{"id":"https://openalex.org/W7213633497","doi":"https://doi.org/10.1080/14796694.2026.2730089","title":"Efficacy of anlotinib plus immune checkpoint inhibitors in soft-tissue sarcoma: systematic review and meta-analysis","display_name":"Efficacy of anlotinib plus immune checkpoint inhibitors in soft-tissue sarcoma: systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7213633497","doi":"https://doi.org/10.1080/14796694.2026.2730089","pmid":"https://pubmed.ncbi.nlm.nih.gov/42762479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733240"},"language":"en","primary_location":{"id":"doi:10.1080/14796694.2026.2730089","doi":"https://doi.org/10.1080/14796694.2026.2730089","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14796694.2026.2730089","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42762479/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042314337","display_name":"Ahmed Farid Gadelmawla","orcid":"https://orcid.org/0000-0002-5802-2291","observed_orcids":["https://orcid.org/0000-0002-5802-2291","https://orcid.org/0009-0009-7065-381X"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Farid Gadelmawla","raw_affiliation_strings":["Menoufia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Menoufia University","institution_ids":["https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111138815","display_name":"Ahmed A. Abo Elnaga","orcid":"https://orcid.org/0009-0004-6446-1313","observed_orcids":["https://orcid.org/0009-0004-6446-1313"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed A. Abo Elnaga","raw_affiliation_strings":["Mansoura University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansoura University","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152233058","display_name":"Abdullah Faisal Albukhari","orcid":"https://orcid.org/0009-0004-1482-4411","observed_orcids":["https://orcid.org/0009-0004-1482-4411"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Faisal Albukhari","raw_affiliation_strings":["King Abdulaziz University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz University","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137752944","display_name":"Raseel B. Almutairi","orcid":"https://orcid.org/0009-0005-0543-0127","observed_orcids":["https://orcid.org/0009-0005-0543-0127"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Raseel B. Almutairi","raw_affiliation_strings":["Imam Abdulrahman Bin Faisal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imam Abdulrahman Bin Faisal University","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152197518","display_name":"Basmah Alamri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Basmah Alamri","raw_affiliation_strings":["University of Jeddah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Jeddah","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119675338","display_name":"Sami Mohammed Alhuways","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sami Mohammed Alhuways","raw_affiliation_strings":["Umm Al-Qura University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Umm Al-Qura University","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152173392","display_name":"Fatemah Althaher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Fatemah Althaher","raw_affiliation_strings":["Arabian Gulf University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arabian Gulf University","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152203152","display_name":"Flwah Aloufi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Flwah Aloufi","raw_affiliation_strings":["Qassim University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qassim University","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152208782","display_name":"Abdullah Mohammed A. Alotaibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Mohammed A. Alotaibi","raw_affiliation_strings":["Taif University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taif University","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152220826","display_name":"Abdullah Alali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Alali","raw_affiliation_strings":["Qassim University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qassim University","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152205243","display_name":"Ali Almatri","orcid":"https://orcid.org/0009-0004-5517-4072","observed_orcids":["https://orcid.org/0009-0004-5517-4072"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali Almatri","raw_affiliation_strings":["King Saud University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120014014","display_name":"Hamad Althawadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hamad Althawadi","raw_affiliation_strings":["Imam Abdulrahman Bin Faisal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imam Abdulrahman Bin Faisal University","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104251503","display_name":"Abdullah Altamimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801911633","display_name":"King Fahd Medical City","ror":"https://ror.org/01jgj2p89","country_code":"SA","type":"funder","lineage":["https://openalex.org/I2801911633"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Altamimi","raw_affiliation_strings":["King Fahad Medical City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Fahad Medical City","institution_ids":["https://openalex.org/I2801911633"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5111138815"],"corresponding_institution_ids":["https://openalex.org/I159247623"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47689423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"22","first_page":"2717","last_page":"2731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anlotinib","display_name":"anlotinib","score":0.996999979019165},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.949999988079071},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.8610000014305115},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8371000289916992},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45210000872612},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3903000056743622},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.37070000171661377},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.3100999891757965},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.3068000078201294},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.288100004196167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.2721000015735626},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2556000053882599},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2531000077724457}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/14796694.2026.2730089","doi":"https://doi.org/10.1080/14796694.2026.2730089","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14796694.2026.2730089","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},{"id":"pmid:42762479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42762479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future oncology (London, England)","raw_type":"Systematic Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733240","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42762479/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13733240","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42762479/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1955072209","https://openalex.org/W1989263890","https://openalex.org/W2006202974","https://openalex.org/W2017044005","https://openalex.org/W2028370869","https://openalex.org/W2091601272","https://openalex.org/W2101776780","https://openalex.org/W2136344041","https://openalex.org/W2152070180","https://openalex.org/W2160060092","https://openalex.org/W2259955047","https://openalex.org/W2471940872","https://openalex.org/W2537836937","https://openalex.org/W2560438049","https://openalex.org/W2592144107","https://openalex.org/W2625310182","https://openalex.org/W2762797139","https://openalex.org/W2783070348","https://openalex.org/W2808043936","https://openalex.org/W2889570909","https://openalex.org/W2942454142","https://openalex.org/W2944423827","https://openalex.org/W2952836581","https://openalex.org/W2967300456","https://openalex.org/W2975424845","https://openalex.org/W2978795816","https://openalex.org/W2998268542","https://openalex.org/W3118615836","https://openalex.org/W3163838529","https://openalex.org/W3163990763","https://openalex.org/W3175051117","https://openalex.org/W3182110147","https://openalex.org/W4200406720","https://openalex.org/W4211038654","https://openalex.org/W4282923909","https://openalex.org/W4282928211","https://openalex.org/W4285097283","https://openalex.org/W4293109969","https://openalex.org/W4294032364","https://openalex.org/W4297473488","https://openalex.org/W4317906803","https://openalex.org/W4323566236","https://openalex.org/W4363676992","https://openalex.org/W4365515385","https://openalex.org/W4386019232","https://openalex.org/W4386091349","https://openalex.org/W4386471099","https://openalex.org/W4386558612","https://openalex.org/W4388081006","https://openalex.org/W4389793431","https://openalex.org/W4391138585","https://openalex.org/W4391612845","https://openalex.org/W4392801670","https://openalex.org/W4395115546","https://openalex.org/W4402106272","https://openalex.org/W4402407634","https://openalex.org/W4403418803","https://openalex.org/W4403761155","https://openalex.org/W4403849374","https://openalex.org/W4404759425","https://openalex.org/W4406253133","https://openalex.org/W4410564566","https://openalex.org/W4411222522","https://openalex.org/W4413791313","https://openalex.org/W4415589249"],"related_works":["https://openalex.org/W4297473488","https://openalex.org/W7212227025","https://openalex.org/W4403849374","https://openalex.org/W3128376340","https://openalex.org/W2891312861","https://openalex.org/W3007595469","https://openalex.org/W4391386678","https://openalex.org/W4286294442","https://openalex.org/W4306147499","https://openalex.org/W4416774459"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advanced":[1],"or":[2,44,73,164],"metastatic":[3,45,74,165],"soft-tissue":[4,46],"sarcoma":[5,47],"(STS)":[6],"responds":[7],"poorly":[8],"to":[9,33,65],"standard":[10],"chemotherapy.":[11],"Anlotinib":[12],"has":[13],"shown":[14],"activity":[15],"across":[16],"multiple":[17],"treatment":[18],"lines,":[19],"including":[20],"first-line":[21],"and":[22,59,114,126,135,172,179,204],"maintenance":[23],"therapies,":[24],"though":[25],"monotherapy":[26],"benefit":[27],"remains":[28,196],"limited.":[29],"This":[30],"study":[31],"aimed":[32],"quantify":[34],"the":[35,92,115,194],"efficacy":[36],"of":[37,56,61],"anlotinib":[38,78,171],"plus":[39,79],"PD-1/PD-L1":[40,81,173],"inhibitors":[41,174],"in":[42,89,130,144],"advanced":[43,72,163],"(STS).":[48],"METHODS:":[49],"We":[50],"conducted":[51],"a":[52,80],"PRISMA-adherent":[53],"systematic":[54],"review":[55],"PubMed,":[57],"Scopus,":[58],"Web":[60],"Science":[62],"from":[63],"inception":[64],"October":[66],"2025.":[67],"Studies":[68],"enrolling":[69],"adults":[70],"with":[71,77,141,170,191],"STS":[75,166],"treated":[76],"inhibitor":[82],"were":[83,87,102],"eligible.":[84],"Pooled":[85],"analyses":[86],"performed":[88],"R":[90],"using":[91],"meta":[93],"package":[94],"under":[95],"inverse-variance":[96],"random-effects":[97],"models.":[98],"RESULTS:":[99],"Seven":[100],"studies":[101],"included.":[103],"The":[104,149],"pooled":[105,116,150],"objective":[106,177],"response":[107],"rate":[108,119,155],"was":[109,120,156],"37.3%":[110],"(95%":[111,122,132,137,146,158],"CI,":[112,123,133,138,147,159],"17.0-60.4),":[113],"disease":[117,143,180],"control":[118],"77.2%":[121],"71.7-82.4).":[124],"Complete":[125],"partial":[127],"responses":[128,178],"occurred":[129],"4.3%":[131],"1.4-8.8)":[134],"29.9%":[136],"13.4-49.6),":[139],"respectively,":[140],"stable":[142],"50.6%":[145],"39.5-61.8).":[148],"6-month":[151],"progression-free":[152],"survival":[153],"(PFS-6)":[154],"61.1%":[157],"22.1-93.1).":[160],"CONCLUSION:":[161],"Among":[162],"cohorts,":[167],"combination":[168],"therapy":[169],"showed":[175],"encouraging":[176],"control.":[181],"These":[182],"outcomes":[183],"appeared":[184],"numerically":[185],"higher":[186],"than":[187],"those":[188],"historically":[189],"reported":[190],"monotherapy,":[192],"although":[193],"evidence":[195],"limited":[197],"by":[198],"small":[199],"sample":[200],"sizes,":[201],"non-randomized":[202],"designs,":[203],"histologic":[205],"heterogeneity.":[206],"PROTOCOL":[207],"REGISTRATION:":[208],"PROSPERO":[209],"(URL:":[210],"https://www.crd.york.ac.uk/PROSPERO/view/CRD420251232427),":[211],"identifier":[212],"is":[213],"CRD420251232427.":[214]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-20T00:00:00"}