{"id":"https://openalex.org/W7213654582","doi":"https://doi.org/10.64898/2026.09.14.750524","title":"Genetic Variation in Organ System Decline Across the Drosophila Genetic Reference Panel","display_name":"Genetic Variation in Organ System Decline Across the Drosophila Genetic Reference Panel","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213654582","doi":"https://doi.org/10.64898/2026.09.14.750524"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.14.750524","doi":"https://doi.org/10.64898/2026.09.14.750524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.14.750524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.14.750524.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152161196","display_name":"James F Del Tito","orcid":"https://orcid.org/0009-0004-7976-1423","observed_orcids":["https://orcid.org/0009-0004-7976-1423"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James F. Del Tito","raw_affiliation_strings":["School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia"],"raw_orcid":"https://orcid.org/0009-0004-7976-1423","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041628955","display_name":"Lesley A. Alton","orcid":"https://orcid.org/0000-0002-4236-2494","observed_orcids":["https://orcid.org/0000-0002-4236-2494"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lesley A. Alton","raw_affiliation_strings":["School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4236-2494","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043122280","display_name":"Matthew D. W. Piper","orcid":"https://orcid.org/0000-0003-3245-7219","observed_orcids":["https://orcid.org/0000-0003-3245-7219"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew D. W. Piper","raw_affiliation_strings":["School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3245-7219","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065809766","display_name":"Christen Kerry Mirth","orcid":"https://orcid.org/0000-0002-9765-4021","observed_orcids":["https://orcid.org/0000-0002-9765-4021"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Christen K. Mirth","raw_affiliation_strings":["School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9765-4021","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Melbourne, Victoria, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065809766"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drosophila-genetic-reference-panel","display_name":"Drosophila Genetic Reference Panel","score":0.9390000104904175},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.6230000257492065},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.781000018119812},{"id":"https://openalex.org/keywords/physiological-decline","display_name":"physiological decline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/activity-rate","display_name":"activity rate","score":0.6079999804496765},{"id":"https://openalex.org/keywords/reproduction","display_name":"reproduction","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8016999959945679},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.6152999997138977},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5787000060081482},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.564300000667572},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5152999758720398},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.3912999927997589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.35019999742507935},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3345000147819519},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.3156000077724457},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C62277055","wikidata":"https://www.wikidata.org/wiki/Q295130","display_name":"Phenotypic plasticity","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C85721925","wikidata":"https://www.wikidata.org/wiki/Q31151","display_name":"Population genetics","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C2993807623","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genetic data","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.25999999046325684},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C539274931","wikidata":"https://www.wikidata.org/wiki/Q7895","display_name":"Reproductive system","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.14.750524","doi":"https://doi.org/10.64898/2026.09.14.750524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.14.750524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.14.750524","doi":"https://doi.org/10.64898/2026.09.14.750524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.14.750524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1191457249","display_name":" Predicting the energetic costs of climate warming for ectothermic animals","funder_award_id":"FT250100816","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G2866140521","display_name":null,"funder_award_id":"doi.org/10.82133/C42F-K220","funder_id":"https://openalex.org/F4320315885","funder_display_name":"Australian Government"},{"id":"https://openalex.org/G5957953577","display_name":null,"funder_award_id":"https://doi.org/10.82133/C42F-K220","funder_id":"https://openalex.org/F4320315885","funder_display_name":"Australian Government"},{"id":"https://openalex.org/G6477687251","display_name":null,"funder_award_id":"/10.82133/C42F-K220","funder_id":"https://openalex.org/F4320315885","funder_display_name":"Australian Government"},{"id":"https://openalex.org/G824476625","display_name":"Manipulative tests of metabolic theory","funder_award_id":"DP220103421","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213654582.pdf","grobid_xml":"https://content.openalex.org/works/W7213654582.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2091838922"],"related_works":["https://openalex.org/W4412392872","https://openalex.org/W3037153917","https://openalex.org/W2530382449","https://openalex.org/W2535079693","https://openalex.org/W2040090307","https://openalex.org/W2165469555","https://openalex.org/W2078309491","https://openalex.org/W2006369305","https://openalex.org/W1971689354","https://openalex.org/W4417087324"],"abstract_inverted_index":{"Abstract":[0],"Genetic":[1,85],"background":[2],"has":[3],"a":[4,18,49,111,182],"significant":[5],"impact":[6],"on":[7,36],"an":[8],"organism\u2019s":[9],"lifespan.":[10],"Underlying":[11],"this":[12],"metric,":[13],"ageing":[14,33,162],"is":[15],"characterised":[16],"by":[17,67],"sequence":[19],"of":[20,31,72,79,93,128,132,154,171,185],"physiological":[21,46,155],"systems":[22,75,105,174],"decline":[23,66,97,106,136,175],"that":[24,90,102,116,145,158],"leads":[25],"to":[26,51,57,178,180],"death.":[27],"Despite":[28],"this,":[29],"much":[30],"the":[32,40,70,77,83,91,159,169],"research":[34],"performed":[35],"model":[37],"organisms":[38],"in":[39,119,176],"lab":[41],"uses":[42],"lifespan,":[43],"rather":[44],"than":[45],"decline,":[47,156],"as":[48],"metric":[50],"measure":[52],"ageing.":[53,186],"Here,":[54],"we":[55],"sought":[56],"establish":[58],"if":[59],"differing":[60],"genotype":[61],"alters":[62],"age-related":[63],"organ":[64,74,95,104,134,173],"system":[65,135],"repeatedly":[68],"measuring":[69],"function":[71],"five":[73],"throughout":[76],"lifespan":[78,179],"19":[80],"lines":[81],"from":[82],"Drosophila":[84],"Reference":[86],"Panel.":[87],"We":[88,113],"found":[89],"magnitude":[92],"each":[94],"system\u2019s":[96],"differs":[98],"across":[99,139],"genotypes,":[100],"and":[101,122],"different":[103,108,148],"at":[107],"rates":[109],"within":[110],"genotype.":[112],"also":[114],"uncovered":[115],"while":[117],"declines":[118],"activity":[120],"rate":[121],"reproduction":[123],"were":[124],"associated":[125],"with":[126,147],"length":[127],"life,":[129],"overall":[130],"patterns":[131,153],"phenotypic":[133],"differed":[137],"significantly":[138],"genotypes.":[140],"Overall,":[141],"these":[142],"data":[143,167],"suggest":[144],"individuals":[146],"genetic":[149],"backgrounds":[150],"have":[151],"distinct":[152],"implying":[157],"mechanisms":[160],"driving":[161],"vary":[163],"between":[164],"individuals.":[165],"These":[166],"underscore":[168],"importance":[170],"studying":[172],"addition":[177],"gain":[181],"full":[183],"understanding":[184]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-20T00:00:00"}
