{"id":"https://openalex.org/W7213636158","doi":"https://doi.org/10.1007/s00415-026-14140-1","title":"Clinical trials in non-ambulatory people with progressive multiple sclerosis: can the nine hole peg test step up as primary outcome measure?","display_name":"Clinical trials in non-ambulatory people with progressive multiple sclerosis: can the nine hole peg test step up as primary outcome measure?","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213636158","doi":"https://doi.org/10.1007/s00415-026-14140-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42763308"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-026-14140-1","doi":"https://doi.org/10.1007/s00415-026-14140-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00415-026-14140-1","pdf_url":null,"source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063224365","display_name":"Miguel D\u2019haeseleer","orcid":"https://orcid.org/0000-0003-4378-0089","observed_orcids":["https://orcid.org/0000-0003-4378-0089"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]},{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Miguel D\u2019Haeseleer","raw_affiliation_strings":["Department of Neurology, University Hospital Brussels, Brussels, Belgium","NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4378-0089","affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Brussels, Brussels, Belgium","institution_ids":["https://openalex.org/I4210126764"]},{"raw_affiliation_string":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023972995","display_name":"Eva M. M. Strijbis","orcid":"https://orcid.org/0000-0001-6705-5864","observed_orcids":["https://orcid.org/0000-0001-6705-5864"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eva M. M. Strijbis","raw_affiliation_strings":["Department of Neurology, MS Center Amsterdam, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, MS Center Amsterdam, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036008316","display_name":"Gary Cutter","orcid":"https://orcid.org/0000-0002-8455-980X","observed_orcids":["https://orcid.org/0000-0002-8455-980X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Cutter","raw_affiliation_strings":["Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069210256","display_name":"Laetitia della Faille","orcid":"https://orcid.org/0000-0002-4464-2617","observed_orcids":["https://orcid.org/0000-0002-4464-2617"]},"institutions":[{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laetitia della Faille","raw_affiliation_strings":["National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059101952","display_name":"Marie Beatrice D'hooghe","orcid":"https://orcid.org/0000-0002-0917-4176","observed_orcids":["https://orcid.org/0000-0002-0917-4176"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marie B. D\u2019hooghe","raw_affiliation_strings":["NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087909822","display_name":"Daphne Kos","orcid":"https://orcid.org/0000-0003-3566-2269","observed_orcids":["https://orcid.org/0000-0003-3566-2269"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]},{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Daphne Kos","raw_affiliation_strings":["Department of Neurology, University Hospital Brussels, Brussels, Belgium","Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium","NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Brussels, Brussels, Belgium","institution_ids":["https://openalex.org/I4210126764"]},{"raw_affiliation_string":"Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135480819","display_name":"Anne-Lotte Lison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]},{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne-Lotte Lison","raw_affiliation_strings":["Department of Neurology, University Hospital Brussels, Brussels, Belgium","National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Brussels, Brussels, Belgium","institution_ids":["https://openalex.org/I4210126764"]},{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006986534","display_name":"Jop P. Mostert","orcid":"https://orcid.org/0000-0003-3640-9935","observed_orcids":["https://orcid.org/0000-0003-3640-9935"]},"institutions":[{"id":"https://openalex.org/I4210152306","display_name":"Rijnstate Hospital","ror":"https://ror.org/0561z8p38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210152306"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jop Mostert","raw_affiliation_strings":["Department of Neurology, Rijnstate Hospital, Arnhem, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rijnstate Hospital, Arnhem, The Netherlands","institution_ids":["https://openalex.org/I4210152306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030665830","display_name":"Guy Nagels","orcid":"https://orcid.org/0000-0002-2597-0383","observed_orcids":["https://orcid.org/0000-0002-2597-0383"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Nagels","raw_affiliation_strings":["AIMS Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","Department of Neurology, University Hospital Brussels, Brussels, Belgium","NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIMS Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"Department of Neurology, University Hospital Brussels, Brussels, Belgium","institution_ids":["https://openalex.org/I4210126764"]},{"raw_affiliation_string":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010590003","display_name":"Pavle Repovic","orcid":"https://orcid.org/0000-0001-7358-6872","observed_orcids":["https://orcid.org/0000-0001-7358-6872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavle Repovic","raw_affiliation_strings":["Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015569020","display_name":"Bernard M.J. Uitdehaag","orcid":"https://orcid.org/0000-0002-9226-7364","observed_orcids":["https://orcid.org/0000-0002-9226-7364"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bernard M. J. Uitdehaag","raw_affiliation_strings":["Department of Neurology, MS Center Amsterdam, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, MS Center Amsterdam, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031225490","display_name":"Ann Van Remoortel","orcid":"https://orcid.org/0000-0003-1392-2891","observed_orcids":["https://orcid.org/0000-0003-1392-2891"]},"institutions":[{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ann Van Remoortel","raw_affiliation_strings":["National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025246248","display_name":"Jeroen Van Schependom","orcid":"https://orcid.org/0000-0003-1200-5872","observed_orcids":["https://orcid.org/0000-0003-1200-5872"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Van Schependom","raw_affiliation_strings":["AIMS Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","ETRO Department, Vrije Universiteit Brussel, Brussels, Belgium","NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIMS Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"ETRO Department, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007367251","display_name":"Marcus Werner Koch","orcid":"https://orcid.org/0000-0001-9972-5092","observed_orcids":["https://orcid.org/0000-0001-9972-5092"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I2802418778","display_name":"Foothills Medical Centre","ror":"https://ror.org/020wfrz93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802418778"]},{"id":"https://openalex.org/I4387154606","display_name":"National MS Center Melsbroek","ror":"https://ror.org/03dgx1q54","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4387154606"]}],"countries":["BE","CA"],"is_corresponding":false,"raw_author_name":"Marcus W. Koch","raw_affiliation_strings":["Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, AB, Canada","National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, AB, Canada","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I2802418778"]},{"raw_affiliation_string":"National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium","institution_ids":["https://openalex.org/I4387154606"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5063224365"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764","https://openalex.org/I4387154606"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"273","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-multiple-sclerosis","display_name":"progressive multiple sclerosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/non-ambulatory-patients","display_name":"non-ambulatory patients","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nine-hole-peg-test","display_name":"Nine-Hole Peg Test","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hand-function","display_name":"hand function","score":0.9760000109672546},{"id":"https://openalex.org/keywords/primary-outcomes","display_name":"primary outcomes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/clinical-trial-eligibility-criteria","display_name":"inclusion and exclusion criteria","score":0.5879999995231628},{"id":"https://openalex.org/keywords/expanded-disability-status-scale","display_name":"Expanded Disability Status Scale","score":0.8939999938011169},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.7689999938011169},{"id":"https://openalex.org/keywords/outcome-trajectories","display_name":"outcome trajectories","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8338000178337097},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6869999766349792},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.6421999931335449},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.578499972820282},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5080000162124634},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3808000087738037},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33959999680519104},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2955000102519989},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.26429998874664307},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.258899986743927}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006225","descriptor_name":"Hand","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00415-026-14140-1","doi":"https://doi.org/10.1007/s00415-026-14140-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00415-026-14140-1","pdf_url":null,"source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:42763308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42763308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:269629","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/(8515cb99-e58b-4cd6-9bd8-e4b3f3ad760c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1596675745","https://openalex.org/W1763205699","https://openalex.org/W1977086599","https://openalex.org/W2046941822","https://openalex.org/W2079556917","https://openalex.org/W2112165124","https://openalex.org/W2119408292","https://openalex.org/W2162978315","https://openalex.org/W2358364508","https://openalex.org/W2565433170","https://openalex.org/W2589005373","https://openalex.org/W2790816436","https://openalex.org/W2896014118","https://openalex.org/W3127250794","https://openalex.org/W3201687379","https://openalex.org/W3202909754","https://openalex.org/W4226087203","https://openalex.org/W4309374247","https://openalex.org/W4310064348","https://openalex.org/W4380291066","https://openalex.org/W4385683760","https://openalex.org/W4391870195","https://openalex.org/W4409640105","https://openalex.org/W4413337880","https://openalex.org/W4415234420","https://openalex.org/W4415566514","https://openalex.org/W7162638170"],"related_works":["https://openalex.org/W4310064348","https://openalex.org/W4416771781","https://openalex.org/W2589005373","https://openalex.org/W2914506108","https://openalex.org/W4404900849","https://openalex.org/W2988118413","https://openalex.org/W823595678","https://openalex.org/W3044520318","https://openalex.org/W4389446070","https://openalex.org/W7134954245"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-20T00:00:00"}