{"id":"https://openalex.org/W7213622656","doi":"https://doi.org/10.1111/dmcn.70534","title":"The utility of the term \u2018Rett\u2010like\u2019 in relation to Rett syndrome: A systematic review","display_name":"The utility of the term \u2018Rett\u2010like\u2019 in relation to Rett syndrome: A systematic review","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213622656","doi":"https://doi.org/10.1111/dmcn.70534","pmid":"https://pubmed.ncbi.nlm.nih.gov/42762077"},"language":"en","primary_location":{"id":"doi:10.1111/dmcn.70534","doi":"https://doi.org/10.1111/dmcn.70534","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.70534","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.70534","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine & Child Neurology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.70534","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114199982","display_name":"Anahita Khot","orcid":"https://orcid.org/0009-0001-2739-4092","observed_orcids":["https://orcid.org/0009-0001-2739-4092"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I4210144851","display_name":"Evelina London Children's Healthcare","ror":"https://ror.org/058pgtg13","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805","https://openalex.org/I4210144851"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anahita Khot","raw_affiliation_strings":["Rett Syndrome Clinic, Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust  London UK"],"raw_orcid":"https://orcid.org/0009-0001-2739-4092","affiliations":[{"raw_affiliation_string":"Rett Syndrome Clinic, Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust  London UK","institution_ids":["https://openalex.org/I200166805","https://openalex.org/I4210144851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004556780","display_name":"Daniel Edward Lumsden","orcid":"https://orcid.org/0000-0002-5524-6177","observed_orcids":["https://orcid.org/0000-0002-5524-6177"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I4210144851","display_name":"Evelina London Children's Healthcare","ror":"https://ror.org/058pgtg13","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805","https://openalex.org/I4210144851"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel E Lumsden","raw_affiliation_strings":["Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences King's College London  London UK","Rett Syndrome Clinic, Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0002-5524-6177","affiliations":[{"raw_affiliation_string":"Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences King's College London  London UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Rett Syndrome Clinic, Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust  London UK","institution_ids":["https://openalex.org/I200166805","https://openalex.org/I4210144851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004556780"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I200166805","https://openalex.org/I4210144851"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":{"value":5300,"currency":"USD","value_usd":5300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67058824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.7390000224113464},{"id":"https://openalex.org/keywords/developmental-regression","display_name":"developmental regression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/stereotypic-hand-movements","display_name":"stereotypic hand movements","score":0.7120000123977661},{"id":"https://openalex.org/keywords/gait-disturbance","display_name":"gait disturbance","score":0.9039999842643738},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.875},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.5910000205039978},{"id":"https://openalex.org/keywords/developmental-disabilities","display_name":"developmental disabilities","score":0.5429999828338623},{"id":"https://openalex.org/keywords/diagnostic-value","display_name":"diagnostic value","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2777543196","wikidata":"https://www.wikidata.org/wiki/Q917357","display_name":"Rett syndrome","level":3,"score":0.866599977016449},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.7013999819755554},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.531000018119812},{"id":"https://openalex.org/C2779760435","wikidata":"https://www.wikidata.org/wiki/Q5396169","display_name":"Minor (academic)","level":2,"score":0.4275999963283539},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4269999861717224},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.42170000076293945},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.39649999141693115},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.37209999561309814},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3677000105381012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3555999994277954},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.3490999937057495},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3237000107765198},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.2806999981403351},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2766000032424927},{"id":"https://openalex.org/C2778594975","wikidata":"https://www.wikidata.org/wiki/Q3087172","display_name":"Developmental disorder","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.2612000107765198},{"id":"https://openalex.org/C2909602630","wikidata":"https://www.wikidata.org/wiki/Q179630","display_name":"Genetic syndromes","level":2,"score":0.2563999891281128}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/dmcn.70534","doi":"https://doi.org/10.1111/dmcn.70534","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.70534","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.70534","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine & Child Neurology","raw_type":"journal-article"},{"id":"pmid:42762077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42762077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental medicine and child neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/dmcn.70534","doi":"https://doi.org/10.1111/dmcn.70534","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.70534","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.70534","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine & Child Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5307787656784058,"display_name":"Quality education","id":"https://metadata.un.org/sdg/4"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213622656.pdf","grobid_xml":"https://content.openalex.org/works/W7213622656.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2042298663","https://openalex.org/W2069466371","https://openalex.org/W2074385487","https://openalex.org/W2131214833","https://openalex.org/W2154057943","https://openalex.org/W2156098321","https://openalex.org/W2469126403","https://openalex.org/W2604808360","https://openalex.org/W2773336881","https://openalex.org/W2783041817","https://openalex.org/W2785755264","https://openalex.org/W2905102681","https://openalex.org/W2941295441","https://openalex.org/W2943681271","https://openalex.org/W2949692005","https://openalex.org/W2959892584","https://openalex.org/W3171849985","https://openalex.org/W4239393537","https://openalex.org/W4402553736"],"related_works":[],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"clinical":[3,8,26,78],"features":[4,37,79],"and":[5,54,74,81,106,113,122,161],"evaluate":[6],"the":[7,11,25,41,67,82],"utility":[9,172],"of":[10,51,103,119,155,173,183,188],"term":[12,142,175],"'Rett-like',":[13],"which":[14,70],"is":[15,169,176],"commonly":[16,144],"used":[17],"to":[18,69,180],"describe":[19],"individuals":[20,62,90,147],"who":[21],"do":[22],"not":[23],"meet":[24],"criteria":[27,128],"for":[28],"a":[29,107],"Rett":[30],"syndrome":[31],"(RTT)":[32],"diagnosis,":[33],"but":[34],"exhibit":[35],"some":[36],"in":[38],"keeping":[39],"with":[40,100,148,152,157,178],"diagnosis.":[42],"METHOD:":[43],"A":[44,131],"systematic":[45],"review":[46],"was":[47],"conducted.":[48],"Literature":[49],"searches":[50],"Medline,":[52],"CINAHL,":[53],"Embase":[55],"(January":[56],"2010-December":[57],"2025)":[58],"were":[59,91,96,116,124,129],"performed,":[60],"identifying":[61],"described":[63,92],"as":[64,93],"Rett-like,":[65],"examining":[66],"extent":[68],"they":[71],"met":[72],"major":[73],"minor":[75],"RTT":[76,127],"criteria,":[77],"defined,":[80],"linked":[83],"genetic":[84,133,164],"landscape.":[85],"RESULTS:":[86],"In":[87],"total,":[88],"166":[89],"Rett-like;":[94],"these":[95],"predominantly":[97],"female,":[98],"most":[99],"no":[101,153,181],"period":[102,154],"typical":[104],"development,":[105],"minority":[108],"experienced":[109],"regression.":[110],"Gait":[111],"abnormalities":[112],"hand":[114,120],"stereotypies":[115],"common;":[117],"loss":[118],"skills":[121],"speech":[123],"not.":[125],"Minor":[126],"uncommon.":[130],"wide":[132],"landscape":[134,165],"emerged,":[135],"encompassing":[136,166],"47":[137],"different":[138],"genes.":[139],"INTERPRETATION:":[140],"The":[141,163],"'Rett-like'":[143],"describes":[145],"female":[146],"developmental":[149],"disability,":[150],"typically":[151],"regression,":[156],"stereotypies,":[158],"abnormal":[159],"gait,":[160],"seizures.":[162],"this":[167,174],"disorder":[168],"broad.":[170],"Clinical":[171],"limited,":[177],"little":[179],"evidence":[182],"diagnostic":[184],"or":[185],"prognostic":[186],"use":[187],"'Rett-like'.":[189]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-09-20T00:00:00"}