{"id":"https://openalex.org/W7213639150","doi":"https://doi.org/10.5281/zenodo.22850665","title":"Super-Refractory Status Epilepticus: Role of Ketamine Infusion and Neuroimmunomodulation in Refractory Seizure Control","display_name":"Super-Refractory Status Epilepticus: Role of Ketamine Infusion and Neuroimmunomodulation in Refractory Seizure Control","publication_year":2026,"publication_date":"2026-09-20","ids":{"openalex":"https://openalex.org/W7213639150","doi":"https://doi.org/10.5281/zenodo.22850665"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22850665","doi":"https://doi.org/10.5281/zenodo.22850665","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22850665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22850665","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152165932","display_name":"Nujeti Vishnu Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154281","display_name":"Institut Nalanda","ror":"https://ror.org/0468dv016","country_code":"ID","type":"education","lineage":["https://openalex.org/I4387154281"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nujeti Vishnu Kumar","raw_affiliation_strings":["Nalanda Institute of Pharmaceutical Sciences, kantepudi (v). Sattenapalli (m), Guntur (Dist.)- 522438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalanda Institute of Pharmaceutical Sciences, kantepudi (v). Sattenapalli (m), Guntur (Dist.)- 522438","institution_ids":["https://openalex.org/I4387154281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5152222738","display_name":"Gayam Ramprasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154281","display_name":"Institut Nalanda","ror":"https://ror.org/0468dv016","country_code":"ID","type":"education","lineage":["https://openalex.org/I4387154281"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Gayam Ramprasad","raw_affiliation_strings":["Nalanda Institute of Pharmaceutical Sciences, kantepudi (v). Sattenapalli (m), Guntur (Dist.)- 522438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalanda Institute of Pharmaceutical Sciences, kantepudi (v). Sattenapalli (m), Guntur (Dist.)- 522438","institution_ids":["https://openalex.org/I4387154281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387154281"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71826472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/super-refractory-status-epilepticus","display_name":"super-refractory status epilepticus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ketamine-infusion","display_name":"ketamine infusion","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuroimmunomodulation","display_name":"neuroimmunomodulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/refractory-seizures","display_name":"refractory seizures","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/autoimmune-epilepsy","display_name":"autoimmune epilepsy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.949999988079071},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.9810000061988831},{"id":"https://openalex.org/keywords/targeted-immunotherapy","display_name":"targeted immunotherapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.5669999718666077},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.828000009059906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7520999908447266},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5909000039100647},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.512499988079071},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4659000039100647},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.40939998626708984},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40470001101493835},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.3806999921798706},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36039999127388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3531000018119812},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2971000075340271},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2535000145435333},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5281/zenodo.22850665","doi":"https://doi.org/10.5281/zenodo.22850665","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22850665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22850665","doi":"https://doi.org/10.5281/zenodo.22850665","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22850665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8151540756225586}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3092719366","https://openalex.org/W4405005260","https://openalex.org/W4411769939","https://openalex.org/W4382450714","https://openalex.org/W4400102345","https://openalex.org/W4412896663","https://openalex.org/W3081900774","https://openalex.org/W4221049258","https://openalex.org/W3205947137","https://openalex.org/W4391111851"],"abstract_inverted_index":{"SRSE":[0,28,170],"(Super-Refractory":[1],"Status":[2],"Epilepticus)":[3],"can":[4,104],"be":[5,115,149],"defined":[6],"as":[7],"a":[8,107,164],"severe":[9],"neurological":[10],"emergency":[11],"involving":[12],"ongoing":[13],"or":[14],"repetitive":[15],"convulsions":[16],"despite":[17],"being":[18],"treated":[19],"with":[20,33,48,121,158],"established":[21],"types":[22],"of":[23,27,36,43,67,78,94,97,134,138,153,169,175,188],"medications.":[24],"The":[25,151],"basis":[26],"is":[29,180,191],"neuronal":[30],"hyperexcitability":[31],"along":[32],"disrupted":[34],"processes":[35,42,77,92,103],"inhibition":[37],"and":[38,46,90,101,145,171],"stimulation":[39,79],"in":[40,109,127],"neurotransmission,":[41],"transporting":[44],"receptors,":[45],"neuroinflammation":[47],"immune":[49],"system":[50],"influences.":[51],"Ketamine":[52,74],"substance":[53],"becomes":[54],"an":[55,125],"efficient":[56],"treatment,":[57],"especially":[58],"when":[59],"standard":[60],"anesthetics":[61],"(often":[62],"intended":[63],"to":[64,81,86,117,162,167,182],"stimulate":[65],"activity":[66],"the":[68,83,95,128,136,173,186,189],"neurotransmitter":[69],"GABA)":[70],"do":[71],"not":[72],"succeed.":[73],"affects":[75],"excessive":[76],"due":[80],"which":[82],"medication":[84],"allows":[85],"balance":[87],"between":[88],"inhibitory":[89],"excitatory":[91],"regardless":[93],"use":[96,137],"other":[98],"anesthetics.":[99],"Neuroinflammation":[100],"autoimmune":[102,122],"also":[105],"play":[106],"role":[108],"obtaining":[110],"refractoriness,":[111],"therefore":[112],"immunomodulatory":[113,159],"may":[114,148],"applied":[116],"see":[118],"whether":[119],"patients":[120],"etiology":[123],"have":[124],"improvement":[126],"clinical":[129],"situation.":[130],"Among":[131],"possible":[132],"methods":[133],"immunotherapy,":[135],"corticosteroids,":[139],"immunoglobulins":[140],"given":[141],"intravenously,":[142],"plasma":[143],"exchange,":[144],"targeted":[146],"immunotherapy":[147],"indicated.":[150],"possibility":[152],"applying":[154],"ketamine":[155],"infusion":[156],"together":[157],"therapy":[160],"seems":[161],"represent":[163],"feasible":[165],"approach":[166],"treatment":[168,190],"improving":[172],"quality":[174],"patients'":[176],"rehabilitation,":[177],"however,":[178],"it":[179],"necessary":[181],"remember":[183],"that":[184],"monitoring":[185],"outcomes":[187],"equally":[192],"important.":[193]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-20T00:00:00"}