{"id":"https://openalex.org/W7213616220","doi":"https://doi.org/10.1186/s13104-026-08031-x","title":"Treatment-associated changes in SESN2, NFATC1, and NRF2 gene expression in rheumatoid arthritis: a comparative study of newly diagnosed and DMARD-treated patients","display_name":"Treatment-associated changes in SESN2, NFATC1, and NRF2 gene expression in rheumatoid arthritis: a comparative study of newly diagnosed and DMARD-treated patients","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7213616220","doi":"https://doi.org/10.1186/s13104-026-08031-x"},"language":"en","primary_location":{"id":"doi:10.1186/s13104-026-08031-x","doi":"https://doi.org/10.1186/s13104-026-08031-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13104-026-08031-x","pdf_url":null,"source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13104-026-08031-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083998511","display_name":"Koushan Sineh Sepehr","orcid":"https://orcid.org/0000-0002-2537-5808","observed_orcids":["https://orcid.org/0000-0002-2537-5808"]},"institutions":[{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Koushan Sineh Sepehr","raw_affiliation_strings":["Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran","institution_ids":["https://openalex.org/I4210127922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152168352","display_name":"Mona Shahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Shahi","raw_affiliation_strings":["Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran","institution_ids":["https://openalex.org/I4210127922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056013152","display_name":"Mehrdad Aghaei","orcid":"https://orcid.org/0000-0002-0143-7306","observed_orcids":["https://orcid.org/0000-0002-0143-7306"]},"institutions":[{"id":"https://openalex.org/I198873322","display_name":"Golestan University","ror":"https://ror.org/046nf9z89","country_code":"IR","type":"education","lineage":["https://openalex.org/I198873322"]},{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Aghaei","raw_affiliation_strings":["Golestan Rheumatology Research Center, Biomedical Research Institute, Golestan University of Medical Science, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Golestan Rheumatology Research Center, Biomedical Research Institute, Golestan University of Medical Science, Gorgan, Iran","institution_ids":["https://openalex.org/I198873322","https://openalex.org/I4210127922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116409821","display_name":"Romina Malakouti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Romina Malakouti","raw_affiliation_strings":["Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran","institution_ids":["https://openalex.org/I4210127922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057222024","display_name":"Zahra Hesari","orcid":"https://orcid.org/0000-0002-5399-8631","observed_orcids":["https://orcid.org/0000-0002-5399-8631"]},"institutions":[{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Zahra Hesari","raw_affiliation_strings":["Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran","institution_ids":["https://openalex.org/I4210127922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057222024"],"corresponding_institution_ids":["https://openalex.org/I4210127922"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/sestrin2","display_name":"Sestrin2","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7279999852180481},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9089999794960022},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7373999953269958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7110000252723694},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6517000198364258},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5824999809265137},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5609999895095825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5486000180244446},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.46950000524520874},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46650001406669617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43939998745918274},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.38350000977516174},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.3529999852180481},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26339998841285706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13104-026-08031-x","doi":"https://doi.org/10.1186/s13104-026-08031-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13104-026-08031-x","pdf_url":null,"source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13104-026-08031-x","doi":"https://doi.org/10.1186/s13104-026-08031-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13104-026-08031-x","pdf_url":null,"source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313256901","https://openalex.org/W4392862217","https://openalex.org/W4408159981","https://openalex.org/W4405030769","https://openalex.org/W2742890916","https://openalex.org/W2360892731","https://openalex.org/W1847132790","https://openalex.org/W2756425874","https://openalex.org/W4409464645","https://openalex.org/W2320619523"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3,186],"an":[4,55,121],"autoimmune":[5],"disorder":[6],"characterized":[7],"by":[8],"uncontrolled":[9],"joint":[10],"inflammation":[11],"and":[12,24,40,72,89,111,132,194,220,225],"progressive":[13],"structural":[14],"damage":[15],"in":[16,74,87,98,124,158,222],"the":[17,64,125,165,189,215],"joints.":[18],"Sestrin":[19],"2":[20,28],"(":[21,29,50,107,113,142,172],"SESN2":[22,68,93,184],")":[23,31,52],"nuclear":[25,43],"factor":[26,44],"erythroid-related":[27],"NRF2":[30,70,118,219],"acts":[32,53],"as":[33,54,84,199],"critical":[34],"regulators":[35],"of":[36,45,59,67,192,218],"cellular":[37],"redox":[38],"homeostasis":[39],"autophagy,":[41],"while":[42],"activated":[46],"T":[47],"cells":[48,78],"1":[49],"NFATC1":[51,73,151,221],"early":[56],"transcriptional":[57,65],"stimulator":[58],"osteoclastogenesis.":[60],"This":[61],"study":[62],"evaluated":[63],"profiles":[66],",":[69,71],"peripheral":[75],"blood":[76],"mononuclear":[77],"(PBMCs)":[79],"to":[80,213,227],"evaluate":[81],"their":[82],"utility":[83],"potential":[85,201,216],"biomarkers":[86],"untreated":[88,126],"DMARD-treated":[90,105],"RA":[91,101,160,193,223],"groups.":[92],"expression":[94,119,185],"was":[95],"significantly":[96],"increased":[97],"newly":[99],"diagnosed":[100],"patients":[102,131,161],"compared":[103,128,163],"with":[104,129,164,188,207],"subjects":[106],"p":[108,114,143,147,173,177],"=":[109,115,144,148,174,178],"0.029)":[110],"controls":[112],"0.004).":[116],"Similarly,":[117],"showed":[120,153],"upward":[122],"trend":[123,157],"group":[127],"treated":[130],"controls,":[133],"although":[134],"these":[135],"differences":[136],"did":[137],"not":[138],"reach":[139],"statistical":[140,170],"significance":[141,171],"0.088":[145],"&":[146,176],"0.103).":[149],"Conversely,":[150],"transcription":[152],"a":[154,200],"subtle":[155],"downward":[156],"both":[159],"subgroups":[162],"control":[166],"group,":[167],"without":[168],"reaching":[169],"0.176":[175],"0.095).":[179],"These":[180],"findings":[181],"suggest":[182],"that":[183],"associated":[187],"clinical/treatment":[190],"status":[191],"may":[195],"warrant":[196],"further":[197,205],"investigation":[198],"molecular":[202],"marker.":[203],"However,":[204],"studies":[206],"larger":[208],"sample":[209],"sizes":[210],"are":[211],"needed":[212],"clarify":[214],"roles":[217],"pathogenesis":[224],"response":[226],"treatment.":[228]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-20T00:00:00"}