{"id":"https://openalex.org/W7213620900","doi":"https://doi.org/10.1016/j.cllc.2026.09.004","title":"Assessment of Prognostic Value of CEACAM5 Expression Using Archival Tissue and Real-World Evidence of Metastatic Patients with NSCLC in United States","display_name":"Assessment of Prognostic Value of CEACAM5 Expression Using Archival Tissue and Real-World Evidence of Metastatic Patients with NSCLC in United States","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213620900","doi":"https://doi.org/10.1016/j.cllc.2026.09.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/42879962"},"language":"en","primary_location":{"id":"doi:10.1016/j.cllc.2026.09.004","doi":"https://doi.org/10.1016/j.cllc.2026.09.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2026.09.004","pdf_url":null,"source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cllc.2026.09.004","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158800783","display_name":"Ashok Krishna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ashok Krishna","raw_affiliation_strings":["Sanofi, Cambridge, MA, USA. Electronic address: ashok.krishna@sanofi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, MA, USA. Electronic address: ashok.krishna@sanofi.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152202137","display_name":"Adam Reich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108991","display_name":"IQVIA (United States)","ror":"https://ror.org/01mk44223","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Reich","raw_affiliation_strings":["IQVIA, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQVIA, WI, USA","institution_ids":["https://openalex.org/I4210108991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071663083","display_name":"Gerald Lebovic","orcid":"https://orcid.org/0000-0003-3540-3339","observed_orcids":["https://orcid.org/0000-0003-3540-3339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald Lebovic","raw_affiliation_strings":["IQVIA, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQVIA, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024185210","display_name":"ROBERT N. LUBWAMA","orcid":"https://orcid.org/0009-0001-5835-3373","observed_orcids":["https://orcid.org/0009-0001-5835-3373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Lubwama","raw_affiliation_strings":["Sanofi, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020033346","display_name":"Andrea McCracken","orcid":"https://orcid.org/0000-0002-4500-7236","observed_orcids":["https://orcid.org/0000-0002-4500-7236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea McCracken","raw_affiliation_strings":["Guardian Research, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guardian Research, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035416012","display_name":"Manmeet Singh Ahluwalia","orcid":"https://orcid.org/0000-0003-3794-9511","observed_orcids":["https://orcid.org/0000-0003-3794-9511"]},"institutions":[{"id":"https://openalex.org/I1292848113","display_name":"Baptist Hospital of Miami","ror":"https://ror.org/000pfrh90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1292848113","https://openalex.org/I4210097785"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manmeet S. Ahluwalia","raw_affiliation_strings":["Miami Cancer Institute, Baptist Health, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami Cancer Institute, Baptist Health, FL, USA","institution_ids":["https://openalex.org/I1292848113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050135291","display_name":"Alex Seluzhytsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Seluzhytsky","raw_affiliation_strings":["Sanofi, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, MA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5158800783"],"corresponding_institution_ids":[],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":{"value":3200,"currency":"USD","value_usd":3200},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66153127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"9","first_page":"25","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceacam5","display_name":"CEACAM5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6570000052452087},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9769999980926514},{"id":"https://openalex.org/keywords/time-to-treatment-discontinuation","display_name":"time to treatment discontinuation","score":0.847000002861023},{"id":"https://openalex.org/keywords/time-to-next-treatment","display_name":"time to next treatment","score":0.8560000061988831},{"id":"https://openalex.org/keywords/archived-tissue","display_name":"archival tissue","score":0.6100000143051147},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8140000104904175},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.927299976348877},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6933000087738037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6837999820709229},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.611299991607666},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4478999972343445},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.2906999886035919},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cllc.2026.09.004","doi":"https://doi.org/10.1016/j.cllc.2026.09.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2026.09.004","pdf_url":null,"source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},{"id":"pmid:42879962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42879962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical lung cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cllc.2026.09.004","doi":"https://doi.org/10.1016/j.cllc.2026.09.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2026.09.004","pdf_url":null,"source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W14783117","https://openalex.org/W1983011271","https://openalex.org/W2054841768","https://openalex.org/W2086160302","https://openalex.org/W2096322385","https://openalex.org/W2128738136","https://openalex.org/W2175747040","https://openalex.org/W2228708999","https://openalex.org/W3029573274","https://openalex.org/W3091018266","https://openalex.org/W3092480328","https://openalex.org/W3152625822","https://openalex.org/W4318820390","https://openalex.org/W4386189919","https://openalex.org/W4404866036"],"related_works":["https://openalex.org/W7093341826","https://openalex.org/W7204041105","https://openalex.org/W7114793570","https://openalex.org/W2150327482","https://openalex.org/W4399519592","https://openalex.org/W7154843805","https://openalex.org/W1984284188","https://openalex.org/W2557079328","https://openalex.org/W2895122873","https://openalex.org/W2077649016"],"abstract_inverted_index":{"PURPOSE:":[0],"Non-small":[1],"cell":[2,28],"lung":[3,12],"cancer":[4,13],"(NSCLC)":[5],"is":[6,15,200],"the":[7,55,59,89,144],"most":[8],"common":[9],"form":[10],"of":[11,58,77,101,143,189],"and":[14,41,109,115,128,154,168,172],"often":[16],"diagnosed":[17],"at":[18],"an":[19],"advanced":[20],"stage,":[21],"leading":[22],"to":[23,124,130,196],"poor":[24],"prognosis.":[25],"Carcinoembryonic":[26],"antigen-related":[27],"adhesion":[29],"molecule":[30],"5":[31],"(CEACAM5)":[32],"has":[33],"emerged":[34],"as":[35],"a":[36],"potential":[37],"biomarker":[38,61],"in":[39,48,62,140,184],"colorectal":[40],"other":[42,116],"gastrointestinal":[43],"cancer;":[44],"however,":[45],"its":[46],"role":[47,57],"NSCLC":[49,66],"remains":[50],"unexplored.":[51],"This":[52],"study":[53,188],"evaluated":[54],"prognostic":[56,182],"CEACAM5":[60,71,102,136,165,178],"metastatic":[63,155,192],"non-squamous":[64],"(mNSQ)":[65],"using":[67],"real-world":[68,119],"data.":[69],"METHODS:":[70],"expression":[72,103,137,166],"was":[73,88,138],"assessed":[74],"via":[75],"immunohistochemistry":[76],"archival":[78],"tissue":[79],"from":[80],"336":[81],"eligible":[82],"patients.":[83],"Real-world":[84],"overall":[85,145],"survival":[86,121],"(rwOS)":[87],"primary":[90,153],"outcome":[91],"analyzed":[92],"across":[93,151,174],"six":[94],"treatment":[95,126,131],"cohorts.":[96,176],"Secondary":[97],"outcomes":[98,117],"included":[99],"prevalence":[100],"(high,":[104],"moderate,":[105],"negative)":[106],"by":[107],"cohort":[108,187],"tumor":[110,156],"site":[111],"(primary":[112],"vs.":[113],"metastatic)":[114],"including":[118],"progression-free":[120],"(rwPFS),":[122],"time":[123,129],"next":[125],"(rwTTNT),":[127],"discontinuation":[132],"(rwTTD).":[133],"RESULTS:":[134],"High":[135],"observed":[139,150],"approximately":[141],"18%":[142],"population,":[146],"with":[147,191],"consistent":[148],"levels":[149,167],"both":[152],"samples.":[157],"No":[158],"significant":[159],"associations":[160],"were":[161],"found":[162],"between":[163],"different":[164],"rwOS,":[169],"rwPFS,":[170],"rwTTNT,":[171],"rwTTD,":[173],"all":[175],"CONCLUSION:":[177],"did":[179],"not":[180],"demonstrate":[181],"value":[183],"this":[185],"retrospective":[186],"patients":[190],"NSCLC.":[193],"Further":[194],"research":[195],"confirm":[197],"our":[198],"findings":[199],"needed.":[201]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-20T00:00:00"}