{"id":"https://openalex.org/W7213633410","doi":"https://doi.org/10.1016/j.jcmgh.2026.101899","title":"Metabolic Dysfunction-Associated Steatohepatitis: Is There Evidence for Fractured CD4+ T-Cell Tolerance in the Immunopathogenesis","display_name":"Metabolic Dysfunction-Associated Steatohepatitis: Is There Evidence for Fractured CD4+ T-Cell Tolerance in the Immunopathogenesis","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213633410","doi":"https://doi.org/10.1016/j.jcmgh.2026.101899","pmid":"https://pubmed.ncbi.nlm.nih.gov/42762950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13734851"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcmgh.2026.101899","doi":"https://doi.org/10.1016/j.jcmgh.2026.101899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2026.101899","pdf_url":"https://www.cmghjournal.org/article/S2352-345X(26)00177-3/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cmghjournal.org/article/S2352-345X(26)00177-3/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016204738","display_name":"Abigail E. Russi","orcid":"https://orcid.org/0000-0003-4725-2574","observed_orcids":["https://orcid.org/0000-0003-4725-2574"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail E. Russi","raw_affiliation_strings":["Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; Riley Children's Health, Indianapolis, Indiana; Nutrition and Molecular Metabolism Center, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: abrussi@iu.edu"],"raw_orcid":"https://orcid.org/0000-0003-4725-2574","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; Riley Children's Health, Indianapolis, Indiana; Nutrition and Molecular Metabolism Center, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: abrussi@iu.edu","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069604908","display_name":"Brian J. DeBosch","orcid":"https://orcid.org/0000-0002-9924-7921","observed_orcids":["https://orcid.org/0000-0002-9924-7921"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. DeBosch","raw_affiliation_strings":["Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; Riley Children's Health, Indianapolis, Indiana; Nutrition and Molecular Metabolism Center, Indiana University School of Medicine, Indianapolis, Indiana; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":"https://orcid.org/0000-0002-9924-7921","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; Riley Children's Health, Indianapolis, Indiana; Nutrition and Molecular Metabolism Center, Indiana University School of Medicine, Indianapolis, Indiana; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016204738"],"corresponding_institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45548451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"101899","last_page":"101899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd4-t-cell-tolerance","display_name":"CD4+ T cell tolerance","score":0.906000018119812},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6187999844551086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4909000098705292},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.44830000400543213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3946000039577484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3490999937057495},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3483999967575073},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31220000982284546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3082999885082245},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2897999882698059},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2993178667","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Cd4 t cell","level":4,"score":0.2700999975204468},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C3017602531","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Lymphocyte activation","level":4,"score":0.25369998812675476}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jcmgh.2026.101899","doi":"https://doi.org/10.1016/j.jcmgh.2026.101899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2026.101899","pdf_url":"https://www.cmghjournal.org/article/S2352-345X(26)00177-3/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13734851","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734851/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734851/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Gastroenterol Hepatol","raw_type":"Text"},{"id":"pmid:42762950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42762950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1851ff208549456aadb6fba03fdc1e7e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1851ff208549456aadb6fba03fdc1e7e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology, Vol 21, Iss 1, Pp 101899-","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jcmgh.2026.101899","doi":"https://doi.org/10.1016/j.jcmgh.2026.101899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2026.101899","pdf_url":"https://www.cmghjournal.org/article/S2352-345X(26)00177-3/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306156","display_name":"Children's Cancer Research Fund","ror":"https://ror.org/02wv5fj21"},{"id":"https://openalex.org/F4320308400","display_name":"American Association for the Study of Liver Diseases","ror":"https://ror.org/005tjs461"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213633410.pdf","grobid_xml":"https://content.openalex.org/works/W7213633410.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W1498929362","https://openalex.org/W1526621387","https://openalex.org/W1533361575","https://openalex.org/W1601692989","https://openalex.org/W1669573844","https://openalex.org/W1905767043","https://openalex.org/W1918238463","https://openalex.org/W1966420007","https://openalex.org/W1967972402","https://openalex.org/W1971197010","https://openalex.org/W1977402753","https://openalex.org/W1992250154","https://openalex.org/W1996424780","https://openalex.org/W1998156781","https://openalex.org/W1999906527","https://openalex.org/W2002726823","https://openalex.org/W2003342633","https://openalex.org/W2010738373","https://openalex.org/W2012923140","https://openalex.org/W2023545075","https://openalex.org/W2030407395","https://openalex.org/W2049339608","https://openalex.org/W2055791442","https://openalex.org/W2060185417","https://openalex.org/W2062632117","https://openalex.org/W2069220094","https://openalex.org/W2069668308","https://openalex.org/W2072679758","https://openalex.org/W2090575179","https://openalex.org/W2091397894","https://openalex.org/W2097811455","https://openalex.org/W2107369528","https://openalex.org/W2115734680","https://openalex.org/W2116676186","https://openalex.org/W2120160949","https://openalex.org/W2134058536","https://openalex.org/W2135232490","https://openalex.org/W2135810789","https://openalex.org/W2135953421","https://openalex.org/W2137969636","https://openalex.org/W2141158324","https://openalex.org/W2149915530","https://openalex.org/W2164866097","https://openalex.org/W2165334726","https://openalex.org/W2166684781","https://openalex.org/W2169772102","https://openalex.org/W2178650688","https://openalex.org/W2204688218","https://openalex.org/W2210672989","https://openalex.org/W2219561900","https://openalex.org/W2280534244","https://openalex.org/W2289068089","https://openalex.org/W2395265369","https://openalex.org/W2567264284","https://openalex.org/W2595908170","https://openalex.org/W2608492464","https://openalex.org/W2616834626","https://openalex.org/W2795554754","https://openalex.org/W2804448077","https://openalex.org/W2807359581","https://openalex.org/W2807476445","https://openalex.org/W2808782057","https://openalex.org/W2884418958","https://openalex.org/W2894856581","https://openalex.org/W2905370254","https://openalex.org/W2915243531","https://openalex.org/W2917099874","https://openalex.org/W2944563907","https://openalex.org/W2970070032","https://openalex.org/W2979595830","https://openalex.org/W2980944208","https://openalex.org/W2987745771","https://openalex.org/W2990182987","https://openalex.org/W2990737360","https://openalex.org/W2992734068","https://openalex.org/W2997490540","https://openalex.org/W3000770138","https://openalex.org/W3013928862","https://openalex.org/W3017326172","https://openalex.org/W3023903811","https://openalex.org/W3034449644","https://openalex.org/W3085537009","https://openalex.org/W3092176013","https://openalex.org/W3092204743","https://openalex.org/W3109708108","https://openalex.org/W3118981406","https://openalex.org/W3131608869","https://openalex.org/W3133358914","https://openalex.org/W3134490967","https://openalex.org/W3138484572","https://openalex.org/W3139423362","https://openalex.org/W3140162710","https://openalex.org/W3159265081","https://openalex.org/W3160603270","https://openalex.org/W3164114613","https://openalex.org/W3175462888","https://openalex.org/W3193797930","https://openalex.org/W3195261594","https://openalex.org/W3199122562","https://openalex.org/W3200935965","https://openalex.org/W4220708949","https://openalex.org/W4221131751","https://openalex.org/W4248219898","https://openalex.org/W4281723938","https://openalex.org/W4283790172","https://openalex.org/W4284888085","https://openalex.org/W4295902096","https://openalex.org/W4308509809","https://openalex.org/W4312126384","https://openalex.org/W4312221280","https://openalex.org/W4315436354","https://openalex.org/W4320730824","https://openalex.org/W4323350886","https://openalex.org/W4323817405","https://openalex.org/W4362521281","https://openalex.org/W4377294019","https://openalex.org/W4380610023","https://openalex.org/W4381334607","https://openalex.org/W4381893710","https://openalex.org/W4386485345","https://openalex.org/W4387241971","https://openalex.org/W4387472657","https://openalex.org/W4387961489","https://openalex.org/W4388452323","https://openalex.org/W4391160549","https://openalex.org/W4391470391","https://openalex.org/W4392155053","https://openalex.org/W4392303931","https://openalex.org/W4393408133","https://openalex.org/W4394575457","https://openalex.org/W4394805741","https://openalex.org/W4394998618","https://openalex.org/W4398204506","https://openalex.org/W4400598504","https://openalex.org/W4400945319","https://openalex.org/W4402950065","https://openalex.org/W4403412719","https://openalex.org/W4405894528","https://openalex.org/W4406550554","https://openalex.org/W4407144113","https://openalex.org/W4408216529","https://openalex.org/W4409030382","https://openalex.org/W4410085891","https://openalex.org/W4410497939","https://openalex.org/W4411211873","https://openalex.org/W4411486961","https://openalex.org/W4412570330","https://openalex.org/W4413437261","https://openalex.org/W4413814840","https://openalex.org/W4414161433","https://openalex.org/W4414563692","https://openalex.org/W4415529019","https://openalex.org/W4415987187","https://openalex.org/W7124423770","https://openalex.org/W7129423151","https://openalex.org/W7140084927","https://openalex.org/W7140846755","https://openalex.org/W7151993801","https://openalex.org/W7154488134","https://openalex.org/W7160144961"],"related_works":["https://openalex.org/W7213559001","https://openalex.org/W7160144961","https://openalex.org/W7128695476","https://openalex.org/W7129423151","https://openalex.org/W4405065146","https://openalex.org/W4410163436","https://openalex.org/W4285589657","https://openalex.org/W4410138901","https://openalex.org/W4410721736","https://openalex.org/W4410173205"],"abstract_inverted_index":{"Metabolic":[0],"dysfunction-associated":[1,33,77,96,101],"liver":[2,21,48,97],"disease":[3,29,98],"is":[4,15],"defined":[5],"by":[6],"hepatic":[7,72],"steatosis":[8,40],"with":[9,41,79],"concomitant":[10],"metabolic":[11,32,76,95,100],"risk":[12],"factors":[13],"and":[14,43,51],"the":[16,28,68,71,92],"leading":[17],"cause":[18],"of":[19,26,70,91,94],"chronic":[20],"disease.":[22],"In":[23,63],"approximately":[24],"one-third":[25],"individuals,":[27],"progresses":[30],"to":[31,47,99],"steatohepatitis,":[34],"a":[35],"more":[36],"severe":[37],"form":[38],"encompassing":[39],"inflammation":[42,60],"hepatocellular":[44,52],"injury":[45],"predisposing":[46],"failure,":[49],"cirrhosis,":[50],"carcinoma.":[53],"The":[54],"mechanism(s)":[55],"responsible":[56],"for":[57],"this":[58,64],"aberrant":[59],"are":[61],"unknown.":[62],"review,":[65],"we":[66],"explore":[67],"breakdown":[69],"tolerogenic":[73],"environment":[74],"in":[75],"steatohepatitis":[78],"discussion":[80],"on":[81],"fractured":[82],"CD4+":[83],"T":[84],"cell":[85],"tolerance":[86],"as":[87],"an":[88],"integral":[89],"driver":[90],"progression":[93],"steatohepatitis.":[102]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-20T00:00:00"}
