{"id":"https://openalex.org/W7213626951","doi":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","title":"Effect of the Bioactive Nutritional Component Piperlongumine on Histone Deacetylase Enzyme Activity in Human Cancer and Normal Cells","display_name":"Effect of the Bioactive Nutritional Component Piperlongumine on Histone Deacetylase Enzyme Activity in Human Cancer and Normal Cells","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213626951","doi":"https://doi.org/10.18016/ksutarimdoga.vi.1735140"},"language":"tr","primary_location":{"id":"doi:10.18016/ksutarimdoga.vi.1735140","doi":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","is_oa":true,"landing_page_url":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","pdf_url":"http://dogadergi.ksu.edu.tr/en/download/article-file/5024287","source":{"id":"https://openalex.org/S4210204552","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","issn_l":"1309-1743","issn":["1309-1743","2619-9149"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://dogadergi.ksu.edu.tr/en/download/article-file/5024287","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004426871","display_name":"Sumeyye Bora","orcid":"https://orcid.org/0000-0002-5807-4788","observed_orcids":["https://orcid.org/0000-0002-5807-4788"]},"institutions":[{"id":"https://openalex.org/I25010766","display_name":"Hali\u00e7 University","ror":"https://ror.org/022xhck05","country_code":"TR","type":"education","lineage":["https://openalex.org/I25010766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sumeyye Bora","raw_affiliation_strings":["HAL\u0130\u00c7 \u00dcN\u0130VERS\u0130TES\u0130, SA\u011eLIK B\u0130L\u0130MLER\u0130 FAK\u00dcLTES\u0130, BESLENME VE D\u0130YETET\u0130K B\u00d6L\u00dcM\u00dc"],"raw_orcid":"https://orcid.org/0000-0002-5807-4788","affiliations":[{"raw_affiliation_string":"HAL\u0130\u00c7 \u00dcN\u0130VERS\u0130TES\u0130, SA\u011eLIK B\u0130L\u0130MLER\u0130 FAK\u00dcLTES\u0130, BESLENME VE D\u0130YETET\u0130K B\u00d6L\u00dcM\u00dc","institution_ids":["https://openalex.org/I25010766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033296641","display_name":"Hande Akalan","orcid":"https://orcid.org/0000-0002-5922-2498","observed_orcids":["https://orcid.org/0000-0002-5922-2498"]},"institutions":[{"id":"https://openalex.org/I40790370","display_name":"Yalova University","ror":"https://ror.org/01x18ax09","country_code":"TR","type":"education","lineage":["https://openalex.org/I40790370"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hande Akalan","raw_affiliation_strings":["YALOVA \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-5922-2498","affiliations":[{"raw_affiliation_string":"YALOVA \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I40790370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039915047","display_name":"Duygu Ya\u015far \u015eirin","orcid":"https://orcid.org/0000-0002-1224-442X","observed_orcids":["https://orcid.org/0000-0002-1224-442X"]},"institutions":[{"id":"https://openalex.org/I125454184","display_name":"Tekirda\u011f Nam\u0131k Kemal University","ror":"https://ror.org/01a0mk874","country_code":"TR","type":"education","lineage":["https://openalex.org/I125454184"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Duygu Ya\u015far \u015eirin","raw_affiliation_strings":["TEK\u0130RDA\u011e NAMIK KEMAL \u00dcN\u0130VERS\u0130TES\u0130, FEN-EDEB\u0130YAT FAK\u00dcLTES\u0130, B\u0130YOLOJ\u0130 B\u00d6L\u00dcM\u00dc"],"raw_orcid":"https://orcid.org/0000-0002-1224-442X","affiliations":[{"raw_affiliation_string":"TEK\u0130RDA\u011e NAMIK KEMAL \u00dcN\u0130VERS\u0130TES\u0130, FEN-EDEB\u0130YAT FAK\u00dcLTES\u0130, B\u0130YOLOJ\u0130 B\u00d6L\u00dcM\u00dc","institution_ids":["https://openalex.org/I125454184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055026727","display_name":"T\u00fcrker Bilgen","orcid":"https://orcid.org/0000-0002-3015-0929","observed_orcids":["https://orcid.org/0000-0002-3015-0929"]},"institutions":[{"id":"https://openalex.org/I125454184","display_name":"Tekirda\u011f Nam\u0131k Kemal University","ror":"https://ror.org/01a0mk874","country_code":"TR","type":"education","lineage":["https://openalex.org/I125454184"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"T\u00fcrker Bilgen","raw_affiliation_strings":["TEK\u0130RDA\u011e NAMIK KEMAL \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-3015-0929","affiliations":[{"raw_affiliation_string":"TEK\u0130RDA\u011e NAMIK KEMAL \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I125454184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"Advanced Online Publication","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperlongumine","display_name":"piperlongumine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hek293t-cells","display_name":"HEK293T cells","score":1.0},{"id":"https://openalex.org/keywords/cell-type-dependent-effects","display_name":"cell type-dependent effects","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.5839999914169312},{"id":"https://openalex.org/keywords/normal-cells","display_name":"normal cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.9478999972343445},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.8223999738693237},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7688000202178955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.605400025844574},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5681999921798706},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47760000824928284},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.43959999084472656},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4350000023841858},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.42010000348091125},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4147999882698059},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4036000072956085},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.39480000734329224},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3537999987602234},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.3343000113964081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32919999957084656},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.31929999589920044},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25600001215934753},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.2531000077724457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18016/ksutarimdoga.vi.1735140","doi":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","is_oa":true,"landing_page_url":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","pdf_url":"http://dogadergi.ksu.edu.tr/en/download/article-file/5024287","source":{"id":"https://openalex.org/S4210204552","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","issn_l":"1309-1743","issn":["1309-1743","2619-9149"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1735140","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/ksutarimdoga/article/1735140","pdf_url":null,"source":{"id":"https://openalex.org/S4210204552","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","issn_l":"1309-1743","issn":["1309-1743","2619-9149"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi, Vol. 29 No. Ek Say\u0131-1","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18016/ksutarimdoga.vi.1735140","doi":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","is_oa":true,"landing_page_url":"https://doi.org/10.18016/ksutarimdoga.vi.1735140","pdf_url":"http://dogadergi.ksu.edu.tr/en/download/article-file/5024287","source":{"id":"https://openalex.org/S4210204552","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","issn_l":"1309-1743","issn":["1309-1743","2619-9149"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi Tar\u0131m ve Do\u011fa Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213626951.pdf","grobid_xml":"https://content.openalex.org/works/W7213626951.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1135478979","https://openalex.org/W1966742872","https://openalex.org/W2043930391","https://openalex.org/W2046345187","https://openalex.org/W2050549679","https://openalex.org/W2067588084","https://openalex.org/W2088700542","https://openalex.org/W2092576475","https://openalex.org/W2102242260","https://openalex.org/W2115593774","https://openalex.org/W2165717337","https://openalex.org/W2271364972","https://openalex.org/W2579259829","https://openalex.org/W2805590406","https://openalex.org/W2810547043","https://openalex.org/W2912904861","https://openalex.org/W2999403306","https://openalex.org/W3011904377","https://openalex.org/W3023938347","https://openalex.org/W3102906640","https://openalex.org/W3111658536","https://openalex.org/W3137513475","https://openalex.org/W3152586787","https://openalex.org/W3154784084","https://openalex.org/W3154872799","https://openalex.org/W3200912530","https://openalex.org/W4212930582","https://openalex.org/W4224992972","https://openalex.org/W4313889618","https://openalex.org/W4396575842","https://openalex.org/W4398201135","https://openalex.org/W4405040543"],"related_works":["https://openalex.org/W6923461647","https://openalex.org/W3049736729","https://openalex.org/W2132493440","https://openalex.org/W2970012650","https://openalex.org/W4399173680","https://openalex.org/W1975837044","https://openalex.org/W4381308545","https://openalex.org/W2001527591","https://openalex.org/W1990414709","https://openalex.org/W2430576959"],"abstract_inverted_index":{"Currently,":[0],"the":[1,19,27,74,116,207],"effects":[2],"of":[3,21,29,46,84,112,191],"various":[4],"bioactive":[5],"compounds":[6],"on":[7,32,179],"Histone":[8],"Deacetylase":[9],"(HDAC)":[10],"enzyme":[11,34],"activity":[12,35,63,95,131,153,187,210],"are":[13],"being":[14],"investigated.":[15],"In":[16,146],"this":[17,22],"context,":[18],"aim":[20],"study":[23],"was":[24,64,96,132,141],"to":[25],"examine":[26],"effect":[28],"Piperlongumine":[30],"(PL)":[31],"HDAC":[33,62,94,117,130,152,186,209],"in":[36,41,70,91,98,129,134,143,156,164,185,203,212,219,228],"HeLa":[37,49,144,157,192],"and":[38,50,58,88,106,121,201,217,233],"HEK293T":[39,51,135,165,213],"cells":[40,79,101,158,214,230],"vitro.":[42,92],"The":[43,182],"IC\u2085\u2080":[44,82,110],"doses":[45,83,111],"PL":[47,85,113,123,171,200,221,225],"for":[48,86],"cell":[52,180],"lines":[53],"were":[54],"determined":[55],"using":[56,66],"MTT":[57],"AO/PI":[59],"staining":[60],"methods.":[61],"measured":[65],"a":[67,125,138,195],"commercial":[68],"kit":[69],"lysates":[71,99,147,193],"obtained":[72],"via":[73,175],"NETN":[75],"lysis":[76],"method":[77],"from":[78,100],"treated":[80,108,149],"with":[81,109,150],"24":[87],"48":[89],"hours":[90],"Additionally,":[93],"assessed":[97],"cultured":[102],"under":[103],"normal":[104,229],"conditions":[105],"directly":[107,148],"immediately":[114],"before":[115],"assay.":[118],"After":[119],"24-":[120,216],"48-hour":[122,218],"treatments,":[124],"statistically":[126],"significant":[127,162,183],"increase":[128,140,184],"observed":[133,211],"cells,":[136],"whereas":[137],"non-significant":[139],"found":[142],"cells.":[145,166,205],"PL,":[151],"significantly":[154],"increased":[155,208],"but":[159],"showed":[160],"no":[161],"change":[163],"These":[167],"findings":[168],"suggest":[169],"that":[170,224],"may":[172,226],"affect":[173],"HDACs":[174,202],"distinct":[176],"mechanisms":[177],"depending":[178],"type.":[181],"upon":[188],"direct":[189],"treatment":[190,222],"suggests":[194],"possible":[196],"physical":[197],"interaction":[198],"between":[199],"cancer":[204],"Conversely,":[206],"following":[215],"vitro":[220],"implies":[223],"act":[227],"through":[231],"indirect":[232],"delayed":[234],"pathways.":[235]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-20T00:00:00"}
