120],"either":[123],"polyP-synthesizing":[125],"kinase":[126],"PPK":[127],"exopolyphosphatase":[130],"PPX,":[131],"pointing":[132],"instead":[133],"to":[134,141,168],"post-translational":[135],"control":[136],"enzyme":[138],"activity":[139],"as-yet-unidentified":[142],"polyamine-dependent":[143],"regulators.":[144],"These":[145],"findings":[146],"establish":[147],"direct":[149],"metabolic":[150],"link":[151],"between":[152],"two":[153],"universal,":[154],"functionally":[155],"intertwined":[156],"biomolecules":[157],"suggest":[159],"decline":[163],"upon":[164],"starvation":[166],"contributes":[167],"observed":[170],"accumulation.":[172]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-20T00:00:00"}
