{"id":"https://openalex.org/W7213626523","doi":"https://doi.org/10.1159/ort/aecag008","title":"Immunotherapy with Pembrolizumab beyond Progression and Local Ablative Therapy in Oligoprogressive Metastatic Non-Small Cell Lung Cancer","display_name":"Immunotherapy with Pembrolizumab beyond Progression and Local Ablative Therapy in Oligoprogressive Metastatic Non-Small Cell Lung Cancer","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213626523","doi":"https://doi.org/10.1159/ort/aecag008","pmid":"https://pubmed.ncbi.nlm.nih.gov/42758663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713048"},"language":"en","primary_location":{"id":"doi:10.1159/ort/aecag008","doi":"https://doi.org/10.1159/ort/aecag008","is_oa":true,"landing_page_url":"https://doi.org/10.1159/ort/aecag008","pdf_url":"https://karger.com/ort/article-pdf/doi/10.1159/ort/aecag008/4585735/000554320.pdf","source":{"id":"https://openalex.org/S2769437601","display_name":"Oncology Research and Treatment","issn_l":"2296-5262","issn":["2296-5262","2296-5270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://karger.com/ort/article-pdf/doi/10.1159/ort/aecag008/4585735/000554320.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001886951","display_name":"Anton Oseledchyk","orcid":"https://orcid.org/0009-0008-8953-5103","observed_orcids":["https://orcid.org/0009-0008-8953-5103"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Anton Oseledchyk","raw_affiliation_strings":["Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland, anton.oseledchyk@usb.ch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland, anton.oseledchyk@usb.ch","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113497434","display_name":"Leopold H\u00e4cker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Leopold H\u00e4cker","raw_affiliation_strings":["Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011578307","display_name":"Andreas Michael Schmitt","orcid":"https://orcid.org/0000-0002-9568-8164","observed_orcids":["https://orcid.org/0000-0002-9568-8164"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Michael Schmitt","raw_affiliation_strings":["Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9568-8164","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077155140","display_name":"Till Wallrabenstein","orcid":"https://orcid.org/0000-0002-6672-3135","observed_orcids":["https://orcid.org/0000-0002-6672-3135"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Till Wallrabenstein","raw_affiliation_strings":["Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009398925","display_name":"Tobias Finazzi","orcid":"https://orcid.org/0000-0002-4118-4171","observed_orcids":["https://orcid.org/0000-0002-4118-4171"]},"institutions":[{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tobias Finazzi","raw_affiliation_strings":["Clinic of Radiotherapy and Radiation Oncology, Cantonal Hospital Baden, Baden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Radiotherapy and Radiation Oncology, Cantonal Hospital Baden, Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121343443","display_name":"D. K\u00f6nig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David K\u00f6nig","raw_affiliation_strings":["Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007155024","display_name":"Sacha I. Rothschild","orcid":"https://orcid.org/0000-0003-1304-9340","observed_orcids":["https://orcid.org/0000-0003-1304-9340"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sacha I. Rothschild","raw_affiliation_strings":["Center of Oncology, Hematology and Comprehensive Cancer Center, Cantonal Hospital Baden, Baden, Switzerland","Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Oncology, Hematology and Comprehensive Cancer Center, Cantonal Hospital Baden, Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]},{"raw_affiliation_string":"Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001886951"],"corresponding_institution_ids":["https://openalex.org/I2802542264"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.7919999957084656},{"id":"https://openalex.org/keywords/treatment-beyond-progression","display_name":"treatment beyond progression","score":0.8270000219345093},{"id":"https://openalex.org/keywords/local-ablative-therapy","display_name":"local ablative therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7160000205039978},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9589999914169312},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9110999703407288},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.9041000008583069},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.720300018787384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6851999759674072},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6183000206947327},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5745999813079834},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.4945000112056732},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4672999978065491},{"id":"https://openalex.org/C19617505","wikidata":"https://www.wikidata.org/wiki/Q156986","display_name":"Ablative case","level":3,"score":0.4027999937534332},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.36800000071525574},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.3375000059604645},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3321000039577484},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.32010000944137573},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.2944999933242798},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2921000123023987},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.2865999937057495},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.28529998660087585},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.2547000050544739}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1159/ort/aecag008","doi":"https://doi.org/10.1159/ort/aecag008","is_oa":true,"landing_page_url":"https://doi.org/10.1159/ort/aecag008","pdf_url":"https://karger.com/ort/article-pdf/doi/10.1159/ort/aecag008/4585735/000554320.pdf","source":{"id":"https://openalex.org/S2769437601","display_name":"Oncology Research and Treatment","issn_l":"2296-5262","issn":["2296-5262","2296-5270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research and Treatment","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5163365","doi":"https://doi.org/10.2139/ssrn.5163365","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5163365","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42758663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42758663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology research and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713048","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713048/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Res Treat","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1159/ort/aecag008","doi":"https://doi.org/10.1159/ort/aecag008","is_oa":true,"landing_page_url":"https://doi.org/10.1159/ort/aecag008","pdf_url":"https://karger.com/ort/article-pdf/doi/10.1159/ort/aecag008/4585735/000554320.pdf","source":{"id":"https://openalex.org/S2769437601","display_name":"Oncology Research and Treatment","issn_l":"2296-5262","issn":["2296-5262","2296-5270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213626523.pdf","grobid_xml":"https://content.openalex.org/works/W7213626523.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2527905628","https://openalex.org/W2791856118","https://openalex.org/W2796582438","https://openalex.org/W2890203489","https://openalex.org/W2892640821","https://openalex.org/W2915440885","https://openalex.org/W2944301866","https://openalex.org/W2996784175","https://openalex.org/W2997721110","https://openalex.org/W3007099934","https://openalex.org/W3016776807","https://openalex.org/W3019405611","https://openalex.org/W3019546741","https://openalex.org/W3032651552","https://openalex.org/W3042573404","https://openalex.org/W3116660326","https://openalex.org/W3154081418","https://openalex.org/W3165293110","https://openalex.org/W4210289312","https://openalex.org/W4283697056","https://openalex.org/W4316810205","https://openalex.org/W4320517213","https://openalex.org/W4361768994","https://openalex.org/W4387208131","https://openalex.org/W4389086456","https://openalex.org/W4389752877","https://openalex.org/W4401432696","https://openalex.org/W4407913168"],"related_works":["https://openalex.org/W4408211833","https://openalex.org/W3215387979","https://openalex.org/W3047911379","https://openalex.org/W4386811547","https://openalex.org/W3138626659","https://openalex.org/W3135876207","https://openalex.org/W4401432696","https://openalex.org/W7155878664","https://openalex.org/W4415199632","https://openalex.org/W3116660326"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Immune":[1],"checkpoint":[2],"inhibitors":[3],"(ICIs)":[4],"targeting":[5],"PD-(L)1":[6],"are":[7],"standard":[8],"first-line":[9,64,107],"treatment":[10,55,82,87,197,227],"for":[11,136],"non-oncogene-addicted":[12],"metastatic":[13],"non-small":[14],"cell":[15],"lung":[16],"cancer":[17],"(mNSCLC).":[18],"While":[19],"disease":[20,77,112,129],"progression":[21,78,84,165,177],"typically":[22],"requires":[23],"therapy":[24,66],"change,":[25],"patients":[26,62,105,221],"with":[27,37,75,202],"oligoprogression":[28],"(\u22645":[29],"progressing":[30],"sites)":[31],"often":[32],"continue":[33],"ICI":[34,108],"in":[35,141],"combination":[36],"local":[38],"ablative":[39],"therapies.":[40],"In":[41,193],"this":[42,54,194,226],"retrospective":[43,195],"study,":[44],"we":[45],"aimed":[46],"to":[47,163,207,214,219],"evaluate":[48],"the":[49,142],"characteristics":[50,97,130],"and":[51,98,122,128,173,189,216],"outcomes":[52],"of":[53,159],"approach.":[56,228],"METHODS:":[57],"We":[58,94],"retrospectively":[59],"analyzed":[60],"mNSCLC":[61],"receiving":[63,106],"ICI-based":[65],"at":[67],"University":[68],"Hospital":[69],"Basel":[70],"(January":[71],"2016-March":[72],"2022).":[73],"Patients":[74],"documented":[76],"were":[79,131,185],"categorized":[80],"into":[81],"beyond":[83],"(BPD),":[85],"second-line":[86],"(2L),":[88],"or":[89],"best":[90],"supportive":[91],"care":[92],"(BSC).":[93],"compared":[95,206],"patient":[96],"overall":[99],"survival":[100],"(OS).":[101],"RESULTS:":[102],"Of":[103],"104":[104],"treatment,":[109],"65":[110],"experienced":[111],"progression:":[113],"21":[114],"(32%)":[115],"received":[116,120,125],"BPD,":[117],"30":[118],"(46%)":[119],"2L,":[121],"14":[123],"(22%)":[124],"BSC.":[126],"Patient":[127],"similar":[132,186],"across":[133],"groups,":[134],"except":[135],"higher":[137],"brain":[138],"metastasis":[139],"frequency":[140],"BPD":[143,188,198],"group":[144],"(BPD:":[145],"67%":[146],"vs.":[147,150,167,179],"2L:":[148],"20%":[149],"BSC:":[151],"29%;":[152],"p":[153,170,182],"=":[154,171,183],"0.002).":[155],"After":[156],"median":[157,174],"follow-up":[158],"17.9":[160],"months,":[161,169,181],"time":[162],"first":[164],"(5.4":[166],"5.3":[168],"0.5)":[172],"OS":[175],"after":[176],"(9.1":[178],"10.9":[180],"0.35)":[184],"between":[187],"2L":[190,208],"groups.":[191],"CONCLUSION:":[192],"analysis,":[196],"was":[199],"not":[200],"associated":[201],"an":[203],"improved":[204],"prognosis":[205],"therapy.":[209],"There":[210],"is":[211],"a":[212],"need":[213],"improve":[215],"implement":[217],"criteria":[218],"select":[220],"who":[222],"truly":[223],"benefit":[224],"from":[225]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-20T00:00:00"}